{"id":"https://openalex.org/W2056659971","doi":"https://doi.org/10.4161/cbt.4.11.2078","title":"NF-\u03baB protects rat ARL-6 hepatocellular carcinoma cells against hydrogen peroxide-induced apoptosis","display_name":"NF-\u03baB protects rat ARL-6 hepatocellular carcinoma cells against hydrogen peroxide-induced apoptosis","publication_year":2005,"publication_date":"2005-11-01","ids":{"openalex":"https://openalex.org/W2056659971","doi":"https://doi.org/10.4161/cbt.4.11.2078","mag":"2056659971","pmid":"https://pubmed.ncbi.nlm.nih.gov/16177566"},"language":"en","primary_location":{"id":"doi:10.4161/cbt.4.11.2078","doi":"https://doi.org/10.4161/cbt.4.11.2078","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.4.11.2078","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.11.2078?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.11.2078?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101423426","display_name":"Liang Qiao","orcid":"https://orcid.org/0000-0002-9731-4166","observed_orcids":["https://orcid.org/0000-0002-9731-4166"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Liang Qiao","raw_affiliation_strings":["Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW214-5, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW214-5, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100614702","display_name":"Jun Qing Yu","orcid":"https://orcid.org/0000-0001-5008-2153","observed_orcids":["https://orcid.org/0000-0001-5008-2153"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jun Yu","raw_affiliation_strings":["Storr Liver Unit ; Westmead Millennium Institute ; University of Sydney at Westmead Hospital ; Westmead , NSW214-5 Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Storr Liver Unit ; Westmead Millennium Institute ; University of Sydney at Westmead Hospital ; Westmead , NSW214-5 Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069980003","display_name":"Paul Dent","orcid":"https://orcid.org/0000-0001-6948-1875","observed_orcids":["https://orcid.org/0000-0001-6948-1875"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Dent","raw_affiliation_strings":["Department of Radiation Oncology ; Massey Cancer Center ; Medical College of Virginia ; Virginia Commonwealth University ; Richmond , Virginia USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology ; Massey Cancer Center ; Medical College of Virginia ; Virginia Commonwealth University ; Richmond , Virginia USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382","https://openalex.org/I72019824"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109955079","display_name":"Geoffrey C. Farrell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Geoffrey Farrell","raw_affiliation_strings":["Storr Liver Unit ; Westmead Millennium Institute ; University of Sydney at Westmead Hospital ; Westmead , NSW214-5 Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Storr Liver Unit ; Westmead Millennium Institute ; University of Sydney at Westmead Hospital ; Westmead , NSW214-5 Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5109955079"],"corresponding_institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"],"apc_list":{"value":2710,"currency":"EUR","value_usd":2970},"apc_paid":null,"fwci":0.5787,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.6867847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"4","issue":"11","first_page":"1195","last_page":"1202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9549999833106995},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.7699999809265137},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ikappabalpha","display_name":"I\u03baB\u03b1","score":0.7889999747276306},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.7670000195503235},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8994436264038086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5446687340736389},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5328083038330078},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4651561379432678},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4512660503387451},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.42903801798820496},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42222100496292114},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.42041507363319397},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38072657585144043},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10735881328582764},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4161/cbt.4.11.2078","doi":"https://doi.org/10.4161/cbt.4.11.2078","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.4.11.2078","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.11.2078?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},{"id":"pmid:16177566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16177566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biology & therapy","raw_type":"Comparative Study"},{"id":"pmh:oai:hub.hku.hk:10722/78315","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/78315","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.4161/cbt.4.11.2078","doi":"https://doi.org/10.4161/cbt.4.11.2078","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.4.11.2078","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.11.2078?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2056659971.pdf","grobid_xml":"https://content.openalex.org/works/W2056659971.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4241482621","https://openalex.org/W2153095542","https://openalex.org/W4245173102","https://openalex.org/W2047141741","https://openalex.org/W2185702474","https://openalex.org/W1987253064","https://openalex.org/W2079550678","https://openalex.org/W2058592332","https://openalex.org/W2046188137","https://openalex.org/W1978990937"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Refractoriness":[1],"of":[2,12,57,99,137,155,162],"some":[3],"tumours":[4],"to":[5,10,41,55,82,140,175,193,197,212],"apoptosis":[6,19,56,119,126,142,194,226],"has":[7],"been":[8],"related":[9],"over-expression":[11],"NF-kappaB,":[13,103],"while":[14],"NF-kappaB":[15,26,48,114,148,156,204,207,216],"inhibition":[16,208],"can":[17],"promote":[18],"in":[20,127,218],"several":[21],"cell":[22,116,179],"types.":[23],"We":[24,60],"compared":[25],"activation":[27,49,217],"profiles":[28],"between":[29],"normal":[30,187],"rat":[31,35,89],"hepatocytes":[32,90,129],"and":[33,45,73,91,118,133,165,199],"ARL-6":[34,58,63,78,92,104,131,138,151,173,189,210],"hepatocellular":[36],"carcinoma":[37],"(HCC)":[38],"cells":[39,64,79,93,105,139,174,190,211,221],"exposed":[40],"hydrogen":[42],"peroxide":[43],"(H2O2),":[44],"examined":[46,74],"whether":[47,75],"could":[50],"explain":[51],"the":[52,134],"observed":[53],"resistance":[54,136],"cells.":[59],"then":[61],"infected":[62],"with":[65,96,108,145,186,203],"recombinant":[66],"adenovirus":[67],"containing":[68],"mutant":[69],"(non-degradable)":[70],"IkBa":[71],"(Adv-mIkappaBalpha),":[72],"this":[76,200],"rendered":[77],"more":[80,125,146],"sensitive":[81],"oxidative":[83,229],"stress-induced":[84],"apoptosis.":[85,214],"METHODS:":[86],"Cultured":[87],"primary":[88,128],"were":[94,106,120],"treated":[95],"graded":[97],"doses":[98],"H2O2.":[100],"To":[101],"block":[102],"incubated":[107],"Adv-mIkappaBalpha":[109,171],"for":[110],"24":[111],"h.":[112,170],"Cytotoxicity,":[113],"activation,":[115],"proliferation,":[117],"determined.":[121],"RESULTS:":[122],"H2O2":[123,164],"induced":[124],"than":[130],"cells,":[132,152],"relative":[135],"H2O2-induced":[141,176,213],"was":[143,181],"associated":[144,202],"pronounced":[147],"activity.":[149],"In":[150],"nuclear":[153],"translocation":[154],"took":[157],"place":[158],"within":[159],"2":[160],"h":[161],"administering":[163],"remained":[166],"prominent":[167],"at":[168],"36":[169],"sensitized":[172],"apoptosis,":[177],"but":[178],"proliferation":[180],"minimally":[182],"suppressed.":[183],"CONCLUSIONS:":[184],"Compared":[185],"hepatocytes,":[188],"are":[191],"refractory":[192],"after":[195],"exposure":[196],"H2O2,":[198],"is":[201],"activation.":[205],"Conversely,":[206],"sensitises":[209],"Sustained":[215],"these":[219],"HCC":[220],"may":[222],"protect":[223],"them":[224],"against":[225],"produced":[227],"by":[228],"stress.":[230]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
