{"id":"https://openalex.org/W2055423905","doi":"https://doi.org/10.1371/journal.pone.0097967","title":"Serum Estradiol Levels Predict Survival and Acute Kidney Injury in Patients with Septic Shock- A Prospective Study","display_name":"Serum Estradiol Levels Predict Survival and Acute Kidney Injury in Patients with Septic Shock- A Prospective Study","publication_year":2014,"publication_date":"2014-06-06","ids":{"openalex":"https://openalex.org/W2055423905","doi":"https://doi.org/10.1371/journal.pone.0097967","mag":"2055423905","pmid":"https://pubmed.ncbi.nlm.nih.gov/24904990","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4048195"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0097967","doi":"https://doi.org/10.1371/journal.pone.0097967","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0097967","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0097967&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0097967&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017489241","display_name":"Jia\u2010Yih Feng","orcid":"https://orcid.org/0000-0001-8840-8112","observed_orcids":["https://orcid.org/0000-0001-8840-8112"]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jia-Yih Feng","raw_affiliation_strings":["Department of Chest Medicine, Taipei Veterans General Hospital, Shipai Road, Taipei, Taiwan, R.O.C; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Linong Street, Taipei, Taiwan, R.O.C","Department of Chest Medicine, Taipei Veterans General Hospital, Shipai Road, Taipei, Taiwan, R.O.C","Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Linong Street, Taipei, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chest Medicine, Taipei Veterans General Hospital, Shipai Road, Taipei, Taiwan, R.O.C; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Linong Street, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I2803004286","https://openalex.org/I4387156312"]},{"raw_affiliation_string":"Department of Chest Medicine, Taipei Veterans General Hospital, Shipai Road, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Linong Street, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073077400","display_name":"Kuan\u2010Ting Liu","orcid":"https://orcid.org/0000-0002-1355-5019","observed_orcids":["https://orcid.org/0000-0002-1355-5019"]},"institutions":[{"id":"https://openalex.org/I3020248675","display_name":"Taipei Municipal YangMing Hospital","ror":"https://ror.org/047n4ns40","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020248675"]},{"id":"https://openalex.org/I4210119487","display_name":"Taipei City Hospital","ror":"https://ror.org/02gzfb532","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210119487"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuan-Ting Liu","raw_affiliation_strings":["Taipei City Hospital, Zhongxiao Branch, Tung Teh Road, Taipei, Taiwan, R.O.C; School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C","School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C","Taipei City Hospital, Zhongxiao Branch, Tung Teh Road, Taipei, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taipei City Hospital, Zhongxiao Branch, Tung Teh Road, Taipei, Taiwan, R.O.C; School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I3020248675","https://openalex.org/I4210119487","https://openalex.org/I4387156312"]},{"raw_affiliation_string":"School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4387156312"]},{"raw_affiliation_string":"Taipei City Hospital, Zhongxiao Branch, Tung Teh Road, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I3020248675","https://openalex.org/I4210119487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102795262","display_name":"Edward H Abraham","orcid":"https://orcid.org/0000-0002-4429-2389","observed_orcids":["https://orcid.org/0000-0002-4429-2389"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Abraham","raw_affiliation_strings":["Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina, United States of America","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006822373","display_name":"Cheng\u2010Yu Chen","orcid":"https://orcid.org/0000-0003-0428-4373","observed_orcids":["https://orcid.org/0000-0003-0428-4373"]},"institutions":[{"id":"https://openalex.org/I4210087697","display_name":"National Yang Ming University Hospital","ror":"https://ror.org/003xdw211","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210087697"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Yu Chen","raw_affiliation_strings":["School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C; Section of Chest Medicine, Department of Internal Medicine, National Yang-Ming University Hospital, Ilan, Taiwan, ROC","School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C","Section of Chest Medicine, Department of Internal Medicine, National Yang-Ming University Hospital, Ilan, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C; Section of Chest Medicine, Department of Internal Medicine, National Yang-Ming University Hospital, Ilan, Taiwan, ROC","institution_ids":["https://openalex.org/I4210087697","https://openalex.org/I4387156312"]},{"raw_affiliation_string":"School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4387156312"]},{"raw_affiliation_string":"Section of Chest Medicine, Department of Internal Medicine, National Yang-Ming University Hospital, Ilan, Taiwan, ROC","institution_ids":["https://openalex.org/I4210087697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060149727","display_name":"Po\u2010Yi Tsai","orcid":"https://orcid.org/0000-0003-4804-5251","observed_orcids":["https://orcid.org/0000-0003-4804-5251"]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Po-Yi Tsai","raw_affiliation_strings":["School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C; Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan, ROC","Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan, ROC","School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C; Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan, ROC","institution_ids":["https://openalex.org/I2803004286","https://openalex.org/I4387156312"]},{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan, ROC","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054214375","display_name":"Yu\u2010Chun Chen","orcid":"https://orcid.org/0000-0002-4124-1949","observed_orcids":["https://orcid.org/0000-0002-4124-1949","https://orcid.org/0000-0002-0711-7602"]},"institutions":[{"id":"https://openalex.org/I4210087697","display_name":"National Yang Ming University Hospital","ror":"https://ror.org/003xdw211","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210087697"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Chun Chen","raw_affiliation_strings":["School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C; Department of Medical Research and Education, National Yang-Ming University Hospital, I-Lan, Taiwan, R.O.C","Department of Medical Research and Education, National Yang-Ming University Hospital, I-Lan, Taiwan, R.O.C","School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C; Department of Medical Research and Education, National Yang-Ming University Hospital, I-Lan, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4210087697","https://openalex.org/I4387156312"]},{"raw_affiliation_string":"Department of Medical Research and Education, National Yang-Ming University Hospital, I-Lan, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4210087697"]},{"raw_affiliation_string":"School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113973756","display_name":"Yu-Chin Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Chin Lee","raw_affiliation_strings":["Department of Chest Medicine, Taipei Veterans General Hospital, Shipai Road, Taipei, Taiwan, R.O.C; School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C","Department of Chest Medicine, Taipei Veterans General Hospital, Shipai Road, Taipei, Taiwan, R.O.C","School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chest Medicine, Taipei Veterans General Hospital, Shipai Road, Taipei, Taiwan, R.O.C; School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I2803004286","https://openalex.org/I4387156312"]},{"raw_affiliation_string":"Department of Chest Medicine, Taipei Veterans General Hospital, Shipai Road, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035619863","display_name":"Kuang\u2010Yao Yang","orcid":"https://orcid.org/0000-0002-2803-980X","observed_orcids":["https://orcid.org/0000-0002-2803-980X"]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Kuang-Yao Yang","raw_affiliation_strings":["Department of Chest Medicine, Immunology Center, Taipei Veterans General Hospital, Shipai Road, Taipei, Taiwan, R.O.C; Immunity and Inflammation Research Center, School of Medicine, National Yang-Ming University, Linong Street, Taipei, Taiwan, R.O.C","Department of Chest Medicine, Immunology Center, Taipei Veterans General Hospital, Shipai Road, Taipei, Taiwan, R.O.C","Immunity and Inflammation Research Center, School of Medicine, National Yang-Ming University, Linong Street, Taipei, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chest Medicine, Immunology Center, Taipei Veterans General Hospital, Shipai Road, Taipei, Taiwan, R.O.C; Immunity and Inflammation Research Center, School of Medicine, National Yang-Ming University, Linong Street, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I2803004286","https://openalex.org/I4387156312"]},{"raw_affiliation_string":"Department of Chest Medicine, Immunology Center, Taipei Veterans General Hospital, Shipai Road, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Immunity and Inflammation Research Center, School of Medicine, National Yang-Ming University, Linong Street, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I4387156312"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5035619863"],"corresponding_institution_ids":["https://openalex.org/I2803004286","https://openalex.org/I4387156312"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.5093,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.8328626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"6","first_page":"e97967","last_page":"e97967"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8190000057220459},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.8930000066757202},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9900000095367432},{"id":"https://openalex.org/keywords/28-day-mortality","display_name":"28-day mortality","score":0.8650000095367432},{"id":"https://openalex.org/keywords/sex-hormones","display_name":"sex hormones","score":0.7620000243186951},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9380000233650208},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.7609999775886536},{"id":"https://openalex.org/keywords/apache-ii","display_name":"APACHE II score","score":0.9350000023841858},{"id":"https://openalex.org/keywords/rifle-criteria","display_name":"RIFLE criteria","score":0.9729999899864197},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7870000004768372},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7847005128860474},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.7306939363479614},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.6512192487716675},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6460778117179871},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.6455680131912231},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6354279518127441},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5265403389930725},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.4913424551486969},{"id":"https://openalex.org/C2780835948","wikidata":"https://www.wikidata.org/wiki/Q1193870","display_name":"Multiple organ dysfunction syndrome","level":3,"score":0.4871384799480438},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4789624512195587},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.43327224254608154},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42903849482536316},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4220609664916992},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.328716516494751}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0097967","doi":"https://doi.org/10.1371/journal.pone.0097967","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0097967","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0097967&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:24904990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24904990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:4048195","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4048195/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1251d078ba7c4e1c8fd116281a21961e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1251d078ba7c4e1c8fd116281a21961e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 6, p e97967 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0097967","doi":"https://doi.org/10.1371/journal.pone.0097967","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0097967","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0097967&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1076733911","display_name":null,"funder_award_id":"V102C-025","funder_id":"https://openalex.org/F4320327358","funder_display_name":"Taipei Veterans General Hospital"},{"id":"https://openalex.org/G2954786900","display_name":null,"funder_award_id":"V103C\u2010078","funder_id":"https://openalex.org/F4320327358","funder_display_name":"Taipei Veterans General Hospital"}],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320327358","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2055423905.pdf","grobid_xml":"https://content.openalex.org/works/W2055423905.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1531755270","https://openalex.org/W1898928487","https://openalex.org/W1964429893","https://openalex.org/W1969528154","https://openalex.org/W1970440745","https://openalex.org/W1973365924","https://openalex.org/W1981493346","https://openalex.org/W1984523604","https://openalex.org/W1985453907","https://openalex.org/W1985776920","https://openalex.org/W2006023826","https://openalex.org/W2010589400","https://openalex.org/W2019089352","https://openalex.org/W2021107769","https://openalex.org/W2026332974","https://openalex.org/W2029583951","https://openalex.org/W2032386758","https://openalex.org/W2044767152","https://openalex.org/W2046370736","https://openalex.org/W2073456616","https://openalex.org/W2077917150","https://openalex.org/W2112242658","https://openalex.org/W2118858814","https://openalex.org/W2131964192","https://openalex.org/W2133641948","https://openalex.org/W2133979383","https://openalex.org/W2139937737","https://openalex.org/W2142895281","https://openalex.org/W2144455872","https://openalex.org/W2152498865","https://openalex.org/W2156499870","https://openalex.org/W2159358807","https://openalex.org/W2159412186","https://openalex.org/W2160219019","https://openalex.org/W2322121630","https://openalex.org/W2402500214","https://openalex.org/W2415009693","https://openalex.org/W2442246762","https://openalex.org/W2599527603","https://openalex.org/W2768146862","https://openalex.org/W3023757607","https://openalex.org/W4211194064"],"related_works":["https://openalex.org/W7161753959","https://openalex.org/W4293873137","https://openalex.org/W2415009693","https://openalex.org/W2008318399","https://openalex.org/W2417879362","https://openalex.org/W4283462902","https://openalex.org/W2537656381","https://openalex.org/W2077802801","https://openalex.org/W2340488429","https://openalex.org/W2006023826"],"abstract_inverted_index":{"Sex":[0],"hormones":[1,21,80],"have":[2,215],"diverse":[3],"immunomodulatory":[4],"effects":[5],"that":[6],"may":[7],"be":[8,131],"involved":[9],"in":[10,22,36,104,153,217,221],"the":[11,16,26,60,68,74,144,194],"pathogenesis":[12],"of":[13,18,28,62,67,77,95,113,134,139,146,162,171,182,196,202,234,240],"sepsis.":[14],"However,":[15],"roles":[17],"serum":[19,53,78,93,111,160,189,210,226],"sex":[20,54,79],"predicting":[23,218],"outcomes":[24],"and":[25,52,85,98,120,177,237],"severity":[27,181,233],"organ":[29],"dysfunction,":[30,87],"especially":[31,88],"acute":[32],"kidney":[33],"injury":[34],"(AKI),":[35],"septic":[37,49,222],"shock":[38,50,63,203,223],"patients":[39,51,154],"remains":[40],"controversial.":[41],"We":[42],"prospectively":[43],"enrolled":[44],"107":[45],"clinically":[46],"diagnosed":[47],"pneumonia-related":[48],"hormone":[55],"levels":[56,81,94,141,191,212,228],"were":[57,101,128],"measured":[58],"on":[59],"day":[61,135],"onset.":[64],"The":[65],"aim":[66],"present":[69],"study":[70],"was":[71,166],"to":[72,130,150,214],"investigate":[73],"predictive":[75],"values":[76],"for":[82],"28-day":[83,219],"mortality":[84,157,220],"organs":[86],"AKI.":[89,242],"Compared":[90],"with":[91,155,180,231],"survivors,":[92],"progesterone":[96],"(p<0.001)":[97,100],"estradiol":[99,114,140,163,190,211,227],"significantly":[102],"elevated":[103],"non-survivors.":[105],"In":[106,208],"multivariate":[107],"Cox":[108],"regression":[109],"analysis,":[110],"level":[112,161],">40":[115,164],"pg/mL":[116,165],"(p":[117,125,174,205],"=":[118,126,175,206],"0.047)":[119],"APACHE":[121,147],"II":[122,148],"score":[123],"\u226525":[124],"<0.001)":[127],"found":[129],"independent":[132,169],"predictors":[133],"28":[136,200],"mortality.":[137],"Inclusion":[138],"further":[142],"enhanced":[143],"ability":[145],"scores":[149],"predict":[151,238],"survival":[152],"high":[156],"risk.":[158],"A":[159],"also":[167,192],"an":[168],"predictor":[170],"concomitant":[172,235],"AKI":[173,198,236],"0.002)":[176],"correlated":[178],"well":[179],"renal":[183],"dysfunction":[184],"using":[185],"RIFLE":[186],"classification.":[187],"Elevated":[188],"predicted":[193],"development":[195,239],"new":[197,241],"within":[199],"days":[201],"onset":[204],"0.013).":[207],"conclusion,":[209],"appear":[213],"value":[216],"patients.":[224],"Increased":[225],"are":[229],"associated":[230],"higher":[232]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
