{"id":"https://openalex.org/W2056435017","doi":"https://doi.org/10.1002/1096-911x(20001201)35:6<516::aid-mpo3>3.0.co;2-z","title":"Identification of the homozygously deleted region at chromosome 1p36.2 in human neuroblastoma","display_name":"Identification of the homozygously deleted region at chromosome 1p36.2 in human neuroblastoma","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2056435017","doi":"https://doi.org/10.1002/1096-911x(20001201)35:6<516::aid-mpo3>3.0.co;2-z","mag":"2056435017","pmid":"https://pubmed.ncbi.nlm.nih.gov/11107106"},"language":"en","primary_location":{"id":"doi:10.1002/1096-911x(20001201)35:6<516::aid-mpo3>3.0.co;2-z","doi":"https://doi.org/10.1002/1096-911x(20001201)35:6<516::aid-mpo3>3.0.co;2-z","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1096-911x(20001201)35:6<516::aid-mpo3>3.0.co;2-z","pdf_url":null,"source":{"id":"https://openalex.org/S179546387","display_name":"Medical and Pediatric Oncology","issn_l":"0098-1532","issn":["0098-1532","1096-911X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320571","host_organization_name":"Alan R. Liss, Inc.","host_organization_lineage":["https://openalex.org/P4310320571"],"host_organization_lineage_names":["Alan R. Liss, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical and Pediatric Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059436010","display_name":"Akira Nakagawara","orcid":"https://orcid.org/0000-0002-7117-9429","observed_orcids":["https://orcid.org/0000-0002-7117-9429"]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akira Nakagawara","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan. akiranak@chiba-cc.pref.chiba.jp","Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan. akiranak@chiba-cc.pref.chiba.jp","institution_ids":["https://openalex.org/I4405286631"]},{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024295857","display_name":"Miki Ohira","orcid":"https://orcid.org/0000-0001-9105-1142","observed_orcids":["https://orcid.org/0000-0001-9105-1142"]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miki Ohira","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","Chiba Cancer Center Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]},{"raw_affiliation_string":"Chiba Cancer Center Hospital","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004803822","display_name":"Hajime Kageyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Kageyama","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","Chiba Cancer Center Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]},{"raw_affiliation_string":"Chiba Cancer Center Hospital","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108854416","display_name":"Motohiro Mihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motohiro Mihara","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","Chiba Cancer Center Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]},{"raw_affiliation_string":"Chiba Cancer Center Hospital","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040584308","display_name":"Shigeyuki Furuta","orcid":"https://orcid.org/0000-0003-1089-4936","observed_orcids":["https://orcid.org/0000-0003-1089-4936"]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeyuki Furuta","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","Chiba Cancer Center Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]},{"raw_affiliation_string":"Chiba Cancer Center Hospital","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Taiichi Machida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taiichi Machida","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","Chiba Cancer Center Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]},{"raw_affiliation_string":"Chiba Cancer Center Hospital","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004095938","display_name":"Hajime Takayasu","orcid":"https://orcid.org/0000-0002-7458-7495","observed_orcids":["https://orcid.org/0000-0002-7458-7495"]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Takayasu","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","Chiba Cancer Center Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]},{"raw_affiliation_string":"Chiba Cancer Center Hospital","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110088729","display_name":"Ashraful Islam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ashraful Islam","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","Chiba Cancer Center Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]},{"raw_affiliation_string":"Chiba Cancer Center Hospital","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029429842","display_name":"Yohko Nakamura","orcid":"https://orcid.org/0000-0002-3655-887X","observed_orcids":["https://orcid.org/0000-0002-3655-887X"]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yohko Nakamura","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","Chiba Cancer Center Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]},{"raw_affiliation_string":"Chiba Cancer Center Hospital","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008946028","display_name":"Masato Takahashi","orcid":"https://orcid.org/0000-0002-6641-9598","observed_orcids":["https://orcid.org/0000-0002-6641-9598"]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Takahashi","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","Chiba Cancer Center Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]},{"raw_affiliation_string":"Chiba Cancer Center Hospital","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040953523","display_name":"Tomotane Shishikura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomotane Shishikura","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","Chiba Cancer Center Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]},{"raw_affiliation_string":"Chiba Cancer Center Hospital","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087018417","display_name":"Yasuhiko Kaneko","orcid":"https://orcid.org/0000-0001-7361-9582","observed_orcids":["https://orcid.org/0000-0001-7361-9582"]},"institutions":[{"id":"https://openalex.org/I4210123465","display_name":"Saitama Cancer Center","ror":"https://ror.org/03a4d7t12","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123465"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiko Kaneko","raw_affiliation_strings":["Saitama Cancer Center, Saitama, Japan","Saitama Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saitama Cancer Center, Saitama, Japan","institution_ids":["https://openalex.org/I4210123465"]},{"raw_affiliation_string":"Saitama Cancer Center","institution_ids":["https://openalex.org/I4210123465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031272026","display_name":"Atsushi Toyoda","orcid":"https://orcid.org/0000-0002-0728-7548","observed_orcids":["https://orcid.org/0000-0002-0728-7548","https://orcid.org/0000-0002-0245-3244"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Toyoda","raw_affiliation_strings":["RIKEN Genome Center, Saitama, Japan","RIKEN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Genome Center, Saitama, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032406231","display_name":"Masahira Hattori","orcid":"https://orcid.org/0000-0001-9467-0344","observed_orcids":["https://orcid.org/0000-0001-9467-0344"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahira Hattori","raw_affiliation_strings":["RIKEN Genome Center, Saitama, Japan","RIKEN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Genome Center, Saitama, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109085203","display_name":"Yoshiyuki Sakaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiyuki Sakaki","raw_affiliation_strings":["Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan","The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103404025","display_name":"Misao Ohki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Misao Ohki","raw_affiliation_strings":["Cancer Genomics Division, National Cancer Center Research Institute, Tokyo, Japan","Nat Cancer Center Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genomics Division, National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"Nat Cancer Center Research Institute","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009665973","display_name":"Akira Horii","orcid":"https://orcid.org/0000-0002-3967-3291","observed_orcids":["https://orcid.org/0000-0002-3967-3291"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Horii","raw_affiliation_strings":["Department of Molecular Pathology, Tohoku University, Tohoku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology, Tohoku University, Tohoku, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111586377","display_name":"Eiichi Soeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eiichi Soeda","raw_affiliation_strings":["RIKEN Gene Bank, Saitama, Japan","RIKEN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Gene Bank, Saitama, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109072351","display_name":"Johji Inazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Johji Inazawa","raw_affiliation_strings":["Department of Cytogenetics, Tokyo Medical and Dental University, Tokyo, Japan","Tokyo Medical and Dental Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytogenetics, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Tokyo Medical and Dental Univ","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090365310","display_name":"Naohiko Seki","orcid":"https://orcid.org/0000-0003-4731-7956","observed_orcids":["https://orcid.org/0000-0003-4731-7956"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naohiko Seki","raw_affiliation_strings":["Department of Cytogenetics, Tokyo Medical and Dental University, Tokyo, Japan","Tokyo Medical and Dental Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytogenetics, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Tokyo Medical and Dental Univ","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048645322","display_name":"Hidekazu Kuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I866586157","display_name":"Hisamitsu Pharmaceutical (Japan)","ror":"https://ror.org/01jxvhp27","country_code":"JP","type":"company","lineage":["https://openalex.org/I866586157"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidekazu Kuma","raw_affiliation_strings":["Hisamitsu Pharmaceutical Co. Inc., Japan","Hisamitsu Pharmaceutical Co., Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hisamitsu Pharmaceutical Co. Inc., Japan","institution_ids":["https://openalex.org/I866586157"]},{"raw_affiliation_string":"Hisamitsu Pharmaceutical Co., Inc","institution_ids":["https://openalex.org/I866586157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013606921","display_name":"Iwao Nozawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I866586157","display_name":"Hisamitsu Pharmaceutical (Japan)","ror":"https://ror.org/01jxvhp27","country_code":"JP","type":"company","lineage":["https://openalex.org/I866586157"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Iwao Nozawa","raw_affiliation_strings":["Hisamitsu Pharmaceutical Co. Inc., Japan","Hisamitsu Pharmaceutical Co., Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hisamitsu Pharmaceutical Co. Inc., Japan","institution_ids":["https://openalex.org/I866586157"]},{"raw_affiliation_string":"Hisamitsu Pharmaceutical Co., Inc","institution_ids":["https://openalex.org/I866586157"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109324325","display_name":"Shigeru Sakiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Sakiyama","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","Chiba Cancer Center Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]},{"raw_affiliation_string":"Chiba Cancer Center Hospital","institution_ids":["https://openalex.org/I4210115246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5059436010"],"corresponding_institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"],"apc_list":null,"apc_paid":null,"fwci":0.5191,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.64886988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"35","issue":"6","first_page":"516","last_page":"521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.8740000128746033},{"id":"https://openalex.org/keywords/homozygous-deletion","display_name":"homozygous deletion","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7649999856948853},{"id":"https://openalex.org/keywords/two-hit-hypothesis","display_name":"two-hit hypothesis","score":0.781000018119812},{"id":"https://openalex.org/keywords/neuroblastoma-cell-lines","display_name":"neuroblastoma cell lines","score":0.8820000290870667},{"id":"https://openalex.org/keywords/gene-expression-analysis","display_name":"gene expression analysis","score":0.6539999842643738},{"id":"https://openalex.org/keywords/gene-mutation-analysis","display_name":"gene mutation analysis","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C59582021","wikidata":"https://www.wikidata.org/wiki/Q1128751","display_name":"Contig","level":4,"score":0.7583402395248413},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.7284365296363831},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7206431031227112},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6395727396011353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5645210146903992},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4412786662578583},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.4306222200393677},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.41878998279571533},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3344009220600128},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.20171597599983215},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.06894639134407043}],"mesh":[{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002872","descriptor_name":"Chromosome Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002878","descriptor_name":"Chromosomes, Human, Pair 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1096-911x(20001201)35:6<516::aid-mpo3>3.0.co;2-z","doi":"https://doi.org/10.1002/1096-911x(20001201)35:6<516::aid-mpo3>3.0.co;2-z","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1096-911x(20001201)35:6<516::aid-mpo3>3.0.co;2-z","pdf_url":null,"source":{"id":"https://openalex.org/S179546387","display_name":"Medical and Pediatric Oncology","issn_l":"0098-1532","issn":["0098-1532","1096-911X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320571","host_organization_name":"Alan R. Liss, Inc.","host_organization_lineage":["https://openalex.org/P4310320571"],"host_organization_lineage_names":["Alan R. Liss, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical and Pediatric Oncology","raw_type":"journal-article"},{"id":"pmid:11107106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11107106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical and pediatric oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1541072818","https://openalex.org/W1553314463","https://openalex.org/W1965864793","https://openalex.org/W1982698039","https://openalex.org/W1985064409","https://openalex.org/W1989337156","https://openalex.org/W1996088728","https://openalex.org/W2002121184","https://openalex.org/W2003900227","https://openalex.org/W2008115232","https://openalex.org/W2014371484","https://openalex.org/W2024280594","https://openalex.org/W2029081617","https://openalex.org/W2037165368","https://openalex.org/W2077003408","https://openalex.org/W2077858999","https://openalex.org/W2082259697","https://openalex.org/W2088784253","https://openalex.org/W2096398040","https://openalex.org/W2115999707","https://openalex.org/W2121071095","https://openalex.org/W2146795350","https://openalex.org/W2155277507","https://openalex.org/W2165053368","https://openalex.org/W2169105754","https://openalex.org/W2312368952","https://openalex.org/W2414982259"],"related_works":["https://openalex.org/W1992763590","https://openalex.org/W2140320405","https://openalex.org/W2025483292","https://openalex.org/W1982698039","https://openalex.org/W2070076501","https://openalex.org/W285933829","https://openalex.org/W2042981959","https://openalex.org/W2168833587","https://openalex.org/W1559669052","https://openalex.org/W2090014102"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1,96],"have":[2,63,82],"identified":[3],"for":[4,91,112],"the":[5,13,31,50,54,68,92,99,113,124,128,144],"first":[6],"time":[7],"a":[8,137],"homozygously":[9,33],"deleted":[10,34,55],"region":[11,15,35,56,114,129],"within":[12,67,127],"smallest":[14],"of":[16,44,53,87,101,106,115,123],"overlap":[17],"at":[18],"1p36.2-3":[19],"in":[20],"two":[21],"neuroblastoma":[22,138],"cell":[23],"lines.":[24],"PROCEDURE:":[25],"The":[26],"800-kb":[27],"PAC":[28],"contig":[29],"covering":[30],"entire":[32],"was":[36,57],"made":[37],"and":[38,49,103],"sequenced.":[39],"To":[40],"date,":[41],"approximately":[42],"70%":[43],"sequencing":[45,111],"has":[46],"been":[47,83],"accomplished,":[48],"estimated":[51],"length":[52],"500":[58],"kb.":[59],"RESULTS:":[60],"Currently,":[61],"we":[62],"found":[64],"six":[65],"genes":[66,74,80,125],"region,":[69],"which":[70],"include":[71],"three":[72,78],"known":[73],"as":[75,77,118,120,141],"well":[76,119],"other":[79],"that":[81],"reported":[84],"during":[85],"processing":[86],"our":[88],"present":[89],"project":[90],"last":[93],"3(1/2)":[94],"years.":[95],"report":[97],"here":[98],"results":[100],"expression":[102],"mutation":[104],"analyses":[105,122],"those":[107],"genes.":[108],"CONCLUSIONS:":[109],"Full":[110],"homozygous":[116],"deletion":[117],"further":[121],"mapped":[126],"may":[130],"reveal":[131],"whether":[132],"or":[133],"not":[134],"there":[135],"is":[136],"suppressor":[139],"gene":[140],"proposed":[142],"by":[143],"Knudson's":[145],"two-hit":[146],"hypothesis.":[147]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}