{"id":"https://openalex.org/W2055592149","doi":"https://doi.org/10.1016/j.jaci.2005.09.053","title":"Is occupational asthma to diisocyanates a non\u2013IgE-mediated disease?","display_name":"Is occupational asthma to diisocyanates a non\u2013IgE-mediated disease?","publication_year":2006,"publication_date":"2006-01-28","ids":{"openalex":"https://openalex.org/W2055592149","doi":"https://doi.org/10.1016/j.jaci.2005.09.053","mag":"2055592149","pmid":"https://pubmed.ncbi.nlm.nih.gov/16522468"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaci.2005.09.053","doi":"https://doi.org/10.1016/j.jaci.2005.09.053","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2005.09.053","pdf_url":"http://www.jacionline.org/article/S0091674905023134/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jacionline.org/article/S0091674905023134/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103371078","display_name":"M. C. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Meinir G. Jones","raw_affiliation_strings":["Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK. meinir.jones@imperial.ac.uk","From the Department of Occupational and Environmental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK. meinir.jones@imperial.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"From the Department of Occupational and Environmental Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061265310","display_name":"Alison Floyd","orcid":"https://orcid.org/0000-0001-7331-2011","observed_orcids":["https://orcid.org/0000-0001-7331-2011"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alison Floyd","raw_affiliation_strings":["From the Department of Occupational and Environmental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Occupational and Environmental Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112084920","display_name":"Kayhan T. Nouri\u2010Aria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kayhan T. Nouri-Aria","raw_affiliation_strings":["Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016205497","display_name":"Mikila R. Jacobson","orcid":"https://orcid.org/0000-0002-2921-6169","observed_orcids":["https://orcid.org/0000-0002-2921-6169"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mikila R. Jacobson","raw_affiliation_strings":["Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043192106","display_name":"Stephen R. Durham","orcid":"https://orcid.org/0000-0001-5264-6207","observed_orcids":["https://orcid.org/0000-0001-5264-6207"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen R. Durham","raw_affiliation_strings":["Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046509454","display_name":"Anthony J. Newman Taylor","orcid":"https://orcid.org/0000-0003-1282-7454","observed_orcids":["https://orcid.org/0000-0003-1282-7454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony Newman Taylor","raw_affiliation_strings":["From the Department of Occupational and Environmental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Occupational and Environmental Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075776335","display_name":"Paul Cullinan","orcid":"https://orcid.org/0000-0002-9314-6468","observed_orcids":["https://orcid.org/0000-0002-9314-6468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Cullinan","raw_affiliation_strings":["From the Department of Occupational and Environmental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Occupational and Environmental Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103371078"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":4900,"currency":"USD","value_usd":4900},"apc_paid":null,"fwci":13.6412,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.9917147,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"117","issue":"3","first_page":"663","last_page":"669"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/occupational-asthma","display_name":"occupational asthma","score":0.9449999928474426},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.906000018119812},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.8450000286102295},{"id":"https://openalex.org/keywords/bronchial-mucosa","display_name":"bronchial mucosa","score":0.8180000185966492},{"id":"https://openalex.org/keywords/endobronchial-biopsy","display_name":"bronchial biopsy","score":0.8220000267028809},{"id":"https://openalex.org/keywords/inhalation-challenge","display_name":"inhalation challenge","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.5249999761581421},{"id":"https://openalex.org/keywords/cd25","display_name":"CD25","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.8069154620170593},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6985612511634827},{"id":"https://openalex.org/C2778781276","wikidata":"https://www.wikidata.org/wiki/Q2551913","display_name":"Occupational asthma","level":3,"score":0.6796073913574219},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.6476646065711975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6054329872131348},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5878816246986389},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5377249121665955},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3688409626483917},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2428576946258545},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.05854523181915283}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001985","descriptor_name":"Bronchial Provocation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001999","descriptor_name":"Bronchoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009784","descriptor_name":"Occupational Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009784","descriptor_name":"Occupational Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015375","descriptor_name":"Receptors, Interleukin-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015848","descriptor_name":"Interleukin-5","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017953","descriptor_name":"Isocyanates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jaci.2005.09.053","doi":"https://doi.org/10.1016/j.jaci.2005.09.053","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2005.09.053","pdf_url":"http://www.jacionline.org/article/S0091674905023134/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:16522468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16522468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of allergy and clinical immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jaci.2005.09.053","doi":"https://doi.org/10.1016/j.jaci.2005.09.053","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2005.09.053","pdf_url":"http://www.jacionline.org/article/S0091674905023134/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2055592149.pdf","grobid_xml":"https://content.openalex.org/works/W2055592149.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W66765440","https://openalex.org/W1556246926","https://openalex.org/W1935514279","https://openalex.org/W1989596114","https://openalex.org/W1994362051","https://openalex.org/W2004660104","https://openalex.org/W2012609425","https://openalex.org/W2013079534","https://openalex.org/W2014025012","https://openalex.org/W2018669855","https://openalex.org/W2021451119","https://openalex.org/W2049312111","https://openalex.org/W2050698975","https://openalex.org/W2052236324","https://openalex.org/W2054038722","https://openalex.org/W2064296795","https://openalex.org/W2064429240","https://openalex.org/W2079049613","https://openalex.org/W2079680460","https://openalex.org/W2080331925","https://openalex.org/W2083838472","https://openalex.org/W2084836114","https://openalex.org/W2088270763","https://openalex.org/W2088465097","https://openalex.org/W2092192775","https://openalex.org/W2109347130","https://openalex.org/W2110661341","https://openalex.org/W2124854965","https://openalex.org/W2128099093","https://openalex.org/W2129441095","https://openalex.org/W2136810125","https://openalex.org/W2137401824","https://openalex.org/W2144838604","https://openalex.org/W2145619296","https://openalex.org/W2170148763","https://openalex.org/W2320360359","https://openalex.org/W2472657029","https://openalex.org/W2993989422"],"related_works":["https://openalex.org/W2145443938","https://openalex.org/W4248627188","https://openalex.org/W1966822010","https://openalex.org/W2006591705","https://openalex.org/W74693748","https://openalex.org/W2019581317","https://openalex.org/W2080522523","https://openalex.org/W1976217090","https://openalex.org/W1994941616","https://openalex.org/W1995716753"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}