{"id":"https://openalex.org/W2056741592","doi":"https://doi.org/10.1111/jce.12015","title":"Conduction Slowing Contributes to Spontaneous Ventricular Arrhythmias in Intrinsically Active Murine RyR2\u2010P2328S Hearts","display_name":"Conduction Slowing Contributes to Spontaneous Ventricular Arrhythmias in Intrinsically Active Murine RyR2\u2010P2328S Hearts","publication_year":2012,"publication_date":"2012-09-17","ids":{"openalex":"https://openalex.org/W2056741592","doi":"https://doi.org/10.1111/jce.12015","mag":"2056741592","pmid":"https://pubmed.ncbi.nlm.nih.gov/23131176"},"language":"en","primary_location":{"id":"doi:10.1111/jce.12015","doi":"https://doi.org/10.1111/jce.12015","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jce.12015","pdf_url":null,"source":{"id":"https://openalex.org/S143832381","display_name":"Journal of Cardiovascular Electrophysiology","issn_l":"1045-3873","issn":["1045-3873","1540-8167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Electrophysiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100623320","display_name":"Yanmin Zhang","orcid":"https://orcid.org/0000-0001-7580-4693","observed_orcids":["https://orcid.org/0000-0001-7580-4693"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"YANMIN ZHANG","raw_affiliation_strings":["Physiological Laboratory, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiological Laboratory, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100746653","display_name":"Jingjing Wu","orcid":"https://orcid.org/0000-0002-6396-817X","observed_orcids":["https://orcid.org/0000-0002-6396-817X"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JINGJING WU","raw_affiliation_strings":["Union Hospital, Huazhong University of Sciences and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Union Hospital, Huazhong University of Sciences and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074565083","display_name":"Kamalan Jeevaratnam","orcid":"https://orcid.org/0000-0002-6232-388X","observed_orcids":["https://orcid.org/0000-0002-6232-388X"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I4210096221","display_name":"Perdana University","ror":"https://ror.org/00wfd0g93","country_code":"MY","type":"education","lineage":["https://openalex.org/I4210096221"]}],"countries":["IE","MY"],"is_corresponding":false,"raw_author_name":"KAMALAN JEEVARATNAM","raw_affiliation_strings":["Perdana University-Royal College of Surgeons in Ireland, Serdang, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perdana University-Royal College of Surgeons in Ireland, Serdang, Selangor, Malaysia","institution_ids":["https://openalex.org/I142762351","https://openalex.org/I4210096221"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113586114","display_name":"James Harmsworth King","orcid":"https://orcid.org/0009-0007-6541-3753","observed_orcids":["https://orcid.org/0009-0007-6541-3753"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"JAMES H. KING","raw_affiliation_strings":["Physiological Laboratory, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiological Laboratory, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047963431","display_name":"Laila Guzadhur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"LAILA GUZADHUR","raw_affiliation_strings":["Physiological Laboratory, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiological Laboratory, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101899375","display_name":"Xiaolei Ren","orcid":"https://orcid.org/0009-0004-6191-3134","observed_orcids":["https://orcid.org/0009-0004-6191-3134"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"XIAOLEI REN","raw_affiliation_strings":["School of Physiology and Pharmacology; University of Bristol; Bristol UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Physiology and Pharmacology; University of Bristol; Bristol UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000336640","display_name":"Andrew A. Grace","orcid":"https://orcid.org/0000-0002-0686-215X","observed_orcids":["https://orcid.org/0000-0002-0686-215X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"ANDREW A. GRACE","raw_affiliation_strings":["Cardiovascular Biology Group, Department of Biochemistry, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Biology Group, Department of Biochemistry, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107094272","display_name":"Ming Lei","orcid":"https://orcid.org/0000-0002-0928-341X","observed_orcids":["https://orcid.org/0000-0002-0928-341X","https://orcid.org/0000-0002-1153-4791"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"MING LEI","raw_affiliation_strings":["Institute of Cardiovascular Science, University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular Science, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018416044","display_name":"Christopher L.-H. Huang","orcid":"https://orcid.org/0000-0001-9553-6112","observed_orcids":["https://orcid.org/0000-0001-9553-6112"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"CHRISTOPHER L.\u2010H. HUANG","raw_affiliation_strings":["Cardiovascular Biology Group, Department of Biochemistry, University of Cambridge, Cambridge, UK","Physiological Laboratory, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Biology Group, Department of Biochemistry, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Physiological Laboratory, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009468759","display_name":"James A. Fraser","orcid":"https://orcid.org/0000-0002-6505-1883","observed_orcids":["https://orcid.org/0000-0002-6505-1883"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"JAMES A. FRASER","raw_affiliation_strings":["\u2002Physiological Laboratory, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2002Physiological Laboratory, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.0637,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.88333604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"2","first_page":"210","last_page":"218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/catecholaminergic-polymorphic-ventricular-tachycardia","display_name":"catecholaminergic polymorphic ventricular tachycardia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ryanodine-receptor-2","display_name":"RyR2","score":0.8209999799728394},{"id":"https://openalex.org/keywords/bidirectional-ventricular-tachycardia","display_name":"bidirectional ventricular tachycardia","score":0.9100000262260437},{"id":"https://openalex.org/keywords/polymorphic-ventricular-tachycardia","display_name":"polymorphic ventricular tachycardia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/arrhythmogenic-substrate","display_name":"arrhythmogenic substrate","score":0.796999990940094},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.8479999899864197},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.949999988079071},{"id":"https://openalex.org/keywords/ventricular-conduction-velocity","display_name":"ventricular conduction velocity","score":0.7260000109672546},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C2778178275","wikidata":"https://www.wikidata.org/wiki/Q1649897","display_name":"Catecholaminergic polymorphic ventricular tachycardia","level":5,"score":0.9460867643356323},{"id":"https://openalex.org/C190712762","wikidata":"https://www.wikidata.org/wiki/Q18031341","display_name":"Ryanodine receptor 2","level":4,"score":0.871898889541626},{"id":"https://openalex.org/C2776331378","wikidata":"https://www.wikidata.org/wiki/Q56002","display_name":"Ventricular tachycardia","level":2,"score":0.7338610887527466},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.724346935749054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7103503346443176},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.7000538110733032},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6981192827224731},{"id":"https://openalex.org/C153430590","wikidata":"https://www.wikidata.org/wiki/Q184855","display_name":"Bigeminy","level":3,"score":0.5828430652618408},{"id":"https://openalex.org/C2781005686","wikidata":"https://www.wikidata.org/wiki/Q848662","display_name":"Ventricular fibrillation","level":2,"score":0.5475583076477051},{"id":"https://openalex.org/C2780283014","wikidata":"https://www.wikidata.org/wiki/Q209583","display_name":"Tachycardia","level":2,"score":0.47662651538848877},{"id":"https://openalex.org/C2777356233","wikidata":"https://www.wikidata.org/wiki/Q1001150","display_name":"Fibrillation","level":3,"score":0.46559298038482666},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.2591869831085205},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09038713574409485}],"mesh":[{"descriptor_ui":"D000098850","descriptor_name":"Polymorphic Catecholaminergic Ventricular Tachycardia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017180","descriptor_name":"Tachycardia, Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/jce.12015","doi":"https://doi.org/10.1111/jce.12015","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jce.12015","pdf_url":null,"source":{"id":"https://openalex.org/S143832381","display_name":"Journal of Cardiovascular Electrophysiology","issn_l":"1045-3873","issn":["1045-3873","1540-8167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Electrophysiology","raw_type":"journal-article"},{"id":"pmid:23131176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23131176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular electrophysiology","raw_type":"Journal Article"},{"id":"pmh:oai:alma.44SUR_INST:11139894560002346","doi":null,"is_oa":false,"landing_page_url":"http://www.ncbi.nlm.nih.gov/pubmed/23131176","pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"Open Research (University of Surrey)","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:epubs.surrey.ac.uk:827841","doi":null,"is_oa":false,"landing_page_url":"http://epubs.surrey.ac.uk/827841/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400680","display_name":"Surrey Research Insight Open Access (The University of Surrey)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28290843","host_organization_name":"University of Surrey","host_organization_lineage":["https://openalex.org/I28290843"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1477167498","display_name":"Regulation of cardiac automaticity and conduction in murine hearts with a cardiac-specific deletion of P21 activated kinase-1","funder_award_id":"PG/11/59/29006","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G2769289633","display_name":"Age-related atrial remodelling and arrhythmogenesis in mice with atrial myocyte specific genetic deficiency of MKK4","funder_award_id":"PG/12/21/29473","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G8787611345","display_name":"Cardiac electrophysiological homeostasis","funder_award_id":"BB/F023863/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1963765306","https://openalex.org/W1967658895","https://openalex.org/W1969120794","https://openalex.org/W1971192897","https://openalex.org/W1971653362","https://openalex.org/W1979173978","https://openalex.org/W1980232262","https://openalex.org/W1983905571","https://openalex.org/W1988998632","https://openalex.org/W1994221403","https://openalex.org/W1996439106","https://openalex.org/W1996943772","https://openalex.org/W1997939828","https://openalex.org/W2011041203","https://openalex.org/W2012760372","https://openalex.org/W2031426329","https://openalex.org/W2044965957","https://openalex.org/W2050824263","https://openalex.org/W2058216677","https://openalex.org/W2060110177","https://openalex.org/W2081524260","https://openalex.org/W2095741885","https://openalex.org/W2100477955","https://openalex.org/W2100922563","https://openalex.org/W2105658413","https://openalex.org/W2105896123","https://openalex.org/W2112547419","https://openalex.org/W2118727366","https://openalex.org/W2120857823","https://openalex.org/W2125554738","https://openalex.org/W2128499270","https://openalex.org/W2130827085","https://openalex.org/W2134407453","https://openalex.org/W2140687234","https://openalex.org/W2147347783","https://openalex.org/W2153869748","https://openalex.org/W2153869960","https://openalex.org/W2161449504","https://openalex.org/W2162709580","https://openalex.org/W2164350848","https://openalex.org/W2170620661","https://openalex.org/W2171543660"],"related_works":["https://openalex.org/W2229704428","https://openalex.org/W1968227643","https://openalex.org/W2162079750","https://openalex.org/W2095741885","https://openalex.org/W2074643515","https://openalex.org/W2140687234","https://openalex.org/W2062112253","https://openalex.org/W3080089693","https://openalex.org/W2107447155","https://openalex.org/W2596494405"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1],"familial":[2],"condition":[3],"catecholaminergic":[4],"polymorphic":[5,17],"ventricular":[6,14,18,22,107,188],"tachycardia":[7,15,19],"(CPVT)":[8],"is":[9,28],"characterized":[10],"by":[11],"episodic":[12],"bidirectional":[13],"(BVT),":[16],"(PVT),":[20],"and":[21,67,109,126,143,156,158],"fibrillation":[23],"following":[24,63],"adrenergic":[25],"challenge.":[26],"It":[27],"associated":[29,199],"with":[30,91,196,200],"mutations":[31],"involving":[32],"the":[33,57,79,92,96,101,205],"cardiac":[34],"ryanodine":[35],"receptor":[36],"(RyR2).":[37],"METHODS":[38],"AND":[39],"RESULTS:":[40],"We":[41,185],"explored":[42],"for":[43,56,204],"a":[44,54,161],"slowing":[45],"of":[46,65,81,103,147,169],"myocardial":[47,189],"conduction":[48,118],"that":[49,60],"could":[50],"potentially":[51,191],"result":[52],"in":[53,69,84,95,113,139,175,193],"substrate":[55,195],"spontaneous":[58],"arrhythmogenesis":[59],"was":[61,166],"observed":[62],"introduction":[64],"isoproterenol":[66],"caffeine":[68],"intrinsically":[70],"beating":[71],"murine":[72],"RyR2-P2328S":[73],"hearts.":[74],"Such":[75],"pharmacological":[76],"challenge":[77,146],"increased":[78],"number":[80],"arrhythmic":[82,163,197],"episodes":[83],"electrocardiographic":[85],"recordings":[86,125],"from":[87],"intact":[88],"anesthetized":[89],"mice,":[90],"greatest":[93],"effects":[94],"homozygote":[97],"RyR2(S/S).":[98,144],"Arrhythmias":[99],"took":[100],"form":[102],"bigeminy,":[104],"BVT,":[105],"monomorphic":[106],"tachycardia,":[108],"PVT,":[110],"as":[111],"found":[112],"human":[114],"CPVT.":[115],"Ventricular":[116],"epicardial":[117],"velocities":[119],"(CVs)":[120],"measured":[121,133],"using":[122,134],"multielectrode":[123],"array":[124],"maximum":[127],"action":[128],"potential":[129],"upstroke":[130],"rates,":[131],"(dV/dt)(max),":[132],"intracellular":[135],"microelectrodes":[136],"were":[137],"indistinguishable":[138],"untreated":[140],"wild-type":[141],"(WT)":[142],"Pharmacological":[145],"RyR2(S/S),":[148],"but":[149],"not":[150],"WT":[151],"hearts,":[152],"then":[153],"reduced":[154],"CV":[155,190],"(dV/dt)(max)":[157],"also":[159],"revealed":[160],"strongly":[162],"phenotype.":[164],"There":[165],"no":[167],"evidence":[168],"gross":[170],"structural":[171],"or":[172,178],"fibrotic":[173],"changes":[174],"either":[176],"RyR2(+/S)":[177],"RyR2(S/S)":[179],"hearts":[180],"on":[181],"light":[182],"microscopy.":[183],"CONCLUSIONS:":[184],"associate":[186],"altered":[187],"resulting":[192],"arrhythmogenic":[194],"properties":[198],"genetic":[201],"RyR2":[202],"alterations":[203],"first":[206],"time.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}