{"id":"https://openalex.org/W2056053069","doi":"https://doi.org/10.3851/imp2474","title":"Therapeutic Levels of Lopinavir in Late Pregnancy and Abacavir Passage into Breast Milk in the Mma Bana Study, Botswana","display_name":"Therapeutic Levels of Lopinavir in Late Pregnancy and Abacavir Passage into Breast Milk in the Mma Bana Study, Botswana","publication_year":2012,"publication_date":"2012-11-26","ids":{"openalex":"https://openalex.org/W2056053069","doi":"https://doi.org/10.3851/imp2474","mag":"2056053069","pmid":"https://pubmed.ncbi.nlm.nih.gov/23183881","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5502724"},"language":"en","primary_location":{"id":"doi:10.3851/imp2474","doi":"https://doi.org/10.3851/imp2474","is_oa":true,"landing_page_url":"https://doi.org/10.3851/imp2474","pdf_url":"https://journals.sagepub.com/doi/pdf/10.3851/IMP2474","source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.3851/IMP2474","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030501259","display_name":"Roger Shapiro","orcid":"https://orcid.org/0000-0002-4832-6275","observed_orcids":["https://orcid.org/0000-0002-4832-6275"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roger L Shapiro","raw_affiliation_strings":["Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA","Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA","The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087117526","display_name":"Steven S. Rossi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Rossi","raw_affiliation_strings":["Department of Pediatrics, Division of Clinical Pharmacology and Developmental Therapeutics, University of California, San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Clinical Pharmacology and Developmental Therapeutics, University of California, San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065935798","display_name":"Anthony Ogwu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Ogwu","raw_affiliation_strings":["The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068404547","display_name":"Mary C. Moss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Moss","raw_affiliation_strings":["Department of Pediatrics, Division of Clinical Pharmacology and Developmental Therapeutics, University of California, San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Clinical Pharmacology and Developmental Therapeutics, University of California, San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026379042","display_name":"Jean Leidner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean Leidner","raw_affiliation_strings":["The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056730246","display_name":"Claire Moffat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire Moffat","raw_affiliation_strings":["The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032863083","display_name":"Shahin Lockman","orcid":"https://orcid.org/0000-0002-5384-9716","observed_orcids":["https://orcid.org/0000-0002-5384-9716"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahin Lockman","raw_affiliation_strings":["Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA","Infectious Disease Unit, Brigham and Women's Hospital, Boston, MA, USA","The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Infectious Disease Unit, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089498228","display_name":"Sikhulile M. Moyo","orcid":"https://orcid.org/0000-0003-3821-4592","observed_orcids":["https://orcid.org/0000-0003-3821-4592"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sikhulile Moyo","raw_affiliation_strings":["The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057590991","display_name":"Joseph M. Makhema","orcid":"https://orcid.org/0000-0003-0017-2438","observed_orcids":["https://orcid.org/0000-0003-0017-2438"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Makhema","raw_affiliation_strings":["The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067331905","display_name":"Max Essex","orcid":"https://orcid.org/0000-0002-4576-7841","observed_orcids":["https://orcid.org/0000-0002-4576-7841"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max Essex","raw_affiliation_strings":["Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA","The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"The Botswana\u2013Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040076878","display_name":"Edmund V. Capparelli","orcid":"https://orcid.org/0000-0002-1630-0505","observed_orcids":["https://orcid.org/0000-0002-1630-0505"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edmund Capparelli","raw_affiliation_strings":["Department of Pediatrics, Division of Clinical Pharmacology and Developmental Therapeutics, University of California, San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Clinical Pharmacology and Developmental Therapeutics, University of California, San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030501259"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":0.8834,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.74701347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"18","issue":"4","first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7103999853134155,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7103999853134155,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.23330000042915344,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lopinavir","display_name":"lopinavir","score":0.9980000257492065},{"id":"https://openalex.org/keywords/abacavir","display_name":"abacavir","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nevirapine","display_name":"nevirapine","score":0.8299999833106995},{"id":"https://openalex.org/keywords/lamivudine","display_name":"lamivudine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/zidovudine","display_name":"zidovudine","score":1.0},{"id":"https://openalex.org/keywords/antiretroviral-pharmacokinetics","display_name":"antiretroviral pharmacokinetics","score":0.7670000195503235},{"id":"https://openalex.org/keywords/late-pregnancy","display_name":"late pregnancy","score":0.7620000243186951},{"id":"https://openalex.org/keywords/breastfeeding","display_name":"breastfeeding","score":0.9729999899864197},{"id":"https://openalex.org/keywords/infant-drug-exposure","display_name":"infant drug exposure","score":0.7289999723434448},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7295593023300171},{"id":"https://openalex.org/C2775871700","wikidata":"https://www.wikidata.org/wiki/Q22728","display_name":"Breast milk","level":2,"score":0.7222803235054016},{"id":"https://openalex.org/C2777182164","wikidata":"https://www.wikidata.org/wiki/Q422585","display_name":"Lopinavir","level":5,"score":0.6873283386230469},{"id":"https://openalex.org/C2776283161","wikidata":"https://www.wikidata.org/wiki/Q174876","display_name":"Breastfeeding","level":2,"score":0.6341878175735474},{"id":"https://openalex.org/C2779465607","wikidata":"https://www.wikidata.org/wiki/Q304330","display_name":"Abacavir","level":5,"score":0.5482093691825867},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5429285764694214},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4986882209777832},{"id":"https://openalex.org/C2779130552","wikidata":"https://www.wikidata.org/wiki/Q263713","display_name":"Nevirapine","level":5,"score":0.4676631987094879},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.4123145341873169},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.40969860553741455},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2794974446296692},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.27296721935272217},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14926475286483765},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.13734152913093567},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.12360993027687073},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11925679445266724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11794605851173401},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.06787365674972534},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099227","descriptor_name":"Abacavir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001902","descriptor_name":"Botswana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001942","descriptor_name":"Breast Feeding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007774","descriptor_name":"Lactation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008895","descriptor_name":"Milk, Human","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011251","descriptor_name":"Pregnancy Complications, Infectious","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015215","descriptor_name":"Zidovudine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D015215","descriptor_name":"Zidovudine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019259","descriptor_name":"Lamivudine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019259","descriptor_name":"Lamivudine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019829","descriptor_name":"Nevirapine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019829","descriptor_name":"Nevirapine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061466","descriptor_name":"Lopinavir","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D061466","descriptor_name":"Lopinavir","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3851/imp2474","doi":"https://doi.org/10.3851/imp2474","is_oa":true,"landing_page_url":"https://doi.org/10.3851/imp2474","pdf_url":"https://journals.sagepub.com/doi/pdf/10.3851/IMP2474","source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},{"id":"pmid:23183881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23183881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral therapy","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4350304","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5502724","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5502724","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5502724","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Antivir Ther","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3851/imp2474","doi":"https://doi.org/10.3851/imp2474","is_oa":true,"landing_page_url":"https://doi.org/10.3851/imp2474","pdf_url":"https://journals.sagepub.com/doi/pdf/10.3851/IMP2474","source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.40450000762939453,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4936169817","display_name":"HAART to Prevent HIV Transmission to Infants In Botswana","funder_award_id":"U01AI066454","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8558435023","display_name":null,"funder_award_id":"1U10 HD045937-01","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2056053069.pdf","grobid_xml":"https://content.openalex.org/works/W2056053069.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1976555027","https://openalex.org/W1976627773","https://openalex.org/W1994008061","https://openalex.org/W2075068500","https://openalex.org/W2080393808","https://openalex.org/W2112601356","https://openalex.org/W2116914456","https://openalex.org/W2124866978","https://openalex.org/W2126184004","https://openalex.org/W2132706976","https://openalex.org/W2134728837","https://openalex.org/W2136127101","https://openalex.org/W2141810510","https://openalex.org/W2155050390","https://openalex.org/W2252572957"],"related_works":["https://openalex.org/W2840948123","https://openalex.org/W2141926064","https://openalex.org/W1992150295","https://openalex.org/W2558259017","https://openalex.org/W2075068500","https://openalex.org/W1997771533","https://openalex.org/W2782368419","https://openalex.org/W2009418600","https://openalex.org/W1980664033","https://openalex.org/W2077012883"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pharmacokinetic":[1],"data":[2,15],"for":[3,16,138],"lopinavir":[4,49],"in":[5,9,18,25,69,117,153,159,166,198,202,228,234,240,252],"late":[6],"pregnancy":[7,229],"and":[8,13,43,57,65,68,86,178,182,205,215,230],"breastfeeding":[10,66,203],"are":[11,21],"limited,":[12],"no":[14,231],"abacavir":[17,51],"breast":[19,45,154,160,219,235,241],"milk":[20,46,161,174,242],"available.":[22],"METHODS:":[23],"Women":[24],"the":[26],"Mma":[27],"Bana":[28],"Study":[29],"initiated":[30],"HAART":[31,81],"from":[32,104],"18":[33],"to":[34,246],"34":[35],"weeks":[36],"of":[37,48,63,71,99,164,176,184,211],"gestation.":[38],"We":[39],"determined":[40],"trough":[41,190],"plasma":[42,70,121,167,185],"whole":[44],"concentrations":[47,175,233,245],"(LPV),":[50],"(ABC),":[52],"nevirapine":[53],"(NVP),":[54],"lamivudine":[55],"(3TC)":[56],"zidovudine":[58],"(ZDV)":[59],"among":[60],"separate":[61],"subsets":[62],"pregnant":[64],"women,":[67],"exposed":[72],"infants.":[73],"Lopinavir":[74],"was":[75,196],"measured":[76,90],"1":[77,83,91],"month":[78,84,92],"after":[79],"starting":[80],"or":[82],"postpartum,":[85],"other":[87],"drugs":[88],"were":[89,115,136,151,162,180],"postpartum.":[93],"RESULTS:":[94],"Sampling":[95],"occurred":[96],"a":[97],"median":[98,112],"14":[100],"h":[101],"(range":[102],"11-17)":[103],"last":[105],"maternal":[106,191,218],"drug":[107],"ingestion.":[108],"Although":[109],"50%":[110],"higher":[111],"LPV":[113,134,146,223],"levels":[114,131,147,158,201,210,227],"seen":[116],"postpartum":[118],"than":[119],"antepartum":[120,130],"(8.29":[122],"\u03bcg/ml":[123,169],"versus":[124,170],"5.51":[125],"\u03bcg/ml;":[126],"P":[127],"=":[128],"0.02),":[129],"with":[132],"standard":[133],"dosing":[135,224],"therapeutic":[137,226],"all":[139],"women":[140],"(>":[141],"1.0":[142],"\u03bcg/ml).":[143,172],"Very":[144],"low":[145],"(<":[148],"0.25":[149],"\u03bcg/ml)":[150],"detected":[152],"milk.":[155,220,236],"Median":[156],"ABC":[157,237],"85%":[163],"those":[165],"(0.057":[168],"0.067":[171],"Breast":[173],"NVP":[177,195],"3TC":[179,216],"27%":[181],"74%":[183],"levels,":[186],"respectively.":[187],"At":[188],"these":[189],"time":[192],"points,":[193],"only":[194],"detectable":[197,239],"potentially":[199],"inhibitory":[200],"infants,":[204],"most":[206],"infants":[207],"had":[208],"non-detectable":[209],"LPV,":[212],"ABC,":[213],"ZDV":[214],"via":[217],"CONCLUSIONS:":[221],"Standard":[222],"achieved":[225],"appreciable":[232,253],"is":[238],"at":[243],"similar":[244],"plasma,":[247],"but":[248],"does":[249],"not":[250],"result":[251],"infant":[254],"exposure.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
