{"id":"https://openalex.org/W2056100153","doi":"https://doi.org/10.1089/thy.2000.10.417","title":"Serum Insulin-Like Growth Factor-I, Insulin-Like Growth Factor Binding Proteins, and Bone Mineral Content in Hyperthyroidism","display_name":"Serum Insulin-Like Growth Factor-I, Insulin-Like Growth Factor Binding Proteins, and Bone Mineral Content in Hyperthyroidism","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2056100153","doi":"https://doi.org/10.1089/thy.2000.10.417","mag":"2056100153","pmid":"https://pubmed.ncbi.nlm.nih.gov/10884189"},"language":"en","primary_location":{"id":"doi:10.1089/thy.2000.10.417","doi":"https://doi.org/10.1089/thy.2000.10.417","is_oa":false,"landing_page_url":"https://doi.org/10.1089/thy.2000.10.417","pdf_url":null,"source":{"id":"https://openalex.org/S27569427","display_name":"Thyroid","issn_l":"1050-7256","issn":["1050-7256","1557-9077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114374181","display_name":"Peter L. Lakatos","orcid":"https://orcid.org/0000-0002-7652-3671","observed_orcids":["https://orcid.org/0000-0002-7652-3671"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Peter Lakatos","raw_affiliation_strings":["1st Department of Medicine, Semmelweis University Medical School, Budapest, Hungary. lakpet@bell.sote.hu","1st Department of Medicine; Semmelweis University Medical School; Budapest Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Medicine, Semmelweis University Medical School, Budapest, Hungary. lakpet@bell.sote.hu","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"1st Department of Medicine; Semmelweis University Medical School; Budapest Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109413100","display_name":"J F\u00f6ldes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Janos Foldes","raw_affiliation_strings":["","Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101865823","display_name":"Zsolt Nagy","orcid":"https://orcid.org/0000-0001-9756-5427","observed_orcids":["https://orcid.org/0000-0001-9756-5427"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zsolt Nagy","raw_affiliation_strings":["","Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070397516","display_name":"Istv\u00e1n Tak\u00e1cs","orcid":"https://orcid.org/0000-0002-7810-4833","observed_orcids":["https://orcid.org/0000-0002-7810-4833"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Istvan Takacs","raw_affiliation_strings":["","Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102117076","display_name":"G\u00e1bor Speer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Gabor Speer","raw_affiliation_strings":["","Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088207270","display_name":"Csaba Horv\u00e1th","orcid":"https://orcid.org/0000-0002-5154-9760","observed_orcids":["https://orcid.org/0000-0002-5154-9760"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Csaba Horvath","raw_affiliation_strings":["","Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054497725","display_name":"Subburaman Mohan","orcid":"https://orcid.org/0000-0003-0063-986X","observed_orcids":["https://orcid.org/0000-0003-0063-986X"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210095401","display_name":"Loma Linda University Health Care","ror":"https://ror.org/00saxze38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subburaman Mohan","raw_affiliation_strings":["","Loma Linda University Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Loma Linda University Health","institution_ids":["https://openalex.org/I26347476","https://openalex.org/I4210095401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102858874","display_name":"David J. Baylink","orcid":"https://orcid.org/0000-0001-9526-7995","observed_orcids":["https://orcid.org/0000-0001-9526-7995"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210095401","display_name":"Loma Linda University Health Care","ror":"https://ror.org/00saxze38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Baylink","raw_affiliation_strings":["","Loma Linda University Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Loma Linda University Health","institution_ids":["https://openalex.org/I26347476","https://openalex.org/I4210095401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049886691","display_name":"Paula H. Stern","orcid":"https://orcid.org/0000-0002-0679-7191","observed_orcids":["https://orcid.org/0000-0002-0679-7191"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula H. Stern","raw_affiliation_strings":["","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3816,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.88421132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"5","first_page":"417","last_page":"423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8291000127792358,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8291000127792358,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.1687999963760376,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.9760000109672546},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9549999833106995},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-proteins","display_name":"IGF binding proteins","score":0.9020000100135803},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":0.949999988079071},{"id":"https://openalex.org/keywords/igfbp-4","display_name":"IGFBP-4","score":1.0},{"id":"https://openalex.org/keywords/igfbp-5","display_name":"IGFBP-5","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.9959999918937683},{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":0.9300000071525574},{"id":"https://openalex.org/keywords/toxic-nodular-goiter","display_name":"toxic nodular goiter","score":0.996999979019165},{"id":"https://openalex.org/keywords/methimazole","display_name":"methimazole","score":0.7570000290870667},{"id":"https://openalex.org/keywords/antithyroid-drug-therapy","display_name":"antithyroid drug therapy","score":0.9129999876022339},{"id":"https://openalex.org/keywords/free-thyroxine","display_name":"free thyroxine","score":0.7950000166893005},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.75},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.5389999747276306},{"id":"https://openalex.org/keywords/lumbar-spine","display_name":"lumbar spine","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8516631722450256},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8239338397979736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7177209258079529},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.5476835370063782},{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.5358136296272278},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5232823491096497},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.48379987478256226},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.48374366760253906},{"id":"https://openalex.org/C2780378035","wikidata":"https://www.wikidata.org/wiki/Q17143674","display_name":"Insulin-like growth factor-binding protein","level":5,"score":0.467180073261261},{"id":"https://openalex.org/C2775854910","wikidata":"https://www.wikidata.org/wiki/Q4844892","display_name":"Femoral neck","level":3,"score":0.4477703869342804},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.4363492429256439},{"id":"https://openalex.org/C2776652619","wikidata":"https://www.wikidata.org/wiki/Q16483","display_name":"Graves' disease","level":3,"score":0.4278528392314911},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.42245158553123474},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.13395264744758606},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10539326071739197}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008713","descriptor_name":"Methimazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011884","descriptor_name":"Radius","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018969","descriptor_name":"Insulin-Like Growth Factor Binding Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/thy.2000.10.417","doi":"https://doi.org/10.1089/thy.2000.10.417","is_oa":false,"landing_page_url":"https://doi.org/10.1089/thy.2000.10.417","pdf_url":null,"source":{"id":"https://openalex.org/S27569427","display_name":"Thyroid","issn_l":"1050-7256","issn":["1050-7256","1557-9077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid","raw_type":"journal-article"},{"id":"pmid:10884189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10884189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid : official journal of the American Thyroid Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1993123054","display_name":"CYTOKINES AND BONE TURNOVER IN THYROID DISORDERS","funder_award_id":"R03TW000167","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"},{"id":"https://openalex.org/G3473757015","display_name":null,"funder_award_id":"ETK 126","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G4827193643","display_name":null,"funder_award_id":"TW-00167-02","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"},{"id":"https://openalex.org/G7031668687","display_name":null,"funder_award_id":"ETT 571/96","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W178768211","https://openalex.org/W1965351031","https://openalex.org/W1980108247","https://openalex.org/W1982729482","https://openalex.org/W1999561771","https://openalex.org/W2010084045","https://openalex.org/W2014843590","https://openalex.org/W2043894889","https://openalex.org/W2044846262","https://openalex.org/W2046284780","https://openalex.org/W2050223388","https://openalex.org/W2068263971","https://openalex.org/W2069890670","https://openalex.org/W2070939672","https://openalex.org/W2081862221","https://openalex.org/W2097477185","https://openalex.org/W2102480293","https://openalex.org/W2111666458","https://openalex.org/W2112167156","https://openalex.org/W2128382721","https://openalex.org/W2145349151","https://openalex.org/W2147907511","https://openalex.org/W2149726839","https://openalex.org/W2443585945","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1532410127","https://openalex.org/W2128382721","https://openalex.org/W2323995116","https://openalex.org/W2335869734","https://openalex.org/W2099621175","https://openalex.org/W2071648601","https://openalex.org/W2922392173","https://openalex.org/W2085349630","https://openalex.org/W3031661049","https://openalex.org/W2074446816"],"abstract_inverted_index":{"The":[0,359],"mechanism":[1],"by":[2,24],"which":[3,26],"thyroid":[4,16,50,348],"hormones":[5,17,349],"promote":[6],"bone":[7,100,391],"growth":[8,20],"has":[9],"not":[10,229,274],"yet":[11],"been":[12,64],"elucidated.":[13],"In":[14],"vitro,":[15],"stimulate":[18],"insulin-like":[19],"factor-I":[21],"(IGF-I)":[22],"production":[23,52],"osteoblasts,":[25],"is":[27,47,53],"important":[28],"for":[29],"the":[30,34,41,105,130,182,278,288,291,326,336,352,374,382,388],"anabolic":[31,360,383],"effects":[32,361,384],"of":[33,154,219,225,233,250,290,332,362,365,376],"hormone":[35,51],"on":[36],"bone.":[37],"To":[38],"determine":[39],"whether":[40],"IGF-I/IGF":[42],"binding":[43,91],"protein":[44],"(IGFBP)":[45],"profile":[46],"affected":[48],"when":[49],"altered":[54],"in":[55,129,151,181,284,325,355,357,370],"vivo,":[56],"we":[57],"studied":[58],"36":[59,81],"women":[60,84],"who":[61],"had":[62],"recently":[63],"diagnosed":[65],"with":[66,72,76,156,171,247,298,311],"hyperthyroidism":[67,371],"(age:":[68],"29-67":[69],"years;":[70],"19":[71],"Graves'":[73,157],"disease,":[74],"17":[75],"toxic":[77,160],"nodular":[78,161],"goiter)":[79],"and":[80,89,95,110,116,159,175,191,201,209,214,265,293,307,335,340,385],"age-matched":[82],"healthy":[83],"as":[85,97,99],"controls.":[86],"Serum":[87,123,163,173,223,240],"IGF-I,":[88],"its":[90],"proteins":[92],"(IGFBP-3,":[93],"IGFBP-4,":[94],"IGFBP-5),":[96],"well":[98],"mineral":[101],"density":[102],"(BMD)":[103],"at":[104,277,287],"lumbar":[106],"spine,":[107],"femoral":[108],"neck,":[109],"radius":[111,279],"midshaft":[112,280],"were":[113,126,178,215],"measured":[114],"before":[115,133,185,236],"1":[117,330],"year":[118,331],"after":[119,169,221,238,329],"antithyroid":[120],"(methimazole)":[121],"treatment.":[122,222],"IGF-I":[124,152,164,251,300,342,366],"levels":[125,153,249,364],"significantly":[127,179,282],"increased":[128,363],"hyperthyroid":[131,183,226,285,327],"patients":[132,155,286],"treatment":[134,170,186],"(214":[135],"+/-":[136,141,188,193,198,203],"18.2":[137],"ng/mL":[138,190,195,200],"vs.":[139,196],"145":[140],"21.3":[142],"ng/mL;":[143,205],"p":[144,206,210,255,262,270,304,316],"<":[145,207,211,256,263,271,305,317],"0.05).":[146,318],"There":[147],"was":[148,228,281],"no":[149],"difference":[150],"disease":[158],"goiter.":[162],"concentrations":[165],"returned":[166],"to":[167,217,373,387],"normal":[168],"methimazole.":[172],"IGFBP-3":[174,258],"IGFBP-4":[176,266,312],"values":[177],"elevated":[180],"group":[184,328],"(3960":[187],"220":[189],"749.7":[192],"53.1":[194],"2701":[197],"180":[199],"489.9":[202],"32.4":[204],"0.05":[208],"0.01,":[212],"respectively)":[213],"reduced":[216],"those":[218],"controls":[220,234],"IGFBP-5":[224],"subjects":[227],"different":[230],"from":[231],"that":[232,347,379],"either":[235],"or":[237],"therapy.":[239],"free":[241],"thyroxine":[242],"showed":[243,294,321],"a":[244,295,308,322],"positive":[245,296],"correlation":[246,297,310,337],"serum":[248,299,341],"(r":[252,259,267,301,313],"=":[253,260,268,302,314],"0.73,":[254],"0.05),":[257,264],"0.59,":[261],"0.67,":[269],"0.05)":[272],"but":[273],"IGFBP-5.":[275],"BMD":[276,320,339],"lower":[283],"start":[289],"study":[292],"0.58;":[303],"0.001)":[306],"negative":[309],"-0.61;":[315],"Radius":[319],"7.2%":[323],"increase":[324],"methimazole":[333],"treatment,":[334],"between":[338],"disappeared.":[343],"Our":[344],"data":[345],"indicate":[346],"may":[350,367],"influence":[351],"IGF-I/IGFBP":[353],"system":[354],"vivo":[356],"hyperthyroidism.":[358],"be":[368],"limited":[369],"due":[372],"increases":[375],"inhibitory":[377],"IGFBPs":[378],"can":[380],"counteract":[381],"contribute":[386],"observed":[389],"net":[390],"loss.":[392]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}