{"id":"https://openalex.org/W2056742885","doi":"https://doi.org/10.1118/1.4734811","title":"SU\u2010E\u2010I\u201094: External Beam Radiation Cherenkov Emission in Tissue Used for Tissue Oxygen Sensing","display_name":"SU\u2010E\u2010I\u201094: External Beam Radiation Cherenkov Emission in Tissue Used for Tissue Oxygen Sensing","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W2056742885","doi":"https://doi.org/10.1118/1.4734811","mag":"2056742885","pmid":"https://pubmed.ncbi.nlm.nih.gov/28517630"},"language":"en","primary_location":{"id":"doi:10.1118/1.4734811","doi":"https://doi.org/10.1118/1.4734811","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.4734811","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047572725","display_name":"R Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Zhang","raw_affiliation_strings":["Dartmouth College, Hanover, NH","University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth College, Hanover, NH","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054868417","display_name":"Stephen Chad Kanick","orcid":"https://orcid.org/0000-0002-2046-8298","observed_orcids":["https://orcid.org/0000-0002-2046-8298"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Kanick","raw_affiliation_strings":["Dartmouth College, Hanover, NH","University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth College, Hanover, NH","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085548406","display_name":"Sergei A. Vinogradov","orcid":"https://orcid.org/0000-0002-4649-5534","observed_orcids":["https://orcid.org/0000-0002-4649-5534"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Vinogradov","raw_affiliation_strings":["Dartmouth College, Hanover, NH","University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth College, Hanover, NH","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082989720","display_name":"Tatiana V. Esipova","orcid":"https://orcid.org/0000-0002-1172-419X","observed_orcids":["https://orcid.org/0000-0002-1172-419X"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Esipova","raw_affiliation_strings":["Dartmouth College, Hanover, NH","University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth College, Hanover, NH","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089497655","display_name":"Brian W. Pogue","orcid":"https://orcid.org/0000-0002-9887-670X","observed_orcids":["https://orcid.org/0000-0002-9887-670X"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Pogue","raw_affiliation_strings":["Dartmouth College, Hanover, NH","University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dartmouth College, Hanover, NH","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15076023,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"6Part5","first_page":"3646","last_page":"3647"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.6323000192642212,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.6323000192642212,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.17100000381469727,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.06679999828338623,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cherenkov-radiation","display_name":"Cherenkov radiation","score":0.847000002861023},{"id":"https://openalex.org/keywords/tissue-oxygenation","display_name":"tissue oxygenation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/phosphorescence-lifetime","display_name":"phosphorescence lifetime","score":0.902999997138977},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.7129999995231628},{"id":"https://openalex.org/keywords/electron-irradiation","display_name":"electron irradiation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tissue-phantoms","display_name":"tissue phantoms","score":0.8960000276565552},{"id":"https://openalex.org/keywords/monte-carlo-simulation","display_name":"Monte Carlo simulation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/radiotherapy-monitoring","display_name":"radiotherapy monitoring","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C72591435","wikidata":"https://www.wikidata.org/wiki/Q192457","display_name":"Cherenkov radiation","level":3,"score":0.7765201926231384},{"id":"https://openalex.org/C104293457","wikidata":"https://www.wikidata.org/wiki/Q28324852","display_name":"Imaging phantom","level":2,"score":0.7750005722045898},{"id":"https://openalex.org/C181817918","wikidata":"https://www.wikidata.org/wiki/Q192275","display_name":"Phosphorescence","level":3,"score":0.6721476316452026},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.6685833930969238},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.6014769673347473},{"id":"https://openalex.org/C180048950","wikidata":"https://www.wikidata.org/wiki/Q836828","display_name":"Linear particle accelerator","level":3,"score":0.5309046506881714},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.512787401676178},{"id":"https://openalex.org/C2780271382","wikidata":"https://www.wikidata.org/wiki/Q4993917","display_name":"Truebeam","level":4,"score":0.47767361998558044},{"id":"https://openalex.org/C194232370","wikidata":"https://www.wikidata.org/wiki/Q162","display_name":"Optical fiber","level":2,"score":0.46192118525505066},{"id":"https://openalex.org/C168834538","wikidata":"https://www.wikidata.org/wiki/Q3705329","display_name":"Beam (structure)","level":2,"score":0.4596623182296753},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.45025834441185},{"id":"https://openalex.org/C153385146","wikidata":"https://www.wikidata.org/wiki/Q18335","display_name":"Radiation","level":2,"score":0.4274214506149292},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3260893225669861},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.22835811972618103},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.17615604400634766},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.126137375831604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07054156064987183},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1118/1.4734811","doi":"https://doi.org/10.1118/1.4734811","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.4734811","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"},{"id":"pmid:28517630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28517630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical physics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2916467405","https://openalex.org/W2050895423","https://openalex.org/W1981361786","https://openalex.org/W1969967347","https://openalex.org/W2061353820","https://openalex.org/W1968179195","https://openalex.org/W2045903837","https://openalex.org/W3188208481","https://openalex.org/W2038962469","https://openalex.org/W2780368862"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"show":[2,226],"that":[3,213,227],"Cherenkov":[4,232],"emission":[5],"is":[6,75,111,143,154,160,214],"generated":[7,90],"by":[8,77,91,145,156,162,168,216,261],"external":[9,79,298],"radiotherapy":[10,80],"beam":[11,82,202,299],"in":[12,48,71,293,295],"tissue,":[13],"and":[14,32,43,68,159,201,250,258],"could":[15,255],"serve":[16],"as":[17],"optical":[18,115,193,218],"source":[19],"to":[20,113,117,121,164,187],"excite":[21],"an":[22,165,236,277],"oxygen":[23,278],"sensitive":[24,279],"phosphor,":[25],"Oxyphor":[26,69],"G4,":[27],"within":[28,210,242],"tissue.":[29],"The":[30],"intensity":[31],"lifetime":[33],"of":[34,87,105,135,137,152,177,182,191,198,220,247,252,283],"the":[35,45,49,106,146,178,189,192,207,211,217,221,231,243,248,253,262],"phosphorescence":[36,138,153,249],"was":[37],"measured":[38,144,257],"with":[39,57,276],"a":[40,84,92,108,118,122,133,196,289],"time-gated":[41],"system":[42,194],"reveals":[44],"oxygenation":[46,131,287],"levels":[47],"tissue":[50,54,244,286,294],"phantom.":[51,245],"METHODS:":[52],"A":[53],"phantom":[55,212,254],"made":[56],"PBS,":[58],"1%":[59,64],"v/v":[60,65],"Intralipid-20%":[61],"(Sigma":[62],"Aldrich),":[63],"whole":[66],"blood":[67],"G4":[70],"1":[72],"\u03bcM":[73],"concentration":[74],"irradiated":[76],"18MeV":[78],"electron":[81],"at":[83,139],"dose":[85],"rate":[86],"4":[88],"Gy/min":[89],"medical":[93],"linear":[94],"accelerator":[95],"(Varian":[96],"LINAC":[97],"2100C,":[98],"Varian":[99],"Medical":[100],"Systems).":[101],"On":[102],"one":[103],"side":[104],"phantom,":[107],"fiber":[109,179],"bundle":[110],"used":[112],"conduct":[114],"signal":[116],"spectrometer":[119],"connected":[120],"fast":[123],"gating":[124,149,265,273],"ICCD":[125],"(PI-MAX3,":[126],"Princeton":[127],"Instruments).":[128],"For":[129],"each":[130],"level,":[132],"series":[134],"spectrum":[136],"different":[140],"time":[141,147,263,271],"points":[142],"domain":[148,170,264,272],"technique.":[150],"Lifetime":[151,246],"analyzed":[155],"exponential":[157],"fitting":[158],"validated":[161],"comparison":[163],"independent":[166],"analysis":[167],"frequency":[169],"phosphorimetry.":[171],"Monte":[172],"Carlo":[173],"simulations":[174],"using":[175],"GEANT4,":[176],"optic":[180],"collection":[181,219],"Cerenkov":[183,222],"light":[184],"were":[185],"performed":[186],"decide":[188],"sensitivity":[190],"for":[195],"range":[197],"specified":[199],"geometries":[200],"types.":[203],"Simulation":[204],"results":[205],"identify":[206],"effective":[208],"depth":[209,240,292],"sampled":[215],"signal.":[223],"RESULTS:":[224],"Simulations":[225],"we":[228],"can":[229],"detect":[230],"signals":[233],"comes":[234],"from":[235,241,288],"approximately":[237],"5":[238],"mm":[239],"pO2":[251],"be":[256],"calculated":[259],"correctly":[260],"system.":[266],"CONCLUSIONS:":[267],"This":[268],"work":[269],"indicates":[270],"techniques":[274],"combined":[275],"phosphor":[280],"are":[281],"capable":[282],"accurately":[284],"monitoring":[285],"reasonable":[290],"sampling":[291],"vivo":[296],"during":[297],"radiotherapy.":[300],"NIH":[301],"grant":[302],"R01CA109558.":[303]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
