{"id":"https://openalex.org/W2056572393","doi":"https://doi.org/10.1615/critrevimmunol.v26.i3.40","title":"T-Cell Receptor Signaling Events Triggering Granule Exocytosis","display_name":"T-Cell Receptor Signaling Events Triggering Granule Exocytosis","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2056572393","doi":"https://doi.org/10.1615/critrevimmunol.v26.i3.40","mag":"2056572393","pmid":"https://pubmed.ncbi.nlm.nih.gov/16928189"},"language":"en","primary_location":{"id":"doi:10.1615/critrevimmunol.v26.i3.40","doi":"https://doi.org/10.1615/critrevimmunol.v26.i3.40","is_oa":false,"landing_page_url":"https://doi.org/10.1615/critrevimmunol.v26.i3.40","pdf_url":null,"source":{"id":"https://openalex.org/S73794665","display_name":"Critical Reviews in Immunology","issn_l":"0197-3355","issn":["0197-3355","1040-8401","2162-6472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews\u2122 in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019394795","display_name":"Sa\u0161a Radoja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sasa Radoja","raw_affiliation_strings":["Center for Cancer and Immunology Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010-2970"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Immunology Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010-2970","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065416200","display_name":"Alan B. Frey","orcid":"https://orcid.org/0000-0003-4151-561X","observed_orcids":["https://orcid.org/0000-0003-4151-561X"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan B. Frey","raw_affiliation_strings":["Department of Cell Biology and Kaplan Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Kaplan Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059688755","display_name":"Stanislav Vukmanovi\u0107","orcid":"https://orcid.org/0000-0003-3547-8349","observed_orcids":["https://orcid.org/0000-0003-3547-8349"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanislav Vukmanovic","raw_affiliation_strings":["Center for Cancer and Immunology Research, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010-2970"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Immunology Research, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010-2970","institution_ids":["https://openalex.org/I1336742384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0184,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.86135873,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":"3","first_page":"265","last_page":"290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.07599999755620956,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":1.0},{"id":"https://openalex.org/keywords/granule-exocytosis","display_name":"granule exocytosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.828000009059906},{"id":"https://openalex.org/keywords/lytic-granules","display_name":"lytic granules","score":0.6919999718666077},{"id":"https://openalex.org/keywords/target-cell-killing","display_name":"target cell killing","score":0.753000020980835},{"id":"https://openalex.org/keywords/degranulation","display_name":"degranulation","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.9054803848266602},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.8098927140235901},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.6744840145111084},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.6187167763710022},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6065742373466492},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.45144766569137573},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.44861900806427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4403618574142456},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42534297704696655},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4247022867202759},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4180341362953186},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3786300718784332},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37702739238739014},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2795606851577759},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.26051273941993713},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23759320378303528},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07788670063018799},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022142","descriptor_name":"Secretory Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051359","descriptor_name":"Lymphohistiocytosis, Hemophagocytic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1615/critrevimmunol.v26.i3.40","doi":"https://doi.org/10.1615/critrevimmunol.v26.i3.40","is_oa":false,"landing_page_url":"https://doi.org/10.1615/critrevimmunol.v26.i3.40","pdf_url":null,"source":{"id":"https://openalex.org/S73794665","display_name":"Critical Reviews in Immunology","issn_l":"0197-3355","issn":["0197-3355","1040-8401","2162-6472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews\u2122 in Immunology","raw_type":"journal-article"},{"id":"pmid:16928189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16928189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3691285831","display_name":null,"funder_award_id":"AI41573","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3700527504","display_name":null,"funder_award_id":"AI48837","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4573394195","display_name":"DYNAMICS OF PERIPHERAL T CELL REPERTOIRE","funder_award_id":"R01AI048837","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7329631172","display_name":"RECEPTOR-LIGAND INTERACTIONS IN T-CELL DIFFERENTIATION","funder_award_id":"R01AI041573","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":213,"referenced_works":["https://openalex.org/W25281948","https://openalex.org/W73595523","https://openalex.org/W1483721930","https://openalex.org/W1487617229","https://openalex.org/W1489286522","https://openalex.org/W1496318196","https://openalex.org/W1505247385","https://openalex.org/W1513811330","https://openalex.org/W1517754137","https://openalex.org/W1540441814","https://openalex.org/W1544291870","https://openalex.org/W1544920052","https://openalex.org/W1546705165","https://openalex.org/W1549249916","https://openalex.org/W1560450744","https://openalex.org/W1585445496","https://openalex.org/W1591608821","https://openalex.org/W1591844699","https://openalex.org/W1592609289","https://openalex.org/W1597146898","https://openalex.org/W1601789294","https://openalex.org/W1612799267","https://openalex.org/W1621186721","https://openalex.org/W1622194040","https://openalex.org/W1717049970","https://openalex.org/W1820329462","https://openalex.org/W1877871145","https://openalex.org/W1888237036","https://openalex.org/W1894859925","https://openalex.org/W1899644955","https://openalex.org/W1900179675","https://openalex.org/W1963711913","https://openalex.org/W1966924980","https://openalex.org/W1967400782","https://openalex.org/W1967684158","https://openalex.org/W1967787805","https://openalex.org/W1969319369","https://openalex.org/W1970405223","https://openalex.org/W1972832014","https://openalex.org/W1973841095","https://openalex.org/W1976340479","https://openalex.org/W1976692326","https://openalex.org/W1976950325","https://openalex.org/W1977598234","https://openalex.org/W1977876194","https://openalex.org/W1978416272","https://openalex.org/W1981182552","https://openalex.org/W1984427686","https://openalex.org/W1984770583","https://openalex.org/W1985618257","https://openalex.org/W1986202661","https://openalex.org/W1986393243","https://openalex.org/W1987240796","https://openalex.org/W1987765983","https://openalex.org/W1988009411","https://openalex.org/W1988488966","https://openalex.org/W1989134194","https://openalex.org/W1989600187","https://openalex.org/W1991241987","https://openalex.org/W1999468332","https://openalex.org/W2000267785","https://openalex.org/W2003939505","https://openalex.org/W2006466204","https://openalex.org/W2007361961","https://openalex.org/W2007836961","https://openalex.org/W2009230593","https://openalex.org/W2009745195","https://openalex.org/W2012120883","https://openalex.org/W2013944173","https://openalex.org/W2015066743","https://openalex.org/W2018468066","https://openalex.org/W2018910710","https://openalex.org/W2020667132","https://openalex.org/W2020955202","https://openalex.org/W2020976163","https://openalex.org/W2021353301","https://openalex.org/W2021911222","https://openalex.org/W2022116029","https://openalex.org/W2024260190","https://openalex.org/W2026422112","https://openalex.org/W2027731275","https://openalex.org/W2028793193","https://openalex.org/W2028847269","https://openalex.org/W2029492709","https://openalex.org/W2033380221","https://openalex.org/W2034439664","https://openalex.org/W2034760582","https://openalex.org/W2034850523","https://openalex.org/W2035642251","https://openalex.org/W2038209572","https://openalex.org/W2039397457","https://openalex.org/W2040380539","https://openalex.org/W2040628293","https://openalex.org/W2041810382","https://openalex.org/W2042081963","https://openalex.org/W2042375386","https://openalex.org/W2044247843","https://openalex.org/W2045500858","https://openalex.org/W2046432457","https://openalex.org/W2046624741","https://openalex.org/W2047365448","https://openalex.org/W2047400913","https://openalex.org/W2048743657","https://openalex.org/W2050382047","https://openalex.org/W2053784823","https://openalex.org/W2055140746","https://openalex.org/W2055314875","https://openalex.org/W2055825597","https://openalex.org/W2058823301","https://openalex.org/W2060846578","https://openalex.org/W2061752926","https://openalex.org/W2062790922","https://openalex.org/W2063372301","https://openalex.org/W2064706357","https://openalex.org/W2065279599","https://openalex.org/W2066096730","https://openalex.org/W2067227287","https://openalex.org/W2068767330","https://openalex.org/W2070618871","https://openalex.org/W2077166985","https://openalex.org/W2079494196","https://openalex.org/W2081262602","https://openalex.org/W2082180699","https://openalex.org/W2082502466","https://openalex.org/W2086815560","https://openalex.org/W2088165891","https://openalex.org/W2088801927","https://openalex.org/W2089907993","https://openalex.org/W2090102698","https://openalex.org/W2092312916","https://openalex.org/W2094491401","https://openalex.org/W2095215267","https://openalex.org/W2095403983","https://openalex.org/W2097863684","https://openalex.org/W2097916072","https://openalex.org/W2098609440","https://openalex.org/W2099943380","https://openalex.org/W2100836636","https://openalex.org/W2101020734","https://openalex.org/W2103228630","https://openalex.org/W2103570593","https://openalex.org/W2103699489","https://openalex.org/W2106645663","https://openalex.org/W2107518823","https://openalex.org/W2108274103","https://openalex.org/W2110077740","https://openalex.org/W2114060183","https://openalex.org/W2114948357","https://openalex.org/W2116025920","https://openalex.org/W2116364705","https://openalex.org/W2116460444","https://openalex.org/W2116967057","https://openalex.org/W2117178015","https://openalex.org/W2117381992","https://openalex.org/W2119936827","https://openalex.org/W2120231489","https://openalex.org/W2120499824","https://openalex.org/W2121870374","https://openalex.org/W2124617618","https://openalex.org/W2126507406","https://openalex.org/W2126749074","https://openalex.org/W2127257067","https://openalex.org/W2129558898","https://openalex.org/W2131656392","https://openalex.org/W2132156332","https://openalex.org/W2132207342","https://openalex.org/W2132279425","https://openalex.org/W2132531216","https://openalex.org/W2133287830","https://openalex.org/W2135723950","https://openalex.org/W2137809238","https://openalex.org/W2137830314","https://openalex.org/W2140498802","https://openalex.org/W2140577722","https://openalex.org/W2141850990","https://openalex.org/W2142285934","https://openalex.org/W2142723366","https://openalex.org/W2143188779","https://openalex.org/W2143232661","https://openalex.org/W2143773760","https://openalex.org/W2144584970","https://openalex.org/W2145280006","https://openalex.org/W2145681560","https://openalex.org/W2146927608","https://openalex.org/W2147703120","https://openalex.org/W2151838794","https://openalex.org/W2152093499","https://openalex.org/W2153742280","https://openalex.org/W2154339682","https://openalex.org/W2154612583","https://openalex.org/W2156638024","https://openalex.org/W2157319245","https://openalex.org/W2158787913","https://openalex.org/W2159115890","https://openalex.org/W2159399808","https://openalex.org/W2159751093","https://openalex.org/W2162814300","https://openalex.org/W2163156894","https://openalex.org/W2165343206","https://openalex.org/W2166219468","https://openalex.org/W2171190856","https://openalex.org/W2172196619","https://openalex.org/W2178740741","https://openalex.org/W2179076164","https://openalex.org/W2184790694","https://openalex.org/W2201242299","https://openalex.org/W2206189887","https://openalex.org/W2339031908","https://openalex.org/W2397620229","https://openalex.org/W2413706160","https://openalex.org/W2460403442","https://openalex.org/W2791218690","https://openalex.org/W4313347645"],"related_works":["https://openalex.org/W3004022161","https://openalex.org/W2096691190","https://openalex.org/W2499823002","https://openalex.org/W1911319710","https://openalex.org/W2104211991","https://openalex.org/W2150125964","https://openalex.org/W1923324809","https://openalex.org/W2011576753","https://openalex.org/W207719265","https://openalex.org/W1997996736"],"abstract_inverted_index":{"T-cell":[0,16],"receptor":[1],"(TCR)":[2],"engagement":[3],"by":[4,100],"antigen":[5],"results":[6],"in":[7],"proliferation,":[8],"differentiation":[9],"and":[10,62],"cytokine":[11,63],"secretion.":[12],"In":[13,88],"the":[14,24,33,37,66,76,103],"CD8+":[15],"subset,":[17],"TCR":[18,78,104],"triggering":[19],"also":[20],"induces":[21],"granule":[22,54,83,98],"exocytosis,":[23],"directional":[25],"release":[26],"of":[27,29,46,60,95,97,102],"contents":[28],"lysosome-like":[30],"granules":[31],"toward":[32],"target":[34,47],"cell":[35],"presenting":[36],"antigen.":[38],"This":[39],"process":[40],"is":[41],"responsible":[42],"for":[43,53,82],"immediate":[44],"death":[45],"cells.":[48],"The":[49],"intracellular":[50],"events":[51,80],"required":[52,81],"exocytosis":[55,84,99],"are":[56],"distinct":[57],"from":[58],"those":[59],"proliferation":[61],"secretion,":[64],"as":[65],"former":[67],"do":[68],"not":[69],"require":[70],"de":[71],"novo":[72],"protein":[73],"synthesis.":[74],"Consequently,":[75],"key":[77],"signaling":[79,105],"may":[85],"be":[86],"distinct.":[87],"this":[89],"article,":[90],"we":[91],"review":[92],"present":[93],"knowledge":[94],"regulation":[96],"molecules":[101],"cascade.":[106]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
