{"id":"https://openalex.org/W2056046583","doi":"https://doi.org/10.1016/j.patbio.2007.05.003","title":"Alpha 1 antitrypsin polymorphism in the tunisian population with special reference to pulmonary disease","display_name":"Alpha 1 antitrypsin polymorphism in the tunisian population with special reference to pulmonary disease","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W2056046583","doi":"https://doi.org/10.1016/j.patbio.2007.05.003","mag":"2056046583","pmid":"https://pubmed.ncbi.nlm.nih.gov/18031952"},"language":"en","primary_location":{"id":"doi:10.1016/j.patbio.2007.05.003","doi":"https://doi.org/10.1016/j.patbio.2007.05.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.patbio.2007.05.003","pdf_url":null,"source":{"id":"https://openalex.org/S30634364","display_name":"Pathologie Biologie","issn_l":"0369-8114","issn":["0369-8114","1768-3114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathologie Biologie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020485394","display_name":"Sabri Denden","orcid":"https://orcid.org/0000-0002-4932-2137","observed_orcids":["https://orcid.org/0000-0002-4932-2137"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"S. Denden","raw_affiliation_strings":["Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, rue Avicenne, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, rue Avicenne, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075581215","display_name":"Amel Haj Khelil","orcid":"https://orcid.org/0000-0001-5404-2116","observed_orcids":["https://orcid.org/0000-0001-5404-2116"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]}],"countries":["TN"],"is_corresponding":true,"raw_author_name":"A. Haj Khelil","raw_affiliation_strings":["Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061101514","display_name":"Pascale Perrin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4387154756","display_name":"Universit\u00e9 Montpellier 2","ror":"https://ror.org/00wh4bp03","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387154756"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Perrin","raw_affiliation_strings":["Evolution Science Institute, University of Montpellier-II, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evolution Science Institute, University of Montpellier-II, France","institution_ids":["https://openalex.org/I19894307","https://openalex.org/I4387154756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009793403","display_name":"Houria Daimi","orcid":"https://orcid.org/0000-0003-0552-1449","observed_orcids":["https://orcid.org/0000-0003-0552-1449"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"H. Daimi","raw_affiliation_strings":["Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. Leban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"N. Leban","raw_affiliation_strings":["Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064641518","display_name":"A. Ouaja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"A. Ouaja","raw_affiliation_strings":["Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019172682","display_name":"Kacem Mahdouani","orcid":"https://orcid.org/0000-0003-1138-0638","observed_orcids":["https://orcid.org/0000-0003-1138-0638"]},"institutions":[{"id":"https://openalex.org/I55167344","display_name":"University of Kairouan","ror":"https://ror.org/024mpte60","country_code":"TN","type":"education","lineage":["https://openalex.org/I55167344"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"K. Mahdouani","raw_affiliation_strings":["Biochemistry and Clinical Biology Laboratory, Ibn-Eljazzar Hospital, Kairouan, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Clinical Biology Laboratory, Ibn-Eljazzar Hospital, Kairouan, Tunisia","institution_ids":["https://openalex.org/I55167344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039881703","display_name":"Loua Hlioui","orcid":"https://orcid.org/0000-0001-9081-2851","observed_orcids":["https://orcid.org/0000-0001-9081-2851"]},"institutions":[{"id":"https://openalex.org/I55167344","display_name":"University of Kairouan","ror":"https://ror.org/024mpte60","country_code":"TN","type":"education","lineage":["https://openalex.org/I55167344"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"L. Hlioui","raw_affiliation_strings":["Department of Pneumology, Ibn-Eljazzar Hospital, Kairouan, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pneumology, Ibn-Eljazzar Hospital, Kairouan, Tunisia","institution_ids":["https://openalex.org/I55167344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107483607","display_name":"G\u00e9rard Lefranc","orcid":"https://orcid.org/0000-0003-1462-5442","observed_orcids":["https://orcid.org/0000-0003-1462-5442"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G. Lefranc","raw_affiliation_strings":["Institute of Human Genetics, CNRS and University of Montpellier-II, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Genetics, CNRS and University of Montpellier-II, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210163339"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053578103","display_name":"Jemni Ben Chibani","orcid":"https://orcid.org/0000-0003-3575-610X","observed_orcids":["https://orcid.org/0000-0003-3575-610X"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"J. Ben Chibani","raw_affiliation_strings":["Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5075581215"],"corresponding_institution_ids":["https://openalex.org/I166928557"],"apc_list":null,"apc_paid":null,"fwci":1.1526,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.81150741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"56","issue":"3","first_page":"106","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.9620000123977661},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.902999997138977},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.8029999732971191},{"id":"https://openalex.org/keywords/tunisian-population","display_name":"Tunisian population","score":0.9649999737739563},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7229999899864197},{"id":"https://openalex.org/keywords/isoelectric-focusing","display_name":"isoelectric focusing","score":0.7509999871253967},{"id":"https://openalex.org/keywords/pcr-rflp","display_name":"PCR-RFLP","score":0.8650000095367432},{"id":"https://openalex.org/keywords/north-african-populations","display_name":"North African populations","score":0.6240000128746033},{"id":"https://openalex.org/keywords/tobacco-and-alcohol-use","display_name":"alcohol and tobacco use","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.7419494390487671},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7313648462295532},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.5456039905548096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5111735463142395},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.49005186557769775},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4588584899902344},{"id":"https://openalex.org/C168007829","wikidata":"https://www.wikidata.org/wiki/Q857299","display_name":"Restriction fragment length polymorphism","level":4,"score":0.418089359998703},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4172112047672272},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3658179044723511},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36102741956710815},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30289626121520996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2713620066642761},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.21316641569137573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18994158506393433},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000515","descriptor_name":"alpha 1-Antitrypsin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.patbio.2007.05.003","doi":"https://doi.org/10.1016/j.patbio.2007.05.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.patbio.2007.05.003","pdf_url":null,"source":{"id":"https://openalex.org/S30634364","display_name":"Pathologie Biologie","issn_l":"0369-8114","issn":["0369-8114","1768-3114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathologie Biologie","raw_type":"journal-article"},{"id":"pmid:18031952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18031952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathologie-biologie","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00287916v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00287916","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pathologie Biologie, 2008, 6 (3), pp.106-110. &#x27E8;10.1016/j.patbio.2007.05.003&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1546422497","https://openalex.org/W1571439091","https://openalex.org/W1588842748","https://openalex.org/W1637069551","https://openalex.org/W1749021515","https://openalex.org/W1768927099","https://openalex.org/W1965064175","https://openalex.org/W1968744037","https://openalex.org/W1981129847","https://openalex.org/W1998289395","https://openalex.org/W2003339322","https://openalex.org/W2033586918","https://openalex.org/W2035192986","https://openalex.org/W2041397397","https://openalex.org/W2043273571","https://openalex.org/W2044956381","https://openalex.org/W2056390007","https://openalex.org/W2059401583","https://openalex.org/W2062741557","https://openalex.org/W2076156870","https://openalex.org/W2078854698","https://openalex.org/W2091312903","https://openalex.org/W2105957892","https://openalex.org/W2121276017","https://openalex.org/W2130880533","https://openalex.org/W2130915430","https://openalex.org/W2131024814","https://openalex.org/W2137240228","https://openalex.org/W2137804258","https://openalex.org/W2145519924","https://openalex.org/W2149012732","https://openalex.org/W2154657665","https://openalex.org/W2163496983","https://openalex.org/W2164705555","https://openalex.org/W2411649793","https://openalex.org/W2418825740","https://openalex.org/W4213042110","https://openalex.org/W6678066707"],"related_works":["https://openalex.org/W2160266975","https://openalex.org/W7132041455","https://openalex.org/W4255869096","https://openalex.org/W2138271981","https://openalex.org/W2765230068","https://openalex.org/W2023483550","https://openalex.org/W2314378023","https://openalex.org/W1991531477","https://openalex.org/W2042975304","https://openalex.org/W1981129847"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
