{"id":"https://openalex.org/W2056543591","doi":"https://doi.org/10.1097/01.tp.0000063220.19441.5c","title":"Spleen transplantation in miniature swine: surgical technique and results in major histocompatibility complex-matched donor and recipient pairs*","display_name":"Spleen transplantation in miniature swine: surgical technique and results in major histocompatibility complex-matched donor and recipient pairs*","publication_year":2003,"publication_date":"2003-06-15","ids":{"openalex":"https://openalex.org/W2056543591","doi":"https://doi.org/10.1097/01.tp.0000063220.19441.5c","mag":"2056543591","pmid":"https://pubmed.ncbi.nlm.nih.gov/12811237"},"language":"en","primary_location":{"id":"doi:10.1097/01.tp.0000063220.19441.5c","doi":"https://doi.org/10.1097/01.tp.0000063220.19441.5c","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000063220.19441.5c","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://archive-ouverte.unige.ch/unige:45065","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001259725","display_name":"Bernd Gollackner","orcid":"https://orcid.org/0000-0002-7313-0960","observed_orcids":["https://orcid.org/0000-0002-7313-0960"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Gollackner","raw_affiliation_strings":["Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA","Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017853747","display_name":"Frank J. M. F. Dor","orcid":"https://orcid.org/0000-0003-2448-7362","observed_orcids":["https://orcid.org/0000-0003-2448-7362"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F.J.M.F. Dor","raw_affiliation_strings":["Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073088808","display_name":"Christoph Knosalla","orcid":"https://orcid.org/0000-0002-8127-5019","observed_orcids":["https://orcid.org/0000-0002-8127-5019"]},"institutions":[{"id":"https://openalex.org/I1322597698","display_name":"Royal Netherlands Academy of Arts and Sciences","ror":"https://ror.org/043c0p156","country_code":"NL","type":"government","lineage":["https://openalex.org/I1322597698"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"C. Knosalla","raw_affiliation_strings":["Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts","Work in our own laboratory was supported in part by the National Institutes of Health Program Project 1PO1 A145897 and by a sponsored research agreement between the Massachusetts General Hospital and Immerge Biotherapeutics. Bernd Gollackner, MD, is a recipient of grants from the Max Kade Foundation of the Austrian Academy of Science, Frank J. M. F. Dor, MD, is a recipient of grants from the Professor Micha\u00ebl-van Vloten Fund, the Netherlands-America Foundation, and the Ter Meulen Fund from the Royal Netherlands Academy of Arts and Sciences, and C. Knosalla, MD, is a recipient of a grant from the Deutsche Forschungsgemeinschaft (KN518,1\u20131)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Work in our own laboratory was supported in part by the National Institutes of Health Program Project 1PO1 A145897 and by a sponsored research agreement between the Massachusetts General Hospital and Immerge Biotherapeutics. Bernd Gollackner, MD, is a recipient of grants from the Max Kade Foundation of the Austrian Academy of Science, Frank J. M. F. Dor, MD, is a recipient of grants from the Professor Micha\u00ebl-van Vloten Fund, the Netherlands-America Foundation, and the Ter Meulen Fund from the Royal Netherlands Academy of Arts and Sciences, and C. Knosalla, MD, is a recipient of a grant from the Deutsche Forschungsgemeinschaft (KN518,1\u20131)","institution_ids":["https://openalex.org/I1322597698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068581881","display_name":"L\u00e9o H. B\u00fchler","orcid":"https://orcid.org/0000-0002-9461-8498","observed_orcids":["https://orcid.org/0000-0002-9461-8498"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Buhler","raw_affiliation_strings":["Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067566994","display_name":"Michael Duggan","orcid":"https://orcid.org/0000-0003-3893-2041","observed_orcids":["https://orcid.org/0000-0003-3893-2041"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Duggan","raw_affiliation_strings":["Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056087489","display_name":"Christene A. Huang","orcid":"https://orcid.org/0000-0001-9824-5716","observed_orcids":["https://orcid.org/0000-0001-9824-5716"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. A. Huang","raw_affiliation_strings":["Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109281174","display_name":"Stuart Lair Houser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. L. Houser","raw_affiliation_strings":["Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073338357","display_name":"David H. Sachs","orcid":"https://orcid.org/0000-0001-9588-8580","observed_orcids":["https://orcid.org/0000-0001-9588-8580"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. H. Sachs","raw_affiliation_strings":["Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009014767","display_name":"Tatsuo Kawai","orcid":"https://orcid.org/0000-0002-6900-4603","observed_orcids":["https://orcid.org/0000-0002-6900-4603"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Kawai","raw_affiliation_strings":["Transplant Unit, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Unit, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113646772","display_name":"Dicken S. C. Ko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. S. C. Ko","raw_affiliation_strings":["Transplant Unit, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Unit, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066156944","display_name":"David K.C. Cooper","orcid":"https://orcid.org/0000-0003-4149-5452","observed_orcids":["https://orcid.org/0000-0003-4149-5452","https://orcid.org/0000-0002-8899-9431"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. K. C. Cooper","raw_affiliation_strings":["D. K. C. Cooper, M.D., Ph.D., F.R.C.S., Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Building 149, 13th Street, Boston, MA 02129. E-mail","Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D. K. C. Cooper, M.D., Ph.D., F.R.C.S., Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Building 149, 13th Street, Boston, MA 02129. E-mail","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5066156944"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":3.1957,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.91362702,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"75","issue":"11","first_page":"1799","last_page":"1806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.38350000977516174,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.38350000977516174,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.30300000309944153,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.23520000278949738,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spleen-transplantation","display_name":"spleen transplantation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/miniature-swine","display_name":"miniature swine","score":0.8180000185966492},{"id":"https://openalex.org/keywords/donor-specific-tolerance","display_name":"donor-specific tolerance","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hematopoietic-chimerism","display_name":"hematopoietic chimerism","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9490000009536743},{"id":"https://openalex.org/keywords/thymic-irradiation","display_name":"thymic irradiation","score":0.996999979019165},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.8040000200271606},{"id":"https://openalex.org/keywords/surgical-technique","display_name":"surgical technique","score":0.5379999876022339},{"id":"https://openalex.org/keywords/graft-survival","display_name":"graft survival","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.8653407096862793},{"id":"https://openalex.org/C3018622758","wikidata":"https://www.wikidata.org/wiki/Q7107413","display_name":"Miniature swine","level":2,"score":0.7515743970870972},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.661221444606781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6503955125808716},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.6162479519844055},{"id":"https://openalex.org/C202965653","wikidata":"https://www.wikidata.org/wiki/Q2664028","display_name":"Histocompatibility","level":4,"score":0.5568543076515198},{"id":"https://openalex.org/C2780520971","wikidata":"https://www.wikidata.org/wiki/Q2264329","display_name":"Abdominal aorta","level":3,"score":0.4377371072769165},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.42106449604034424},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.40896928310394287},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3945273756980896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3661540746688843},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3555111289024353},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.32942861318588257},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.27196091413497925},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17373031377792358},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.07333210110664368}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006650","descriptor_name":"Histocompatibility Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D013156","descriptor_name":"Splenectomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013556","descriptor_name":"Swine, Miniature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014019","descriptor_name":"Tissue Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016038","descriptor_name":"Skin Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018183","descriptor_name":"Transplantation Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/01.tp.0000063220.19441.5c","doi":"https://doi.org/10.1097/01.tp.0000063220.19441.5c","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000063220.19441.5c","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:12811237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12811237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"},{"id":"pmh:oai:unige.ch:unige:45065","doi":null,"is_oa":false,"landing_page_url":"https://archive-ouverte.unige.ch/unige:45065","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 0041-1337","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:aou:unige:45065","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:45065","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0041-1337","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:unige.ch:aou:unige:45065","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:45065","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0041-1337","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2410596345","display_name":null,"funder_award_id":"1P01A145897","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1484496765","https://openalex.org/W1599651003","https://openalex.org/W1981284886","https://openalex.org/W1983201855","https://openalex.org/W1985270036","https://openalex.org/W1999915014","https://openalex.org/W2053208297","https://openalex.org/W2056682001","https://openalex.org/W2075297448","https://openalex.org/W2078745963","https://openalex.org/W2081827903","https://openalex.org/W2088962680","https://openalex.org/W2091336611","https://openalex.org/W2109958525","https://openalex.org/W4244413983"],"related_works":["https://openalex.org/W1981965431","https://openalex.org/W2144922821","https://openalex.org/W2059443179","https://openalex.org/W1649304528","https://openalex.org/W2069397360","https://openalex.org/W2024091616","https://openalex.org/W2576837937","https://openalex.org/W1975294422","https://openalex.org/W2120509045","https://openalex.org/W2064080168"],"abstract_inverted_index":{"BACKGROUND:":[0],"Spleen":[1,151,220],"transplantation":[2],"(Tx)":[3],"between":[4],"some":[5],"strains":[6],"of":[7,21,50,56,72,89,120,241],"rodents":[8],"can":[9],"lead":[10],"to":[11,35,64,80,245],"donor-specific":[12],"tolerance":[13],"either":[14],"spontaneously":[15],"or":[16],"after":[17],"a":[18,26,41,117],"short":[19],"course":[20,119],"immunosuppression.":[22],"This":[23],"study":[24],"developed":[25],"surgical":[27,48],"technique":[28,49],"for":[29,104,168,178,202,213],"spleen":[30,51,59],"Tx":[31,52,152,221],"in":[32,40,95,163,199,222,232,242],"miniature":[33],"swine":[34],"investigate":[36],"its":[37,61],"immunologic":[38],"impact":[39],"large":[42],"animal":[43],"model.":[44],"METHODS:":[45],"The":[46,93],"preferred":[47],"(n=8)":[53],"involved":[54],"excision":[55],"the":[57,65,81,90,105,164,200,239,246],"donor":[58,73],"with":[60,211,228,238],"vascular":[62],"pedicle":[63],"aorta":[66,74,83],"and":[67,75,84,125,132,143,170,173,180,204,207,215,235],"portal":[68,76],"vein.":[69],"Carrel":[70],"patches":[71],"vein":[77],"were":[78,102,113],"anastomosed":[79],"abdominal":[82],"inferior":[85],"vena":[86],"cava,":[87],"respectively,":[88],"(splenectomized)":[91],"recipient.":[92],"results":[94,231],"four":[96],"major":[97,223],"histocompatibility":[98,224],"complex-matched":[99,225],"pairs":[100,226],"that":[101],"mismatched":[103],"porcine":[106],"allelic":[107],"antigen":[108],"are":[109],"reported.":[110],"Two":[111],"recipients":[112],"untreated,":[114],"one":[115,126],"received":[116,127],"12-day":[118],"cyclosporine":[121],"A":[122],"(CsA)":[123],"alone,":[124],"thymic":[128],"irradiation":[129,230],"(700":[130],"cGy)":[131],"CsA.":[133],"Hematopoietic":[134],"cell":[135,141],"chimerism":[136,160,196,234],"was":[137,146,153,161,197,209],"followed":[138],"by":[139,148,189],"fluorescence-activated":[140],"sorter,":[142],"graft":[144],"survival":[145],"assessed":[147],"histology.":[149],"RESULTS:":[150],"technically":[154],"successful.":[155],"In":[156,192],"two":[157,193],"untreated":[158],"pigs,":[159,195],"detected":[162],"blood":[165,201],"(maximum":[166,176],"5%":[167],"17":[169],"25":[171],"days)":[172],"lymph":[174],"nodes":[175],"6%":[177],"28":[179],"56":[181],"days),":[182],"but":[183],"both":[184],"grafts":[185],"showed":[186],"histologic":[187],"rejection":[188,208],"day":[190],"28.":[191],"treated":[194,227],"present":[198],"47":[203],"57":[205,214],"days,":[206,217],"prevented,":[210],"follow-up":[212],"217":[216],"respectively.":[218],"CONCLUSION:":[219],"CsA+/-thymic":[229],"prolonged":[233],"is":[236],"associated":[237],"development":[240],"vivo":[243],"unresponsiveness":[244],"transplanted":[247],"spleen.":[248]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
