{"id":"https://openalex.org/W2055428569","doi":"https://doi.org/10.1161/01.hyp.37.3.898","title":"Early Alteration in Glomerular Reserve in Humans at Genetic Risk of Essential Hypertension","display_name":"Early Alteration in Glomerular Reserve in Humans at Genetic Risk of Essential Hypertension","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W2055428569","doi":"https://doi.org/10.1161/01.hyp.37.3.898","mag":"2055428569","pmid":"https://pubmed.ncbi.nlm.nih.gov/11244015"},"language":"en","primary_location":{"id":"doi:10.1161/01.hyp.37.3.898","doi":"https://doi.org/10.1161/01.hyp.37.3.898","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.hyp.37.3.898","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103420852","display_name":"Daniel T. O\u2019Connor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel T. O\u2019Connor","raw_affiliation_strings":["From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","VA San Diego Healthcare System, San Diego, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026822692","display_name":"Elizabeth A. Tyrell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth A. Tyrell","raw_affiliation_strings":["From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","VA San Diego Healthcare System, San Diego, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010256200","display_name":"Mala T. Kailasam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mala T. Kailasam","raw_affiliation_strings":["From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","VA San Diego Healthcare System, San Diego, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lucy M. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucy M. Miller","raw_affiliation_strings":["From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","VA San Diego Healthcare System, San Diego, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080989134","display_name":"Joseph A. Martinez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Martinez","raw_affiliation_strings":["From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","VA San Diego Healthcare System, San Diego, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045462483","display_name":"Robert R. Henry","orcid":"https://orcid.org/0000-0002-4821-0117","observed_orcids":["https://orcid.org/0000-0002-4821-0117"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert R. Henry","raw_affiliation_strings":["From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","VA San Diego Healthcare System, San Diego, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009194991","display_name":"Robert J. Parmer","orcid":"https://orcid.org/0000-0003-4197-0241","observed_orcids":["https://orcid.org/0000-0003-4197-0241"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Parmer","raw_affiliation_strings":["From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","VA San Diego Healthcare System, San Diego, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062292415","display_name":"Francis B. Gabbai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis B. Gabbai","raw_affiliation_strings":["From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","VA San Diego Healthcare System, San Diego, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Center for Molecular Genetics, University of California at San Diego; and VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"VA San Diego Healthcare System, San Diego, Calif","institution_ids":["https://openalex.org/I4210099595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3664,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.83102184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"37","issue":"3","first_page":"898","last_page":"906"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9950000047683716},{"id":"https://openalex.org/keywords/family-history-of-hypertension","display_name":"family history of hypertension","score":0.7950000166893005},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.9629999995231628},{"id":"https://openalex.org/keywords/amino-acid-infusion","display_name":"amino acid infusion","score":0.8690000176429749},{"id":"https://openalex.org/keywords/nitric-oxide-metabolites","display_name":"nitric oxide metabolites","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.9539999961853027},{"id":"https://openalex.org/keywords/arginine-metabolism","display_name":"arginine metabolism","score":0.6940000057220459},{"id":"https://openalex.org/keywords/proximal-tubular-reabsorption","display_name":"proximal tubular reabsorption","score":0.8040000200271606},{"id":"https://openalex.org/keywords/lithium-excretion","display_name":"lithium excretion","score":0.722000002861023},{"id":"https://openalex.org/keywords/serum-insulin","display_name":"serum insulin","score":0.781000018119812},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8087757229804993},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.805135190486908},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6397610902786255},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.532026469707489},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5296874642372131},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.5155127048492432},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.47922924160957336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4408145546913147},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4278469979763031},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.41894644498825073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35203516483306885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10734686255455017}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009566","descriptor_name":"Nitrates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D009573","descriptor_name":"Nitrites","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015290","descriptor_name":"Second Messenger Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016651","descriptor_name":"Lithium Carbonate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.hyp.37.3.898","doi":"https://doi.org/10.1161/01.hyp.37.3.898","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.hyp.37.3.898","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.537.827","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.537.827","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"http://hyper.ahajournals.org/content/37/3/898.full.pdf","raw_type":"text"},{"id":"pmid:11244015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11244015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1018.8419","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1018.8419","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://hyper.ahajournals.org/content/hypertensionaha/37/3/898.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W181100153","https://openalex.org/W1509696066","https://openalex.org/W1967027578","https://openalex.org/W1991056591","https://openalex.org/W2002548814","https://openalex.org/W2006493697","https://openalex.org/W2010359331","https://openalex.org/W2025570653","https://openalex.org/W2026384750","https://openalex.org/W2026431974","https://openalex.org/W2027867025","https://openalex.org/W2032168680","https://openalex.org/W2049219401","https://openalex.org/W2059720805","https://openalex.org/W2066301620","https://openalex.org/W2066581418","https://openalex.org/W2082043223","https://openalex.org/W2090802397","https://openalex.org/W2097427106","https://openalex.org/W2111791656","https://openalex.org/W2116494737","https://openalex.org/W2123466824","https://openalex.org/W2165846827","https://openalex.org/W2277082686","https://openalex.org/W2335606123","https://openalex.org/W2394950413","https://openalex.org/W2414339156","https://openalex.org/W2422859583","https://openalex.org/W2467296907","https://openalex.org/W2496616162","https://openalex.org/W4243688755","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2016692789","https://openalex.org/W2140919744","https://openalex.org/W1979956142","https://openalex.org/W2400705018","https://openalex.org/W2410088983","https://openalex.org/W1994391031","https://openalex.org/W1975980916","https://openalex.org/W2156659332","https://openalex.org/W2960021900","https://openalex.org/W7098448573"],"abstract_inverted_index":{"Essential":[0],"hypertension":[1,59,345],"has":[2,13],"a":[3,20,122,153,167,178,190,304,390],"familial":[4],"predisposition,":[5],"but":[6],"the":[7,17,108,146,162,171,211,237,268,280,300,311,355,382,393],"phenotype":[8,335,405],"of":[9,23,39,58,73,92,113,236,248,288,307,315,344,352,364,386,412],"elevated":[10],"blood":[11,24],"pressure":[12,25],"delayed":[14],"penetrance.":[15],"Because":[16],"kidney":[18],"is":[19,332,347,375],"crucial":[21],"determinant":[22],"homeostasis,":[26],"we":[27,83],"studied":[28],"early":[29,377],"glomerular":[30,85,324,403],"alterations":[31],"in":[32,126,140,148,156,161,239,243,254,260,279,299,317,327,338,354,359,392,399,409],"still-normotensive":[33,339],"young":[34],"subjects":[35,340],"at":[36,196,341],"genetic":[37,52,342,410],"risk":[38,53,343],"hypertension.":[40,419],"Thirty-nine":[41],"normotensive":[42],"adults":[43],"(mean":[44],"age":[45],"29":[46],"to":[47,128,181,184,228,273,329,349,381,396,418],"31":[48],"years),":[49],"stratified":[50],"by":[51],"(parental":[54],"family":[55],"history":[56],"[FH])":[57],"(26":[60],"with":[61,66,145],"positive":[62],"FH":[63,68,176,216,269],"[FH+],":[64],"13":[65],"negative":[67],"[FH-]),":[69],"underwent":[70],"intravenous":[71],"infusion":[72,214,276],"mixed":[74],"amino":[75,80,93,104,129,137,212,229,265,274,290,312,330,373,383,397],"acids.":[76],"Before":[77],"and":[78,99,103,107,220,297,346,361],"during":[79,210,264],"acid":[81,105,213,275],"administration,":[82],"measured":[84],"filtration":[86,325],"rate":[87],"(GFR),":[88],"putative":[89],"second":[90],"messengers":[91],"acids":[94,130,230,266,291,331,374,398],"(nitric":[95],"oxide":[96],"[NO.]":[97],"metabolites":[98],"cGMP),":[100],"serum":[101,222,286],"insulin":[102,223,308,387],"concentrations,":[106],"FE(Li)+":[109],"as":[110],"an":[111,245,333,376],"index":[112,247],"renal":[114,413],"proximal":[115,249,261,369],"tubular":[116,250,262,370],"reabsorption.":[117],"The":[118,136,186],"FH+":[119,163,187,281,301,318],"group":[120,164,188,282],"had":[121,189],"blunted":[123,278,323],"GFR":[124,141,173,226,240,255,271,360],"rise":[125,155],"response":[127,227,272,328,395],"(2.43+/-8.16%":[131],"versus":[132,199],"31.0+/-13.4%":[133],"rise,":[134],"P:=0.0126).":[135],"acid-induced":[138],"change":[139,147,209],"correlated":[142],"(r=0.786,":[143],"P:<0.01)":[144],"urinary":[149,157],"NO.":[150,158,185,353],"metabolite":[151,159],"excretion;":[152],"diminished":[154],"excretion":[160,195,363],"(P:=0.0105)":[165],"suggested":[166],"biochemical":[168],"mechanism":[169],"for":[170,233],"different":[172],"responses":[174],"between":[175,267],"groups:":[177],"relative":[179],"inability":[180],"convert":[182],"arginine":[183],"far":[191],"lower":[192],"initial":[193],"cGMP":[194,206],"baseline":[197,218,221],"(261+/-21.1":[198],"579+/-84.9":[200],"nmol.":[201],"h(-1)/1.73":[202],"m(2),":[203],"P:=0.001),":[204],"although":[205],"did":[207],"not":[208],"(P:=0.703).":[215],"status,":[217],"GFR,":[219],"jointly":[224],"predicted":[225],"(P:=0.0013),":[231],"accounting":[232],"approximately":[234],"45%":[235],"variance":[238],"response.":[241],"Decline":[242],"FE(Li)+,":[244],"inverse":[246],"reabsorption,":[251],"paralleled":[252],"increase":[253],"(r=-0.506,":[256],"P:=0.01),":[257],"suggesting":[258,303],"differences":[259],"reabsorption":[263,371],"groups.":[270],"was":[277],"despite":[283],"significantly":[284],"higher":[285],"concentrations":[287],"6":[289],"(arginine,":[292],"isoleucine,":[293],"leucine,":[294],"methionine,":[295],"phenylalanine,":[296],"valine)":[298],"group,":[302],"novel":[305],"form":[306],"resistance":[309],"(to":[310],"acid-translocating":[313,384],"action":[314],"insulin)":[316],"subjects.":[319],"We":[320],"conclude":[321],"that":[322,367],"reserve":[326,404],"early-penetrance":[334],"seen":[336],"even":[337],"linked":[348],"impaired":[350],"formation":[351],"kidney.":[356],"Corresponding":[357],"changes":[358],"fractional":[362],"Li(+)":[365],"suggest":[366],"altered":[368],"after":[372],"pathophysiologic":[378],"mechanism.":[379],"Resistance":[380],"actions":[385],"may":[388,406],"play":[389],"role":[391],"biological":[394],"this":[400],"setting.":[401],"This":[402],"be":[407],"useful":[408],"studies":[411],"traits":[414],"preceding":[415],"or":[416],"predisposing":[417]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
