{"id":"https://openalex.org/W2056540318","doi":"https://doi.org/10.1016/j.cmet.2013.01.011","title":"TCF7L2 and Diabetes: A Tale of Two Tissues, and of Two Species","display_name":"TCF7L2 and Diabetes: A Tale of Two Tissues, and of Two Species","publication_year":2013,"publication_date":"2013-02-01","ids":{"openalex":"https://openalex.org/W2056540318","doi":"https://doi.org/10.1016/j.cmet.2013.01.011","mag":"2056540318","pmid":"https://pubmed.ncbi.nlm.nih.gov/23395164"},"language":"en","primary_location":{"id":"doi:10.1016/j.cmet.2013.01.011","doi":"https://doi.org/10.1016/j.cmet.2013.01.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmet.2013.01.011","pdf_url":"http://www.cell.com/article/S1550413113000193/pdf","source":{"id":"https://openalex.org/S177533077","display_name":"Cell Metabolism","issn_l":"1550-4131","issn":["1550-4131","1932-7420"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1550413113000193/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064948585","display_name":"Mark I. McCarthy","orcid":"https://orcid.org/0000-0002-4393-0510","observed_orcids":["https://orcid.org/0000-0002-4393-0510"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210088942","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I4210129944","display_name":"Oxford Centre for Diabetes, Endocrinology and Metabolism","ror":"https://ror.org/03myafa32","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210129944","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mark\u00a0I. McCarthy","raw_affiliation_strings":["Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK. mark.mccarthy@drl.ox.ac.uk","Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK","Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK","Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK. mark.mccarthy@drl.ox.ac.uk","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149","https://openalex.org/I4210129944"]},{"raw_affiliation_string":"Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149","https://openalex.org/I4210129944"]},{"raw_affiliation_string":"Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I4210088942"]},{"raw_affiliation_string":"Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089848866","display_name":"Patrik Rorsman","orcid":"https://orcid.org/0000-0001-7578-0767","observed_orcids":["https://orcid.org/0000-0001-7578-0767"]},"institutions":[{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210088942","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I4210129944","display_name":"Oxford Centre for Diabetes, Endocrinology and Metabolism","ror":"https://ror.org/03myafa32","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210129944","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patrik Rorsman","raw_affiliation_strings":["Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK","Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149","https://openalex.org/I4210129944"]},{"raw_affiliation_string":"Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I4210088942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017761772","display_name":"Anna L. Gloyn","orcid":"https://orcid.org/0000-0003-1205-1844","observed_orcids":["https://orcid.org/0000-0003-1205-1844"]},"institutions":[{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210088942","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I4210129944","display_name":"Oxford Centre for Diabetes, Endocrinology and Metabolism","ror":"https://ror.org/03myafa32","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210129944","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna\u00a0L. Gloyn","raw_affiliation_strings":["Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK","Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149","https://openalex.org/I4210129944"]},{"raw_affiliation_string":"Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I4210088942"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5064948585"],"corresponding_institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I2801179840","https://openalex.org/I40120149","https://openalex.org/I4210088942","https://openalex.org/I4210129944"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":2.6877,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.9017255,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"17","issue":"2","first_page":"157","last_page":"159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6128000020980835,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6128000020980835,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.17980000376701355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tcf7l2","display_name":"TCF7L2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9779999852180481},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.6520000100135803},{"id":"https://openalex.org/keywords/diabetes-susceptibility","display_name":"diabetes susceptibility","score":0.4440000057220459},{"id":"https://openalex.org/keywords/rodent-models","display_name":"rodent models","score":0.7770000100135803},{"id":"https://openalex.org/keywords/metabolic-regulation","display_name":"metabolic regulation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tissue-specific-effects","display_name":"tissue-specific effects","score":0.6909999847412109},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C39263347","wikidata":"https://www.wikidata.org/wiki/Q14913892","display_name":"TCF7L2","level":5,"score":0.741104245185852},{"id":"https://openalex.org/C83867959","wikidata":"https://www.wikidata.org/wiki/Q371467","display_name":"Scopus","level":3,"score":0.5872206687927246},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5589411854743958},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.554153323173523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4183049201965332},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3932027518749237},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3749661445617676},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36826038360595703},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32145148515701294},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27564334869384766},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.250529944896698},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15115609765052795},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.11678287386894226},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1087704598903656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cmet.2013.01.011","doi":"https://doi.org/10.1016/j.cmet.2013.01.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmet.2013.01.011","pdf_url":"http://www.cell.com/article/S1550413113000193/pdf","source":{"id":"https://openalex.org/S177533077","display_name":"Cell Metabolism","issn_l":"1550-4131","issn":["1550-4131","1932-7420"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Metabolism","raw_type":"journal-article"},{"id":"pmid:23395164","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23395164","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell metabolism","raw_type":"Comment"}],"best_oa_location":{"id":"doi:10.1016/j.cmet.2013.01.011","doi":"https://doi.org/10.1016/j.cmet.2013.01.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmet.2013.01.011","pdf_url":"http://www.cell.com/article/S1550413113000193/pdf","source":{"id":"https://openalex.org/S177533077","display_name":"Cell Metabolism","issn_l":"1550-4131","issn":["1550-4131","1932-7420"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2582754266","display_name":"Bridging the gap from type 2 diabetes genetics to functional mechanisms of disease.","funder_award_id":"095101","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6648230576","display_name":"Metabolic and hormonal regulation of pancreatic hormone secretion.","funder_award_id":"095531/Z/11/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7004411822","display_name":"Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics.","funder_award_id":"090532","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G869816443","display_name":"Metabolic and hormonal regulation of pancreatic hormone secretion.","funder_award_id":"095531","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2056540318.pdf"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1966650637","https://openalex.org/W2067387842","https://openalex.org/W2068201869","https://openalex.org/W2082793267","https://openalex.org/W2087104293","https://openalex.org/W2111824788","https://openalex.org/W2123713421","https://openalex.org/W2144472637","https://openalex.org/W2161556085","https://openalex.org/W2168992353"],"related_works":["https://openalex.org/W2828109831","https://openalex.org/W3202807120","https://openalex.org/W2121670731","https://openalex.org/W2098679983","https://openalex.org/W2067453751","https://openalex.org/W3106831851","https://openalex.org/W2044983866","https://openalex.org/W2789454317","https://openalex.org/W1966650637","https://openalex.org/W2084000495"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
