{"id":"https://openalex.org/W2056681983","doi":"https://doi.org/10.1021/bp970080j","title":"Practical Identification of Unstructured Growth Kinetics by Application of Optimal Experimental Design","display_name":"Practical Identification of Unstructured Growth Kinetics by Application of Optimal Experimental Design","publication_year":1997,"publication_date":"1997-10-07","ids":{"openalex":"https://openalex.org/W2056681983","doi":"https://doi.org/10.1021/bp970080j","mag":"2056681983"},"language":"en","primary_location":{"id":"doi:10.1021/bp970080j","doi":"https://doi.org/10.1021/bp970080j","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bp970080j","pdf_url":null,"source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112188918","display_name":"Karina J.E. Versyck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"K.J. Versyck","raw_affiliation_strings":["Department of Food and Microbial Technology, Katholieke Universiteit Leuven, Kardinaal Mercierlaan 92, B-3001 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Microbial Technology, Katholieke Universiteit Leuven, Kardinaal Mercierlaan 92, B-3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055143468","display_name":"JOHAN E. CLAES","orcid":"https://orcid.org/0000-0003-2565-9138","observed_orcids":["https://orcid.org/0000-0003-2565-9138"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J.E. Claes","raw_affiliation_strings":["Department of Food and Microbial Technology, Katholieke Universiteit Leuven, Kardinaal Mercierlaan 92, B-3001 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Microbial Technology, Katholieke Universiteit Leuven, Kardinaal Mercierlaan 92, B-3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003764514","display_name":"Jan Frans M. van Impe","orcid":"https://orcid.org/0000-0002-5904-1638","observed_orcids":["https://orcid.org/0000-0002-5904-1638"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Jan van Impe","raw_affiliation_strings":["Department of Food and Microbial Technology, Katholieke Universiteit Leuven, Kardinaal Mercierlaan 92, B-3001 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Microbial Technology, Katholieke Universiteit Leuven, Kardinaal Mercierlaan 92, B-3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003764514"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":null,"fwci":6.5112,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.96534533,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"5","first_page":"524","last_page":"531"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11236","display_name":"Control Systems and Identification","score":0.07649999856948853,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10864","display_name":"Fluid Dynamics and Mixing","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parameter-estimation","display_name":"parameter estimation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/optimal-experimental-design","display_name":"optimal experimental design","score":0.9490000009536743},{"id":"https://openalex.org/keywords/fed-batch-bioreactor","display_name":"fed-batch bioreactor","score":0.9700000286102295},{"id":"https://openalex.org/keywords/haldane-kinetics","display_name":"Haldane kinetics","score":0.7310000061988831},{"id":"https://openalex.org/keywords/monod-kinetics","display_name":"Monod kinetics","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fisher-information-matrix","display_name":"Fisher information matrix","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C29406490","wikidata":"https://www.wikidata.org/wiki/Q1420659","display_name":"Fisher information","level":2,"score":0.5591737031936646},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.5121276378631592},{"id":"https://openalex.org/C2778312390","wikidata":"https://www.wikidata.org/wiki/Q4139973","display_name":"Growth rate","level":2,"score":0.5057845115661621},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5012383460998535},{"id":"https://openalex.org/C186394612","wikidata":"https://www.wikidata.org/wiki/Q7098942","display_name":"Optimal design","level":2,"score":0.49507585167884827},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.49008285999298096},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.48775964975357056},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4731524884700775},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.47233954071998596},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.46299630403518677},{"id":"https://openalex.org/C115540264","wikidata":"https://www.wikidata.org/wiki/Q2945560","display_name":"Biomass (ecology)","level":2,"score":0.45560920238494873},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4497249126434326},{"id":"https://openalex.org/C208081375","wikidata":"https://www.wikidata.org/wiki/Q274502","display_name":"Degrees of freedom (physics and chemistry)","level":2,"score":0.4353589713573456},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.4150771498680115},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.40644457936286926},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40333136916160583},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2330731749534607},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21682488918304443},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.17728880047798157},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.14449083805084229},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1242654025554657},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/bp970080j","doi":"https://doi.org/10.1021/bp970080j","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bp970080j","pdf_url":null,"source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/144270","doi":null,"is_oa":false,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/144270","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biotechnology Progress, vol. 13 (5), (524-531)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2526135526","https://openalex.org/W2464310369","https://openalex.org/W1547704915","https://openalex.org/W2617229590","https://openalex.org/W2043693566","https://openalex.org/W2066233746","https://openalex.org/W294186936","https://openalex.org/W2140650937","https://openalex.org/W2524186257","https://openalex.org/W2525137243"],"abstract_inverted_index":{"This":[0],"paper":[1,112],"deals":[2],"with":[3,74,149,156],"the":[4,8,32,40,52,60,85,95,98,102,124,135,170,177,189],"practical":[5],"identification":[6],"of":[7,10,16,39,46,69,94,101,110,137,153,166,169],"parameters":[9,155],"unstructured":[11],"growth":[12,15,34],"kinetics":[13],"during":[14],"biomass":[17],"on":[18],"one":[19],"limiting":[20],"substrate":[21,41],"in":[22,30,134],"a":[23,37,55,63,75,163,180],"fed-batch":[24],"bioreactor.":[25],"We":[26],"consider":[27],"kinetic":[28],"models":[29,47],"which":[31,131,187],"specific":[33],"rate":[35,79,129,147,172],"is":[36,81,113,132,140,188],"function":[38],"concentration":[42],"only.":[43],"Two":[44],"classes":[45],"are":[48],"distinguished:":[49],"non-monotonickinetics":[50],"(with":[51,59],"Haldanemodel":[53],"as":[54,62],"prototype)":[56,64],"and":[57,118],"monotonickinetics":[58],"Monodmodel":[61],".":[65,106],"The":[66,107],"information":[67,104],"content":[68],"several":[70],"simulation":[71],"experiments,":[72],"each":[73],"different":[76],"volumetric":[77],"feed":[78,128,146,171],"profile":[80],"evaluated":[82],"by":[83],"using":[84],"modified":[86,181],"E-criterion":[87,182],"for":[88,123,145,176,192],"optimal":[89,133,190],"experimental":[90],"design":[91],"(i.e.,":[92],"ratio":[93],"largest":[96],"to":[97,114,119,151,185],"smallest":[99],"eigenvalue":[100],"Fisher":[103],"matrix)":[105],"main":[108],"contribution":[109],"this":[111,193],"provide":[115],"theoretical":[116],"evidence":[117],"present":[120],"illustrative":[121],"examples":[122],"following":[125],"conjecture:":[126],"A":[127],"strategy":[130],"sense":[136],"process":[138,160],"performance,":[139],"an":[141],"excellent":[142],"starting":[143],"point":[144],"optimization":[148,168],"respect":[150],"estimation":[152],"those":[154],"large":[157],"influence":[158],"upon":[159],"performance.":[161],"For":[162],"two":[164],"degrees":[165],"freedom":[167],"profile,":[173],"we":[174],"obtain":[175],"first":[178],"time":[179],"value":[183,191],"equal":[184],"1,":[186],"criterion.":[194]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}