{"id":"https://openalex.org/W2055397385","doi":"https://doi.org/10.1213/00000539-199710000-00002","title":"Propofol Attenuates Ischemia-Reperfusion Injury in the Isolated Rat Heart","display_name":"Propofol Attenuates Ischemia-Reperfusion Injury in the Isolated Rat Heart","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W2055397385","doi":"https://doi.org/10.1213/00000539-199710000-00002","mag":"2055397385","pmid":"https://pubmed.ncbi.nlm.nih.gov/9322445"},"language":"en","primary_location":{"id":"doi:10.1213/00000539-199710000-00002","doi":"https://doi.org/10.1213/00000539-199710000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-199710000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087835019","display_name":"Seonghoon Ko","orcid":"https://orcid.org/0000-0003-2742-9985","observed_orcids":["https://orcid.org/0000-0003-2742-9985"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seong-Hoon Ko","raw_affiliation_strings":["Department of Anesthesiology, Chonbuk National University Medical School, Republic of Korea","Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Chonbuk National University Medical School, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]},{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040404682","display_name":"Choon-Won Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Choon-Won Yu","raw_affiliation_strings":["Departments of (Ko, Yu, Lee, Choe, Kwak, Song) Anesthesiology, (Chung) Pathology, and (Chae) Pharmacology","Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of (Ko, Yu, Lee, Choe, Kwak, Song) Anesthesiology, (Chung) Pathology, and (Chae) Pharmacology","institution_ids":[]},{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110039140","display_name":"Sang Kyi Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sang-Kyi Lee","raw_affiliation_strings":["Departments of (Ko, Yu, Lee, Choe, Kwak, Song) Anesthesiology, (Chung) Pathology, and (Chae) Pharmacology","Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of (Ko, Yu, Lee, Choe, Kwak, Song) Anesthesiology, (Chung) Pathology, and (Chae) Pharmacology","institution_ids":[]},{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112123426","display_name":"Huhn Choe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huhn Choe","raw_affiliation_strings":["Departments of (Ko, Yu, Lee, Choe, Kwak, Song) Anesthesiology, (Chung) Pathology, and (Chae) Pharmacology","Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of (Ko, Yu, Lee, Choe, Kwak, Song) Anesthesiology, (Chung) Pathology, and (Chae) Pharmacology","institution_ids":[]},{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103571007","display_name":"Myoung\u2010Ja Chung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Myoung-Ja Chung","raw_affiliation_strings":["Departments of (Ko, Yu, Lee, Choe, Kwak, Song) Anesthesiology, (Chung) Pathology, and (Chae) Pharmacology","Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of (Ko, Yu, Lee, Choe, Kwak, Song) Anesthesiology, (Chung) Pathology, and (Chae) Pharmacology","institution_ids":[]},{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014037760","display_name":"Yong\u2010Geun Kwak","orcid":"https://orcid.org/0000-0003-2831-9040","observed_orcids":["https://orcid.org/0000-0003-2831-9040"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-Geun Kwak","raw_affiliation_strings":["Departments of (Ko, Yu, Lee, Choe, Kwak, Song) Anesthesiology, (Chung) Pathology, and (Chae) Pharmacology","Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of (Ko, Yu, Lee, Choe, Kwak, Song) Anesthesiology, (Chung) Pathology, and (Chae) Pharmacology","institution_ids":[]},{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050666299","display_name":"Soo\u2010Wan Chae","orcid":"https://orcid.org/0000-0003-3660-8272","observed_orcids":["https://orcid.org/0000-0003-3660-8272"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soo-Wan Chae","raw_affiliation_strings":["Departments of (Ko, Yu, Lee, Choe, Kwak, Song) Anesthesiology, (Chung) Pathology, and (Chae) Pharmacology","Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of (Ko, Yu, Lee, Choe, Kwak, Song) Anesthesiology, (Chung) Pathology, and (Chae) Pharmacology","institution_ids":[]},{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108582330","display_name":"He Sun Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"He-Sun Song","raw_affiliation_strings":["Departments of (Ko, Yu, Lee, Choe, Kwak, Song) Anesthesiology, (Chung) Pathology, and (Chae) Pharmacology","Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of (Ko, Yu, Lee, Choe, Kwak, Song) Anesthesiology, (Chung) Pathology, and (Chae) Pharmacology","institution_ids":[]},{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087835019","https://openalex.org/A5108582330"],"corresponding_institution_ids":["https://openalex.org/I80611190"],"apc_list":null,"apc_paid":null,"fwci":2.0415,"has_fulltext":false,"cited_by_count":132,"citation_normalized_percentile":{"value":0.87838444,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"85","issue":"4","first_page":"719","last_page":"724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":1.0},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9990000128746033},{"id":"https://openalex.org/keywords/global-myocardial-ischemia","display_name":"global myocardial ischemia","score":0.968999981880188},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.6380000114440918},{"id":"https://openalex.org/keywords/lactate-dehydrogenase-release","display_name":"lactate dehydrogenase release","score":0.8519999980926514},{"id":"https://openalex.org/keywords/left-ventricular-developed-pressure","display_name":"left ventricular developed pressure","score":0.8299999833106995},{"id":"https://openalex.org/keywords/intralipid","display_name":"Intralipid","score":0.8040000200271606},{"id":"https://openalex.org/keywords/isolated-perfused-rat-heart","display_name":"isolated perfused rat heart","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.9512408375740051},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9182707071304321},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.7525537014007568},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6166795492172241},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.5776075124740601},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.5774895548820496},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.38727477192878723},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3488353192806244},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018686","descriptor_name":"Anesthetics, Intravenous","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1213/00000539-199710000-00002","doi":"https://doi.org/10.1213/00000539-199710000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-199710000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"doi:10.1097/00000539-199710000-00002","doi":"https://doi.org/10.1097/00000539-199710000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000539-199710000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"pmid:9322445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9322445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W154684765","https://openalex.org/W323227379","https://openalex.org/W1556814137","https://openalex.org/W1571274258","https://openalex.org/W1967672430","https://openalex.org/W1970169551","https://openalex.org/W1975835567","https://openalex.org/W1984510165","https://openalex.org/W1987350248","https://openalex.org/W2008220442","https://openalex.org/W2013247387","https://openalex.org/W2014219907","https://openalex.org/W2015059403","https://openalex.org/W2024560631","https://openalex.org/W2026132964","https://openalex.org/W2034155248","https://openalex.org/W2046321849","https://openalex.org/W2054220851","https://openalex.org/W2054319024","https://openalex.org/W2059286323","https://openalex.org/W2064214063","https://openalex.org/W2065340708","https://openalex.org/W2074295722","https://openalex.org/W2079714141","https://openalex.org/W2092670040","https://openalex.org/W2099543787","https://openalex.org/W2109739100","https://openalex.org/W2151492304","https://openalex.org/W2158395982","https://openalex.org/W2444268315"],"related_works":["https://openalex.org/W2358575789","https://openalex.org/W2387123418","https://openalex.org/W2378727242","https://openalex.org/W2973593984","https://openalex.org/W7210147408","https://openalex.org/W2144010702","https://openalex.org/W2130456414","https://openalex.org/W2085414286","https://openalex.org/W2157083692","https://openalex.org/W2887833219"],"abstract_inverted_index":{"UNLABELLED:":[0],"The":[1,147,257],"purpose":[2],"of":[3,12,66,114],"this":[4],"study":[5,259],"was":[6,50,139],"to":[7,122,247],"examine":[8],"the":[9,64,129,144,163,249,263],"direct":[10],"effects":[11,239],"propofol":[13,62,96,153,208,229,267],"on":[14,240],"ischemia-reperfusion":[15,241],"injury":[16,198,252],"using":[17],"an":[18],"isolated":[19,264],"Langendorff":[20],"rat":[21,265],"heart":[22,250],"preparation.":[23],"Hearts":[24,40],"were":[25,41],"perfused":[26],"with":[27,52,59,71,106,150,162,202,205],"Krebs-Henseleit":[28],"(K-H)":[29],"solution":[30,54],"(control);":[31],"intralipid;":[32],"or":[33,73,83,108,165,179],"10,":[34],"30,":[35],"and":[36,100,124,131,193,212,232,255,271,277],"100":[37,60,94,132,151,206],"microM":[38,61,95,133,152,207],"propofol.":[39],"rendered":[42],"globally":[43],"ischemic":[44],"for":[45,55],"25":[46],"min,":[47,87],"then":[48],"reperfusion":[49,171],"begun":[51],"K-H":[53],"30":[56,112,130,168],"min.":[57],"Treatment":[58],"delayed":[63],"onset":[65],"contracture":[67],"during":[68,233],"ischemia":[69,236,254,276],"compared":[70,105,161,201],"control":[72,107,145,164,192],"intralipid":[74,109,166,194],"treatments":[75],"(6.4":[76],"+/-":[77,81,85,173,177,181,210,214,218],"2.1":[78],"vs":[79,175,216],"4.4":[80],"1.4":[82],"4.1":[84],"0.7":[86],"respectively;":[88,185,220],"P":[89,186,221],"<":[90,187,222],"0.05).":[91,188,223],"During":[92],"reperfusion,":[93,115],"increased":[97,197],"coronary":[98],"flow":[99],"reduced":[101],"lactate":[102],"dehydrogenase":[103],"release":[104],"treatments.":[110],"After":[111],"min":[113,169],"left":[116,157],"ventricular":[117,158],"developed":[118],"pressure":[119,160],"(LVDP)":[120],"returned":[121],"55":[123],"76":[125],"mm":[126,141,183],"Hg":[127,142],"in":[128,143,262],"propofol-treated":[134],"groups,":[135],"respectively,":[136],"whereas":[137],"LVDP":[138],"39":[140],"group.":[146],"hearts":[148,195,203],"treated":[149,204],"showed":[154],"significantly":[155],"lower":[156],"end-diastolic":[159],"groups":[167],"after":[170],"(29":[172],"13":[174],"48":[176,180],"5":[178],"11":[182],"Hg,":[184],"In":[189,224],"histological":[190,272],"evaluation,":[191],"had":[196],"severity":[199],"scores":[200],"(1.8":[209],"0.9":[211],"1.7":[213],"0.8":[215],"1.0":[217],"0.7,":[219],"conclusion,":[225],"we":[226],"suggest":[227],"that":[228,261],"administered":[230],"before":[231],"global":[234],"myocardial":[235],"has":[237],"cardioprotective":[238],"injury.":[242],"IMPLICATIONS:":[243],"It":[244],"is":[245],"important":[246],"protect":[248],"from":[251],"by":[253,275],"reperfusion.":[256,278],"current":[258],"demonstrates":[260],"heart,":[266],"attenuates":[268],"mechanical,":[269],"biochemical,":[270],"changes":[273],"causes":[274]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
