{"id":"https://openalex.org/W2055844162","doi":"https://doi.org/10.1167/iovs.11-8957","title":"FK962 Promotes Neurite Elongation and Regeneration of Cultured Rat Trigeminal Ganglion Cells: Possible Involvement of GDNF","display_name":"FK962 Promotes Neurite Elongation and Regeneration of Cultured Rat Trigeminal Ganglion Cells: Possible Involvement of GDNF","publication_year":2012,"publication_date":"2012-06-20","ids":{"openalex":"https://openalex.org/W2055844162","doi":"https://doi.org/10.1167/iovs.11-8957","mag":"2055844162","pmid":"https://pubmed.ncbi.nlm.nih.gov/22714891"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.11-8957","doi":"https://doi.org/10.1167/iovs.11-8957","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.11-8957","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064006153","display_name":"Yayoi Kishimoto","orcid":"https://orcid.org/0000-0002-1674-2696","observed_orcids":["https://orcid.org/0000-0002-1674-2696"]},"institutions":[{"id":"https://openalex.org/I4210133062","display_name":"Senju Pharmaceutical (Japan)","ror":"https://ror.org/03hq4qb06","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210133062"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yayoi Kishimoto","raw_affiliation_strings":["From the Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Kobe, Hyogo, Japan; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Kobe, Hyogo, Japan; and the","institution_ids":["https://openalex.org/I4210133062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029736829","display_name":"Chiho Yabuta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133062","display_name":"Senju Pharmaceutical (Japan)","ror":"https://ror.org/03hq4qb06","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210133062"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Chiho Yabuta","raw_affiliation_strings":["From the Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Kobe, Hyogo, Japan; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Kobe, Hyogo, Japan; and the","institution_ids":["https://openalex.org/I4210133062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060601520","display_name":"Thomas R. Shearer","orcid":"https://orcid.org/0000-0002-1123-0878","observed_orcids":["https://orcid.org/0000-0002-1123-0878"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas R. Shearer","raw_affiliation_strings":["Department of Integrative Biosciences, Oregon Health and Science University, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biosciences, Oregon Health and Science University, Portland, Oregon","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103730861","display_name":"Mitsuyoshi Azuma","orcid":"https://orcid.org/0000-0002-3593-1476","observed_orcids":["https://orcid.org/0000-0002-3593-1476"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4210133062","display_name":"Senju Pharmaceutical (Japan)","ror":"https://ror.org/03hq4qb06","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210133062"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Mitsuyoshi Azuma","raw_affiliation_strings":["From the Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Kobe, Hyogo, Japan; and the2Department of Integrative Biosciences, Oregon Health and Science University, Portland, Oregon","Department of Integrative Biosciences, Oregon Health and Science University, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Kobe, Hyogo, Japan; and the2Department of Integrative Biosciences, Oregon Health and Science University, Portland, Oregon","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4210133062"]},{"raw_affiliation_string":"Department of Integrative Biosciences, Oregon Health and Science University, Portland, Oregon","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029736829","https://openalex.org/A5060601520","https://openalex.org/A5064006153","https://openalex.org/A5103730861"],"corresponding_institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4210133062"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"53","issue":"9","first_page":"5312","last_page":"5312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurite-elongation","display_name":"neurite elongation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/neurite-regeneration","display_name":"neurite regeneration","score":0.8370000123977661},{"id":"https://openalex.org/keywords/trigeminal-ganglion-neurons","display_name":"trigeminal ganglion neurons","score":0.9079999923706055},{"id":"https://openalex.org/keywords/glial-cell-line-derived-neurotrophic-factor","display_name":"glial cell line-derived neurotrophic factor","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9789999723434448},{"id":"https://openalex.org/keywords/corneal-sensitivity","display_name":"corneal sensitivity","score":0.7940000295639038},{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.8199999928474426},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.7879999876022339},{"id":"https://openalex.org/keywords/lasik","display_name":"LASIK","score":0.4230000078678131},{"id":"https://openalex.org/keywords/neuronal-ablation","display_name":"neuronal ablation","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.9753419160842896},{"id":"https://openalex.org/C185856081","wikidata":"https://www.wikidata.org/wiki/Q14916286","display_name":"Glial cell line-derived neurotrophic factor","level":4,"score":0.9090014696121216},{"id":"https://openalex.org/C94296188","wikidata":"https://www.wikidata.org/wiki/Q5513091","display_name":"GDNF family of ligands","level":5,"score":0.749354898929596},{"id":"https://openalex.org/C2776352249","wikidata":"https://www.wikidata.org/wiki/Q776972","display_name":"Trigeminal ganglion","level":3,"score":0.6774146556854248},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6192034482955933},{"id":"https://openalex.org/C33947775","wikidata":"https://www.wikidata.org/wiki/Q271439","display_name":"Elongation","level":3,"score":0.5515159368515015},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.5263042449951172},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4482203722000122},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4309147298336029},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.42747771739959717},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33508479595184326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27957528829574585},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24531394243240356},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.20358595252037048},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1764158010482788},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15743809938430786},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06665730476379395},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.05770346522331238},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C112950240","wikidata":"https://www.wikidata.org/wiki/Q76005","display_name":"Ultimate tensile strength","level":2,"score":0.0},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009416","descriptor_name":"Nerve Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012668","descriptor_name":"Trigeminal Ganglion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051100","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1167/iovs.11-8957","doi":"https://doi.org/10.1167/iovs.11-8957","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.11-8957","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},{"id":"pmid:22714891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22714891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W31615410","https://openalex.org/W1584251348","https://openalex.org/W1971208141","https://openalex.org/W1980111531","https://openalex.org/W1981491762","https://openalex.org/W2001046353","https://openalex.org/W2002637457","https://openalex.org/W2012617770","https://openalex.org/W2017856583","https://openalex.org/W2020758244","https://openalex.org/W2027975733","https://openalex.org/W2039412868","https://openalex.org/W2045032238","https://openalex.org/W2048790911","https://openalex.org/W2059435366","https://openalex.org/W2063893203","https://openalex.org/W2066005663","https://openalex.org/W2074600897","https://openalex.org/W2075968446","https://openalex.org/W2083187517","https://openalex.org/W2096222742","https://openalex.org/W2103490623","https://openalex.org/W2124618998","https://openalex.org/W2127934652","https://openalex.org/W2141506602","https://openalex.org/W2146918064","https://openalex.org/W2166684356"],"related_works":["https://openalex.org/W2535292639","https://openalex.org/W3176023214","https://openalex.org/W929503502","https://openalex.org/W2001046353","https://openalex.org/W2991877062","https://openalex.org/W1169191702","https://openalex.org/W2749853594","https://openalex.org/W2741582033","https://openalex.org/W2299996201","https://openalex.org/W4402544710"],"abstract_inverted_index":{"PURPOSE:":[0],"Amputation":[1],"of":[2,34,41,65,78,88,109,122,165,218,228],"the":[3,19,48,63,66,86,153,229],"trigeminal":[4,27],"nerve":[5],"leads":[6],"to":[7,52,70,84,106,128,151],"decreased":[8],"corneal":[9,35],"sensitivity":[10,36],"and":[11,31,56,76,83,102,136,140,163,174,184],"dry":[12],"eye.":[13],"Our":[14,211],"previous":[15],"study":[16],"showed":[17],"that":[18,214],"drug":[20],"FK962":[21,73,160,215],"(N-[1-acetylpiperidin-4-yl]-4-fluorobenzamide)":[22],"induced":[23,181,192],"neurite":[24,54,90,110,157,172,179,193,208,234],"elongation":[25,55,75,162,173,180],"from":[26,220],"ganglion":[28],"(TG)":[29],"cells":[30,82,95],"accelerated":[32],"recovery":[33],"in":[37,42,117,119,167,236],"a":[38,226],"rabbit":[39],"model":[40,121],"situ":[43],"keratomileusis":[44],"(LASIK)":[45],"surgery.":[46],"However,":[47],"molecular":[49],"pathways":[50],"leading":[51],"FK962-induced":[53,89,156,207,233],"regeneration":[57,77,113,164],"are":[58],"not":[59,205],"well":[60],"defined.":[61],"Thus,":[62],"purposes":[64],"present":[67],"experiments":[68],"were":[69,96],"determine":[71,152],"if":[72],"induces":[74],"cultured":[79,97],"rat":[80,237],"TG":[81,94,168,221,238],"investigate":[85],"mechanism":[87,154],"elongation.":[91,111,209],"METHODS:":[92],"Mixed":[93],"with":[98],"or":[99],"without":[100],"FK962,":[101],"immunocytochemistry":[103],"was":[104,114,126,143,149,196],"used":[105,127,150],"detect":[107,129],"stimulation":[108],"Neurite":[112],"also":[115,191],"tested":[116],"an":[118],"vitro":[120],"neuronal":[123],"ablation.":[124],"ELISA":[125],"glial":[130],"cell":[131],"line-derived":[132],"neurotrophic":[133],"factor":[134,188],"(GDNF)":[135],"somatostatin":[137],"(SST)":[138],"release,":[139],"mRNA":[141],"expression":[142],"measured":[144],"by":[145,182,198],"qPCR.":[146],"Antibody":[147],"neutralization":[148],"for":[155,232],"elongation/regeneration.":[158],"RESULTS:":[159],"enhanced":[161],"neurites":[166],"neurons.":[169,239],"GDNF":[170,175,183,219,223],"treatment-induced":[171],"antibody":[176,203],"significantly":[177],"inhibited":[178,197],"FK962.":[185],"Nerve":[186],"growth":[187],"(NGF)":[189],"treatment":[190],"elongation,":[194],"which":[195],"NGF":[199,202],"antibody,":[200],"but":[201],"did":[204],"inhibit":[206],"CONCLUSIONS:":[210],"data":[212],"suggested":[213],"stimulated":[216],"induction":[217],"cells.":[222],"may":[224],"be":[225],"part":[227],"signaling":[230],"pathway":[231],"elongation/regeneration":[235]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}