{"id":"https://openalex.org/W2056086692","doi":"https://doi.org/10.1164/ajrccm/146.1.109","title":"Allergic and Nonallergic Asthmatics Have Distinct Patterns of T-Cell Activation and Cytokine Production in Peripheral Blood and Bronchoalveolar Lavage","display_name":"Allergic and Nonallergic Asthmatics Have Distinct Patterns of T-Cell Activation and Cytokine Production in Peripheral Blood and Bronchoalveolar Lavage","publication_year":1992,"publication_date":"1992-07-01","ids":{"openalex":"https://openalex.org/W2056086692","doi":"https://doi.org/10.1164/ajrccm/146.1.109","mag":"2056086692","pmid":"https://pubmed.ncbi.nlm.nih.gov/1626792"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm/146.1.109","doi":"https://doi.org/10.1164/ajrccm/146.1.109","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm/146.1.109","pdf_url":null,"source":{"id":"https://openalex.org/S2751726451","display_name":"American Review of Respiratory Disease","issn_l":"0003-0805","issn":["0003-0805","2376-3752"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Review of Respiratory Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043208437","display_name":"Christoph Walker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christoph Walker","raw_affiliation_strings":["Swiss Institute of Allergy and Asthma Research, Davos, Switzerland","Swiss institute of Allergy & Asthma research, Davos, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Institute of Allergy and Asthma Research, Davos, Switzerland","institution_ids":[]},{"raw_affiliation_string":"Swiss institute of Allergy & Asthma research, Davos, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060343477","display_name":"Erhard Bode","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erhard Bode","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109168591","display_name":"Laurens Julius de Boer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liesbeth Boer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056795918","display_name":"Trevor T. Hansel","orcid":"https://orcid.org/0000-0003-3786-8105","observed_orcids":["https://orcid.org/0000-0003-3786-8105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Trevor T. Hansel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112202611","display_name":"Kurt Blaser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kurt Blaser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108743393","display_name":"Johann-Christian Virchow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johann-Christian Virchow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":46.1478,"has_fulltext":false,"cited_by_count":762,"citation_normalized_percentile":{"value":0.99930016,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"146","issue":"1","first_page":"109","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/non-allergic-asthma","display_name":"non-allergic asthma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.9319999814033508},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.8659999966621399},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/il-2-receptor","display_name":"interleukin-2 receptor","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cd23","display_name":"CD23","score":0.8669999837875366},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.7540000081062317},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8690000176429749},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9940000176429749},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/eosinophilia","display_name":"eosinophilia","score":0.8059999942779541},{"id":"https://openalex.org/keywords/ige","display_name":"IgE","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.9739999771118164},{"id":"https://openalex.org/keywords/vla-1","display_name":"VLA-1","score":0.8740000128746033},{"id":"https://openalex.org/keywords/lymphocyte-subsets","display_name":"lymphocyte subsets","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7853622436523438},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.6305060386657715},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5957470536231995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.565792441368103},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.5530317425727844},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5405125021934509},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5232899785041809},{"id":"https://openalex.org/C181901479","wikidata":"https://www.wikidata.org/wiki/Q14877650","display_name":"Interleukin 5","level":4,"score":0.5159409642219543},{"id":"https://openalex.org/C34814297","wikidata":"https://www.wikidata.org/wiki/Q4845302","display_name":"CD23","level":4,"score":0.5153593420982361},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.43968719244003296},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.31115370988845825},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2798601984977722},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.23406589031219482},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14880728721618652},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.10511493682861328}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1164/ajrccm/146.1.109","doi":"https://doi.org/10.1164/ajrccm/146.1.109","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm/146.1.109","pdf_url":null,"source":{"id":"https://openalex.org/S2751726451","display_name":"American Review of Respiratory Disease","issn_l":"0003-0805","issn":["0003-0805","2376-3752"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Review of Respiratory Disease","raw_type":"journal-article"},{"id":"pmid:1626792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1626792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Journal Article"},{"id":"pmh:oai:freidok.uni-freiburg.de:37003","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/37003","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Review of Respiratory Disease. - 146, 1 (1992) , 109-115, ISSN: 0003-0805","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1480813099","https://openalex.org/W1771396631","https://openalex.org/W1829148295","https://openalex.org/W2011658825","https://openalex.org/W2097520491","https://openalex.org/W2120012263","https://openalex.org/W2146851076","https://openalex.org/W2160572043","https://openalex.org/W2170161832","https://openalex.org/W2414340546","https://openalex.org/W4236639597","https://openalex.org/W4290319988"],"related_works":["https://openalex.org/W2736501869","https://openalex.org/W2044733111","https://openalex.org/W4232091995","https://openalex.org/W1981811832","https://openalex.org/W2021753844","https://openalex.org/W2440470013","https://openalex.org/W1995797755","https://openalex.org/W4003777","https://openalex.org/W2010373881","https://openalex.org/W2378028757"],"abstract_inverted_index":{"Activation":[0],"of":[1,10,19,26,43,69,117,143,156,161,175,181,189],"lymphocyte":[2,108],"subpopulations":[3],"was":[4],"determined":[5,93],"in":[6,12,31,53,75,84,88,94,132,186,191],"conjunction":[7],"with":[8,41,147,164],"levels":[9,91,116,130,142,163],"cytokines":[11,190],"peripheral":[13,32,101],"blood":[14,33,63,85,102],"and":[15,34,36,58,64,72,97,105,119,121,145,193],"bronchoalveolar":[16],"lavage":[17],"(BAL)":[18],"asthmatics.":[20],"Allergic":[21,110],"asthmatics":[22,55,78,111,139],"had":[23,66,140],"increased":[24,67,87,115],"numbers":[25,42],"CD4+":[27,57],"IL-2R+":[28],"T":[29,60,80,103],"cells":[30,61,81,104],"BAL,":[35],"T-cell":[37,151,183],"activation":[38,184],"closely":[39],"correlated":[40],"low-affinity":[44],"IgE":[45,129],"receptor":[46],"(CD23)":[47],"bearing":[48],"B":[49],"cells.":[50],"In":[51,136,153],"contrast,":[52,137],"nonallergic":[54,77,138,194],"both":[56,154],"CD8+":[59,79],"from":[62,99],"BAL":[65,95,107],"expression":[68],"IL-2R,":[70],"HLA-DR,":[71],"VLA-1.":[73],"Furthermore,":[74],"the":[76,127,158,172],"were":[82,92,112],"decreased":[83],"but":[86],"BAL.":[89],"Cytokine":[90],"fluid":[96],"supernatants":[98],"purified":[100],"enriched":[106],"preparations.":[109],"characterized":[113],"by":[114],"IL-4":[118,124],"IL-5,":[120,146],"this":[122],"elevated":[123,128,141],"contributed":[125],"to":[126,150],"found":[131],"these":[133],"allergic":[134,192],"subjects.":[135],"IL-2":[144,148],"contributing":[149],"activation.":[152],"types":[155],"asthma,":[157],"close":[159],"correlation":[160],"IL-5":[162,168],"eosinophilia":[165,174],"suggests":[166],"that":[167],"is":[169],"responsible":[170],"for":[171],"characteristic":[173],"asthma.":[176,195],"Thus,":[177],"we":[178],"provide":[179],"evidence":[180],"distinct":[182],"resulting":[185],"different":[187],"spectra":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}