{"id":"https://openalex.org/W2055644686","doi":"https://doi.org/10.1016/j.neulet.2013.07.024","title":"Isoflurane inhibits bronchopulmonary C-fiber-mediated apneic response to phenylbiguanide by depressing 5-HT3 receptor function in anesthetized rats","display_name":"Isoflurane inhibits bronchopulmonary C-fiber-mediated apneic response to phenylbiguanide by depressing 5-HT3 receptor function in anesthetized rats","publication_year":2013,"publication_date":"2013-07-26","ids":{"openalex":"https://openalex.org/W2055644686","doi":"https://doi.org/10.1016/j.neulet.2013.07.024","mag":"2055644686","pmid":"https://pubmed.ncbi.nlm.nih.gov/23896531","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3857219"},"language":"en","primary_location":{"id":"doi:10.1016/j.neulet.2013.07.024","doi":"https://doi.org/10.1016/j.neulet.2013.07.024","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neulet.2013.07.024","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3857219","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026205697","display_name":"Zhenxiong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhenxiong Zhang","raw_affiliation_strings":["Pathophysiology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, SE, Albuquerque, NM 87108, United States. Electronic address: zzhang6@salud.unm.edu","Pathophysiology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, SE, Albuquerque, NM 87108, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathophysiology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, SE, Albuquerque, NM 87108, United States. Electronic address: zzhang6@salud.unm.edu","institution_ids":["https://openalex.org/I1305258596"]},{"raw_affiliation_string":"Pathophysiology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, SE, Albuquerque, NM 87108, United States","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101945947","display_name":"Jianguo Zhuang","orcid":"https://orcid.org/0000-0002-4579-046X","observed_orcids":["https://orcid.org/0000-0002-4579-046X"]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianguo Zhuang","raw_affiliation_strings":["Pathophysiology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, SE, Albuquerque, NM 87108, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathophysiology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, SE, Albuquerque, NM 87108, United States","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102992856","display_name":"Cancan Zhang","orcid":"https://orcid.org/0009-0006-6132-9530","observed_orcids":["https://orcid.org/0009-0006-6132-9530"]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cancan Zhang","raw_affiliation_strings":["Pathophysiology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, SE, Albuquerque, NM 87108, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathophysiology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, SE, Albuquerque, NM 87108, United States","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046859138","display_name":"Fadi Xu","orcid":"https://orcid.org/0000-0003-2345-3785","observed_orcids":["https://orcid.org/0000-0003-2345-3785"]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fadi Xu","raw_affiliation_strings":["Pathophysiology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, SE, Albuquerque, NM 87108, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathophysiology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, SE, Albuquerque, NM 87108, United States","institution_ids":["https://openalex.org/I1305258596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026205697"],"corresponding_institution_ids":["https://openalex.org/I1305258596"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"552","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isoflurane","display_name":"isoflurane","score":1.0},{"id":"https://openalex.org/keywords/phenylbiguanide","display_name":"phenylbiguanide","score":0.8130000233650208},{"id":"https://openalex.org/keywords/5-ht3-receptor","display_name":"5-HT3 receptor","score":0.9539999961853027},{"id":"https://openalex.org/keywords/apnea","display_name":"apnea","score":0.6499999761581421},{"id":"https://openalex.org/keywords/nodose-ganglion-neurons","display_name":"nodose ganglion neurons","score":0.7860000133514404},{"id":"https://openalex.org/keywords/volatile-anesthetics","display_name":"volatile anesthetics","score":0.7429999709129333},{"id":"https://openalex.org/keywords/airway-reflexes","display_name":"airway reflexes","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2776359302","wikidata":"https://www.wikidata.org/wiki/Q413918","display_name":"Isoflurane","level":2,"score":0.6785545349121094},{"id":"https://openalex.org/C2780204788","wikidata":"https://www.wikidata.org/wiki/Q3454515","display_name":"5-HT3 receptor","level":5,"score":0.6332572102546692},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.5484151244163513},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5441896915435791},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.521875262260437},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5166811943054199},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5065919160842896},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.47673141956329346},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4221063256263733},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41455787420272827},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33350151777267456},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.19033044576644897},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.16919460892677307}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001645","descriptor_name":"Biguanides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D007530","descriptor_name":"Isoflurane","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007530","descriptor_name":"Isoflurane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009620","descriptor_name":"Nodose Ganglion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009620","descriptor_name":"Nodose Ganglion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D036421","descriptor_name":"Nerve Fibers, Unmyelinated","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D036421","descriptor_name":"Nerve Fibers, Unmyelinated","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058827","descriptor_name":"Serotonin 5-HT3 Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D058831","descriptor_name":"Serotonin 5-HT3 Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neulet.2013.07.024","doi":"https://doi.org/10.1016/j.neulet.2013.07.024","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neulet.2013.07.024","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},{"id":"pmid:23896531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23896531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience letters","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3145231","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3857219","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3857219","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3857219/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neurosci Lett","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3145231","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3857219","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6818341175","display_name":"Effect of Prenatal Nicotinic Exposure on Control of Hypoxic Ventilatory Response","funder_award_id":"R01HL107462","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1504117327","https://openalex.org/W1963552543","https://openalex.org/W1972078008","https://openalex.org/W1983565109","https://openalex.org/W1984210151","https://openalex.org/W1987513889","https://openalex.org/W1988973105","https://openalex.org/W2010321930","https://openalex.org/W2018728162","https://openalex.org/W2023028936","https://openalex.org/W2033734484","https://openalex.org/W2033796406","https://openalex.org/W2037512992","https://openalex.org/W2044725133","https://openalex.org/W2054113403","https://openalex.org/W2059113766","https://openalex.org/W2063630842","https://openalex.org/W2073399262","https://openalex.org/W2080400253","https://openalex.org/W2089628724","https://openalex.org/W2103901309","https://openalex.org/W2138514579","https://openalex.org/W2150773909","https://openalex.org/W2298128791","https://openalex.org/W2406276809","https://openalex.org/W2414104833","https://openalex.org/W2415669575","https://openalex.org/W6675667497","https://openalex.org/W6697458139"],"related_works":["https://openalex.org/W3172462298","https://openalex.org/W3176804272","https://openalex.org/W2089628724","https://openalex.org/W3096465973","https://openalex.org/W2086421505","https://openalex.org/W2149179613","https://openalex.org/W3173763315","https://openalex.org/W1995706095","https://openalex.org/W1978380411","https://openalex.org/W1997913073"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}