{"id":"https://openalex.org/W2056564558","doi":"https://doi.org/10.1212/wnl.46.5.1445","title":"Elevated serum levels of manganese superoxide dismutase in polymyositis and dermatomyositis","display_name":"Elevated serum levels of manganese superoxide dismutase in polymyositis and dermatomyositis","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2056564558","doi":"https://doi.org/10.1212/wnl.46.5.1445","mag":"2056564558","pmid":"https://pubmed.ncbi.nlm.nih.gov/8628497"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.46.5.1445","doi":"https://doi.org/10.1212/wnl.46.5.1445","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.46.5.1445","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110047563","display_name":"Kenji Mokuno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Mokuno","raw_affiliation_strings":["Department of Neurology, Nagoya University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nagoya University School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063941260","display_name":"Kazuhiro Kiyosawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Kiyosawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062452954","display_name":"Hiroyuki Honda","orcid":"https://orcid.org/0000-0002-4225-7248","observed_orcids":["https://orcid.org/0000-0002-4225-7248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Honda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014654359","display_name":"Yuichi Hirose","orcid":"https://orcid.org/0000-0002-1305-1830","observed_orcids":["https://orcid.org/0000-0002-1305-1830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Hirose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024502680","display_name":"Tomonori Murayama","orcid":"https://orcid.org/0000-0003-2371-8421","observed_orcids":["https://orcid.org/0000-0003-2371-8421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Murayama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S. Yoneyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Yoneyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109966689","display_name":"Kiyoshi Kato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Kato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"46","issue":"5","first_page":"1445","last_page":"1445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.972000002861023},{"id":"https://openalex.org/keywords/copper-zinc-superoxide-dismutase","display_name":"copper-zinc superoxide dismutase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/polymyositis","display_name":"polymyositis","score":0.984000027179718},{"id":"https://openalex.org/keywords/dermatomyositis","display_name":"dermatomyositis","score":1.0},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8510000109672546},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.9470000267028809},{"id":"https://openalex.org/keywords/muscular-dystrophy","display_name":"muscular dystrophy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/connective-tissue-diseases","display_name":"connective tissue diseases","score":0.9200000166893005},{"id":"https://openalex.org/keywords/duchenne-muscular-dystrophy","display_name":"Duchenne muscular dystrophy","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.849867045879364},{"id":"https://openalex.org/C2778751314","wikidata":"https://www.wikidata.org/wiki/Q681160","display_name":"Dermatomyositis","level":2,"score":0.7683329582214355},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.6958444714546204},{"id":"https://openalex.org/C2779387793","wikidata":"https://www.wikidata.org/wiki/Q980926","display_name":"Polymyositis","level":2,"score":0.680036723613739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6081255078315735},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.5921629667282104},{"id":"https://openalex.org/C2778248901","wikidata":"https://www.wikidata.org/wiki/Q5282371","display_name":"Dismutase","level":4,"score":0.54362952709198},{"id":"https://openalex.org/C2779030066","wikidata":"https://www.wikidata.org/wiki/Q1137767","display_name":"Muscular dystrophy","level":2,"score":0.4802308678627014},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4785933196544647},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46100375056266785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4608461856842041},{"id":"https://openalex.org/C528890316","wikidata":"https://www.wikidata.org/wiki/Q731","display_name":"Manganese","level":2,"score":0.41276800632476807},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.33581697940826416},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10972708463668823},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003095","descriptor_name":"Collagen Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003095","descriptor_name":"Collagen Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003882","descriptor_name":"Dermatomyositis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003882","descriptor_name":"Dermatomyositis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004796","descriptor_name":"Clinical Enzyme Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009136","descriptor_name":"Muscular Dystrophies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009136","descriptor_name":"Muscular Dystrophies","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014652","descriptor_name":"Vascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014652","descriptor_name":"Vascular Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017285","descriptor_name":"Polymyositis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017285","descriptor_name":"Polymyositis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1212/wnl.46.5.1445","doi":"https://doi.org/10.1212/wnl.46.5.1445","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.46.5.1445","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:8628497","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8628497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1986568164","https://openalex.org/W2013136575","https://openalex.org/W2030618322","https://openalex.org/W2097983535","https://openalex.org/W2109639179","https://openalex.org/W2128507501","https://openalex.org/W2394971280","https://openalex.org/W4231524173"],"related_works":["https://openalex.org/W2418237575","https://openalex.org/W2411427487","https://openalex.org/W1983688249","https://openalex.org/W4286561326","https://openalex.org/W2411333119","https://openalex.org/W2054113806","https://openalex.org/W2400606285","https://openalex.org/W2141795986","https://openalex.org/W1989772420","https://openalex.org/W2126226396"],"abstract_inverted_index":{"We":[0],"studied":[1],"serum":[2,116],"concentrations":[3],"of":[4,29,48,72,109],"manganese":[5],"superoxide":[6,12],"dismutase":[7,13],"(Mn":[8],"SOD)":[9,15],"and":[10,21,38,59,61,83],"copper-zinc":[11],"(Cu/Zn":[14],"in":[16,54,67,78,93],"22":[17],"patients":[18,25,33,40,56,80,88],"with":[19,26,34,41,57,69,81,89],"polymyositis":[20],"dermatomyositis":[22],"(PM/DM),":[23],"87":[24],"four":[27],"types":[28],"muscular":[30,85],"dystrophy,":[31],"20":[32],"amyotrophic":[35],"lateral":[36],"sclerosis,":[37],"15":[39],"collagen":[42],"vascular":[43],"diseases":[44],"(CVD).":[45],"Serum":[46],"levels":[47,96],"Mn":[49,94,117],"SOD":[50,74,95,118],"were":[51,75],"increased":[52],"only":[53],"the":[55,62,91],"PM/DM":[58,82],"CVD,":[60],"elevation":[63],"was":[64],"more":[65,105],"prominent":[66],"those":[68,108],"PM/DM.":[70,126],"Levels":[71],"Cu/Zn":[73],"slightly":[76],"elevated":[77],"some":[79],"Duchenne":[84],"dystrophy.":[86],"In":[87],"PM/DM,":[90],"change":[92],"corresponded":[97],"to":[98],"disease":[99],"activity":[100],"as":[101,103],"closely":[102,106],"or":[104],"than":[107],"creatine":[110],"kinase.":[111],"The":[112],"results":[113],"indicate":[114],"that":[115],"may":[119],"be":[120],"a":[121],"useful":[122],"clinical":[123],"marker":[124],"for":[125]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}