{"id":"https://openalex.org/W2056425629","doi":"https://doi.org/10.1038/bjc.1996.378","title":"Enhanced paracellular barrier function of rat mesothelial cells partially protects against cancer cell penetration","display_name":"Enhanced paracellular barrier function of rat mesothelial cells partially protects against cancer cell penetration","publication_year":1996,"publication_date":"1996-08-01","ids":{"openalex":"https://openalex.org/W2056425629","doi":"https://doi.org/10.1038/bjc.1996.378","mag":"2056425629","pmid":"https://pubmed.ncbi.nlm.nih.gov/8695361","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2074641"},"language":"en","primary_location":{"id":"doi:10.1038/bjc.1996.378","doi":"https://doi.org/10.1038/bjc.1996.378","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.1996.378","pdf_url":"https://www.nature.com/articles/bjc1996378.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/bjc1996378.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111988718","display_name":"Hirotoshi Tobioka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Tobioka","raw_affiliation_strings":["Department of Pathology, Sapporo Medical University, School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sapporo Medical University, School of Medicine, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112097475","display_name":"N Sawada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Sawada","raw_affiliation_strings":["Department of Pathology, Sapporo Medical University School of Medicine, Japan","Department of Pathology, Sapporo Medical University School of Medicine, S.1, W. 17, Chuo-ku, Sapporo 060, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sapporo Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Department of Pathology, Sapporo Medical University School of Medicine, S.1, W. 17, Chuo-ku, Sapporo 060, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046702759","display_name":"Yun Zhong","orcid":"https://orcid.org/0000-0003-3952-1260","observed_orcids":["https://orcid.org/0000-0003-3952-1260"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]},{"id":"https://openalex.org/I4210124603","display_name":"Sapporo Medical University Hospital","ror":"https://ror.org/02a7zgk95","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210124603"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Zhong","raw_affiliation_strings":["Department of Pathology, Sapporo Medical University School of Medicine, Japan","Department of Pathology, Sapporo Medical University School of Medicine and the 2Department of Clinical Pathology, Sapporo Medical University Hospital, S.1. W.17, Chuo-ku, Sapporo 060, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sapporo Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Department of Pathology, Sapporo Medical University School of Medicine and the 2Department of Clinical Pathology, Sapporo Medical University Hospital, S.1. W.17, Chuo-ku, Sapporo 060, Japan","institution_ids":["https://openalex.org/I141882310","https://openalex.org/I4210124603"]}]},{"author_position":"last","author":{"id":null,"display_name":"M Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]},{"id":"https://openalex.org/I4210124603","display_name":"Sapporo Medical University Hospital","ror":"https://ror.org/02a7zgk95","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210124603"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Mori","raw_affiliation_strings":["Department of Pathology, Sapporo Medical University School of Medicine, Japan","Department of Pathology, Sapporo Medical University School of Medicine and the 2Department of Clinical Pathology, Sapporo Medical University Hospital, S.1. W.17, Chuo-ku, Sapporo 060, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sapporo Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Department of Pathology, Sapporo Medical University School of Medicine and the 2Department of Clinical Pathology, Sapporo Medical University Hospital, S.1. W.17, Chuo-ku, Sapporo 060, Japan","institution_ids":["https://openalex.org/I141882310","https://openalex.org/I4210124603"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":1.4853,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.78914328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"74","issue":"3","first_page":"439","last_page":"445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paracellular-barrier","display_name":"paracellular barrier","score":0.8040000200271606},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.8209999799728394},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9300000071525574},{"id":"https://openalex.org/keywords/mammary-cancer-cells","display_name":"mammary cancer cells","score":0.8130000233650208},{"id":"https://openalex.org/keywords/abdominal-cavity","display_name":"abdominal cavity","score":0.4830000102519989},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2909640154","wikidata":"https://www.wikidata.org/wiki/Q35970","display_name":"Mesothelial Cell","level":2,"score":0.8392338156700134},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.7471950054168701},{"id":"https://openalex.org/C2779747549","wikidata":"https://www.wikidata.org/wiki/Q35970","display_name":"Mesothelium","level":3,"score":0.575989842414856},{"id":"https://openalex.org/C60903277","wikidata":"https://www.wikidata.org/wiki/Q2051926","display_name":"Paracellular transport","level":4,"score":0.5633793473243713},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.5519388318061829},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5012149810791016},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4170435667037964},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41545018553733826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40804800391197205},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3784458637237549},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3421676456928253},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33148592710494995},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2580670118331909},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21396860480308533},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08724874258041382},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.0674390196800232},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/bjc.1996.378","doi":"https://doi.org/10.1038/bjc.1996.378","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.1996.378","pdf_url":"https://www.nature.com/articles/bjc1996378.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1520481","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2074641","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:8695361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8695361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2074641","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2074641/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/bjc.1996.378","doi":"https://doi.org/10.1038/bjc.1996.378","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.1996.378","pdf_url":"https://www.nature.com/articles/bjc1996378.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2056425629.pdf","grobid_xml":"https://content.openalex.org/works/W2056425629.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W62928356","https://openalex.org/W214317437","https://openalex.org/W1549390145","https://openalex.org/W1554900315","https://openalex.org/W1574826999","https://openalex.org/W1583291735","https://openalex.org/W1603975601","https://openalex.org/W1836988923","https://openalex.org/W1896475013","https://openalex.org/W1903276221","https://openalex.org/W1938617858","https://openalex.org/W1971256445","https://openalex.org/W1978807481","https://openalex.org/W1989370400","https://openalex.org/W1997469925","https://openalex.org/W2009211256","https://openalex.org/W2009890257","https://openalex.org/W2010641543","https://openalex.org/W2013495290","https://openalex.org/W2014586430","https://openalex.org/W2022393971","https://openalex.org/W2022633638","https://openalex.org/W2028175040","https://openalex.org/W2046704927","https://openalex.org/W2047108476","https://openalex.org/W2053313289","https://openalex.org/W2056004041","https://openalex.org/W2068305315","https://openalex.org/W2074864607","https://openalex.org/W2089425858","https://openalex.org/W2091721680","https://openalex.org/W2096844835","https://openalex.org/W2097589101","https://openalex.org/W2119788271","https://openalex.org/W2129294561","https://openalex.org/W2130516208","https://openalex.org/W2131405896","https://openalex.org/W2155579605","https://openalex.org/W2165227755","https://openalex.org/W2192971349","https://openalex.org/W2240300013","https://openalex.org/W2266560927","https://openalex.org/W2404541893","https://openalex.org/W2404712168","https://openalex.org/W2406890050","https://openalex.org/W2414431364","https://openalex.org/W2437457294","https://openalex.org/W2468531694"],"related_works":["https://openalex.org/W2284826191","https://openalex.org/W2080691584","https://openalex.org/W2085663442","https://openalex.org/W2074307439","https://openalex.org/W1547007124","https://openalex.org/W2596785913","https://openalex.org/W2065904376","https://openalex.org/W2893974361","https://openalex.org/W2036019161","https://openalex.org/W2089936487"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}