{"id":"https://openalex.org/W2055605136","doi":null,"title":"Assignment of common allele loss in osteosarcoma to the subregion 17p13.","display_name":"Assignment of common allele loss in osteosarcoma to the subregion 17p13.","publication_year":1989,"publication_date":"1989-11-15","ids":{"openalex":"https://openalex.org/W2055605136","mag":"2055605136","pmid":"https://pubmed.ncbi.nlm.nih.gov/2572320"},"language":"en","primary_location":{"id":"pmid:2572320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2572320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007116908","display_name":"Junya Toguchida","orcid":"https://orcid.org/0000-0002-0184-9685","observed_orcids":["https://orcid.org/0000-0002-0184-9685"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4405285708","display_name":"Radiation Biology Center, Kyoto University","ror":"https://ror.org/0006k6163","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4405285708"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J Toguchida","raw_affiliation_strings":["Radiation Biology Center, Faculty of Medicine, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Biology Center, Faculty of Medicine, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4405285708"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K Ishizaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Ishizaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101940701","display_name":"Yusuke Nakamura","orcid":"https://orcid.org/0009-0009-8461-749X","observed_orcids":["https://orcid.org/0009-0009-8461-749X","https://orcid.org/0000-0003-2956-382X","https://orcid.org/0000-0002-2310-0587","https://orcid.org/0000-0003-4425-4216","https://orcid.org/0009-0004-6320-7030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Nakamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108410144","display_name":"M.S. Sasaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M S Sasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063751701","display_name":"Mituo Ikenaga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ikenaga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012875959","display_name":"Mitsuo V. Kato","orcid":"https://orcid.org/0000-0002-1783-1084","observed_orcids":["https://orcid.org/0000-0002-1783-1084"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Sugimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Sugimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109057180","display_name":"Yoshihiko Kotoura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Kotoura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108570938","display_name":"T. Yamamuro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Yamamuro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.579,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.96233285,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"49","issue":"22","first_page":"6247","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chromosome-17p13","display_name":"chromosome 17p13","score":0.8270000219345093},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8140000104904175},{"id":"https://openalex.org/keywords/chromosome-17","display_name":"chromosome 17","score":0.6200000047683716},{"id":"https://openalex.org/keywords/retinoblastoma-gene","display_name":"retinoblastoma gene","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.8797740936279297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7313779592514038},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7188145518302917},{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.7126731276512146},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6934474110603333},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.677107572555542},{"id":"https://openalex.org/C127764415","wikidata":"https://www.wikidata.org/wiki/Q6356161","display_name":"Mitotic crossover","level":4,"score":0.6381028890609741},{"id":"https://openalex.org/C167752854","wikidata":"https://www.wikidata.org/wiki/Q220677","display_name":"Chromosome 17 (human)","level":4,"score":0.5756853818893433},{"id":"https://openalex.org/C2780907584","wikidata":"https://www.wikidata.org/wiki/Q840734","display_name":"Chromosome 13","level":4,"score":0.5007779598236084},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.47161155939102173},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4689825177192688},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3285902440547943}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002872","descriptor_name":"Chromosome Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002886","descriptor_name":"Chromosomes, Human, Pair 17","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015252","descriptor_name":"Deoxyribonucleases, Type II Site-Specific","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:2572320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2572320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.327.7235","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.7235","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/49/22/6247.full.pdf","raw_type":"text"},{"id":"mag:2055605136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2572320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1467794802","https://openalex.org/W1976875150","https://openalex.org/W1983171715","https://openalex.org/W1984762045","https://openalex.org/W1989752636","https://openalex.org/W1992682395","https://openalex.org/W1993125488","https://openalex.org/W1995259307","https://openalex.org/W2002965287","https://openalex.org/W2006874765","https://openalex.org/W2011423159","https://openalex.org/W2034440981","https://openalex.org/W2034892057","https://openalex.org/W2039050546","https://openalex.org/W2040834490","https://openalex.org/W2058403714","https://openalex.org/W2070854644","https://openalex.org/W2072627259","https://openalex.org/W2073564321","https://openalex.org/W2088706525","https://openalex.org/W2091723114","https://openalex.org/W2099742439","https://openalex.org/W2154191201","https://openalex.org/W2165696859","https://openalex.org/W2918044717"],"related_works":["https://openalex.org/W7097287587","https://openalex.org/W1480416633","https://openalex.org/W2066421148","https://openalex.org/W1491635442","https://openalex.org/W2053274143","https://openalex.org/W2398742591","https://openalex.org/W6980635203","https://openalex.org/W1504841439","https://openalex.org/W2048380916","https://openalex.org/W2402916230"],"abstract_inverted_index":{"Human":[0],"osteosarcomas":[1],"frequently":[2],"show":[3],"loss":[4,66,95],"of":[5,25,41,52,67,89,115],"alleles":[6],"on":[7,14,29,56,69],"chromosome":[8,15,30,42,57,70,84],"17":[9],"as":[10,12],"well":[11],"those":[13],"13":[16],"that":[17],"harbors":[18],"the":[19,34,50,90,113],"retinoblastoma":[20],"gene,":[21],"indicating":[22],"concerted":[23],"operation":[24],"another":[26],"tumor-suppressing":[27,117],"gene":[28,36,118],"17.":[31,58,71],"To":[32],"assign":[33],"affected":[35,73],"to":[37,85,108],"a":[38,82,86,116],"defined":[39,121],"region":[40],"17,":[43],"we":[44],"performed":[45],"mitotic":[46],"recombination/deletion":[47],"mapping":[48],"by":[49],"use":[51],"10":[53],"polymorphic":[54],"loci":[55],"Of":[59],"37":[60],"tumors":[61],"studied,":[62],"28":[63,110],"(75.7%)":[64],"showed":[65],"heterozygosity":[68],"The":[72],"regions":[74],"varied":[75],"among":[76],"tumors,":[77,111],"ranging":[78],"in":[79,96,100,119],"extent":[80],"from":[81],"whole":[83],"distal":[87],"segment":[88],"short":[91],"arm.":[92],"However,":[93],"allele":[94],"one":[97],"region,":[98],"notably":[99],"17p13":[101],"between":[102],"D17S1":[103],"and":[104],"D17S30,":[105],"was":[106],"common":[107],"all":[109],"suggesting":[112],"presence":[114],"this":[120],"region.":[122]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}