{"id":"https://openalex.org/W2055840957","doi":"https://doi.org/10.2323/jgam.16.5_373","title":"MICROBIAL PRODUCTION OF L-LYSINE","display_name":"MICROBIAL PRODUCTION OF L-LYSINE","publication_year":1970,"publication_date":"1970-01-01","ids":{"openalex":"https://openalex.org/W2055840957","doi":"https://doi.org/10.2323/jgam.16.5_373","mag":"2055840957"},"language":"en","primary_location":{"id":"doi:10.2323/jgam.16.5_373","doi":"https://doi.org/10.2323/jgam.16.5_373","is_oa":true,"landing_page_url":"https://doi.org/10.2323/jgam.16.5_373","pdf_url":"https://www.jstage.jst.go.jp/article/jgam1955/16/5/16_5_373/_pdf","source":{"id":"https://openalex.org/S27908214","display_name":"The Journal of General and Applied Microbiology","issn_l":"0022-1260","issn":["0022-1260","1349-8037"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4323999590","host_organization_name":"Microbiology Research Foundation","host_organization_lineage":["https://openalex.org/P4323999590"],"host_organization_lineage_names":["Microbiology Research Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of General and Applied Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jgam1955/16/5/16_5_373/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039846882","display_name":"Konosuke Sano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146667","display_name":"Ajinomoto (Japan)","ror":"https://ror.org/044mkdq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210146667"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KONOSUKE SANO","raw_affiliation_strings":["Central Research Laboratories, Ajinomoto Co., Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratories, Ajinomoto Co., Inc","institution_ids":["https://openalex.org/I4210146667"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003545267","display_name":"Isamu Shiio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146667","display_name":"Ajinomoto (Japan)","ror":"https://ror.org/044mkdq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210146667"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"ISAMU SHIIO","raw_affiliation_strings":["Central Research Laboratories, Ajinomoto Co., Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratories, Ajinomoto Co., Inc","institution_ids":["https://openalex.org/I4210146667"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210146667"],"apc_list":null,"apc_paid":null,"fwci":0.704,"has_fulltext":true,"cited_by_count":112,"citation_normalized_percentile":{"value":0.64101282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"16","issue":"5","first_page":"373","last_page":"391"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.11969999969005585,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-lysine-production","display_name":"L-lysine production","score":0.9610000252723694},{"id":"https://openalex.org/keywords/s-2-aminoethyl-l-cysteine","display_name":"S-(2-aminoethyl)-L-cysteine","score":0.9290000200271606},{"id":"https://openalex.org/keywords/brevibacterium-flavum","display_name":"Brevibacterium flavum","score":0.847000002861023},{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9919999837875366},{"id":"https://openalex.org/keywords/threonine","display_name":"threonine","score":0.6759999990463257},{"id":"https://openalex.org/keywords/growth-inhibition","display_name":"growth inhibition","score":0.6349999904632568},{"id":"https://openalex.org/keywords/feedback-inhibition","display_name":"product inhibition","score":0.7929999828338623},{"id":"https://openalex.org/keywords/aspartokinase","display_name":"aspartokinase","score":0.9779999852180481},{"id":"https://openalex.org/keywords/lysine-biosynthesis","display_name":"lysine biosynthesis","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.8854247331619263},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.8722692728042603},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.7578988075256348},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6278355717658997},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6247611045837402},{"id":"https://openalex.org/C20950039","wikidata":"https://www.wikidata.org/wiki/Q578111","display_name":"Auxotrophy","level":4,"score":0.6137853860855103},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.6024008393287659},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.530652642250061},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4766879081726074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38320302963256836},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.37271010875701904},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2682119309902191},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.2243361473083496},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06263065338134766},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.052770912647247314},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2323/jgam.16.5_373","doi":"https://doi.org/10.2323/jgam.16.5_373","is_oa":true,"landing_page_url":"https://doi.org/10.2323/jgam.16.5_373","pdf_url":"https://www.jstage.jst.go.jp/article/jgam1955/16/5/16_5_373/_pdf","source":{"id":"https://openalex.org/S27908214","display_name":"The Journal of General and Applied Microbiology","issn_l":"0022-1260","issn":["0022-1260","1349-8037"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4323999590","host_organization_name":"Microbiology Research Foundation","host_organization_lineage":["https://openalex.org/P4323999590"],"host_organization_lineage_names":["Microbiology Research Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of General and Applied Microbiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2323/jgam.16.5_373","doi":"https://doi.org/10.2323/jgam.16.5_373","is_oa":true,"landing_page_url":"https://doi.org/10.2323/jgam.16.5_373","pdf_url":"https://www.jstage.jst.go.jp/article/jgam1955/16/5/16_5_373/_pdf","source":{"id":"https://openalex.org/S27908214","display_name":"The Journal of General and Applied Microbiology","issn_l":"0022-1260","issn":["0022-1260","1349-8037"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4323999590","host_organization_name":"Microbiology Research Foundation","host_organization_lineage":["https://openalex.org/P4323999590"],"host_organization_lineage_names":["Microbiology Research Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of General and Applied Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4359000027179718,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2055840957.pdf","grobid_xml":"https://content.openalex.org/works/W2055840957.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W338295599","https://openalex.org/W1604711952","https://openalex.org/W4256582704","https://openalex.org/W4242214041","https://openalex.org/W2042956743","https://openalex.org/W2595470637","https://openalex.org/W2397940576","https://openalex.org/W1175521484","https://openalex.org/W7097873413","https://openalex.org/W2305086889"],"abstract_inverted_index":{"S-(2-Aminoethyl)-L-cysteine":[0],"(AEC),":[1],"a":[2],"sulphur":[3],"analog":[4],"of":[5,10,19,33,49,60,90,99],"L-lysine,":[6],"inhibited":[7,24],"the":[8,17,25,31,35,47,76,80,87,96],"growth":[9,26],"Bacillus":[11],"subtilis":[12],"and":[13,68],"Escherichia":[14],"coli.":[15],"In":[16],"case":[18],"Brevibacterium":[20],"flavum,":[21],"AEC":[22],"alone":[23],"rather":[27],"weakly":[28],"but":[29],"in":[30,65],"presence":[32],"threonine":[34],"inhibitory":[36,42],"effect":[37],"was":[38],"markedly":[39],"enhanced.":[40],"These":[41],"effects":[43],"were":[44,52,69],"diminished":[45],"by":[46,72],"addition":[48],"L-lysine.AEC-Resistant":[50],"mutants":[51],"derived":[53],"from":[54,75],"B.":[55],"flavum":[56],"No.":[57],"2247.":[58],"Some":[59],"them":[61],"produced":[62],"much":[63],"lysine":[64,84],"minimal":[66],"medium":[67],"not":[70],"affected":[71],"threonine,":[73],"differing":[74],"lysine-producing":[77,91],"auxotrophs":[78],"or":[79,82],"threonine-":[81],"methionine-sensitive":[83],"producer.":[85],"Therefore,":[86],"mutation":[88],"site":[89,98],"AEC-resistants":[92],"is":[93],"deduced":[94],"as":[95],"feedback":[97],"aspartokinase.":[100]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":10},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}