{"id":"https://openalex.org/W2055829151","doi":"https://doi.org/10.3892/mmr.2014.3104","title":"Tumor necrosis factor receptor-associated factor 6 promotes migration of rheumatoid arthritis fibroblast-like synoviocytes","display_name":"Tumor necrosis factor receptor-associated factor 6 promotes migration of rheumatoid arthritis fibroblast-like synoviocytes","publication_year":2014,"publication_date":"2014-12-17","ids":{"openalex":"https://openalex.org/W2055829151","doi":"https://doi.org/10.3892/mmr.2014.3104","mag":"2055829151","pmid":"https://pubmed.ncbi.nlm.nih.gov/25522907"},"language":"en","primary_location":{"id":"doi:10.3892/mmr.2014.3104","doi":"https://doi.org/10.3892/mmr.2014.3104","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2014.3104","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2014.3104/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/mmr.2014.3104/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100708882","display_name":"Huiqin Wang","orcid":"https://orcid.org/0000-0002-5327-1432","observed_orcids":["https://orcid.org/0000-0002-5327-1432"]},"institutions":[{"id":"https://openalex.org/I4210097338","display_name":"Zaozhuang Municipal Hospital","ror":"https://ror.org/01nvdh647","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097338"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HUIQIN WANG","raw_affiliation_strings":["Department of Clinical Laboratory, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277102, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277102, P.R. China","institution_ids":["https://openalex.org/I4210097338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003395898","display_name":"Weixia Chen","orcid":"https://orcid.org/0000-0002-7422-0730","observed_orcids":["https://orcid.org/0000-0002-7422-0730"]},"institutions":[{"id":"https://openalex.org/I4210097338","display_name":"Zaozhuang Municipal Hospital","ror":"https://ror.org/01nvdh647","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097338"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"WEIXIA CHEN","raw_affiliation_strings":["Department of Clinical Laboratory, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277102, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277102, P.R. China","institution_ids":["https://openalex.org/I4210097338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398721","display_name":"Ling Wang","orcid":"https://orcid.org/0000-0003-1578-8171","observed_orcids":["https://orcid.org/0000-0003-1578-8171"]},"institutions":[{"id":"https://openalex.org/I4210097338","display_name":"Zaozhuang Municipal Hospital","ror":"https://ror.org/01nvdh647","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097338"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"LING WANG","raw_affiliation_strings":["Department of Rheumatology, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277102, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277102, P.R. China","institution_ids":["https://openalex.org/I4210097338"]}]},{"author_position":"middle","author":{"id":null,"display_name":"FAXIN LI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106451","display_name":"Jinan Central Hospital","ror":"https://ror.org/01fr19c68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106451"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"FAXIN LI","raw_affiliation_strings":["Department of Rheumatology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250204, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250204, P.R. China","institution_ids":["https://openalex.org/I4210106451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100439732","display_name":"Chunling Zhang","orcid":"https://orcid.org/0000-0001-6983-7050","observed_orcids":["https://orcid.org/0000-0001-6983-7050"]},"institutions":[{"id":"https://openalex.org/I4210106451","display_name":"Jinan Central Hospital","ror":"https://ror.org/01fr19c68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106451"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"CHUNLING ZHANG","raw_affiliation_strings":["Department of Rheumatology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250204, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250204, P.R. China","institution_ids":["https://openalex.org/I4210106451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101309892","display_name":"Li Xu","orcid":"https://orcid.org/0009-0003-8234-1473","observed_orcids":["https://orcid.org/0009-0003-8234-1473"]},"institutions":[{"id":"https://openalex.org/I4210097338","display_name":"Zaozhuang Municipal Hospital","ror":"https://ror.org/01nvdh647","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097338"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"LI XU","raw_affiliation_strings":["Department of Clinical Laboratory, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277102, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277102, P.R. China","institution_ids":["https://openalex.org/I4210097338"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1364,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.75659111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"4","first_page":"2761","last_page":"2766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traf6","display_name":"TRAF6","score":0.9399999976158142},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.9480000138282776},{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9120000004768372},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.8389999866485596},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":1.0},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":1.0},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8309999704360962},{"id":"https://openalex.org/keywords/joint-inflammation","display_name":"joint inflammation","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.7096613049507141},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5663176774978638},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.5419796705245972},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5400048494338989},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5282979011535645},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.5220746397972107},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5203958749771118},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5161612629890442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49659019708633423},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.49405649304389954},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.4714542329311371},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4385553002357483},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4154508709907532},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.37581250071525574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37284499406814575},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.36877769231796265},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25282859802246094},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.1895654797554016},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.13405227661132812},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024043","descriptor_name":"Collagen Type II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048029","descriptor_name":"TNF Receptor-Associated Factor 6","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048029","descriptor_name":"TNF Receptor-Associated Factor 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048029","descriptor_name":"TNF Receptor-Associated Factor 6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/mmr.2014.3104","doi":"https://doi.org/10.3892/mmr.2014.3104","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2014.3104","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2014.3104/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},{"id":"pmid:25522907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25522907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular medicine reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/mmr.2014.3104","doi":"https://doi.org/10.3892/mmr.2014.3104","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2014.3104","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2014.3104/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2055829151.pdf","grobid_xml":"https://content.openalex.org/works/W2055829151.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W41125336","https://openalex.org/W1489141558","https://openalex.org/W1538894063","https://openalex.org/W1539853698","https://openalex.org/W1542442227","https://openalex.org/W1564492456","https://openalex.org/W1981916590","https://openalex.org/W1983836953","https://openalex.org/W1989921387","https://openalex.org/W1994174953","https://openalex.org/W2012749276","https://openalex.org/W2026189702","https://openalex.org/W2027225108","https://openalex.org/W2038773696","https://openalex.org/W2052408514","https://openalex.org/W2053949885","https://openalex.org/W2065023235","https://openalex.org/W2072803699","https://openalex.org/W2073404631","https://openalex.org/W2083498707","https://openalex.org/W2092138471","https://openalex.org/W2122058168","https://openalex.org/W2128952811","https://openalex.org/W2138606042","https://openalex.org/W2253462571","https://openalex.org/W2305857834","https://openalex.org/W2413217851","https://openalex.org/W6691917542"],"related_works":["https://openalex.org/W2613296025","https://openalex.org/W3037653215","https://openalex.org/W3108665015","https://openalex.org/W2976150935","https://openalex.org/W4304014685","https://openalex.org/W7117997515","https://openalex.org/W3100103317","https://openalex.org/W2803967954","https://openalex.org/W2546351037","https://openalex.org/W2991804513"],"abstract_inverted_index":{"Fibroblast\u2011like":[0],"synoviocytes":[1],"(FLSs)":[2],"have":[3],"a":[4,24,171,188],"pivotal":[5],"role":[6,172],"in":[7,12,27,50,55,64,83,90,92,136,175,191],"the":[8,28,33,40,51,96,102,116,160,176,183,192],"destruction":[9],"of":[10,32,35,39,53,98,106,109,118,143,165,178,194],"joints":[11],"rheumatoid":[13],"arthritis":[14,58,119],"(RA).":[15],"Tumor":[16],"necrosis":[17],"factor":[18,20],"receptor\u2011associated":[19],"6":[21],"(TRAF6)":[22],"is":[23,48],"critical":[25],"mediator":[26],"inflammatory":[29],"pathway":[30],"and":[31,60,78,104,120,131,163,180],"activity":[34],"osteoclasts.":[36],"The":[37,141],"aim":[38],"present":[41],"study":[42],"was":[43,81],"to":[44,94],"investigate":[45],"whether":[46],"TRAF6":[47,73,79,99,110,156,174,184],"involved":[49],"progression":[52],"RA":[54,62],"mouse":[56,68,112],"collagen\u2011induced":[57],"(CIA)":[59],"human":[61,148,166],"FLSs":[63,84],"vitro.":[65],"In":[66],"vivo":[67],"models":[69],"were":[70,133,150],"transfected":[71],"with":[72],"small":[74],"interfering":[75],"(si)RNA":[76],"(siTRAF6)":[77],"inhibition":[80,100],"achieved":[82],"using":[85,111],"an":[86],"anti\u2011TRAF6":[87,153],"monoclonal":[88,154],"antibody":[89],"vitro":[91],"order":[93],"assess":[95],"effects":[97],"on":[101],"migration":[103,162],"invasion":[105,164],"FLSs.":[107],"Inhibition":[108],"specific":[113],"siTRAF6":[114],"reduced":[115,151],"severity":[117],"joint":[121],"inflammation.":[122],"Serum":[123],"anti\u2011collagen":[124],"II":[125],"antibodies,":[126],"matrix":[127],"metalloproteinase":[128],"(MMP)\u20111,":[129],"MMP\u20113":[130],"MMP\u20119":[132],"also":[134],"inhibited":[135],"CIA":[137],"mice":[138],"by":[139,146,152],"siTRAF6.":[140],"levels":[142],"MMPs":[144],"produced":[145],"IL\u20111\u03b2\u2011stimulated":[147,161],"RA\u2011FLSs":[149],"antibody.":[155],"blockade":[157,185],"significantly":[158],"suppressed":[159],"RA\u2011FLSs.":[167],"These":[168],"results":[169],"support":[170],"for":[173],"pathogenesis":[177],"RA,":[179],"suggest":[181],"that":[182],"may":[186],"be":[187],"potential":[189],"strategy":[190],"management":[193],"RA.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
