{"id":"https://openalex.org/W2055837433","doi":"https://doi.org/10.1158/1535-7163.targ-13-b60","title":"Abstract B60: FUCCI cell cycle imaging identifies drug-resistant quiescent cancer cells within tumors.","display_name":"Abstract B60: FUCCI cell cycle imaging identifies drug-resistant quiescent cancer cells within tumors.","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2055837433","doi":"https://doi.org/10.1158/1535-7163.targ-13-b60","mag":"2055837433"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-13-b60","doi":"https://doi.org/10.1158/1535-7163.targ-13-b60","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-13-b60","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062335013","display_name":"Shuya Yano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuya Yano","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009618026","display_name":"Yasunori Tome","orcid":"https://orcid.org/0000-0002-3716-1866","observed_orcids":["https://orcid.org/0000-0002-3716-1866"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasunori Tome","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419770","display_name":"Yong Zhang","orcid":"https://orcid.org/0000-0002-1303-0458","observed_orcids":["https://orcid.org/0000-0002-1303-0458","https://orcid.org/0000-0002-9916-3832","https://orcid.org/0000-0001-6577-5235"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Zhang","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010692199","display_name":"Shinji Miwa","orcid":"https://orcid.org/0000-0002-5962-8287","observed_orcids":["https://orcid.org/0000-0002-5962-8287"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shinji Miwa","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037875479","display_name":"Atsushi Suetsugu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atsushi Suetsugu","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035456514","display_name":"Hiroyuki Kishimoto","orcid":"https://orcid.org/0000-0001-8174-3508","observed_orcids":["https://orcid.org/0000-0001-8174-3508"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Kishimoto","raw_affiliation_strings":["2Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015421086","display_name":"Hiroshi Tazawa","orcid":"https://orcid.org/0000-0003-4658-1050","observed_orcids":["https://orcid.org/0000-0003-4658-1050"]},"institutions":[{"id":"https://openalex.org/I4210100185","display_name":"Okayama University Hospital","ror":"https://ror.org/019tepx80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210100185"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Tazawa","raw_affiliation_strings":["3Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan","institution_ids":["https://openalex.org/I4210100185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009960666","display_name":"Michael Bouvet","orcid":"https://orcid.org/0000-0002-0086-2159","observed_orcids":["https://orcid.org/0000-0002-0086-2159"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Bouvet","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068717107","display_name":"Toshiyoshi Fujiwara","orcid":"https://orcid.org/0000-0002-5377-6051","observed_orcids":["https://orcid.org/0000-0002-5377-6051"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyoshi Fujiwara","raw_affiliation_strings":["2Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Hoffman","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"11_Supplement","first_page":"B60","last_page":"B60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.3813000023365021,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.3813000023365021,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.3334999978542328,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.06379999965429306,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.6179999709129333},{"id":"https://openalex.org/keywords/quiescent-tumor-cells","display_name":"quiescent cancer cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9079999923706055},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.7129999995231628},{"id":"https://openalex.org/keywords/g0-g1-phase","display_name":"G0/G1 phase","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.6370000243186951},{"id":"https://openalex.org/keywords/longitudinal-tumor-imaging","display_name":"longitudinal tumor imaging","score":0.6320000290870667},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7915730476379395},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6168492436408997},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5762555599212646},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5707806944847107},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5461068153381348},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4814702570438385},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43247321248054504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28694409132003784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22148025035858154},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15086489915847778},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10850939154624939}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-13-b60","doi":"https://doi.org/10.1158/1535-7163.targ-13-b60","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-13-b60","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2004295263","https://openalex.org/W2012873903","https://openalex.org/W3086088575","https://openalex.org/W2556283756","https://openalex.org/W2080068744","https://openalex.org/W3127202769","https://openalex.org/W2048962575","https://openalex.org/W1593629705","https://openalex.org/W2921580357","https://openalex.org/W2896465339"],"abstract_inverted_index":{"Abstract":[0],"Fluorescence":[1],"ubiquitination":[2],"cell":[3,13,179],"cycle":[4,14,180],"indicator":[5],"(FUCCI)":[6],"imaging":[7,82,181],"was":[8],"used":[9,87],"to":[10],"identify":[11],"the":[12,33,36,39,89,97,100,114,132,193],"phase":[15],"of":[16,32,38,57,67,99,117,192],"cancer":[17,58,68,94,110,143,185],"cells":[18,34,59,69,95,111,144,186],"in":[19,27,35,42,47,51,61,78,88,103,131],"small":[20],"and":[21,44,199],"large":[22,53],"tumors.":[23,188],"In":[24,49],"nascent":[25],"tumors":[26,101,126],"nude":[28],"mice,":[29],"approximately":[30,55,65],"30%":[31],"center":[37],"tumor":[40,74],"were":[41,46,60,77],"G0/G1":[43,62],"70%":[45],"S/G2/M.":[48],"contrast":[50],"a":[52],"tumor,":[54],"90%":[56],"phase.":[63],"Similarly,":[64],"75%":[66],"far":[70],"from":[71],"(>100":[72],"\u00b5m)":[73],"blood":[75],"vessels":[76],"G0/G1.":[79],"Longitudinal":[80],"real-time":[81],"demonstrated":[83],"that":[84,112,138,140],"cytotoxic":[85],"drugs":[86,139],"clinic":[90],"killed":[91],"only":[92],"proliferating":[93],"at":[96],"surface":[98],"and,":[102],"contrast,":[104],"had":[105],"little":[106],"effect":[107],"on":[108],"quiescent":[109,142,184],"are":[113,127,145],"vast":[115],"majority":[116],"an":[118],"established":[119],"tumor.":[120],"These":[121],"results":[122,135],"demonstrate":[123],"why":[124],"solid":[125],"usually":[128],"drug":[129],"resistant":[130],"clinic.":[133],"The":[134],"also":[136],"suggest":[137],"target":[141],"urgently":[146],"needed.":[147],"Citation":[148,155],"Information:":[149],"Mol":[150,210],"Cancer":[151,200,211],"Ther":[152,212],"2013;12(11":[153,213],"Suppl):B60.":[154],"Format:":[156],"Shuya":[157],"Yano,":[158],"Yasunori":[159],"Tome,":[160],"Yong":[161],"Zhang,":[162],"Shinji":[163],"Miwa,":[164],"Atsushi":[165],"Suetsugu,":[166],"Hiroyuki":[167],"Kishimoto,":[168],"Hiroshi":[169],"Tazawa,":[170],"Michael":[171],"Bouvet,":[172],"Toshiyoshi":[173],"Fujiwara,":[174],"Robert":[175],"M.":[176],"Hoffman.":[177],"FUCCI":[178],"identifies":[182],"drug-resistant":[183],"within":[187],"[abstract].":[189],"In:":[190],"Proceedings":[191],"AACR-NCI-EORTC":[194],"International":[195],"Conference:":[196],"Molecular":[197],"Targets":[198],"Therapeutics;":[201],"2013":[202],"Oct":[203],"19-23;":[204],"Boston,":[205],"MA.":[206],"Philadelphia":[207],"(PA):":[208],"AACR;":[209],"Suppl):Abstract":[214],"nr":[215],"B60.":[216]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
