{"id":"https://openalex.org/W2056716955","doi":"https://doi.org/10.1021/ac201950g","title":"Enhanced Sensitivity of Lateral Flow Tests Using a Two-Dimensional Paper Network Format","display_name":"Enhanced Sensitivity of Lateral Flow Tests Using a Two-Dimensional Paper Network Format","publication_year":2011,"publication_date":"2011-09-21","ids":{"openalex":"https://openalex.org/W2056716955","doi":"https://doi.org/10.1021/ac201950g","mag":"2056716955","pmid":"https://pubmed.ncbi.nlm.nih.gov/21936486","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3219509"},"language":"en","primary_location":{"id":"doi:10.1021/ac201950g","doi":"https://doi.org/10.1021/ac201950g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac201950g","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3219509","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044609990","display_name":"Elain S. Fu","orcid":"https://orcid.org/0000-0001-7675-1677","observed_orcids":["https://orcid.org/0000-0001-7675-1677"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elain Fu","raw_affiliation_strings":["Box 355061, Department of Bioengineering, University of Washington, Seattle, Washington, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Box 355061, Department of Bioengineering, University of Washington, Seattle, Washington, United States","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109956380","display_name":"Tinny Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tinny Liang","raw_affiliation_strings":["Box 355061, Department of Bioengineering, University of Washington, Seattle, Washington, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Box 355061, Department of Bioengineering, University of Washington, Seattle, Washington, United States","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009145209","display_name":"Jared Houghtaling","orcid":"https://orcid.org/0000-0003-1557-9716","observed_orcids":["https://orcid.org/0000-0003-1557-9716"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared Houghtaling","raw_affiliation_strings":["Box 355061, Department of Bioengineering, University of Washington, Seattle, Washington, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Box 355061, Department of Bioengineering, University of Washington, Seattle, Washington, United States","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103429063","display_name":"Sujatha Ramachandran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujatha Ramachandran","raw_affiliation_strings":["Box 355061, Department of Bioengineering, University of Washington, Seattle, Washington, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Box 355061, Department of Bioengineering, University of Washington, Seattle, Washington, United States","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091354698","display_name":"Stephen A. Ramsey","orcid":"https://orcid.org/0000-0002-2168-5403","observed_orcids":["https://orcid.org/0000-0002-2168-5403"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen A. Ramsey","raw_affiliation_strings":["Box 355061, Department of Bioengineering, University of Washington, Seattle, Washington, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Box 355061, Department of Bioengineering, University of Washington, Seattle, Washington, United States","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026718720","display_name":"Barry R. Lutz","orcid":"https://orcid.org/0000-0003-4298-4901","observed_orcids":["https://orcid.org/0000-0003-4298-4901"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry Lutz","raw_affiliation_strings":["Box 355061, Department of Bioengineering, University of Washington, Seattle, Washington, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Box 355061, Department of Bioengineering, University of Washington, Seattle, Washington, United States","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016470862","display_name":"Paul Yager","orcid":"https://orcid.org/0000-0003-1271-4599","observed_orcids":["https://orcid.org/0000-0003-1271-4599"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Yager","raw_affiliation_strings":["Box 355061, Department of Bioengineering, University of Washington, Seattle, Washington, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Box 355061, Department of Bioengineering, University of Washington, Seattle, Washington, United States","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044609990"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":11.3177,"has_fulltext":false,"cited_by_count":218,"citation_normalized_percentile":{"value":0.99144293,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"83","issue":"20","first_page":"7941","last_page":"7946"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lateral-flow-tests","display_name":"lateral flow tests","score":0.8650000095367432},{"id":"https://openalex.org/keywords/signal-amplification","display_name":"signal amplification","score":0.8479999899864197},{"id":"https://openalex.org/keywords/immunoassay","display_name":"immunoassay","score":0.8090000152587891},{"id":"https://openalex.org/keywords/human-chorionic-gonadotropin","display_name":"human chorionic gonadotropin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/pregnancy-test","display_name":"pregnancy testing","score":0.8830000162124634},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.9459999799728394},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.9909999966621399},{"id":"https://openalex.org/keywords/resource-limited-settings","display_name":"resource-limited settings","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.7325725555419922},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.5732461214065552},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.5446871519088745},{"id":"https://openalex.org/C2780367336","wikidata":"https://www.wikidata.org/wiki/Q4808618","display_name":"Assay sensitivity","level":3,"score":0.5270695090293884},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.5198886394500732},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5114325881004333},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.502734899520874},{"id":"https://openalex.org/C2994380379","wikidata":"https://www.wikidata.org/wiki/Q1135142","display_name":"Pregnancy test","level":3,"score":0.4956246614456177},{"id":"https://openalex.org/C151201525","wikidata":"https://www.wikidata.org/wiki/Q177239","display_name":"Limit (mathematics)","level":2,"score":0.46139761805534363},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.4544858932495117},{"id":"https://openalex.org/C64841741","wikidata":"https://www.wikidata.org/wiki/Q491983","display_name":"Point-of-care testing","level":2,"score":0.45069438219070435},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.41030463576316833},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39484748244285583},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3532116115093231},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.2280285358428955},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.16619116067886353},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.15637293457984924},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13542580604553223},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.10401993989944458},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0988035500049591},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.09465283155441284},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09097525477409363},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010209","descriptor_name":"Paper","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019095","descriptor_name":"Point-of-Care Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/ac201950g","doi":"https://doi.org/10.1021/ac201950g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac201950g","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:21936486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21936486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3219509","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3219509","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3219509","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3219509","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Chem","raw_type":"Text"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5147072793","display_name":"A sensitive multiplexed diagnostic platform using disposable 2D paper networks","funder_award_id":"RC1EB010593","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W51665425","https://openalex.org/W173414011","https://openalex.org/W610126998","https://openalex.org/W1973911704","https://openalex.org/W1975713674","https://openalex.org/W1977634974","https://openalex.org/W1978363318","https://openalex.org/W1985752725","https://openalex.org/W1990837884","https://openalex.org/W1991280445","https://openalex.org/W2006041114","https://openalex.org/W2010659423","https://openalex.org/W2011131769","https://openalex.org/W2020463107","https://openalex.org/W2043275365","https://openalex.org/W2045784555","https://openalex.org/W2048452903","https://openalex.org/W2061641339","https://openalex.org/W2064715286","https://openalex.org/W2066863708","https://openalex.org/W2076353832","https://openalex.org/W2079875315","https://openalex.org/W2087496745","https://openalex.org/W2114578308","https://openalex.org/W2129847650","https://openalex.org/W2132667217","https://openalex.org/W2142194643","https://openalex.org/W2146367394","https://openalex.org/W2160470359","https://openalex.org/W2177564156"],"related_works":["https://openalex.org/W2023672403","https://openalex.org/W2254921814","https://openalex.org/W2997668023","https://openalex.org/W2968091333","https://openalex.org/W4386119629","https://openalex.org/W2894684962","https://openalex.org/W2745004560","https://openalex.org/W6940405785","https://openalex.org/W1627681018","https://openalex.org/W4206508920"],"abstract_inverted_index":{"Point-of-care":[0],"diagnostic":[1,148],"assays":[2],"that":[3,63],"are":[4,9,57],"rapid,":[5],"easy-to-use,":[6,99],"and":[7,119,156],"low-cost":[8],"needed":[10,47],"for":[11,35,81,109],"use":[12],"in":[13,26,150,153],"low-resource":[14,151],"settings;":[15],"the":[16,22,45,65,87,113,136,139,154],"lateral":[17,41,67,92,130],"flow":[18,42,68,93,131],"test":[19,69,108],"has":[20],"become":[21],"standard":[23],"bioassay":[24],"format":[25],"such":[27],"settings":[28,152],"because":[29],"it":[30],"meets":[31],"those":[32],"criteria.":[33],"However,":[34],"a":[36,59,104,128],"number":[37],"of":[38,78,90,124,138],"analytes,":[39],"conventional":[40,66,91,129],"tests":[43],"lack":[44],"sensitivity":[46],"to":[48,70,116,127,143,146],"have":[49],"clinical":[50],"utility.":[51],"To":[52],"address":[53],"this":[54],"limitation,":[55],"we":[56,96],"developing":[58,157],"paper":[60,140],"network":[61,141],"platform":[62,142],"extends":[64],"two":[71],"dimensions.":[72],"The":[73],"two-dimensional":[74],"structures":[75],"allow":[76],"incorporation":[77],"multistep":[79],"processes":[80],"improved":[82,122],"sensitivity,":[83],"while":[84],"still":[85],"retaining":[86],"positive":[88],"aspects":[89],"tests.":[94],"Here":[95],"create":[97],"an":[98,121],"signal-amplified":[100],"immunoassay":[101],"based":[102],"on":[103],"modified":[105],"commercial":[106],"strip":[107],"human":[110],"chorionic":[111],"gonadotropin,":[112],"hormone":[114],"used":[115],"detect":[117],"pregnancy,":[118],"demonstrate":[120],"limit":[123],"detection":[125],"compared":[126],"assay.":[132],"These":[133],"results":[134],"highlight":[135],"potential":[137],"enhance":[144],"access":[145],"high-quality":[147],"capabilities":[149],"developed":[155],"worlds.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}