{"id":"https://openalex.org/W2055650412","doi":"https://doi.org/10.1159/000226756","title":"Do CA 19-9 and TPA Play a Minor Role as Compared to AFP in Diagnosing Primary Hepatocellular Carcinoma?","display_name":"Do CA 19-9 and TPA Play a Minor Role as Compared to AFP in Diagnosing Primary Hepatocellular Carcinoma?","publication_year":2009,"publication_date":"2009-06-26","ids":{"openalex":"https://openalex.org/W2055650412","doi":"https://doi.org/10.1159/000226756","mag":"2055650412","pmid":"https://pubmed.ncbi.nlm.nih.gov/2479897"},"language":"en","primary_location":{"id":"doi:10.1159/000226756","doi":"https://doi.org/10.1159/000226756","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000226756","pdf_url":null,"source":{"id":"https://openalex.org/S198727964","display_name":"Oncology","issn_l":"0030-2414","issn":["0030-2414","1423-0232"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001722887","display_name":"Gioacchino Leandro","orcid":"https://orcid.org/0000-0001-6624-4532","observed_orcids":["https://orcid.org/0000-0001-6624-4532"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Leandro","raw_affiliation_strings":["Istituto di Medicina Interna, Universit\u00e0 degli Studi di Padova, Italia","Istituto di Ricovero e Cura a Carattere Scientifico Specializzato in Gastroenterologia, Castellana Grotte, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna, Universit\u00e0 degli Studi di Padova, Italia","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"Istituto di Ricovero e Cura a Carattere Scientifico Specializzato in Gastroenterologia, Castellana Grotte, Italia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082008096","display_name":"S. Zizzari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Zizzari","raw_affiliation_strings":["Istituto di Ricovero e Cura a Carattere Scientifico Specializzato in Gastroenterologia, Castellana Grotte, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ricovero e Cura a Carattere Scientifico Specializzato in Gastroenterologia, Castellana Grotte, Italia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113588549","display_name":"Carlo Fabris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Fabris","raw_affiliation_strings":["Istituto di Medicina Interna, Cattedra di Malattie Apparato Digerente, Universit\u00e0 degli Studi di Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna, Cattedra di Malattie Apparato Digerente, Universit\u00e0 degli Studi di Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037249662","display_name":"Daniela Basso","orcid":"https://orcid.org/0000-0001-8745-6171","observed_orcids":["https://orcid.org/0000-0001-8745-6171"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D. Basso","raw_affiliation_strings":["Istituto di Medicina Interna, Cattedra di Malattie Apparato Digerente, Universit\u00e0 degli Studi di Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna, Cattedra di Malattie Apparato Digerente, Universit\u00e0 degli Studi di Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110167177","display_name":"S. Elba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Elba","raw_affiliation_strings":["Istituto di Ricovero e Cura a Carattere Scientifico Specializzato in Gastroenterologia, Castellana Grotte, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ricovero e Cura a Carattere Scientifico Specializzato in Gastroenterologia, Castellana Grotte, Italia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050131333","display_name":"Giuseppe Del Favero","orcid":"https://orcid.org/0000-0001-5325-9313","observed_orcids":["https://orcid.org/0000-0001-5325-9313"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Del Favero","raw_affiliation_strings":["Istituto di Medicina Interna, Cattedra di Malattie Apparato Digerente, Universit\u00e0 degli Studi di Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna, Cattedra di Malattie Apparato Digerente, Universit\u00e0 degli Studi di Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007793529","display_name":"Tamara Meggiato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"T. Meggiato","raw_affiliation_strings":["Istituto di Medicina Interna, Cattedra di Malattie Apparato Digerente, Universit\u00e0 degli Studi di Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna, Cattedra di Malattie Apparato Digerente, Universit\u00e0 degli Studi di Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. Angonese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Angonese","raw_affiliation_strings":["Istituto di Medicina Interna, Cattedra di Malattie Apparato Digerente, Universit\u00e0 degli Studi di Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna, Cattedra di Malattie Apparato Digerente, Universit\u00e0 degli Studi di Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021006462","display_name":"Francesco Di Mario","orcid":"https://orcid.org/0000-0002-8189-7336","observed_orcids":["https://orcid.org/0000-0002-8189-7336"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Di Mario","raw_affiliation_strings":["Istituto di Medicina Interna, Cattedra di Malattie Apparato Digerente, Universit\u00e0 degli Studi di Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna, Cattedra di Malattie Apparato Digerente, Universit\u00e0 degli Studi di Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071093851","display_name":"Onofrio Giuseppe Manghisi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O.G. Manghisi","raw_affiliation_strings":["Istituto di Ricovero e Cura a Carattere Scientifico Specializzato in Gastroenterologia, Castellana Grotte, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ricovero e Cura a Carattere Scientifico Specializzato in Gastroenterologia, Castellana Grotte, Italia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036404845","display_name":"Remo Naccarato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R. Naccarato","raw_affiliation_strings":["Istituto di Medicina Interna, Cattedra di Malattie Apparato Digerente, Universit\u00e0 degli Studi di Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna, Cattedra di Malattie Apparato Digerente, Universit\u00e0 degli Studi di Padova","institution_ids":["https://openalex.org/I138689650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1957,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.6182661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"46","issue":"6","first_page":"381","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9269999861717224},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.8220000267028809},{"id":"https://openalex.org/keywords/ca19-9","display_name":"CA19-9","score":0.9710000157356262},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tissue-polypeptide-antigen","display_name":"tissue polypeptide antigen","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.8119999766349792},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.6129999756813049},{"id":"https://openalex.org/keywords/liver-function-tests","display_name":"liver function tests","score":0.6430000066757202},{"id":"https://openalex.org/keywords/cancer-detection","display_name":"cancer detection","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8687189817428589},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.8670107126235962},{"id":"https://openalex.org/C2777387746","wikidata":"https://www.wikidata.org/wiki/Q769706","display_name":"Carcinoembryonic antigen","level":3,"score":0.7526229619979858},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7297194004058838},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6454864144325256},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6027835607528687},{"id":"https://openalex.org/C2780624289","wikidata":"https://www.wikidata.org/wiki/Q306076","display_name":"Alpha-fetoprotein","level":3,"score":0.4730317294597626},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4561646580696106},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.43402528762817383},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.4161718189716339},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2993601858615875}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015295","descriptor_name":"Antigens, Tumor-Associated, Carbohydrate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D019396","descriptor_name":"Tissue Polypeptide Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000226756","doi":"https://doi.org/10.1159/000226756","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000226756","pdf_url":null,"source":{"id":"https://openalex.org/S198727964","display_name":"Oncology","issn_l":"0030-2414","issn":["0030-2414","1423-0232"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"journal-article"},{"id":"pmid:2479897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2479897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2397283828","https://openalex.org/W2085503165","https://openalex.org/W2091448722","https://openalex.org/W92443348","https://openalex.org/W2354612579","https://openalex.org/W2997368362","https://openalex.org/W2349383516","https://openalex.org/W124828919","https://openalex.org/W1978502443","https://openalex.org/W2378453210"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,79,96,107],"undertaken":[3],"in":[4,41,48,53,65,85,109,120,148,167,171],"order":[5],"to":[6,14,62,81,90,145,185],"compare":[7],"the":[8,74,91,140,172],"ability":[9],"of":[10,68,73,76,174],"4":[11,57],"tumour":[12],"markers":[13,59],"discriminate":[15],"between":[16,112,125],"liver":[17,45,54,69,126,149],"cirrhosis":[18,46,70],"patients":[19,43,50,87,111,124],"with":[20,44,51],"or":[21,180],"without":[22],"hepatocellular":[23],"carcinoma":[24],"(HCC).":[25],"Serum":[26],"alpha-fetoprotein":[27],"(AFP),":[28],"carcinoembryonic":[29],"antigen":[30,37],"(CEA),":[31],"CA":[32,99,156],"19-9":[33,157],"and":[34,47,102,114,129],"tissue":[35],"polypeptide":[36],"(TPA)":[38],"were":[39,60,118],"determined":[40],"63":[42],"25":[49],"HCC":[52,86,110,123,147],"cirrhosis.":[55,150],"All":[56],"serum":[58,154],"found":[61,80],"be":[63,82],"increased":[64],"a":[66,183],"number":[67],"patients,":[71],"regardless":[72],"presence":[75],"HCC.":[77],"AFP":[78,113,135],"more":[83],"elevated":[84],"as":[88,138,159],"compared":[89],"other":[92],"group;":[93],"no":[94],"difference":[95],"observed":[97],"for":[98,163],"19-9,":[100],"CEA":[101],"TPA.":[103,115,130],"A":[104],"significant":[105],"correlation":[106,117],"detected":[108,119],"Significant":[116],"all":[121],"except":[122],"function":[127],"tests":[128],"We":[131],"can":[132,166],"conclude":[133],"that":[134],"determination":[136],"remains":[137],"yet":[139],"only":[141],"suitable":[142],"marker":[143,155],"able":[144],"detect":[146],"The":[151],"newly":[152],"introduced":[153],"is,":[158],"previously":[160],"reported,":[161],"unhelpful":[162],"CEA.":[164],"TPA":[165],"some":[168],"instances":[169],"(i.e.":[170],"absence":[173],"an":[175],"important":[176],"hepatic":[177],"cell":[178],"necrosis":[179],"cholestasis)":[181],"provide":[182],"clue":[184],"neoplastic":[186],"growth.":[187]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
