{"id":"https://openalex.org/W205669661","doi":null,"title":"Role of the endocrine pancreas in control of fuel metabolism by the liver during exercise.","display_name":"Role of the endocrine pancreas in control of fuel metabolism by the liver during exercise.","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W205669661","mag":"205669661","pmid":"https://pubmed.ncbi.nlm.nih.gov/8581091"},"language":"en","primary_location":{"id":"pmid:8581091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8581091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002368934","display_name":"David H. Wasserman","orcid":"https://orcid.org/0000-0002-3095-2665","observed_orcids":["https://orcid.org/0000-0002-3095-2665"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D H Wasserman","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044213015","display_name":"Robert Martin O'Doherty","orcid":"https://orcid.org/0000-0003-3031-4409","observed_orcids":["https://orcid.org/0000-0003-3031-4409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M O'Doherty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007388418","display_name":"Bradley A. Zinker","orcid":"https://orcid.org/0009-0002-1295-3354","observed_orcids":["https://orcid.org/0009-0002-1295-3354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B A Zinker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3592,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.57909998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"19 Suppl 4","issue":null,"first_page":"S22","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.3386000096797943,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.3386000096797943,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.2754000127315521,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.10329999774694443,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocrine-pancreas","display_name":"endocrine pancreas","score":0.9480000138282776},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.6389999985694885},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.953000009059906},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hepatic-glycogenolysis","display_name":"hepatic glycogenolysis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.9160000085830688},{"id":"https://openalex.org/keywords/amino-acid-extraction","display_name":"amino acid extraction","score":0.7630000114440918},{"id":"https://openalex.org/keywords/portal-vein","display_name":"portal vein","score":0.5019999742507935},{"id":"https://openalex.org/keywords/pancreatic-hormone-secretion","display_name":"pancreatic hormone secretion","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.8670979142189026},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8595216274261475},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8466526865959167},{"id":"https://openalex.org/C2779772378","wikidata":"https://www.wikidata.org/wiki/Q6953452","display_name":"NEFA","level":3,"score":0.728405237197876},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.72220778465271},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.6242678165435791},{"id":"https://openalex.org/C20904676","wikidata":"https://www.wikidata.org/wiki/Q191835","display_name":"Gluconeogenesis","level":3,"score":0.5763871073722839},{"id":"https://openalex.org/C2777949327","wikidata":"https://www.wikidata.org/wiki/Q680603","display_name":"Glycogenolysis","level":3,"score":0.4818590581417084},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.42930740118026733},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.4280155599117279},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3745243549346924},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.34008657932281494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3400841951370239},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3088136315345764},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.26235800981521606}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8581091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8581091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity","raw_type":"Journal Article"},{"id":"mag:205669661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8581091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1932762496","https://openalex.org/W2137220572","https://openalex.org/W2036837987","https://openalex.org/W2110582111","https://openalex.org/W1859469442","https://openalex.org/W1758367068","https://openalex.org/W2013534058","https://openalex.org/W2180722474","https://openalex.org/W120483238","https://openalex.org/W2012840101"],"abstract_inverted_index":{"The":[0,75,91,119,142],"secretions":[1],"of":[2,12,22,32,45,59,70,88,126,137,149,181,194,198],"the":[3,7,13,26,36,43,50,60,68,86,97,111,124,135,140,147,159,174,179,199,221],"pancreas":[4,51],"drain":[5],"into":[6],"portal":[8],"vein":[9],"just":[10],"upstream":[11],"liver.":[14,37,141,160],"This":[15,57],"anatomical":[16],"arrangement":[17],"is":[18,65,94,166],"an":[19],"important":[20,84,109,200],"component":[21],"hepatic":[23,89,114],"function":[24],"since":[25],"pancreatic":[27],"hormones":[28],"are":[29,83,107],"key":[30],"regulators":[31],"intermediary":[33],"metabolism":[34],"in":[35,77,81,100,113,121,144,176,192],"In":[38,102],"response":[39,62,93,223],"to":[40,63,67,110,139,185,224],"moderate-intensity":[41],"exercise,":[42],"secretion":[44,215],"glucagon":[46,78,92,104,145,169,177,203],"and":[47,54,79,105,131,187,204],"insulin":[48,82,106,122,205],"from":[49,128],"generally":[52],"increase":[53,99,112,143,175],"decrease,":[55],"respectively.":[56],"element":[58],"endocrine":[61],"exercise":[64],"critical":[66],"maintenance":[69],"glucose":[71,186],"homeostasis":[72],"during":[73,117,171],"exercise.":[74,118,172,225],"rise":[76],"fall":[80,120],"for":[85,96,155],"stimulation":[87],"glycogenolysis.":[90],"essential":[95],"exercise-induced":[98],"gluconeogenesis.":[101],"addition,":[103],"also":[108],"fat":[115,156],"oxidation":[116,148,157],"enhances":[123,146],"mobilization":[125],"NEFA's":[127,138,151],"adipose":[129],"tissue":[130],"as":[132],"a":[133,190],"result":[134],"availability":[136],"these":[150],"by":[152,168],"stimulating":[153],"pathways":[154],"inside":[158],"Hepatic":[161],"fractional":[162],"amino":[163,182],"acid":[164,183],"extraction":[165],"increased":[167],"action":[170],"Moreover,":[173],"facilitates":[178],"channeling":[180],"carbons":[184],"may":[188],"play":[189],"role":[191],"disposal":[193],"associated":[195],"nitrogen.":[196],"Because":[197],"roles":[201],"that":[202,212],"play,":[206],"any":[207],"physiological":[208],"or":[209,216],"pathological":[210],"condition":[211],"affects":[213],"their":[214],"efficacy":[217],"will":[218],"impact":[219],"on":[220],"metabolic":[222]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}