{"id":"https://openalex.org/W2056700437","doi":"https://doi.org/10.1016/j.semcdb.2014.08.011","title":"Architecture of tight junctions and principles of molecular composition","display_name":"Architecture of tight junctions and principles of molecular composition","publication_year":2014,"publication_date":"2014-08-27","ids":{"openalex":"https://openalex.org/W2056700437","doi":"https://doi.org/10.1016/j.semcdb.2014.08.011","mag":"2056700437","pmid":"https://pubmed.ncbi.nlm.nih.gov/25171873","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4254347"},"language":"en","primary_location":{"id":"doi:10.1016/j.semcdb.2014.08.011","doi":"https://doi.org/10.1016/j.semcdb.2014.08.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semcdb.2014.08.011","pdf_url":null,"source":{"id":"https://openalex.org/S105347553","display_name":"Seminars in Cell and Developmental Biology","issn_l":"1084-9521","issn":["1084-9521","1096-3634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Cell &amp; Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4254347","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059725025","display_name":"Christina M. Van Itallie","orcid":"https://orcid.org/0000-0003-1687-731X","observed_orcids":["https://orcid.org/0000-0003-1687-731X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christina M. Van Itallie","raw_affiliation_strings":["The Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 4525, 50 South Drive, Bethesda, MD 20892, USA. Electronic address: christina.vanitallie@nih.gov","The Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 4525, 50 South Drive, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 4525, 50 South Drive, Bethesda, MD 20892, USA. Electronic address: christina.vanitallie@nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"The Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 4525, 50 South Drive, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024216881","display_name":"James Melvin Anderson","orcid":"https://orcid.org/0000-0003-2765-7996","observed_orcids":["https://orcid.org/0000-0003-2765-7996","https://orcid.org/0000-0001-8210-6527"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Anderson","raw_affiliation_strings":["The Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 4525, 50 South Drive, Bethesda, MD 20892, USA. Electronic address: james.anderson2@nih.gov","The Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 4525, 50 South Drive, Bethesda, MD 20892, USA"],"raw_orcid":"https://orcid.org/0000-0003-2765-7996","affiliations":[{"raw_affiliation_string":"The Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 4525, 50 South Drive, Bethesda, MD 20892, USA. Electronic address: james.anderson2@nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"The Laboratory of Tight Junction Structure and Function, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 4525, 50 South Drive, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059725025"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"],"apc_list":{"value":4670,"currency":"USD","value_usd":4670},"apc_paid":null,"fwci":3.777,"has_fulltext":false,"cited_by_count":567,"citation_normalized_percentile":{"value":0.964,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"36","issue":null,"first_page":"157","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9599999785423279},{"id":"https://openalex.org/keywords/paracellular-barrier","display_name":"paracellular barrier","score":0.7829999923706055},{"id":"https://openalex.org/keywords/epithelial-barrier-function","display_name":"epithelial barrier function","score":0.7059999704360962},{"id":"https://openalex.org/keywords/claudins","display_name":"claudins","score":0.9760000109672546},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/jam-a","display_name":"JAM-A","score":0.9520000219345093},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.968999981880188},{"id":"https://openalex.org/keywords/afadin","display_name":"afadin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/magi1","display_name":"MAGI1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cingulin","display_name":"cingulin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/myosin","display_name":"myosin","score":0.8730000257492065},{"id":"https://openalex.org/keywords/protein-4-1","display_name":"protein 4.1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/actin","display_name":"actin","score":0.6340000033378601},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pdz-domain","display_name":"PDZ domain","score":0.800000011920929},{"id":"https://openalex.org/keywords/scaffold-proteins","display_name":"scaffold proteins","score":0.7630000114440918},{"id":"https://openalex.org/keywords/signaling-proteins","display_name":"signaling proteins","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.8445534110069275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8041769862174988},{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.7121080160140991},{"id":"https://openalex.org/C51872919","wikidata":"https://www.wikidata.org/wiki/Q420863","display_name":"Claudin","level":3,"score":0.6813266277313232},{"id":"https://openalex.org/C60903277","wikidata":"https://www.wikidata.org/wiki/Q2051926","display_name":"Paracellular transport","level":4,"score":0.6260852813720703},{"id":"https://openalex.org/C118322738","wikidata":"https://www.wikidata.org/wiki/Q7452050","display_name":"Septate junctions","level":4,"score":0.6199344396591187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.594141960144043},{"id":"https://openalex.org/C154428179","wikidata":"https://www.wikidata.org/wiki/Q24721050","display_name":"PDZ domain","level":2,"score":0.5464606881141663},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5260531902313232},{"id":"https://openalex.org/C53645450","wikidata":"https://www.wikidata.org/wiki/Q907093","display_name":"Scaffold protein","level":3,"score":0.47446805238723755},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.42119234800338745},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.4126739203929901},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.227181077003479},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.210666686296463},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.20178404450416565},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14855697751045227},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1305089294910431},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D062726","descriptor_name":"Junctional Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.semcdb.2014.08.011","doi":"https://doi.org/10.1016/j.semcdb.2014.08.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semcdb.2014.08.011","pdf_url":null,"source":{"id":"https://openalex.org/S105347553","display_name":"Seminars in Cell and Developmental Biology","issn_l":"1084-9521","issn":["1084-9521","1096-3634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Cell &amp; Developmental Biology","raw_type":"journal-article"},{"id":"pmid:25171873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25171873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in cell & developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4254347","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4254347","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Semin Cell Dev Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4254347","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4254347","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Semin Cell Dev Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6242474206","display_name":"Expanding the tight junction inventory through proteomics","funder_award_id":"1ziahl006176-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":127,"referenced_works":["https://openalex.org/W190843812","https://openalex.org/W191402491","https://openalex.org/W1574816972","https://openalex.org/W1600063873","https://openalex.org/W1897118574","https://openalex.org/W1916793731","https://openalex.org/W1969012119","https://openalex.org/W1970040522","https://openalex.org/W1972431425","https://openalex.org/W1976369464","https://openalex.org/W1976532305","https://openalex.org/W1977947961","https://openalex.org/W1979996406","https://openalex.org/W1981819658","https://openalex.org/W1982974412","https://openalex.org/W1987356191","https://openalex.org/W1989931839","https://openalex.org/W1990258395","https://openalex.org/W1990811421","https://openalex.org/W1993029728","https://openalex.org/W1994837626","https://openalex.org/W1995022882","https://openalex.org/W2000422049","https://openalex.org/W2002167899","https://openalex.org/W2004205827","https://openalex.org/W2006965597","https://openalex.org/W2010375822","https://openalex.org/W2011338170","https://openalex.org/W2011583083","https://openalex.org/W2015734787","https://openalex.org/W2018397538","https://openalex.org/W2019284666","https://openalex.org/W2023375965","https://openalex.org/W2024349959","https://openalex.org/W2028224423","https://openalex.org/W2031096207","https://openalex.org/W2033080179","https://openalex.org/W2036073843","https://openalex.org/W2037188897","https://openalex.org/W2040509610","https://openalex.org/W2040531646","https://openalex.org/W2040645020","https://openalex.org/W2040692282","https://openalex.org/W2044999404","https://openalex.org/W2045084108","https://openalex.org/W2047871421","https://openalex.org/W2050126106","https://openalex.org/W2050174110","https://openalex.org/W2052005310","https://openalex.org/W2053881066","https://openalex.org/W2054220475","https://openalex.org/W2057822166","https://openalex.org/W2059382399","https://openalex.org/W2060384627","https://openalex.org/W2061724183","https://openalex.org/W2061955387","https://openalex.org/W2064390634","https://openalex.org/W2065232644","https://openalex.org/W2066378083","https://openalex.org/W2067045943","https://openalex.org/W2071402881","https://openalex.org/W2072106617","https://openalex.org/W2072267994","https://openalex.org/W2076265532","https://openalex.org/W2076361875","https://openalex.org/W2077468217","https://openalex.org/W2080694884","https://openalex.org/W2085767196","https://openalex.org/W2088138181","https://openalex.org/W2089505716","https://openalex.org/W2090033168","https://openalex.org/W2095636141","https://openalex.org/W2099321759","https://openalex.org/W2100483442","https://openalex.org/W2101295963","https://openalex.org/W2101379456","https://openalex.org/W2102090879","https://openalex.org/W2103729492","https://openalex.org/W2103831817","https://openalex.org/W2104518242","https://openalex.org/W2106203228","https://openalex.org/W2106500404","https://openalex.org/W2107336169","https://openalex.org/W2107903378","https://openalex.org/W2109116221","https://openalex.org/W2109598795","https://openalex.org/W2111024111","https://openalex.org/W2111245936","https://openalex.org/W2120351662","https://openalex.org/W2120914031","https://openalex.org/W2123136020","https://openalex.org/W2123230988","https://openalex.org/W2123248918","https://openalex.org/W2124318163","https://openalex.org/W2124517680","https://openalex.org/W2126449113","https://openalex.org/W2127225495","https://openalex.org/W2128826029","https://openalex.org/W2129797406","https://openalex.org/W2130599353","https://openalex.org/W2140308222","https://openalex.org/W2141672217","https://openalex.org/W2143169044","https://openalex.org/W2144272339","https://openalex.org/W2147810729","https://openalex.org/W2147977611","https://openalex.org/W2149899704","https://openalex.org/W2153798418","https://openalex.org/W2155127862","https://openalex.org/W2155579605","https://openalex.org/W2157195501","https://openalex.org/W2158371473","https://openalex.org/W2158926036","https://openalex.org/W2162399161","https://openalex.org/W2163830368","https://openalex.org/W2164227785","https://openalex.org/W2168568712","https://openalex.org/W2170379027","https://openalex.org/W2171143508","https://openalex.org/W2313932305","https://openalex.org/W2328192806","https://openalex.org/W2329191923","https://openalex.org/W2333150484","https://openalex.org/W2345609573","https://openalex.org/W2414805370","https://openalex.org/W2419823030","https://openalex.org/W6717236935"],"related_works":["https://openalex.org/W1589010135","https://openalex.org/W2107601924","https://openalex.org/W118499635","https://openalex.org/W4254414519","https://openalex.org/W155491691","https://openalex.org/W1028482277","https://openalex.org/W4235772797","https://openalex.org/W2116946576","https://openalex.org/W7164159396","https://openalex.org/W2177243316"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":37},{"year":2025,"cited_by_count":34},{"year":2024,"cited_by_count":44},{"year":2023,"cited_by_count":48},{"year":2022,"cited_by_count":45},{"year":2021,"cited_by_count":53},{"year":2020,"cited_by_count":63},{"year":2019,"cited_by_count":60},{"year":2018,"cited_by_count":38},{"year":2017,"cited_by_count":60},{"year":2016,"cited_by_count":39},{"year":2015,"cited_by_count":42},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
