{"id":"https://openalex.org/W2056674993","doi":"https://doi.org/10.1167/iovs.03-0943","title":"Basement Membrane-Dependent Modification of Phenotype and Gene Expression in Human Retinal Pigment Epithelial ARPE-19 Cells","display_name":"Basement Membrane-Dependent Modification of Phenotype and Gene Expression in Human Retinal Pigment Epithelial ARPE-19 Cells","publication_year":2004,"publication_date":"2004-07-26","ids":{"openalex":"https://openalex.org/W2056674993","doi":"https://doi.org/10.1167/iovs.03-0943","mag":"2056674993","pmid":"https://pubmed.ncbi.nlm.nih.gov/15277505"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.03-0943","doi":"https://doi.org/10.1167/iovs.03-0943","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.03-0943","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052711234","display_name":"Patric Turowski","orcid":"https://orcid.org/0000-0002-7660-5802","observed_orcids":["https://orcid.org/0000-0002-7660-5802"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patric Turowski","raw_affiliation_strings":["From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075831896","display_name":"Peter Adamson","orcid":"https://orcid.org/0000-0001-8234-1818","observed_orcids":["https://orcid.org/0000-0001-8234-1818"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Adamson","raw_affiliation_strings":["From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090058424","display_name":"Julie Sathia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325675289","display_name":"Moorfields Eye Hospital NHS Foundation Trust","ror":"https://ror.org/03zaddr67","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325675289"]},{"id":"https://openalex.org/I4210150574","display_name":"Moorfields Eye Hospital","ror":"https://ror.org/03tb37539","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325675289","https://openalex.org/I4210150574"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julie Sathia","raw_affiliation_strings":["From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and3Moorfields Eye Hospital Trust, London, United Kingdom","Moorfields Eye Hospital Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and3Moorfields Eye Hospital Trust, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Moorfields Eye Hospital Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325675289","https://openalex.org/I4210150574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051164315","display_name":"Jin Jun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jin Jun Zhang","raw_affiliation_strings":["From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068986246","display_name":"Stephen E. Moss","orcid":"https://orcid.org/0000-0002-7304-8879","observed_orcids":["https://orcid.org/0000-0002-7304-8879"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen E. Moss","raw_affiliation_strings":["From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111699226","display_name":"G. William Aylward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325675289","display_name":"Moorfields Eye Hospital NHS Foundation Trust","ror":"https://ror.org/03zaddr67","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325675289"]},{"id":"https://openalex.org/I4210150574","display_name":"Moorfields Eye Hospital","ror":"https://ror.org/03tb37539","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325675289","https://openalex.org/I4210150574"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. William Aylward","raw_affiliation_strings":["Moorfields Eye Hospital Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moorfields Eye Hospital Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325675289","https://openalex.org/I4210150574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030755271","display_name":"Matthew John Hayes","orcid":"https://orcid.org/0000-0003-1651-0956","observed_orcids":["https://orcid.org/0000-0003-1651-0956","https://orcid.org/0000-0002-2127-898X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew J. Hayes","raw_affiliation_strings":["From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032891461","display_name":"Naheed Kanuga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Naheed Kanuga","raw_affiliation_strings":["From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062547178","display_name":"John Greenwood","orcid":"https://orcid.org/0000-0003-4496-2984","observed_orcids":["https://orcid.org/0000-0003-4496-2984","https://orcid.org/0000-0002-4288-8488","https://orcid.org/0000-0002-2861-0914"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Greenwood","raw_affiliation_strings":["From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom; and","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":3.7545,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.92141734,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"45","issue":"8","first_page":"2786","last_page":"2786"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9390000104904175},{"id":"https://openalex.org/keywords/arpe-19-cells","display_name":"ARPE-19 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.8849999904632568},{"id":"https://openalex.org/keywords/epithelial-differentiation","display_name":"epithelial differentiation","score":0.800000011920929},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"cell polarity","score":0.6809999942779541},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.7889999747276306},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":1.0},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9430000185966492},{"id":"https://openalex.org/keywords/transepithelial-electrical-resistance","display_name":"transepithelial electrical resistance","score":0.8610000014305115},{"id":"https://openalex.org/keywords/rod-outer-segment-phagocytosis","display_name":"rod outer segment phagocytosis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/microvilli","display_name":"microvilli","score":0.8330000042915344},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5950000286102295},{"id":"https://openalex.org/keywords/suppression-subtractive-hybridization","display_name":"suppression subtractive hybridization","score":0.7929999828338623},{"id":"https://openalex.org/keywords/differentially-expressed-transcripts","display_name":"differentially expressed transcripts","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7003016471862793},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.6961380839347839},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5751217603683472},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5476582646369934},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5120134949684143},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.4776909649372101},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4267580509185791},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.271687388420105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14754962921142578},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10401484370231628},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004553","descriptor_name":"Electric Conductivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007903","descriptor_name":"Lens Capsule, Crystalline","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D062793","descriptor_name":"Occludin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062826","descriptor_name":"Zonula Occludens-1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1167/iovs.03-0943","doi":"https://doi.org/10.1167/iovs.03-0943","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.03-0943","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},{"id":"pmid:15277505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15277505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:8653","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/8653/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"INVEST OPHTH VIS SCI , 45 (8) 2786 - 2794. (2004)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W126134659","https://openalex.org/W611106571","https://openalex.org/W1577898165","https://openalex.org/W1578786432","https://openalex.org/W1677153055","https://openalex.org/W1932669647","https://openalex.org/W1970849988","https://openalex.org/W1974997884","https://openalex.org/W1978403167","https://openalex.org/W1987190877","https://openalex.org/W1990202885","https://openalex.org/W1999059713","https://openalex.org/W2001991657","https://openalex.org/W2004354426","https://openalex.org/W2008292129","https://openalex.org/W2008384111","https://openalex.org/W2011690901","https://openalex.org/W2012505775","https://openalex.org/W2012617920","https://openalex.org/W2015363453","https://openalex.org/W2047393488","https://openalex.org/W2048107972","https://openalex.org/W2050279879","https://openalex.org/W2058946639","https://openalex.org/W2069397272","https://openalex.org/W2094762675","https://openalex.org/W2096871091","https://openalex.org/W2097967657","https://openalex.org/W2100861163","https://openalex.org/W2101763295","https://openalex.org/W2122658884","https://openalex.org/W2131019246","https://openalex.org/W2134421016","https://openalex.org/W2136501493","https://openalex.org/W2144634347","https://openalex.org/W2147469756","https://openalex.org/W2153561315","https://openalex.org/W2158714788","https://openalex.org/W2159895855","https://openalex.org/W2227187219","https://openalex.org/W2439579602","https://openalex.org/W7096186325"],"related_works":["https://openalex.org/W2047393488","https://openalex.org/W2077559124","https://openalex.org/W2077480943","https://openalex.org/W2605167569","https://openalex.org/W3024295568","https://openalex.org/W1547275353","https://openalex.org/W2124512458","https://openalex.org/W1983713003","https://openalex.org/W1606179410","https://openalex.org/W2137454157"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"use":[2],"porcine":[3],"lens":[4],"capsule":[5],"(PLC)":[6],"as":[7],"basement":[8],"membrane":[9,107,139],"for":[10],"ARPE-19":[11,28,65,103,168],"cells":[12,29,66,104,169],"and":[13,21,40,46,70,88,114,133,141,158,179,197],"to":[14,117,127],"characterize":[15],"its":[16],"effects":[17],"on":[18,32,68,105,155,170],"cell":[19],"differentiation":[20],"gene":[22],"expression.":[23],"METHODS:":[24],"Postconfluent":[25],"cultures":[26],"of":[27,58,64,102,111,131,137,167,182,186],"were":[30,73,82,163],"established":[31],"either":[33],"porous":[34],"polyester":[35,69],"filters":[36],"or":[37,95],"PLC":[38,71,106,156,171],"membranes":[39,72,157,172],"characterized":[41],"by":[42,55,75,85,93,153],"electron":[43],"microscopy,":[44],"immunocytochemistry,":[45],"transepithelial":[47,146],"electrical":[48],"resistance":[49],"measurements.":[50],"Metabolic":[51],"activity":[52],"was":[53,150],"assessed":[54],"measuring":[56],"phagocytosis":[57],"rod":[59,119],"outer":[60,120],"segments.":[61,121],"mRNA":[62],"populations":[63],"grown":[67],"compared":[74],"suppressive":[76],"subtractive":[77],"hybridization.":[78],"Differentially":[79],"regulated":[80],"messages":[81],"subsequently":[83],"identified":[84],"DNA":[86],"sequencing":[87],"their":[89],"altered":[90,152],"expression":[91,149,181],"confirmed":[92],"Northern":[94,97],"virtual":[96],"blot":[98],"analysis.":[99],"RESULTS:":[100],"Culture":[101,166],"induced":[108],"the":[109,115,135],"formation":[110,136],"apical":[112],"microvilli":[113],"ability":[116],"phagocytose":[118],"These":[122],"culture":[123],"conditions":[124],"also":[125],"led":[126],"enhanced":[128],"junctional":[129],"distribution":[130],"ZO-1":[132],"occludin,":[134],"polarized":[138],"domains,":[140],"a":[142,175,183],"significant":[143],"increase":[144],"in":[145,174,180],"resistance.":[147],"Gene":[148],"significantly":[151],"growth":[154],"29":[159],"differentially":[160],"expressed":[161],"transcripts":[162,187],"identified.":[164],"CONCLUSIONS:":[165],"resulted":[173],"more":[176],"differentiated":[177],"phenotype":[178],"specific":[184],"set":[185],"encoding":[188],"protein":[189],"products":[190],"that":[191],"may":[192],"affect":[193],"epithelial":[194],"differentiation,":[195],"polarity":[196],"survival.":[198]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}