{"id":"https://openalex.org/W2056458080","doi":"https://doi.org/10.1371/journal.pone.0036632","title":"Co-Stimulation of PAFR and CD36 Is Required for oxLDL-Induced Human Macrophages Activation","display_name":"Co-Stimulation of PAFR and CD36 Is Required for oxLDL-Induced Human Macrophages Activation","publication_year":2012,"publication_date":"2012-05-03","ids":{"openalex":"https://openalex.org/W2056458080","doi":"https://doi.org/10.1371/journal.pone.0036632","mag":"2056458080","pmid":"https://pubmed.ncbi.nlm.nih.gov/22570732","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3343035"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0036632","doi":"https://doi.org/10.1371/journal.pone.0036632","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0036632","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036632&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036632&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086285174","display_name":"Francisco J. O. Rios","orcid":"https://orcid.org/0000-0002-8194-0787","observed_orcids":["https://orcid.org/0000-0002-8194-0787"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Francisco J. O. Rios","raw_affiliation_strings":["Department of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Sao Paulo, Brazil. fjorios@usp.br","Dept of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Sao Paulo, Brazil. fjorios@usp.br","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Dept of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039621195","display_name":"Marianna M. Koga","orcid":"https://orcid.org/0000-0003-3244-9059","observed_orcids":["https://orcid.org/0000-0003-3244-9059"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mariana M. Koga","raw_affiliation_strings":["Department of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Sao Paulo, Brazil","Dept of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Dept of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043381589","display_name":"Matheus Ferracini","orcid":"https://orcid.org/0000-0003-1523-6457","observed_orcids":["https://orcid.org/0000-0003-1523-6457"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Matheus Ferracini","raw_affiliation_strings":["Department of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Sao Paulo, Brazil","Dept of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Dept of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056072064","display_name":"S\u00f4nia Jancar","orcid":"https://orcid.org/0000-0001-7983-3459","observed_orcids":["https://orcid.org/0000-0001-7983-3459"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sonia Jancar","raw_affiliation_strings":["Department of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Sao Paulo, Brazil","Dept of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Dept of Immunology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086285174"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.2484,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.92347213,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"5","first_page":"e36632","last_page":"e36632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.05640000104904175,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-activating-factor-receptor","display_name":"platelet-activating factor receptor","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cd36","display_name":"CD36","score":0.9940000176429749},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.9829999804496765},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7730000019073486},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8209999799728394},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/macrophage-foam-cell-formation","display_name":"macrophage foam cell formation","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2779828298","wikidata":"https://www.wikidata.org/wiki/Q4035577","display_name":"CD36","level":3,"score":0.8366338014602661},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7285559177398682},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.708366870880127},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.611996054649353},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5826076865196228},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.5442999601364136},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5407206416130066},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5119122266769409},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5075117349624634},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.4617045521736145},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.45597895979881287},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42208772897720337},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41230690479278564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25920915603637695},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18840724229812622},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14308863878250122},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018955","descriptor_name":"CD36 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018955","descriptor_name":"CD36 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019206","descriptor_name":"GTP-Binding Protein alpha Subunits, Gi-Go","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0036632","doi":"https://doi.org/10.1371/journal.pone.0036632","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0036632","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036632&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2353660","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3343035","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22570732","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22570732","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3343035","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3343035/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:www.producao.usp.br:BDPI/35793","doi":null,"is_oa":false,"landing_page_url":"http://www.producao.usp.br/handle/BDPI/35793","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da USP","raw_type":"publishedVersion"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.270.4758","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.270.4758","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/08/d8/PLoS_One_2012_May_3_7(5)_e36632.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:8f2ad5f95ca24ac8ab58b9abff554894","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8f2ad5f95ca24ac8ab58b9abff554894","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 5, p e36632 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0036632","doi":"https://doi.org/10.1371/journal.pone.0036632","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0036632","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036632&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1081296863","display_name":null,"funder_award_id":"2006/03982-5","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G4863557422","display_name":"Molecular aspects involved in leukocytes microbicidal and inflammatory activities in the lung","funder_award_id":"06/03982-5","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2056458080.pdf","grobid_xml":"https://content.openalex.org/works/W2056458080.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W57335222","https://openalex.org/W1541686926","https://openalex.org/W1650965741","https://openalex.org/W1913200510","https://openalex.org/W1963608570","https://openalex.org/W1968167945","https://openalex.org/W1985801255","https://openalex.org/W2002320827","https://openalex.org/W2021586469","https://openalex.org/W2027753136","https://openalex.org/W2036111255","https://openalex.org/W2045772297","https://openalex.org/W2055530781","https://openalex.org/W2069276202","https://openalex.org/W2083583542","https://openalex.org/W2087647782","https://openalex.org/W2087928272","https://openalex.org/W2091799228","https://openalex.org/W2093100161","https://openalex.org/W2093782393","https://openalex.org/W2094045593","https://openalex.org/W2097167993","https://openalex.org/W2105067802","https://openalex.org/W2107277218","https://openalex.org/W2129819015","https://openalex.org/W2131918803","https://openalex.org/W2149122802","https://openalex.org/W2149720080","https://openalex.org/W2153245546","https://openalex.org/W2155556672","https://openalex.org/W2158603123","https://openalex.org/W2164461974","https://openalex.org/W2322681212","https://openalex.org/W2391191430"],"related_works":["https://openalex.org/W1963608570","https://openalex.org/W2160121844","https://openalex.org/W2000508685","https://openalex.org/W1967821910","https://openalex.org/W1551426505","https://openalex.org/W2060439746","https://openalex.org/W2084994074","https://openalex.org/W7099880045","https://openalex.org/W2078890386","https://openalex.org/W7098460592"],"abstract_inverted_index":{"The":[0,180,202],"oxidative":[1],"process":[2],"of":[3,19,46,69,82,116,142,150,169,174,182,188,236,263],"LDL":[4,21],"particles":[5],"generates":[6],"molecules":[7],"which":[8,159],"are":[9,196],"structurally":[10],"similar":[11],"to":[12,26,71,152,253],"platelet-activating":[13],"factor":[14],"(PAF),":[15],"and":[16,48,66,84,94,101,106,137,166,176,185,211,239,255],"some":[17],"effects":[18],"oxidized":[20],"(oxLDL)":[22],"have":[23],"been":[24],"shown":[25],"be":[27,267],"dependent":[28,197,208],"on":[29,198,209],"PAF":[30],"receptor":[31],"(PAFR)":[32],"activation.":[33,201],"In":[34,51],"a":[35,177,247],"previous":[36],"study,":[37],"we":[38,55],"showed":[39,220],"that":[40,147,221,244,257],"PAFR":[41,70,134,175,210,227,238,245,264],"is":[42,207],"required":[43],"for":[44],"upregulation":[45,181],"CD36":[47,85,183,204],"oxLDL":[49,62,83,151,189,222,254],"uptake.":[50],"the":[52,57,67,114,117,133,148,156,163,172,186,193,234,261],"present":[53],"study":[54],"analyzed":[56],"molecular":[58],"mechanisms":[59],"activated":[60],"by":[61,89,97,104,109],"in":[63,160,250,269],"human":[64,153],"macrophages":[65,124,251],"contribution":[68],"this":[72],"response.":[73],"Human":[74],"adherent":[75],"monocytes/macrophages":[76,154],"were":[77,87,125],"stimulated":[78],"with":[79,127,132,225],"oxLDL.":[80,143],"Uptake":[81],"expression":[86,108,206],"determined":[88],"flow":[90],"cytometry;":[91],"MAP":[92],"kinases":[93],"Akt":[95,170],"phosphorylation":[96],"Western":[98],"blot;":[99],"IL-8":[100,194,231],"MCP-1":[102],"concentration":[103],"ELISA":[105],"mRNA":[107],"real-time":[110],"PCR.":[111],"To":[112],"investigate":[113],"participation":[115],"PI3K/Akt":[118,157,199],"pathway,":[119],"G\u03b1i-coupled":[120,178,212],"protein":[121,184,205],"or":[122,131,228],"PAFR,":[123],"treated":[126],"LY294002,":[128],"pertussis":[129],"toxin":[130],"antagonists":[135],"WEB2170":[136],"CV3988,":[138],"respectively":[139],"before":[140],"addition":[141,149],"It":[144],"was":[145],"found":[146],"activates":[155,162],"pathway":[158,200],"turn":[161],"MAPK":[164],"(p38":[165],"JNK).":[167],"Phosphorylation":[168],"requires":[171,233],"engagement":[173],"protein.":[179,213],"uptake":[187,223],"as":[190,192],"well":[191],"production":[195,232],"increased":[203],"Transfection":[214],"studies":[215],"using":[216],"HEK":[217],"293t":[218],"cells":[219],"occurs":[224],"either":[226],"CD36,":[229],"but":[230],"co-transfection":[235],"both":[237],"CD36.":[240],"These":[241],"findings":[242],"show":[243],"has":[246],"pivotal":[248],"role":[249],"response":[252],"suggest":[256],"pharmacological":[258],"intervention":[259],"at":[260],"level":[262],"activation":[265],"might":[266],"beneficial":[268],"atherosclerosis.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
