{"id":"https://openalex.org/W2055949050","doi":"https://doi.org/10.1016/j.resp.2014.10.013","title":"Orexin-B antagonized respiratory depression induced by sevoflurane, propofol, and remifentanil in isolated brainstem-spinal cords of neonatal rats","display_name":"Orexin-B antagonized respiratory depression induced by sevoflurane, propofol, and remifentanil in isolated brainstem-spinal cords of neonatal rats","publication_year":2014,"publication_date":"2014-10-24","ids":{"openalex":"https://openalex.org/W2055949050","doi":"https://doi.org/10.1016/j.resp.2014.10.013","mag":"2055949050","pmid":"https://pubmed.ncbi.nlm.nih.gov/25448395"},"language":"en","primary_location":{"id":"doi:10.1016/j.resp.2014.10.013","doi":"https://doi.org/10.1016/j.resp.2014.10.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.resp.2014.10.013","pdf_url":null,"source":{"id":"https://openalex.org/S72042703","display_name":"Respiratory Physiology & Neurobiology","issn_l":"1569-9048","issn":["1569-9048","1878-1519"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Physiology & Neurobiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2055949050"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001771518","display_name":"Nobuo Umezawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47951555","display_name":"Kanagawa Dental University","ror":"https://ror.org/0514c4d93","country_code":"JP","type":"education","lineage":["https://openalex.org/I47951555"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuo Umezawa","raw_affiliation_strings":["Department of Anesthesiology, Kanagawa Dental University, Yokosuka City 238-8580, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Kanagawa Dental University, Yokosuka City 238-8580, Japan","institution_ids":["https://openalex.org/I47951555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010267497","display_name":"Hirofumi Arisaka","orcid":"https://orcid.org/0000-0002-1452-5057","observed_orcids":["https://orcid.org/0000-0002-1452-5057"]},"institutions":[{"id":"https://openalex.org/I47951555","display_name":"Kanagawa Dental University","ror":"https://ror.org/0514c4d93","country_code":"JP","type":"education","lineage":["https://openalex.org/I47951555"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Arisaka","raw_affiliation_strings":["Department of Anesthesiology, Kanagawa Dental University, Yokosuka City 238-8580, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Kanagawa Dental University, Yokosuka City 238-8580, Japan","institution_ids":["https://openalex.org/I47951555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103434067","display_name":"Shigeki Sakuraba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47951555","display_name":"Kanagawa Dental University","ror":"https://ror.org/0514c4d93","country_code":"JP","type":"education","lineage":["https://openalex.org/I47951555"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeki Sakuraba","raw_affiliation_strings":["Department of Anesthesiology, Kanagawa Dental University, Yokosuka City 238-8580, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Kanagawa Dental University, Yokosuka City 238-8580, Japan","institution_ids":["https://openalex.org/I47951555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070057612","display_name":"Takeo Sugita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47951555","display_name":"Kanagawa Dental University","ror":"https://ror.org/0514c4d93","country_code":"JP","type":"education","lineage":["https://openalex.org/I47951555"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeo Sugita","raw_affiliation_strings":["Department of Anesthesiology, Kanagawa Dental University, Yokosuka City 238-8580, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Kanagawa Dental University, Yokosuka City 238-8580, Japan","institution_ids":["https://openalex.org/I47951555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031438879","display_name":"Akiko Matsumoto","orcid":"https://orcid.org/0000-0002-8445-4071","observed_orcids":["https://orcid.org/0000-0002-8445-4071"]},"institutions":[{"id":"https://openalex.org/I47951555","display_name":"Kanagawa Dental University","ror":"https://ror.org/0514c4d93","country_code":"JP","type":"education","lineage":["https://openalex.org/I47951555"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Matsumoto","raw_affiliation_strings":["Department of Anesthesiology, Kanagawa Dental University, Yokosuka City 238-8580, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Kanagawa Dental University, Yokosuka City 238-8580, Japan","institution_ids":["https://openalex.org/I47951555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086184672","display_name":"Yuki Kaku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113848333","display_name":"Ibaraki Prefectural University of Health Sciences","ror":"https://ror.org/04vgkzj18","country_code":"JP","type":"education","lineage":["https://openalex.org/I113848333"]},{"id":"https://openalex.org/I215895447","display_name":"Uekusa Gakuen University","ror":"https://ror.org/03vejgn42","country_code":"JP","type":"education","lineage":["https://openalex.org/I215895447"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Kaku","raw_affiliation_strings":["Department of Physiology, Faculty of Health Sciences, Uekusa Gakuen University, Chiba City 264-0007, Japan; Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki-ken 300-0394, Japan","Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki-ken 300-0394, Japan","Department of Physiology, Faculty of Health Sciences, Uekusa Gakuen University, Chiba City 264-0007, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Health Sciences, Uekusa Gakuen University, Chiba City 264-0007, Japan; Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki-ken 300-0394, Japan","institution_ids":["https://openalex.org/I113848333","https://openalex.org/I215895447"]},{"raw_affiliation_string":"Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki-ken 300-0394, Japan","institution_ids":["https://openalex.org/I113848333"]},{"raw_affiliation_string":"Department of Physiology, Faculty of Health Sciences, Uekusa Gakuen University, Chiba City 264-0007, Japan","institution_ids":["https://openalex.org/I215895447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102226895","display_name":"Kazu-ichi Yoshida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47951555","display_name":"Kanagawa Dental University","ror":"https://ror.org/0514c4d93","country_code":"JP","type":"education","lineage":["https://openalex.org/I47951555"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazu-ichi Yoshida","raw_affiliation_strings":["Department of Anesthesiology, Kanagawa Dental University, Yokosuka City 238-8580, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Kanagawa Dental University, Yokosuka City 238-8580, Japan","institution_ids":["https://openalex.org/I47951555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109107584","display_name":"Shun\u2010ichi Kuwana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I215895447","display_name":"Uekusa Gakuen University","ror":"https://ror.org/03vejgn42","country_code":"JP","type":"education","lineage":["https://openalex.org/I215895447"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shun-ichi Kuwana","raw_affiliation_strings":["Department of Physiology, Faculty of Health Sciences, Uekusa Gakuen University, Chiba City 264-0007, Japan. Electronic address: s-kuwana@uekusa.ac.jp","Department of Physiology, Faculty of Health Sciences, Uekusa Gakuen University, Chiba City 264-0007, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Health Sciences, Uekusa Gakuen University, Chiba City 264-0007, Japan. Electronic address: s-kuwana@uekusa.ac.jp","institution_ids":["https://openalex.org/I215895447"]},{"raw_affiliation_string":"Department of Physiology, Faculty of Health Sciences, Uekusa Gakuen University, Chiba City 264-0007, Japan","institution_ids":["https://openalex.org/I215895447"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109107584"],"corresponding_institution_ids":["https://openalex.org/I215895447"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":null,"fwci":0.2574,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.47736626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"205","issue":null,"first_page":"61","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orexin-b","display_name":"orexin B","score":0.9940000176429749},{"id":"https://openalex.org/keywords/orexin","display_name":"orexin","score":0.902999997138977},{"id":"https://openalex.org/keywords/respiratory-depression","display_name":"respiratory depression","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sevoflurane","display_name":"sevoflurane","score":0.9670000076293945},{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":1.0},{"id":"https://openalex.org/keywords/remifentanil","display_name":"remifentanil","score":1.0},{"id":"https://openalex.org/keywords/brainstem-spinal-cord-preparation","display_name":"brainstem-spinal cord preparation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/inspiratory-activity","display_name":"inspiratory activity","score":0.75},{"id":"https://openalex.org/keywords/neonatal-rats","display_name":"neonatal rats","score":0.8199999928474426},{"id":"https://openalex.org/keywords/respiratory-neurons","display_name":"respiratory neurons","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C2778891214","wikidata":"https://www.wikidata.org/wiki/Q417902","display_name":"Remifentanil","level":3,"score":0.8750772476196289},{"id":"https://openalex.org/C2779680196","wikidata":"https://www.wikidata.org/wiki/Q410857","display_name":"Orexin","level":4,"score":0.8169295191764832},{"id":"https://openalex.org/C2781453256","wikidata":"https://www.wikidata.org/wiki/Q419394","display_name":"Sevoflurane","level":2,"score":0.7750459909439087},{"id":"https://openalex.org/C2776119998","wikidata":"https://www.wikidata.org/wiki/Q1070023","display_name":"Orexin-A","level":5,"score":0.7109876275062561},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.6907168030738831},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.6511163711547852},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6502640247344971},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.575744092464447},{"id":"https://openalex.org/C2780906327","wikidata":"https://www.wikidata.org/wiki/Q7315911","display_name":"Respiratory center","level":3,"score":0.49510541558265686},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45726829767227173},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.4567992687225342},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3869340121746063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3756847679615021},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37410199642181396},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.20074152946472168},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13686180114746094},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068797","descriptor_name":"Orexins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077149","descriptor_name":"Sevoflurane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077208","descriptor_name":"Remifentanil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000777","descriptor_name":"Anesthetics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008738","descriptor_name":"Methyl Ethers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012131","descriptor_name":"Respiratory Insufficiency","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012131","descriptor_name":"Respiratory Insufficiency","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.resp.2014.10.013","doi":"https://doi.org/10.1016/j.resp.2014.10.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.resp.2014.10.013","pdf_url":null,"source":{"id":"https://openalex.org/S72042703","display_name":"Respiratory Physiology & Neurobiology","issn_l":"1569-9048","issn":["1569-9048","1878-1519"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Physiology & Neurobiology","raw_type":"journal-article"},{"id":"pmid:25448395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25448395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory physiology & neurobiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6963394853","display_name":"The influences of cognition and intention of corrective movement for motor error on motor learning.","funder_award_id":"24700613","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W183409290","https://openalex.org/W1627229807","https://openalex.org/W1971130088","https://openalex.org/W1972473633","https://openalex.org/W1991082652","https://openalex.org/W1999331745","https://openalex.org/W2004991425","https://openalex.org/W2006270675","https://openalex.org/W2009076067","https://openalex.org/W2009966086","https://openalex.org/W2012253032","https://openalex.org/W2013655437","https://openalex.org/W2015622305","https://openalex.org/W2024348439","https://openalex.org/W2027740042","https://openalex.org/W2056563604","https://openalex.org/W2058912668","https://openalex.org/W2067572657","https://openalex.org/W2071248779","https://openalex.org/W2087235458","https://openalex.org/W2092864574","https://openalex.org/W2105878062","https://openalex.org/W2122196568","https://openalex.org/W2122619723","https://openalex.org/W2129357751","https://openalex.org/W2148913502","https://openalex.org/W2152211310","https://openalex.org/W2154097721","https://openalex.org/W2157846762","https://openalex.org/W2158478796","https://openalex.org/W2318276447"],"related_works":["https://openalex.org/W2157846762","https://openalex.org/W2092864574","https://openalex.org/W7208207459","https://openalex.org/W7169780760","https://openalex.org/W2085493486","https://openalex.org/W3174135702","https://openalex.org/W4210602705","https://openalex.org/W4380046342","https://openalex.org/W1969000101","https://openalex.org/W2318276447"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}