{"id":"https://openalex.org/W2055843283","doi":"https://doi.org/10.1172/jci108876","title":"Biosynthesis of the third component of complement (C3) in vitro by monocytes from both normal and homozygous C3-deficient humans.","display_name":"Biosynthesis of the third component of complement (C3) in vitro by monocytes from both normal and homozygous C3-deficient humans.","publication_year":1977,"publication_date":"1977-11-01","ids":{"openalex":"https://openalex.org/W2055843283","doi":"https://doi.org/10.1172/jci108876","mag":"2055843283","pmid":"https://pubmed.ncbi.nlm.nih.gov/332718","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/372447"},"language":"en","primary_location":{"id":"doi:10.1172/jci108876","doi":"https://doi.org/10.1172/jci108876","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci108876","pdf_url":"http://www.jci.org/articles/view/108876/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/108876/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068148101","display_name":"L. Peter Einstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L P Einstein","raw_affiliation_strings":["Department of Pediatrics , Harvard Medical School , Bostoni , Massachusetts 02115 ,","Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","Harvard Medical School","Public Health Service Research Career Development","The Children's Hospital Aledical Center and Center for Blood Research,","University of Connecticut Medical School, Farmington, Connecticut 06032","University of Virginia, Charlottesville, Virginia 22901, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics , Harvard Medical School , Bostoni , Massachusetts 02115 ,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Public Health Service Research Career Development","institution_ids":[]},{"raw_affiliation_string":"The Children's Hospital Aledical Center and Center for Blood Research,","institution_ids":[]},{"raw_affiliation_string":"University of Connecticut Medical School, Farmington, Connecticut 06032","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"University of Virginia, Charlottesville, Virginia 22901, and","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063408276","display_name":"Prudence J. Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P J Hansen","raw_affiliation_strings":["The Children's Hospital Aledical Center and Center for Blood Research,","Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","Harvard Medical School","Public Health Service Research Career Development","University of Connecticut Medical School, Farmington, Connecticut 06032","University of Virginia, Charlottesville, Virginia 22901, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital Aledical Center and Center for Blood Research,","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Public Health Service Research Career Development","institution_ids":[]},{"raw_affiliation_string":"University of Connecticut Medical School, Farmington, Connecticut 06032","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"University of Virginia, Charlottesville, Virginia 22901, and","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037734477","display_name":"Mark C. Ballow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Ballow","raw_affiliation_strings":["Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","Harvard Medical School","Public Health Service Research Career Development","The Children's Hospital Aledical Center and Center for Blood Research,","University of Connecticut Medical School, Farmington, Connecticut 06032","University of Virginia, Charlottesville, Virginia 22901, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Public Health Service Research Career Development","institution_ids":[]},{"raw_affiliation_string":"The Children's Hospital Aledical Center and Center for Blood Research,","institution_ids":[]},{"raw_affiliation_string":"University of Connecticut Medical School, Farmington, Connecticut 06032","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"University of Virginia, Charlottesville, Virginia 22901, and","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036645205","display_name":"A E Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A E Davis","raw_affiliation_strings":["The Children's Hospital Aledical Center and Center for Blood Research,","Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","Harvard Medical School","Public Health Service Research Career Development","University of Connecticut Medical School, Farmington, Connecticut 06032","University of Virginia, Charlottesville, Virginia 22901, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital Aledical Center and Center for Blood Research,","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Public Health Service Research Career Development","institution_ids":[]},{"raw_affiliation_string":"University of Connecticut Medical School, Farmington, Connecticut 06032","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"University of Virginia, Charlottesville, Virginia 22901, and","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J S Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J S Davis","raw_affiliation_strings":["Department of Pediatrics , Harvard Medical School , Bostoni , Massachusetts 02115 ,","Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","Harvard Medical School","Public Health Service Research Career Development","The Children's Hospital Aledical Center and Center for Blood Research,","University of Connecticut Medical School, Farmington, Connecticut 06032","University of Virginia, Charlottesville, Virginia 22901, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics , Harvard Medical School , Bostoni , Massachusetts 02115 ,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Public Health Service Research Career Development","institution_ids":[]},{"raw_affiliation_string":"The Children's Hospital Aledical Center and Center for Blood Research,","institution_ids":[]},{"raw_affiliation_string":"University of Connecticut Medical School, Farmington, Connecticut 06032","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"University of Virginia, Charlottesville, Virginia 22901, and","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113519981","display_name":"Chester A. Alper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C A Alper","raw_affiliation_strings":["Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","Harvard Medical School","Public Health Service Research Career Development","The Children's Hospital Aledical Center and Center for Blood Research,","University of Connecticut Medical School, Farmington, Connecticut 06032","University of Virginia, Charlottesville, Virginia 22901, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Public Health Service Research Career Development","institution_ids":[]},{"raw_affiliation_string":"The Children's Hospital Aledical Center and Center for Blood Research,","institution_ids":[]},{"raw_affiliation_string":"University of Connecticut Medical School, Farmington, Connecticut 06032","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"University of Virginia, Charlottesville, Virginia 22901, and","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111433586","display_name":"Fred S. Rosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F S Rosen","raw_affiliation_strings":["The Children's Hospital Aledical Center and Center for Blood Research,","Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","Harvard Medical School","Public Health Service Research Career Development","University of Connecticut Medical School, Farmington, Connecticut 06032","University of Virginia, Charlottesville, Virginia 22901, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital Aledical Center and Center for Blood Research,","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Public Health Service Research Career Development","institution_ids":[]},{"raw_affiliation_string":"University of Connecticut Medical School, Farmington, Connecticut 06032","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"University of Virginia, Charlottesville, Virginia 22901, and","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111705492","display_name":"Harvey R. Colten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H R Colten","raw_affiliation_strings":["The Children's Hospital Aledical Center and Center for Blood Research,","Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","Harvard Medical School","Public Health Service Research Career Development","University of Connecticut Medical School, Farmington, Connecticut 06032","University of Virginia, Charlottesville, Virginia 22901, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital Aledical Center and Center for Blood Research,","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Bostoni, Massachusetts 02115, the","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Public Health Service Research Career Development","institution_ids":[]},{"raw_affiliation_string":"University of Connecticut Medical School, Farmington, Connecticut 06032","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"University of Virginia, Charlottesville, Virginia 22901, and","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":2.3295,"has_fulltext":true,"cited_by_count":113,"citation_normalized_percentile":{"value":0.87685428,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"60","issue":"5","first_page":"963","last_page":"969"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.8169999718666077},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9509999752044678},{"id":"https://openalex.org/keywords/c3-deficiency","display_name":"C3 deficiency","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cycloheximide-inhibition","display_name":"cycloheximide inhibition","score":0.8009999990463257},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.8128201961517334},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.7866146564483643},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.6087873578071594},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.537127673625946},{"id":"https://openalex.org/C2780889450","wikidata":"https://www.wikidata.org/wiki/Q1432692","display_name":"Allotype","level":3,"score":0.5185152292251587},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.4583633840084076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45587438344955444},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.43341511487960815},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4244949221611023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41979289054870605},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36839747428894043},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3333612084388733},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2015342116355896},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16609838604927063},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004587","descriptor_name":"Electrophoresis, Agar Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007163","descriptor_name":"Immunosorbent Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci108876","doi":"https://doi.org/10.1172/jci108876","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci108876","pdf_url":"http://www.jci.org/articles/view/108876/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:372447","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/372447","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:332718","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/332718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci108876","doi":"https://doi.org/10.1172/jci108876","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci108876","pdf_url":"http://www.jci.org/articles/view/108876/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2055843283.pdf","grobid_xml":"https://content.openalex.org/works/W2055843283.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W86147855","https://openalex.org/W1483670183","https://openalex.org/W1557712139","https://openalex.org/W1625660792","https://openalex.org/W1893828203","https://openalex.org/W1931838382","https://openalex.org/W1968792719","https://openalex.org/W1990986783","https://openalex.org/W2019101074","https://openalex.org/W2022838108","https://openalex.org/W2023732820","https://openalex.org/W2025123467","https://openalex.org/W2028815084","https://openalex.org/W2048788660","https://openalex.org/W2077593421","https://openalex.org/W2081211220","https://openalex.org/W2089402466","https://openalex.org/W2090327351","https://openalex.org/W2107549694","https://openalex.org/W2134409316","https://openalex.org/W2138132183","https://openalex.org/W2148862244","https://openalex.org/W2149550178"],"related_works":["https://openalex.org/W2046450825","https://openalex.org/W1541942464","https://openalex.org/W2417614955","https://openalex.org/W2412908983","https://openalex.org/W2054501475","https://openalex.org/W88778322","https://openalex.org/W2162305392","https://openalex.org/W1974812457","https://openalex.org/W64088374","https://openalex.org/W2399125085"],"abstract_inverted_index":{"Human":[0],"monocytes":[1,120,145],"synthesized":[2],"the":[3,35,45,51,107,114,129,149,152,176],"third":[4],"component":[5],"of":[6,25,34,37,44,53,57,63,70,81,106,113,128,148,155,178,186],"complement":[7],"(C3)":[8],"up":[9],"to":[10,126],"5":[11],"wk":[12,136],"in":[13,40,50,74,137,142],"vitro.":[14,138],"Evidence":[15],"for":[16],"net":[17],"C3":[18,30,38,55,71,82,98,116,122,140,158],"synthesis":[19,99],"was":[20],"based":[21],"on":[22,175],"(a)":[23],"incorporation":[24],"14C-labeled":[26],"amino":[27],"acids":[28],"into":[29],"protein,":[31],"(b)":[32],"indentity":[33],"allotype":[36],"produced":[39,73,121,141],"vitro":[41,75,143],"with":[42,76,84,181],"that":[43,96],"doner's":[46],"serum":[47,77,157],"C3,":[48],"even":[49],"presence":[52],"carrier":[54],"protein":[56,72,190],"a":[58],"different":[59],"allotype;":[60],"(c)":[61],"correspondence":[62],"electrophoretic":[64],"mobility,":[65],"size,":[66],"and":[67,159,188],"subunit":[68],"structure":[69],"C3;":[78],"(d)":[79],"inhibition":[80],"production":[83],"cycloheximide.":[85],"Monocytes":[86,165],"from":[87,104,146,166,173],"two":[88],"unrelated":[89],"C3-deficient":[90,167],"patients":[91,108,150,168],"were":[92],"studied":[93,133],"under":[94,162],"conditions":[95],"supported":[97],"by":[100,144],"normal":[101,115,130,156],"monocytes.":[102],"Serum":[103],"each":[105],"contained":[109],"less":[110],"than":[111],"1%":[112],"concentration,":[117],"buth":[118],"their":[119],"at":[123],"approximately":[124],"equal":[125],"25%":[127],"rate":[131],"when":[132],"after":[134],"2":[135],"The":[139],"one":[147],"had":[151],"molecular":[153],"weight":[154],"dissociated":[160],"appropriately":[161],"reducing":[163],"conditions.":[164],"could":[169],"not":[170],"be":[171],"distinguished":[172],"normals":[174],"basis":[177],"morphology,":[179],"rosetting":[180],"C3-coated":[182],"erythrocytes,":[183],"or":[184],"rates":[185],"C2,":[187],"total":[189],"synthesis.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
