{"id":"https://openalex.org/W2056445902","doi":"https://doi.org/10.1021/bc7002346","title":"Novel Method for in Vitro O-Glycosylation of Proteins: Application for Bioconjugation","display_name":"Novel Method for in Vitro O-Glycosylation of Proteins: Application for Bioconjugation","publication_year":2007,"publication_date":"2007-10-23","ids":{"openalex":"https://openalex.org/W2056445902","doi":"https://doi.org/10.1021/bc7002346","mag":"2056445902","pmid":"https://pubmed.ncbi.nlm.nih.gov/17953440"},"language":"en","primary_location":{"id":"doi:10.1021/bc7002346","doi":"https://doi.org/10.1021/bc7002346","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc7002346","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109347236","display_name":"Boopathy Ramakrishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boopathy Ramakrishnan","raw_affiliation_strings":["Structural Glycobiology Section, and Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Glycobiology Section, and Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057328666","display_name":"Elizabeth E. Boeggeman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Boeggeman","raw_affiliation_strings":["Structural Glycobiology Section, and Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Glycobiology Section, and Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013727307","display_name":"Pradman K. Qasba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pradman K. Qasba","raw_affiliation_strings":["Structural Glycobiology Section, and Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Glycobiology Section, and Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013727307"],"corresponding_institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.7942,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.68984114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"18","issue":"6","first_page":"1912","last_page":"1918"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/o-glycosylation","display_name":"O-glycosylation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/bioconjugation","display_name":"bioconjugation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/in-vitro-protein-folding","display_name":"in vitro protein folding","score":0.6940000057220459},{"id":"https://openalex.org/keywords/inclusion-bodies","display_name":"inclusion bodies","score":0.7990000247955322},{"id":"https://openalex.org/keywords/bionanoparticles","display_name":"bionanoparticles","score":0.8050000071525574},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.9729999899864197}],"concepts":[{"id":"https://openalex.org/C23963754","wikidata":"https://www.wikidata.org/wiki/Q4914729","display_name":"Bioconjugation","level":2,"score":0.9096623659133911},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8651589155197144},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.6242908239364624},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.6171273589134216},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6063493490219116},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5787615776062012},{"id":"https://openalex.org/C49853544","wikidata":"https://www.wikidata.org/wiki/Q206229","display_name":"Biomolecule","level":2,"score":0.43199270963668823},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.4232466220855713},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.40143871307373047},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.28558558225631714},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bc7002346","doi":"https://doi.org/10.1021/bc7002346","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc7002346","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:17953440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17953440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1356092923","display_name":null,"funder_award_id":"N01CO12400","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G174812244","display_name":"DCTD Computer Support","funder_award_id":"n01co12400-79-0-22","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1894661133","https://openalex.org/W1972074273","https://openalex.org/W1975985649","https://openalex.org/W1981358768","https://openalex.org/W1983639577","https://openalex.org/W1988046546","https://openalex.org/W1992607565","https://openalex.org/W1993575340","https://openalex.org/W1997943615","https://openalex.org/W1998640866","https://openalex.org/W2006831634","https://openalex.org/W2027432022","https://openalex.org/W2029489645","https://openalex.org/W2043621834","https://openalex.org/W2048313558","https://openalex.org/W2055991021","https://openalex.org/W2063432830","https://openalex.org/W2065248209","https://openalex.org/W2079313678","https://openalex.org/W2083483697","https://openalex.org/W2083510841","https://openalex.org/W2083541735","https://openalex.org/W2084414069","https://openalex.org/W2093471257","https://openalex.org/W2098927273","https://openalex.org/W2106869414","https://openalex.org/W2115063969","https://openalex.org/W2138605813","https://openalex.org/W2145164461"],"related_works":["https://openalex.org/W2035590565","https://openalex.org/W1972074273","https://openalex.org/W2399972750","https://openalex.org/W1991750906","https://openalex.org/W2043070664","https://openalex.org/W4292937355","https://openalex.org/W1997494187","https://openalex.org/W1985036163","https://openalex.org/W2015413175","https://openalex.org/W7166740659"],"abstract_inverted_index":{"Here,":[0],"we":[1,19,75],"describe":[2],"a":[3,10,21,26,60,69,82,94,136,156,188],"new":[4],"method":[5,124,195],"for":[6,72,177,187,227],"the":[7,39,48,53,73,87,103,107,132,146,160,164,171,202,222,225],"bioconjugation":[8],"of":[9,42,131,138,173,181,185,224],"nonglycoprotein":[11],"with":[12,52,81,106,155,215],"biomolecules.":[13],"Using":[14],"polypeptide-alpha-":[15],"N-acetylgalactosaminyltransferase":[16],"II":[17],"(ppGalNAc-T2),":[18],"transfer":[20],"C2-modified":[22,153],"galactose":[23,55,154,174],"that":[24,62,90],"has":[25],"chemical":[27,157,168],"handle,":[28],"such":[29,206],"as":[30,93,113,207],"ketone":[31],"or":[32,212],"azide,":[33],"from":[34,135,145],"its":[35],"respective":[36],"UDP-sugars":[37,147],"to":[38,47,59,127,159,198],"Ser/Thr":[40,161],"residue(s)":[41,162],"an":[43,64,120,216],"acceptor":[44],"polypeptide":[45],"fused":[46],"nonglycoprotein.":[49],"The":[50,100,167],"protein":[51,80,96],"modified":[54],"is":[56,175],"then":[57],"coupled":[58],"biomolecule":[61],"carries":[63],"orthogonal":[65],"reactive":[66],"group.":[67],"As":[68],"model":[70],"system":[71],"nonglycoprotein,":[74],"engineered":[76,217],"glutathione-":[77],"S-transferase":[78],"(GST)":[79],"17-amino-acid-long":[83],"fusion":[84,165],"peptide":[85,219],"at":[86,170,221],"C-terminal":[88,108],"end":[89],"was":[91,111,125],"expressed":[92,112],"soluble":[95],"in":[97,116,121,163],"E.":[98,117],"coli.":[99],"ppGalNAc-T2":[101,142],"protein,":[102],"catalytic":[104],"domain":[105],"lectin":[109],"domain,":[110],"inclusion":[114],"bodies":[115],"coli,":[118],"and":[119,179,183,229],"vitro":[122],"folding":[123],"developed":[126],"produce":[128],"milligram":[129],"quantities":[130],"active":[133],"enzyme":[134,143],"liter":[137],"bacterial":[139,213],"culture.":[140],"This":[141,193],"transfers":[144],"not":[148],"only":[149],"GalNAc":[150],"but":[151],"also":[152],"handle":[158,169],"peptide.":[166],"C2":[172],"used":[176],"conjugation":[178,228],"assembly":[180],"bionanoparticles":[182],"preparation":[184],"immuno-liposomes":[186],"targeted":[189],"drug":[190],"delivery":[191],"system.":[192],"novel":[194],"enables":[196],"one":[197],"glycosylate,":[199],"using":[200],"ppGalNAc-T2,":[201],"important":[203],"biological":[204],"nonglycoproteins,":[205],"single-chain":[208],"antibodies,":[209],"growth":[210],"factors,":[211],"toxins,":[214],"17-residue":[218],"sequence":[220],"C-terminus":[223],"molecule,":[226],"coupling.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
