{"id":"https://openalex.org/W2055985489","doi":"https://doi.org/10.1017/s0952523800173134","title":"Second messenger pathways involved in up-regulation of an L-type calcium channel","display_name":"Second messenger pathways involved in up-regulation of an L-type calcium channel","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2055985489","doi":"https://doi.org/10.1017/s0952523800173134","mag":"2055985489","pmid":"https://pubmed.ncbi.nlm.nih.gov/10910113"},"language":"en","primary_location":{"id":"doi:10.1017/s0952523800173134","doi":"https://doi.org/10.1017/s0952523800173134","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s0952523800173134","pdf_url":null,"source":{"id":"https://openalex.org/S34730769","display_name":"Visual Neuroscience","issn_l":"0952-5238","issn":["0952-5238","1469-8714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Visual Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004541786","display_name":"Cindy L. Linn","orcid":"https://orcid.org/0000-0001-7840-066X","observed_orcids":["https://orcid.org/0000-0001-7840-066X"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"CINDY L. LINN","raw_affiliation_strings":["Louisiana State University Health Sciences Center, Department of Cell Biology and Anatomy, New Orleans 70112, USA. clinn@lsumc.edu","Louisiana State University Health Sciences Center, Department of Cell Biology and Anatomy, New Orleans 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University Health Sciences Center, Department of Cell Biology and Anatomy, New Orleans 70112, USA. clinn@lsumc.edu","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]},{"raw_affiliation_string":"Louisiana State University Health Sciences Center, Department of Cell Biology and Anatomy, New Orleans 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004541786"],"corresponding_institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":null,"fwci":0.6017,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.64572089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"17","issue":"3","first_page":"473","last_page":"482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.12099999934434891,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.8529999852180481},{"id":"https://openalex.org/keywords/metabotropic-glutamate-receptors","display_name":"metabotropic glutamate receptors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/group-i-mglurs","display_name":"group I mGluRs","score":0.9190000295639038},{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.7519999742507935},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.996999979019165},{"id":"https://openalex.org/keywords/second-messenger-pathways","display_name":"second messenger pathways","score":0.621999979019165},{"id":"https://openalex.org/keywords/pertussis-toxin-sensitive-g-proteins","display_name":"pertussis toxin-sensitive G proteins","score":0.781000018119812},{"id":"https://openalex.org/keywords/ip3","display_name":"IP3","score":0.5220000147819519},{"id":"https://openalex.org/keywords/intracellular-calcium-stores","display_name":"intracellular calcium stores","score":0.7860000133514404},{"id":"https://openalex.org/keywords/catfish-retina","display_name":"catfish retina","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C2778684643","wikidata":"https://www.wikidata.org/wiki/Q5514740","display_name":"GTPgammaS","level":4,"score":0.6762180924415588},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.6155271530151367},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6136506199836731},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.6058192849159241},{"id":"https://openalex.org/C30979828","wikidata":"https://www.wikidata.org/wiki/Q2487620","display_name":"T-type calcium channel","level":4,"score":0.5909043550491333},{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.5502826571464539},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.5280683040618896},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.5226090550422668},{"id":"https://openalex.org/C92645518","wikidata":"https://www.wikidata.org/wiki/Q26916851","display_name":"N-type calcium channel","level":5,"score":0.5062793493270874},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.5006556510925293},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.47643572092056274},{"id":"https://openalex.org/C174293024","wikidata":"https://www.wikidata.org/wiki/Q3001149","display_name":"R-type calcium channel","level":5,"score":0.47586530447006226},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4690055549144745},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.4194491505622864},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3920572102069855},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3902395963668823},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.32219019532203674},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30691808462142944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28580063581466675},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2847049832344055},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2008659541606903},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002397","descriptor_name":"Catfishes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004075","descriptor_name":"Diglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004533","descriptor_name":"Egtazic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012118","descriptor_name":"Resorcinols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015290","descriptor_name":"Second Messenger Systems","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015544","descriptor_name":"Inositol 1,4,5-Trisphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016244","descriptor_name":"Guanosine 5'-O-(3-Thiotriphosphate)","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1017/s0952523800173134","doi":"https://doi.org/10.1017/s0952523800173134","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s0952523800173134","pdf_url":null,"source":{"id":"https://openalex.org/S34730769","display_name":"Visual Neuroscience","issn_l":"0952-5238","issn":["0952-5238","1469-8714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Visual Neuroscience","raw_type":"journal-article"},{"id":"pmid:10910113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10910113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Visual neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5369046347","display_name":null,"funder_award_id":"EY-11133","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8646407141","display_name":"MODULATION OF A RETINAL CALCIUM CURRENT","funder_award_id":"7r29ey011133-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7100167079","https://openalex.org/W2214465946","https://openalex.org/W2131024077","https://openalex.org/W7098187677","https://openalex.org/W1502099631","https://openalex.org/W2123217186","https://openalex.org/W2037882476","https://openalex.org/W1908085218","https://openalex.org/W2409697517","https://openalex.org/W1967023620"],"abstract_inverted_index":{"Catfish":[0],"cone":[1,267,353],"horizontal":[2,268,354],"cells":[3,269],"contain":[4],"a":[5,116,166,225],"voltage-gated":[6,348,361],"L-type":[7,81],"calcium":[8,35,50,70,82,106,132,138,188,217,240,259,275,285,302,310,326,349,362,366],"channel":[9,107,139,189,350,363],"that":[10,87,157,333],"is":[11,224],"modulated":[12],"by":[13,140,229],"activation":[14,52,63,88,158,230],"of":[15,21,64,69,79,89,118,128,136,159,186,195,231,258,273,280,293,300,308,316,323,346],"metabotropic":[16],"glutamate":[17],"receptors":[18],"(mGluRs).":[19],"Activation":[20],"group":[22,160,232],"I":[23,28,161,233],"mGluRs":[24,66,90,162],"with":[25,67,211],"the":[26,39,49,60,65,80,92,126,137,172,187,193,208,249,274,291,301,309,321,324,335,347,360],"mGluR":[27],"agonist,":[29],"(S)-3,5-dihydroxyphenylglycine":[30],"[(S)":[31],"3,5-DHPG],":[32],"potentiated":[33],"peak":[34,44,373],"current":[36,45,71,133,218,303,311,374],"amplitude,":[37],"shifted":[38],"membrane":[40],"potential":[41],"corresponding":[42],"to":[43,98,165,180,205,215,265,283],"activity,":[46],"and":[47,104,121,191,337],"widened":[48],"current's":[51],"range.":[53],"In":[54,290],"this":[55],"study,":[56],"we":[57,84],"have":[58],"examined":[59],"mechanisms":[61],"linking":[62],"\"up-regulation\"":[68],"activity.":[72,108,134,219],"Under":[73],"whole-cell":[74],"voltage-clamp":[75,183],"conditions":[76],"favoring":[77],"expression":[78],"current,":[83],"provide":[85],"evidence":[86,110],"initiate":[91],"diacylglyceral":[93],"(DG)":[94],"second":[95,226,251,339],"messenger":[96,252,340],"pathway":[97,358],"activate":[99],"protein":[100],"kinase":[101],"C":[102],"(PKC)":[103],"up-regulate":[105],"This":[109],"was":[111,146,178,203,254,263,305,318],"based":[112],"on":[113,131],"results":[114,154,331],"using":[115],"number":[117],"PKC":[119,123,141,149],"activators":[120,124,142],"inhibitors.":[122],"mimicked":[125,192],"effect":[127,194],"(S)":[129,144,196,261,297],"3,5-DHPG":[130,145,262],"Up-regulation":[135],"or":[143],"eliminated":[147,319],"if":[148,248],"inhibitors":[150],"were":[151,163],"present.":[152],"These":[153,330],"also":[155],"demonstrated":[156],"linked":[164],"pertussis":[167,200],"toxin":[168,201],"sensitive":[169],"G-protein.":[170],"When":[171],"GTP":[173],"analog,":[174],"guanosine":[175],"5-0-(3-thiotriphosphate":[176],"(GTPgammaS),":[177],"allowed":[179,204],"diffuse":[181,206],"into":[182,207],"cells,":[184],"up-regulation":[185,257],"occurred":[190],"3,5-DHPG.":[197],"However,":[198],"when":[199],"(PTX)":[202],"cell":[209],"along":[210],"GTPgammaS,":[212],"GTPgammaS":[213],"failed":[214,282],"modulate":[216],"IP3":[220,237,250,338,369],"(inositol":[221],"1,4,5":[222],"triphosphate)":[223],"product":[227],"produced":[228],"mGluRs.":[234],"Once":[235],"formed,":[236],"can":[238],"trigger":[239],"release":[241],"from":[242,287,368],"IP3-sensitive":[243],"intracellular":[244,288,325,370],"stores.":[245,289],"To":[246],"determine":[247],"system":[253],"involved":[255,343],"in":[256,313,320,344,351],"channel,":[260],"applied":[264],"voltage-clamped":[266],"containing":[270],"different":[271],"concentrations":[272,279,315],"buffer,":[276],"EGTA.":[277],"Low":[278],"EGTA":[281,295,317],"buffer":[284],"released":[286,367],"presence":[292,322],"low":[294,314],"concentrations,":[296],"3,5-DHPG's":[298],"enhancement":[299],"amplitude":[304,312],"reduced.":[306],"Inhibition":[307],"store":[327],"blocker,":[328],"heparin.":[329],"suggest":[332],"both":[334],"DG":[336,357],"pathways":[341],"are":[342],"modulation":[345],"catfish":[352],"cells.":[355],"The":[356],"up-regulates":[359],"activity":[364],"whereas":[365],"stores":[371],"inhibits":[372],"amplitude.":[375]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}