{"id":"https://openalex.org/W2055865653","doi":"https://doi.org/10.1186/ar4158","title":"Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation","display_name":"Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation","publication_year":2013,"publication_date":"2013-01-29","ids":{"openalex":"https://openalex.org/W2055865653","doi":"https://doi.org/10.1186/ar4158","mag":"2055865653","pmid":"https://pubmed.ncbi.nlm.nih.gov/23363614","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3672796"},"language":"en","primary_location":{"id":"doi:10.1186/ar4158","doi":"https://doi.org/10.1186/ar4158","is_oa":true,"landing_page_url":"https://doi.org/10.1186/ar4158","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar4158","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar4158","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019284316","display_name":"Rowan Hardy","orcid":"https://orcid.org/0000-0001-6938-6739","observed_orcids":["https://orcid.org/0000-0001-6938-6739"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I4210152689","display_name":"Anzac Research Institute","ror":"https://ror.org/05kf27764","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801351115","https://openalex.org/I4210152689"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["AU","GB"],"is_corresponding":true,"raw_author_name":"Rowan S Hardy","raw_affiliation_strings":["Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia","Centre for Endocrinology, Diabetes and Metabolism, Institute of Biomedical Research, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I4210152689"]},{"raw_affiliation_string":"Centre for Endocrinology, Diabetes and Metabolism, Institute of Biomedical Research, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112604379","display_name":"Claudia H\u00fclso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I4210152689","display_name":"Anzac Research Institute","ror":"https://ror.org/05kf27764","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801351115","https://openalex.org/I4210152689"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Claudia H\u00fclso","raw_affiliation_strings":["Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I4210152689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083234940","display_name":"Yingling Liu","orcid":"https://orcid.org/0000-0002-5005-482X","observed_orcids":["https://orcid.org/0000-0002-5005-482X"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I4210152689","display_name":"Anzac Research Institute","ror":"https://ror.org/05kf27764","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801351115","https://openalex.org/I4210152689"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yingling Liu","raw_affiliation_strings":["Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I4210152689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027708192","display_name":"Sylvia Jane Gasparini","orcid":"https://orcid.org/0000-0002-3612-6428","observed_orcids":["https://orcid.org/0000-0002-3612-6428"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I4210152689","display_name":"Anzac Research Institute","ror":"https://ror.org/05kf27764","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801351115","https://openalex.org/I4210152689"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sylvia J Gasparini","raw_affiliation_strings":["Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I4210152689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025592687","display_name":"Colette Fong-Yee","orcid":"https://orcid.org/0000-0002-6049-5338","observed_orcids":["https://orcid.org/0000-0002-6049-5338"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I4210152689","display_name":"Anzac Research Institute","ror":"https://ror.org/05kf27764","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801351115","https://openalex.org/I4210152689"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Colette Fong-Yee","raw_affiliation_strings":["Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I4210152689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110163078","display_name":"Jinwen Tu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I4210152689","display_name":"Anzac Research Institute","ror":"https://ror.org/05kf27764","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801351115","https://openalex.org/I4210152689"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jinwen Tu","raw_affiliation_strings":["Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I4210152689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057184079","display_name":"Shihani P. Stoner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I4210152689","display_name":"Anzac Research Institute","ror":"https://ror.org/05kf27764","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801351115","https://openalex.org/I4210152689"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shihani Stoner","raw_affiliation_strings":["Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I4210152689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050877182","display_name":"Paul M. Stewart","orcid":"https://orcid.org/0000-0002-1749-9640","observed_orcids":["https://orcid.org/0000-0002-1749-9640"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul M Stewart","raw_affiliation_strings":["Centre for Endocrinology, Diabetes and Metabolism, Institute of Biomedical Research, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Endocrinology, Diabetes and Metabolism, Institute of Biomedical Research, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065756541","display_name":"Karim Raza","orcid":"https://orcid.org/0000-0003-1570-1232","observed_orcids":["https://orcid.org/0000-0003-1570-1232"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karim Raza","raw_affiliation_strings":["Department of Immunity and Infection, Institute of Biomedical Research, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunity and Infection, Institute of Biomedical Research, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039317852","display_name":"Mark Stuart Cooper","orcid":"https://orcid.org/0000-0003-3112-7728","observed_orcids":["https://orcid.org/0000-0003-3112-7728"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark S Cooper","raw_affiliation_strings":["Centre for Endocrinology, Diabetes and Metabolism, Institute of Biomedical Research, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Endocrinology, Diabetes and Metabolism, Institute of Biomedical Research, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020640133","display_name":"Markus J. Seibel","orcid":"https://orcid.org/0000-0002-2701-378X","observed_orcids":["https://orcid.org/0000-0002-2701-378X"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800249840","display_name":"Concord Repatriation General Hospital","ror":"https://ror.org/04b0n4406","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800249840"]},{"id":"https://openalex.org/I4210152689","display_name":"Anzac Research Institute","ror":"https://ror.org/05kf27764","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801351115","https://openalex.org/I4210152689"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Markus J Seibel","raw_affiliation_strings":["Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia","Department of Endocrinology & Metabolism, Concord Repatriation Hospital, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I4210152689"]},{"raw_affiliation_string":"Department of Endocrinology & Metabolism, Concord Repatriation Hospital, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800249840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006386397","display_name":"Hong Zhou","orcid":"https://orcid.org/0000-0001-5899-9660","observed_orcids":["https://orcid.org/0000-0001-5899-9660"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I4210152689","display_name":"Anzac Research Institute","ror":"https://ror.org/05kf27764","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801351115","https://openalex.org/I4210152689"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Hong Zhou","raw_affiliation_strings":["Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I4210152689"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5006386397","https://openalex.org/A5019284316"],"corresponding_institution_ids":["https://openalex.org/I129604602","https://openalex.org/I4210152689","https://openalex.org/I79619799"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":2.237,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.86503702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"R24","last_page":"R24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12800","display_name":"Musculoskeletal synovial abnormalities and treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":0.9980000257492065},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.6039999723434448},{"id":"https://openalex.org/keywords/k-bxn-mice","display_name":"K/BxN mice","score":0.8859999775886536},{"id":"https://openalex.org/keywords/murine-arthritis-model","display_name":"murine arthritis model","score":0.6010000109672546},{"id":"https://openalex.org/keywords/joint-inflammation","display_name":"joint inflammation","score":0.5799999833106995},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6209999918937683},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9200000166893005},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.8379999995231628},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.718999981880188},{"id":"https://openalex.org/keywords/proinflammatory-gene-expression","display_name":"pro-inflammatory gene expression","score":0.7850000262260437},{"id":"https://openalex.org/keywords/glucocorticoid-regulation","display_name":"glucocorticoid regulation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.8193795680999756},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.8118232488632202},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.6083298325538635},{"id":"https://openalex.org/C18555067","wikidata":"https://www.wikidata.org/wiki/Q8375051","display_name":"Joint (building)","level":2,"score":0.581323504447937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.568456768989563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39475953578948975},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3453872799873352},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19096925854682922},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1431201994419098},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09486380219459534},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09366291761398315},{"id":"https://openalex.org/C170154142","wikidata":"https://www.wikidata.org/wiki/Q150737","display_name":"Architectural engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/ar4158","doi":"https://doi.org/10.1186/ar4158","is_oa":true,"landing_page_url":"https://doi.org/10.1186/ar4158","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar4158","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2674265","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3672796","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3672796","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3672796","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Res Ther","raw_type":"Text"},{"id":"pmid:23363614","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23363614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:81074","doi":null,"is_oa":false,"landing_page_url":"http://eprints.whiterose.ac.uk/81074/1/Characterisation%20of%20fibroblast-like%20synoviocytes%20from%20a%20murine%20model%20of%20joint%20inflammation..pdf","pdf_url":"http://eprints.whiterose.ac.uk/81074/1/Characterisation%20of%20fibroblast-like%20synoviocytes%20from%20a%20murine%20model%20of%20joint%20inflammation..pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.411.5373","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.411.5373","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/6d/b4/ar4158.PMC3672796.pdf","raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/d42db104-4932-4b83-baca-bc8eb38ce806","doi":null,"is_oa":true,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/d42db104-4932-4b83-baca-bc8eb38ce806","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hardy, R S, H\u00fclso, C, Liu, Y, Gasparini, S J, Fong-Yee, C, Tu, J, Stoner, S, Stewart, P M, Raza, K, Cooper, M, Seibel, M J & Zhou, H 2013, 'Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation', Arthritis Research & Therapy, vol. 15, R24. https://doi.org/10.1186/ar4158","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/ar4158","doi":"https://doi.org/10.1186/ar4158","is_oa":true,"landing_page_url":"https://doi.org/10.1186/ar4158","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar4158","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G419802756","display_name":"Centre for Musculoskeletal Ageing Research","funder_award_id":"MR/K00414X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6393107930","display_name":null,"funder_award_id":"19552","funder_id":"https://openalex.org/F4320327444","funder_display_name":"Versus Arthritis"},{"id":"https://openalex.org/G6817321199","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0508-10356","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6920383813","display_name":"The Role of Endogenous Glucocorticoids in Autoimmune Arthritis","funder_award_id":"632818","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320327444","display_name":"Versus Arthritis","ror":"https://ror.org/02jkpm469"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2055865653.pdf","grobid_xml":"https://content.openalex.org/works/W2055865653.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W96352593","https://openalex.org/W132781887","https://openalex.org/W1494419854","https://openalex.org/W1542224354","https://openalex.org/W1542422583","https://openalex.org/W1580864524","https://openalex.org/W1588921208","https://openalex.org/W1670519844","https://openalex.org/W1963609754","https://openalex.org/W1969708241","https://openalex.org/W1970920684","https://openalex.org/W1971903796","https://openalex.org/W1973974275","https://openalex.org/W1976400563","https://openalex.org/W1982796244","https://openalex.org/W2000468514","https://openalex.org/W2000605787","https://openalex.org/W2005246753","https://openalex.org/W2007157616","https://openalex.org/W2011002011","https://openalex.org/W2013917575","https://openalex.org/W2020313726","https://openalex.org/W2024778783","https://openalex.org/W2024971094","https://openalex.org/W2025193872","https://openalex.org/W2025474884","https://openalex.org/W2033611477","https://openalex.org/W2043287930","https://openalex.org/W2045984032","https://openalex.org/W2050526972","https://openalex.org/W2056696895","https://openalex.org/W2056813079","https://openalex.org/W2058177171","https://openalex.org/W2060660496","https://openalex.org/W2064681913","https://openalex.org/W2073472995","https://openalex.org/W2073618125","https://openalex.org/W2077678979","https://openalex.org/W2077694972","https://openalex.org/W2078309867","https://openalex.org/W2078624814","https://openalex.org/W2080880169","https://openalex.org/W2081829590","https://openalex.org/W2084542824","https://openalex.org/W2084708250","https://openalex.org/W2086350454","https://openalex.org/W2098903427","https://openalex.org/W2100208042","https://openalex.org/W2101840353","https://openalex.org/W2114370145","https://openalex.org/W2117439999","https://openalex.org/W2137530456","https://openalex.org/W2138460987","https://openalex.org/W2143183772","https://openalex.org/W2155702314","https://openalex.org/W2158734690","https://openalex.org/W2196454906","https://openalex.org/W2203570993","https://openalex.org/W2328587823","https://openalex.org/W2331507609","https://openalex.org/W2416129203","https://openalex.org/W7128548183"],"related_works":["https://openalex.org/W1851147669","https://openalex.org/W4313523809","https://openalex.org/W3114211246","https://openalex.org/W2788302741","https://openalex.org/W3212708482","https://openalex.org/W1838220155","https://openalex.org/W2312899605","https://openalex.org/W2976150935","https://openalex.org/W2370423181","https://openalex.org/W1524209515"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Fibroblast-like":[1],"synoviocytes":[2],"(FLS)":[3],"play":[4],"a":[5,18,28,166,240,323],"central":[6],"role":[7],"in":[8,13,70,118,149,169,223,244,306,332,364],"defining":[9],"the":[10,52,59,154,170,185,224,374],"stromal":[11],"environment":[12],"inflammatory":[14,26,186,237,303,329],"joint":[15],"diseases.":[16],"Despite":[17],"growing":[19],"use":[20],"of":[21,31,48,86,129,137,142,153,172,184,226,235,327,380],"FLS":[22,42,130,157,174,203,246,307,334,366,382],"isolated":[23,44,175,204,336],"from":[24,45,176,205,337],"murine":[25,381],"models,":[27],"detailed":[29],"characterisation":[30],"these":[32,271],"cells":[33],"has":[34,321,352],"not":[35],"been":[36,353],"performed.":[37],"METHODS:":[38],"In":[39],"this":[40,369],"study,":[41],"were":[43,158],"inflamed":[46],"joints":[47],"mice":[49,178,339],"expressing":[50],"both":[51,347],"T":[53],"cell":[54,125,195,251],"receptor":[55],"transgene":[56],"KRN":[57],"and":[58,67,75,105,113,146,162,193,290,295,297,316,340,349,355,378],"MHC":[60],"class":[61],"II":[62],"molecule":[63,197],"Ag7":[64],"(K/BxN":[65],"mice)":[66],"their":[68],"purity":[69],"culture":[71,131],"determined":[72,90],"by":[73,91,100,108,134],"immunofluorescence":[74],"real-time":[76,92],"reverse":[77],"transcription":[78],"polymerase":[79],"chain":[80],"reaction":[81],"(real-time":[82],"RT-PCR).":[83],"Basal":[84],"expression":[85,136,183,220,234,305],"proinflammatory":[87],"genes":[88,330],"was":[89,98,132,221,308],"RT-PCR.":[93],"Secreted":[94],"interleukin":[95],"6":[96],"(IL-6)":[97],"measured":[99,120],"enzyme-linked":[101],"immunosorbent":[102],"assay":[103],"(ELISA),":[104],"its":[106],"regulation":[107],"tumor":[109],"necrosis":[110],"factor-alpha":[111],"(TNF-\u03b1":[112],"corticosterone":[114,227,294],"(the":[115],"major":[116],"glucocorticoid":[117],"rodents)":[119],"relative":[121,247],"to":[122,160,202,239,248,310,346,357],"other":[123,249],"mesenchymal":[124,250],"populations.":[126],"RESULTS:":[127],"Purity":[128],"identified":[133],"positive":[135],"fibronectin,":[138],"prolyl":[139],"4-hydroxylase,":[140],"cluster":[141],"differentiation":[143],"90.2":[144],"(CD90.2)":[145],"248":[147],"(CD248)":[148],"greater":[150,181,242],"than":[151],"98%":[152],"population.":[155],"Cultured":[156],"able":[159],"migrate":[161],"invade":[163],"through":[164],"matrigel,":[165],"process":[167],"enhanced":[168],"presence":[171,225],"TNF-\u03b1.":[173],"K/BxN":[177,245,338],"possessed":[179],"significantly":[180,232],"basal":[182],"markers":[187,238],"IL-6,":[188,254],"chemokine":[189],"ligand":[190],"2":[191],"(CCL-2)":[192],"vascular":[194],"adhesion":[196],"1":[198,296],"(VCAM-1)":[199],"when":[200],"compared":[201],"non-inflamed":[206,341],"tissue":[207],"(IL-6,":[208],"3.6":[209],"fold;":[210,213,216,256,259,262,265],"CCL-2,":[211,257],"11.2":[212],"VCAM-1,":[214,260],"9":[215],"P<0.05).":[217,281],"This":[218,319],"elevated":[219],"abrogated":[222],"at":[228],"100":[229,291],"nmol/l.":[230],"TNF-\u03b1":[231],"increased":[233],"all":[236],"much":[241],"degree":[243],"lines":[252],"(K/BxN;":[253,273],"40.8":[255],"1343.2":[258],"17.8":[261],"ICAM-1,":[263],"13.8":[264],"P<0.05),":[266],"with":[267],"secreted":[268],"IL-6":[269],"mirroring":[270],"results":[272],"con,":[274],"169\u00b129.7":[275],"versus":[276],"TNF-\u03b1,":[277,301],"923\u00b1378.8":[278],"pg/ml/1\u00d710\u2075":[279],"cells;":[280],"Dose":[282],"response":[283,345],"experiments":[284],"confirmed":[285],"effective":[286,375],"concentrations":[287],"between":[288,313],"10":[289,298],"nmol/l":[292],"for":[293,300,331,373],"ng/ml":[299],"whilst":[302],"gene":[304],"shown":[309,356],"be":[311],"stable":[312],"passages":[314],"four":[315],"seven.":[317],"CONCLUSIONS:":[318],"study":[320,370],"established":[322],"well":[324],"characterised":[325],"set":[326],"key":[328],"vitro":[333],"culture,":[335],"wild-type":[342],"controls.":[343],"Their":[344],"pro-":[348],"anti-inflammatory":[350],"signalling":[351],"assessed":[354],"strongly":[358],"resemble":[359],"that":[360],"which":[361],"is":[362],"seen":[363],"human":[365],"culture.":[367,383],"Additionally,":[368],"provides":[371],"guidelines":[372],"characterisation,":[376],"duration":[377],"treatment":[379]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}