{"id":"https://openalex.org/W2056728945","doi":"https://doi.org/10.1073/pnas.81.5.1302","title":"beta-Lactamase-catalyzed hydrolysis of acyclic depsipeptides and acyl transfer to specific amino acid acceptors.","display_name":"beta-Lactamase-catalyzed hydrolysis of acyclic depsipeptides and acyl transfer to specific amino acid acceptors.","publication_year":1984,"publication_date":"1984-03-01","ids":{"openalex":"https://openalex.org/W2056728945","doi":"https://doi.org/10.1073/pnas.81.5.1302","mag":"2056728945","pmid":"https://pubmed.ncbi.nlm.nih.gov/6424114","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/344821"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.81.5.1302","doi":"https://doi.org/10.1073/pnas.81.5.1302","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.81.5.1302","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC344821","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082781225","display_name":"Rex F. Pratt","orcid":"https://orcid.org/0000-0002-1381-2556","observed_orcids":["https://orcid.org/0000-0002-1381-2556"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R F Pratt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073784193","display_name":"Chandrika P. Govardhan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C P Govardhan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9769,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.94480755,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"81","issue":"5","first_page":"1302","last_page":"1306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13489","display_name":"Synthesis of \u03b2-Lactam Compounds","score":0.21809999644756317,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.06849999725818634,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-lactamase","display_name":"beta-lactamase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/acyl-transfer","display_name":"acyl transfer","score":0.8149999976158142},{"id":"https://openalex.org/keywords/class-a-beta-lactamase","display_name":"class A beta-lactamase","score":0.8379999995231628},{"id":"https://openalex.org/keywords/class-b-beta-lactamases","display_name":"class B beta-lactamases","score":0.9919999837875366},{"id":"https://openalex.org/keywords/class-c-beta-lactamase","display_name":"class C beta-lactamase","score":1.0},{"id":"https://openalex.org/keywords/acyl-enzyme-intermediate","display_name":"acyl-enzyme intermediate","score":0.9779999852180481},{"id":"https://openalex.org/keywords/penicillin-resistance","display_name":"penicillin resistance","score":0.6629999876022339},{"id":"https://openalex.org/keywords/bacterial-cell-wall","display_name":"bacterial cell wall","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C168831097","wikidata":"https://www.wikidata.org/wiki/Q413248","display_name":"Depsipeptide","level":2,"score":0.9474211931228638},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6566389203071594},{"id":"https://openalex.org/C178907741","wikidata":"https://www.wikidata.org/wiki/Q745930","display_name":"Nucleophile","level":3,"score":0.6359153985977173},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5410446524620056},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.533793568611145},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.530741274356842},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5077884793281555},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.48515066504478455},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.458302766084671},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.40778034925460815},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3629800081253052},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000215","descriptor_name":"Acylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001409","descriptor_name":"Bacillus cereus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004754","descriptor_name":"Enterobacter","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.81.5.1302","doi":"https://doi.org/10.1073/pnas.81.5.1302","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.81.5.1302","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:57239","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC344821","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:344821","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/344821","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:6424114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6424114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:57239","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC344821","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W124983324","https://openalex.org/W1488645162","https://openalex.org/W1519296568","https://openalex.org/W1572934889","https://openalex.org/W1668400918","https://openalex.org/W1678903690","https://openalex.org/W1828053777","https://openalex.org/W1844485090","https://openalex.org/W1965606033","https://openalex.org/W1982460733","https://openalex.org/W1996960109","https://openalex.org/W2009168924","https://openalex.org/W2023755203","https://openalex.org/W2042640333","https://openalex.org/W2050863088","https://openalex.org/W2090536074","https://openalex.org/W2095173710","https://openalex.org/W2102843520","https://openalex.org/W2111436492","https://openalex.org/W2140713565","https://openalex.org/W2143874510","https://openalex.org/W2178936247","https://openalex.org/W2314369203","https://openalex.org/W2427345436"],"related_works":["https://openalex.org/W2027406860","https://openalex.org/W2000070665","https://openalex.org/W2076279309","https://openalex.org/W1970711921","https://openalex.org/W2040076446","https://openalex.org/W2771744188","https://openalex.org/W2051059314","https://openalex.org/W1981763112","https://openalex.org/W2338885120","https://openalex.org/W2033123159"],"abstract_inverted_index":{"beta-Lactamases":[0],"from":[1],"all":[2],"three":[3],"classes,":[4],"A,":[5],"B,":[6],"and":[7,65,75,113],"C,":[8],"catalyze":[9,69],"the":[10,41,48,109],"hydrolysis":[11],"of":[12,18,43,50,82,96,129],"specific":[13,76],"acyclic":[14],"depsipeptide":[15],"(PhCH2CONHCR1R2CO2CHR3CO2H)":[16],"analogs":[17],"acyl-D-alanyl-D-alanine":[19],"peptides.":[20],"The":[21],"depsipeptides":[22,74],"investigated,":[23],"which":[24],"are":[25,33,126],"chemically":[26],"as":[27,31],"reactive":[28],"toward":[29],"nucleophiles":[30],"penicillins,":[32],"in":[34,100],"general":[35],"poor":[36],"substrates,":[37],"although":[38],"differences":[39],"between":[40,72],"classes":[42],"beta-lactamases":[44,67,125],"have":[45,103],"been":[46,104],"observed:":[47],"order":[49],"effectiveness":[51],"seems":[52],"to":[53],"be":[54],"C":[55,66],"greater":[56,59],"than":[57,60,91],"B":[58],"A.":[61],"Certain":[62],"class":[63],"A":[64],"also":[68],"phenylacetylglycyl":[70,73],"transfer":[71],"amino":[77],"acid":[78],"acceptors,":[79],"a":[80],"type":[81],"reaction":[83],"hitherto":[84],"identified":[85],"more":[86],"closely":[87],"with":[88,92],"D-alanyl-D-alanine":[89,133],"transpeptidases":[90],"beta-lactamases.":[93],"Preliminary":[94],"indications":[95],"an":[97],"acyl-enzyme":[98],"intermediate":[99],"these":[101],"reactions":[102],"obtained.":[105],"These":[106],"results":[107],"support":[108],"suggestion":[110],"[Tipper,":[111],"D.J.":[112],"Strominger,":[114],"J.L.":[115],"(1965)":[116],"Proc.":[117],"Natl.":[118],"Acad.":[119],"Sci.":[120],"USA":[121],"54,":[122],"1133-1141]":[123],"that":[124],"evolutionary":[127],"descendants":[128],"bacterial":[130],"cell":[131],"wall":[132],"transpeptidases.":[134]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
