{"id":"https://openalex.org/W2055928484","doi":"https://doi.org/10.1074/jbc.m000989200","title":"Targeting of High Mobility Group-14/-17 Proteins in Chromatin Is Independent of DNA Sequence","display_name":"Targeting of High Mobility Group-14/-17 Proteins in Chromatin Is Independent of DNA Sequence","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2055928484","doi":"https://doi.org/10.1074/jbc.m000989200","mag":"2055928484","pmid":"https://pubmed.ncbi.nlm.nih.gov/10973947"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m000989200","doi":"https://doi.org/10.1074/jbc.m000989200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m000989200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m000989200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066222244","display_name":"Hitoshi Shirakawa","orcid":"https://orcid.org/0000-0002-4828-5274","observed_orcids":["https://orcid.org/0000-0002-4828-5274"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hitoshi Shirakawa","raw_affiliation_strings":["Protein Section, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Section, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052799305","display_name":"Julio E. Herrera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julio E. Herrera","raw_affiliation_strings":["Protein Section, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892","From the Protein Section, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Section, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"From the Protein Section, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039096120","display_name":"Michael Bustin","orcid":"https://orcid.org/0000-0002-5147-7242","observed_orcids":["https://orcid.org/0000-0002-5147-7242"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Bustin","raw_affiliation_strings":["Protein Section, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892","From the Protein Section, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Section, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"From the Protein Section, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112842771","display_name":"Yuri V. Postnikov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuri Postnikov","raw_affiliation_strings":["Protein Section, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892","From the Protein Section, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Section, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"From the Protein Section, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112842771"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.9627,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.73152685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"275","issue":"48","first_page":"37937","last_page":"37944"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-mobility-group-proteins","display_name":"high mobility group proteins","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hmg14","display_name":"HMG14","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hmg-17","display_name":"HMG17","score":1.0},{"id":"https://openalex.org/keywords/chromatin-targeting","display_name":"chromatin targeting","score":0.7559999823570251},{"id":"https://openalex.org/keywords/nucleosome-binding","display_name":"nucleosome binding","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cg-dinucleotides","display_name":"CG dinucleotides","score":0.7360000014305115},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.4580000042915344},{"id":"https://openalex.org/keywords/chromatin-organization","display_name":"chromatin organization","score":0.48899999260902405},{"id":"https://openalex.org/keywords/protein-complexes","display_name":"protein complexes","score":0.722000002861023},{"id":"https://openalex.org/keywords/nuclear-proteins","display_name":"nuclear proteins","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8324306011199951},{"id":"https://openalex.org/C30683889","wikidata":"https://www.wikidata.org/wiki/Q926211","display_name":"High-mobility group","level":3,"score":0.8226969242095947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6192187666893005},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.600745439529419},{"id":"https://openalex.org/C5179208","wikidata":"https://www.wikidata.org/wiki/Q3782057","display_name":"HMG-box","level":5,"score":0.5616520047187805},{"id":"https://openalex.org/C176619506","wikidata":"https://www.wikidata.org/wiki/Q5065899","display_name":"ChIP-sequencing","level":5,"score":0.5005548000335693},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47272413969039917},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.4358656406402588},{"id":"https://openalex.org/C87026931","wikidata":"https://www.wikidata.org/wiki/Q3408226","display_name":"Non-histone protein","level":4,"score":0.43473783135414124},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4305349886417389},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.4176226258277893},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.41286787390708923},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.39813926815986633},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33043110370635986},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2032116949558258},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18768778443336487},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.1613822877407074}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019105","descriptor_name":"Random Amplified Polymorphic DNA Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m000989200","doi":"https://doi.org/10.1074/jbc.m000989200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m000989200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:10973947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10973947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m000989200","doi":"https://doi.org/10.1074/jbc.m000989200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m000989200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W572535119","https://openalex.org/W1480950437","https://openalex.org/W1635552303","https://openalex.org/W1773515121","https://openalex.org/W1784996751","https://openalex.org/W1964686686","https://openalex.org/W1971765644","https://openalex.org/W1988008377","https://openalex.org/W2007801829","https://openalex.org/W2017764481","https://openalex.org/W2026618781","https://openalex.org/W2037818544","https://openalex.org/W2047529459","https://openalex.org/W2058721022","https://openalex.org/W2063240132","https://openalex.org/W2070663406","https://openalex.org/W2080476991","https://openalex.org/W2085953256","https://openalex.org/W2094034118","https://openalex.org/W2141402301","https://openalex.org/W2161619169","https://openalex.org/W2164252400","https://openalex.org/W2168676935","https://openalex.org/W2171114940"],"related_works":["https://openalex.org/W2085953256","https://openalex.org/W2037818544","https://openalex.org/W1970299413","https://openalex.org/W1515556329","https://openalex.org/W2031391057","https://openalex.org/W2077671872","https://openalex.org/W2474002158","https://openalex.org/W1988008377","https://openalex.org/W2035727353","https://openalex.org/W2082054385"],"abstract_inverted_index":{"Chromosomal":[0],"proteins":[1,10,97,135,159,183],"high":[2],"mobility":[3],"group":[4],"(HMG)-14":[5],"and":[6,16,27,33,142,178],"HMG-17":[7,53,96,134,155],"are":[8],"nucleosomal-binding":[9],"that":[11,52,92,121,148,166],"unfold":[12],"the":[13,77,105,114,128,170,176,182],"chromatin":[14,20,60],"fiber":[15],"enhance":[17],"transcription":[18],"from":[19],"templates.":[21],"Their":[22],"intracellular":[23],"organization":[24,172],"is":[25,55],"dynamic":[26,171],"related":[28],"to":[29,43,83,136,146,180,184],"both":[30],"cell":[31],"cycle":[32],"transcription.":[34],"Here":[35],"we":[36],"examine":[37],"possible":[38],"mechanisms":[39],"for":[40,127],"targeting":[41,125],"HMG-14/-17":[42,174],"specific":[44,70,124,185],"regions":[45,61],"in":[46,86,103,160,175,187],"chromatin.":[47,188],"Chromatin":[48],"immunoprecipitation":[49],"assays":[50],"indicate":[51],"protein":[54],"not":[56,117],"preferentially":[57,98],"associated":[58,156],"with":[59,100,157],"containing":[62],"transcriptionally":[63],"active":[64],"genes,":[65],"or":[66,95,133],"any":[67],"type":[68],"of":[69,76,111,130,154,173],"DNA.":[71],"We":[72,90,138,164],"used":[73,139],"a":[74,108,151,161],"modification":[75],"random":[78],"amplified":[79],"polymorphic":[80],"DNA":[81,85,106],"method":[82],"analyze":[84],"various":[87],"HMG-14/-17.nucleosome":[88],"complexes.":[89],"found":[91],"although":[93],"HMG-14":[94,132],"associate":[99],"core":[101],"particles":[102],"which":[104],"has":[107],"low":[109],"frequency":[110],"CG":[112],"dinucleotides,":[113],"genome":[115],"does":[116],"contain":[118,150],"consensus":[119],"sequences":[120],"serve":[122,179],"as":[123],"sites":[126,186],"binding":[129],"either":[131],"nucleosomes.":[137],"size":[140],"exclusion":[141],"ion":[143],"exchange":[144],"chromatography":[145],"demonstrate":[147],"nuclei":[149],"large":[152],"portion":[153],"other":[158],"multiprotein":[162],"complex.":[163],"suggest":[165],"these":[167],"complexes":[168],"regulate":[169],"nucleus":[177],"target":[181]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}