{"id":"https://openalex.org/W2056760026","doi":"https://doi.org/10.1161/01.str.24.12.1874","title":"Lacunar infarcts and white matter attenuation. Ophthalmologic and microcirculatory aspects of the pathophysiology.","display_name":"Lacunar infarcts and white matter attenuation. Ophthalmologic and microcirculatory aspects of the pathophysiology.","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W2056760026","doi":"https://doi.org/10.1161/01.str.24.12.1874","mag":"2056760026","pmid":"https://pubmed.ncbi.nlm.nih.gov/8248970"},"language":"en","primary_location":{"id":"doi:10.1161/01.str.24.12.1874","doi":"https://doi.org/10.1161/01.str.24.12.1874","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.str.24.12.1874","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111102486","display_name":"R Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Schneider","raw_affiliation_strings":["Department of Neurology, Rheinisch-Westfaelische Technische Hochschule Aachen, University Hospital, FRG","R Schneider Department of Neurology, Rheinisch-Westfaelische Technische Hochschule Aachen, University Hospital, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Rheinisch-Westfaelische Technische Hochschule Aachen, University Hospital, FRG","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]},{"raw_affiliation_string":"R Schneider Department of Neurology, Rheinisch-Westfaelische Technische Hochschule Aachen, University Hospital, FRG","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048019085","display_name":"Michael Rademacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Rademacher","raw_affiliation_strings":["Department of Neurology, Rheinisch-Westfaelische Technische Hochschule Aachen, University Hospital, FRG","M Rademacher Department of Neurology, Rheinisch-Westfaelische Technische Hochschule Aachen, University Hospital, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Rheinisch-Westfaelische Technische Hochschule Aachen, University Hospital, FRG","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]},{"raw_affiliation_string":"M Rademacher Department of Neurology, Rheinisch-Westfaelische Technische Hochschule Aachen, University Hospital, FRG","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015339066","display_name":"Sebasti\u00e1n Wolf","orcid":"https://orcid.org/0000-0002-7467-7028","observed_orcids":["https://orcid.org/0000-0002-7467-7028","https://orcid.org/0000-0002-6852-8798"]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Wolf","raw_affiliation_strings":["Department of Neurology, Rheinisch-Westfaelische Technische Hochschule Aachen, University Hospital, FRG","S Wolf Department of Neurology, Rheinisch-Westfaelische Technische Hochschule Aachen, University Hospital, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Rheinisch-Westfaelische Technische Hochschule Aachen, University Hospital, FRG","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]},{"raw_affiliation_string":"S Wolf Department of Neurology, Rheinisch-Westfaelische Technische Hochschule Aachen, University Hospital, FRG","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"12","first_page":"1874","last_page":"1879"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.26899999380111694,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.26899999380111694,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.21089999377727509,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12599","display_name":"Retinal and Optic Conditions","score":0.1404000073671341,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lacunar-infarction","display_name":"lacunar infarction","score":0.8830000162124634},{"id":"https://openalex.org/keywords/retinal-microvasculature","display_name":"retinal microvasculature","score":0.9860000014305115},{"id":"https://openalex.org/keywords/arteriosclerosis","display_name":"arteriosclerosis","score":0.5180000066757202},{"id":"https://openalex.org/keywords/stroke-pathophysiology","display_name":"stroke pathophysiology","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.956303596496582},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.7889484763145447},{"id":"https://openalex.org/C2779285336","wikidata":"https://www.wikidata.org/wiki/Q6469117","display_name":"Lacunar stroke","level":4,"score":0.6504984498023987},{"id":"https://openalex.org/C3020298707","wikidata":"https://www.wikidata.org/wiki/Q6469117","display_name":"Lacunar infarction","level":4,"score":0.583512544631958},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.5833048820495605},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4867246448993683},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4680561423301697},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34696558117866516},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.29970312118530273},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.27842748165130615},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.2624218463897705},{"id":"https://openalex.org/C2779450755","wikidata":"https://www.wikidata.org/wiki/Q1209150","display_name":"Cerebral infarction","level":3,"score":0.19941195845603943},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.19757506251335144},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005128","descriptor_name":"Eye Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009898","descriptor_name":"Optic Disk","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1161/01.str.24.12.1874","doi":"https://doi.org/10.1161/01.str.24.12.1874","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.str.24.12.1874","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},{"id":"pmid:8248970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8248970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"Journal Article"},{"id":"pmh:oai:publications.rwth-aachen.de:232729","doi":null,"is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/record/232729","pdf_url":null,"source":{"id":"https://openalex.org/S4306401033","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stroke 24(12), 1874-1879 (1993). doi:10.1161/01.STR.24.12.1874","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2189056002","doi":null,"is_oa":false,"landing_page_url":"https://stroke.ahajournals.org/content/24/12/1874.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:3149660543","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/str.24.12.8248970?related-urls=yes&legid=strokeaha%3B24%2F12%2F1874&legid=strokeaha%3B24%2F12%2F1874&cited-by=yes","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Stroke","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W713818","https://openalex.org/W1972942629","https://openalex.org/W1981357666","https://openalex.org/W1981413846","https://openalex.org/W1987647647","https://openalex.org/W1988148555","https://openalex.org/W1994118653","https://openalex.org/W2003637316","https://openalex.org/W2017159332","https://openalex.org/W2025089581","https://openalex.org/W2037716738","https://openalex.org/W2038313195","https://openalex.org/W2039378019","https://openalex.org/W2047098083","https://openalex.org/W2048086951","https://openalex.org/W2050414132","https://openalex.org/W2051568551","https://openalex.org/W2052024499","https://openalex.org/W2059195201","https://openalex.org/W2059792495","https://openalex.org/W2062675775","https://openalex.org/W2071837886","https://openalex.org/W2072243647","https://openalex.org/W2075670434","https://openalex.org/W2083406033","https://openalex.org/W2084085931","https://openalex.org/W2099203231","https://openalex.org/W2101620652","https://openalex.org/W2106358053","https://openalex.org/W2121044470","https://openalex.org/W2129767636","https://openalex.org/W2135876850","https://openalex.org/W2136432656","https://openalex.org/W2155664133","https://openalex.org/W2163219446","https://openalex.org/W2274873430","https://openalex.org/W2410903642","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7048856904","https://openalex.org/W1987694495","https://openalex.org/W1997168958","https://openalex.org/W1985514129","https://openalex.org/W7151441881","https://openalex.org/W2355327753","https://openalex.org/W2044578296","https://openalex.org/W1995082060","https://openalex.org/W169457017","https://openalex.org/W2509906608"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"By":[3],"means":[4],"of":[5,233,237],"neurological":[6,49,116],"and":[7,22,29,90,97,102,129,134,212,240,249],"ophthalmologic":[8,103,122,162],"examinations":[9],"we":[10],"considered":[11],"whether":[12,30],"there":[13,31],"is":[14],"a":[15,52,147],"microcirculatory":[16,33],"disorder":[17,232],"not":[18],"related":[19],"to":[20,66],"hypertension":[21,239],"diabetes":[23],"in":[24,35,184,195],"patients":[25,36,50,71,75,85,92,117,123,142,185,196],"with":[26,37,41,43,51,76,86,93,120,143,186,197,224,255],"lacunar":[27,38,53,82,87,95,144,198,213,225,250],"infarcts":[28,39,88,96,145,199,214,226,251],"are":[32,227],"differences":[34],"compared":[40,119],"those":[42],"white":[44,77,98,187,209,246],"matter":[45,78,99,188,210,247],"attenuation.":[46,100],"METHODS:":[47],"Eighty":[48],"infarct":[54],"underwent":[55],"computed":[56],"tomography":[57],"and,":[58],"based":[59],"on":[60],"the":[61,140,161,174],"results,":[62],"were":[63,105,118],"prospectively":[64],"assigned":[65],"subgroups":[67],"as":[68],"follows:":[69],"(1)":[70],"without":[72,81],"changes;":[73],"(2)":[74],"attenuation":[79,189,211,248],"but":[80,191],"infarcts;":[83],"(3)":[84],"alone;":[89],"(4)":[91],"both":[94,208],"Clinical":[101],"parameters":[104],"monitored.":[106],"The":[107],"retinal":[108,175,234],"microcirculation":[109,176,235],"was":[110,177,192],"studied":[111],"by":[112,229],"videofluorescence":[113],"angiography.":[114],"These":[115],"control":[121,163],"matched":[124],"for":[125],"age,":[126],"sex,":[127],"hypertensive":[128],"diabetic":[130],"ocular":[131],"fundus":[132],"changes,":[133],"smoking":[135],"habits.":[136],"RESULTS:":[137],"On":[138],"average,":[139],"80":[141],"had":[146],"significantly":[148,193],"(P":[149],"=":[150,205,220],".0001)":[151],"slower":[152],"arteriovenous":[153],"passage":[154,171],"time":[155,172],"(2.6":[156],"+/-":[157,166,181,201,216],"0.7":[158],"seconds)":[159,183],"than":[160],"subjects":[164],"(1.6":[165],"0.6":[167],"seconds).":[168],"Arteriovenous":[169],"dye":[170],"through":[173],"nearly":[178],"normal":[179],"(2.2":[180],"0.8":[182,202],"alone,":[190],"prolonged":[194],"(2.9":[200],"seconds,":[203,218],"P":[204,219],".00085)":[206],"or":[207],"(2.8":[215],"0.4":[217],".008).":[221],"CONCLUSIONS:":[222],"Patients":[223],"characterized":[228],"an":[230],"additional":[231],"independent":[236],"arterial":[238],"diabetes.":[241],"Our":[242],"data":[243],"suggested":[244],"that":[245],"may":[252],"be":[253],"phenomena":[254],"only":[256],"weak":[257],"interdependence.":[258]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}