{"id":"https://openalex.org/W2055868308","doi":"https://doi.org/10.1016/s0022-5193(88)80125-5","title":"Kinetics of drug activities as influenced by their physico-chemical properties: Antibacterial effects of alkylating 2-furylethylenes","display_name":"Kinetics of drug activities as influenced by their physico-chemical properties: Antibacterial effects of alkylating 2-furylethylenes","publication_year":1988,"publication_date":"1988-03-01","ids":{"openalex":"https://openalex.org/W2055868308","doi":"https://doi.org/10.1016/s0022-5193(88)80125-5","mag":"2055868308","pmid":"https://pubmed.ncbi.nlm.nih.gov/3419189"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5193(88)80125-5","doi":"https://doi.org/10.1016/s0022-5193(88)80125-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5193(88)80125-5","pdf_url":null,"source":{"id":"https://openalex.org/S109682412","display_name":"Journal of Theoretical Biology","issn_l":"0022-5193","issn":["0022-5193","1095-8541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Theoretical Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089020337","display_name":"\u0160tefan Bal\u00e1\u017e","orcid":"https://orcid.org/0000-0003-4378-8945","observed_orcids":["https://orcid.org/0000-0003-4378-8945"]},"institutions":[{"id":"https://openalex.org/I110757952","display_name":"Slovak University of Technology in Bratislava","ror":"https://ror.org/0561ghm58","country_code":"SK","type":"education","lineage":["https://openalex.org/I110757952"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"\u0160. Bal\u00e1\u017e","raw_affiliation_strings":["Department of Biochemical Technology, Slovak Polytechnic University, Bratislava, Czechoslovakia","Department of Biochemical Technology, Department of Applied Microbiology and Biochemistry, Slovak Polytechnic University, Radlinsk\u00e9ho 9, CS-812 37 Bratislava, Czechoslovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Technology, Slovak Polytechnic University, Bratislava, Czechoslovakia","institution_ids":["https://openalex.org/I110757952"]},{"raw_affiliation_string":"Department of Biochemical Technology, Department of Applied Microbiology and Biochemistry, Slovak Polytechnic University, Radlinsk\u00e9ho 9, CS-812 37 Bratislava, Czechoslovakia","institution_ids":["https://openalex.org/I110757952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017628199","display_name":"Ernest \u0160turd\u0131\u0301k","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110757952","display_name":"Slovak University of Technology in Bratislava","ror":"https://ror.org/0561ghm58","country_code":"SK","type":"education","lineage":["https://openalex.org/I110757952"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"E. \u0160turd\u00edk","raw_affiliation_strings":["Department of Biochemical Technology, Department of Applied Microbiology and Biochemistry, Slovak Polytechnic University, Radlinsk\u00e9ho 9, CS-812 37 Bratislava, Czechoslovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Technology, Department of Applied Microbiology and Biochemistry, Slovak Polytechnic University, Radlinsk\u00e9ho 9, CS-812 37 Bratislava, Czechoslovakia","institution_ids":["https://openalex.org/I110757952"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Rosenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110757952","display_name":"Slovak University of Technology in Bratislava","ror":"https://ror.org/0561ghm58","country_code":"SK","type":"education","lineage":["https://openalex.org/I110757952"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"M. Rosenberg","raw_affiliation_strings":["Department of Biochemical Technology, Department of Applied Microbiology and Biochemistry, Slovak Polytechnic University, Radlinsk\u00e9ho 9, CS-812 37 Bratislava, Czechoslovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Technology, Department of Applied Microbiology and Biochemistry, Slovak Polytechnic University, Radlinsk\u00e9ho 9, CS-812 37 Bratislava, Czechoslovakia","institution_ids":["https://openalex.org/I110757952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109638118","display_name":"J. August\u00edn","orcid":"https://orcid.org/0000-0001-6055-779X","observed_orcids":["https://orcid.org/0000-0001-6055-779X"]},"institutions":[{"id":"https://openalex.org/I110757952","display_name":"Slovak University of Technology in Bratislava","ror":"https://ror.org/0561ghm58","country_code":"SK","type":"education","lineage":["https://openalex.org/I110757952"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"J. August\u00edn","raw_affiliation_strings":["Department of Biochemical Technology, Department of Applied Microbiology and Biochemistry, Slovak Polytechnic University, Radlinsk\u00e9ho 9, CS-812 37 Bratislava, Czechoslovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Technology, Department of Applied Microbiology and Biochemistry, Slovak Polytechnic University, Radlinsk\u00e9ho 9, CS-812 37 Bratislava, Czechoslovakia","institution_ids":["https://openalex.org/I110757952"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012297398","display_name":"B. \u0160k\u00e1ra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110757952","display_name":"Slovak University of Technology in Bratislava","ror":"https://ror.org/0561ghm58","country_code":"SK","type":"education","lineage":["https://openalex.org/I110757952"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"B. \u0160k\u00e1ra","raw_affiliation_strings":["Department of Biochemical Technology, Department of Applied Microbiology and Biochemistry, Slovak Polytechnic University, Radlinsk\u00e9ho 9, CS-812 37 Bratislava, Czechoslovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Technology, Department of Applied Microbiology and Biochemistry, Slovak Polytechnic University, Radlinsk\u00e9ho 9, CS-812 37 Bratislava, Czechoslovakia","institution_ids":["https://openalex.org/I110757952"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I110757952"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":null,"fwci":1.8842,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.84770115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"131","issue":"1","first_page":"115","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6389999985694885},{"id":"https://openalex.org/keywords/drug-receptor-interactions","display_name":"drug-receptor interactions","score":0.824999988079071},{"id":"https://openalex.org/keywords/law-of-mass-action","display_name":"mass action law","score":0.9100000262260437},{"id":"https://openalex.org/keywords/physicochemical-properties","display_name":"physicochemical properties","score":0.6830000281333923},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.7219591736793518},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.5845465660095215},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5593798160552979},{"id":"https://openalex.org/C36543247","wikidata":"https://www.wikidata.org/wiki/Q17103208","display_name":"Mass action law","level":2,"score":0.5169886350631714},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5020616054534912},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5003504753112793},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4965417981147766},{"id":"https://openalex.org/C67425144","wikidata":"https://www.wikidata.org/wiki/Q899494","display_name":"Law of mass action","level":2,"score":0.482543408870697},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34901514649391174},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28157418966293335},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.24238860607147217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22859013080596924},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.19848152995109558},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.14402204751968384},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11372444033622742},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07209014892578125},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005030","descriptor_name":"Ethylenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5193(88)80125-5","doi":"https://doi.org/10.1016/s0022-5193(88)80125-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5193(88)80125-5","pdf_url":null,"source":{"id":"https://openalex.org/S109682412","display_name":"Journal of Theoretical Biology","issn_l":"0022-5193","issn":["0022-5193","1095-8541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Theoretical Biology","raw_type":"journal-article"},{"id":"pmid:3419189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3419189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of theoretical biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W4425695","https://openalex.org/W607527914","https://openalex.org/W1996222937","https://openalex.org/W2010002181","https://openalex.org/W2018643495","https://openalex.org/W2022772618","https://openalex.org/W2030823283","https://openalex.org/W2030924205","https://openalex.org/W2031923243","https://openalex.org/W2048617946","https://openalex.org/W2051185147","https://openalex.org/W2052226480","https://openalex.org/W2057786288","https://openalex.org/W2070174327","https://openalex.org/W2071438703","https://openalex.org/W2074568090","https://openalex.org/W2168703963","https://openalex.org/W2184491303","https://openalex.org/W2276249230","https://openalex.org/W2324227497","https://openalex.org/W2327898709","https://openalex.org/W2328945358","https://openalex.org/W2414843923","https://openalex.org/W2477609041","https://openalex.org/W2505697330","https://openalex.org/W2753867027","https://openalex.org/W2777515761","https://openalex.org/W2796557543","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1974027787","https://openalex.org/W1984362713","https://openalex.org/W2000848847","https://openalex.org/W2159413235","https://openalex.org/W2030449924","https://openalex.org/W2004009564","https://openalex.org/W6996059024","https://openalex.org/W1578246010","https://openalex.org/W792869909","https://openalex.org/W7219405638"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}