{"id":"https://openalex.org/W2055306367","doi":"https://doi.org/10.1089/dia.2009.0173","title":"An Advisory Protocol for Rapid- and Slow-Acting Insulin Therapy Based on a Run-to-Run Methodology","display_name":"An Advisory Protocol for Rapid- and Slow-Acting Insulin Therapy Based on a Run-to-Run Methodology","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W2055306367","doi":"https://doi.org/10.1089/dia.2009.0173","mag":"2055306367","pmid":"https://pubmed.ncbi.nlm.nih.gov/20597831"},"language":"en","primary_location":{"id":"doi:10.1089/dia.2009.0173","doi":"https://doi.org/10.1089/dia.2009.0173","is_oa":false,"landing_page_url":"https://doi.org/10.1089/dia.2009.0173","pdf_url":null,"source":{"id":"https://openalex.org/S67495602","display_name":"Diabetes Technology & Therapeutics","issn_l":"1520-9156","issn":["1520-9156","1557-8593"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Technology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036721111","display_name":"F. Campos-Cornejo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabiola Campos-Cornejo","raw_affiliation_strings":["Faculty of Engineering, Center for Research and Graduate Studies, San Luis Potos\u00ed, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering, Center for Research and Graduate Studies, San Luis Potos\u00ed, M\u00e9xico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079293471","display_name":"Daniel Ulises Campos-Delgado","orcid":"https://orcid.org/0000-0002-1555-0131","observed_orcids":["https://orcid.org/0000-0002-1555-0131"]},"institutions":[{"id":"https://openalex.org/I196664497","display_name":"Autonomous University of San Luis Potos\u00ed","ror":"https://ror.org/000917t60","country_code":"MX","type":"education","lineage":["https://openalex.org/I196664497"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Daniel U. Campos-Delgado","raw_affiliation_strings":["Faculty of Sciences, Autonomous University of San Luis Potos\u00ed, San Luis Potos\u00ed, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Sciences, Autonomous University of San Luis Potos\u00ed, San Luis Potos\u00ed, M\u00e9xico","institution_ids":["https://openalex.org/I196664497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063357897","display_name":"D.R. Espinoza-Trejo","orcid":"https://orcid.org/0000-0002-4113-3526","observed_orcids":["https://orcid.org/0000-0002-4113-3526","https://orcid.org/0000-0002-7238-5793"]},"institutions":[{"id":"https://openalex.org/I196664497","display_name":"Autonomous University of San Luis Potos\u00ed","ror":"https://ror.org/000917t60","country_code":"MX","type":"education","lineage":["https://openalex.org/I196664497"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Diego Espinoza-Trejo","raw_affiliation_strings":["COARA, Autonomous University of San Luis Potos\u00ed, San Luis Potos\u00ed, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"COARA, Autonomous University of San Luis Potos\u00ed, San Luis Potos\u00ed, M\u00e9xico","institution_ids":["https://openalex.org/I196664497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058224179","display_name":"Howard Zisser","orcid":"https://orcid.org/0000-0001-9766-7554","observed_orcids":["https://orcid.org/0000-0001-9766-7554","https://orcid.org/0000-0002-8927-9671"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I4210104828","display_name":"Sansum Diabetes Research Institute","ror":"https://ror.org/01kq6ye20","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210104828"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Zisser","raw_affiliation_strings":["Department of Chemical Engineering, University of California Santa Barbara, California","Sansum Diabetes Research Institute, Santa Barbara, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of California Santa Barbara, California","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Sansum Diabetes Research Institute, Santa Barbara, California","institution_ids":["https://openalex.org/I4210104828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013326892","display_name":"Lois Jovanovi\u010d","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I4210104828","display_name":"Sansum Diabetes Research Institute","ror":"https://ror.org/01kq6ye20","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210104828"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lois Jovanovi\u010d","raw_affiliation_strings":["Biomolecular Science &amp; Engineering Program, University of California Santa Barbara, California","Department of Chemical Engineering, University of California Santa Barbara, California","Sansum Diabetes Research Institute, Santa Barbara, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomolecular Science &amp; Engineering Program, University of California Santa Barbara, California","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of California Santa Barbara, California","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Sansum Diabetes Research Institute, Santa Barbara, California","institution_ids":["https://openalex.org/I4210104828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081288689","display_name":"Francis J. Doyle","orcid":"https://orcid.org/0000-0002-3293-9114","observed_orcids":["https://orcid.org/0000-0002-3293-9114"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I4210104828","display_name":"Sansum Diabetes Research Institute","ror":"https://ror.org/01kq6ye20","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210104828"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis J. Doyle","raw_affiliation_strings":["Biomolecular Science &amp; Engineering Program, University of California Santa Barbara, California","Department of Chemical Engineering, University of California Santa Barbara, California","Sansum Diabetes Research Institute, Santa Barbara, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomolecular Science &amp; Engineering Program, University of California Santa Barbara, California","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of California Santa Barbara, California","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Sansum Diabetes Research Institute, Santa Barbara, California","institution_ids":["https://openalex.org/I4210104828"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007855159","display_name":"Eyal Dassau","orcid":"https://orcid.org/0000-0001-5333-6892","observed_orcids":["https://orcid.org/0000-0001-5333-6892"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I4210104828","display_name":"Sansum Diabetes Research Institute","ror":"https://ror.org/01kq6ye20","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210104828"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eyal Dassau","raw_affiliation_strings":["Biomolecular Science &amp; Engineering Program, University of California Santa Barbara, California","Department of Chemical Engineering, University of California Santa Barbara, California","Sansum Diabetes Research Institute, Santa Barbara, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomolecular Science &amp; Engineering Program, University of California Santa Barbara, California","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of California Santa Barbara, California","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Sansum Diabetes Research Institute, Santa Barbara, California","institution_ids":["https://openalex.org/I4210104828"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079293471"],"corresponding_institution_ids":["https://openalex.org/I196664497"],"apc_list":null,"apc_paid":null,"fwci":1.2062,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.81195133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"7","first_page":"555","last_page":"565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/run-to-run-control","display_name":"run-to-run control","score":0.8769999742507935},{"id":"https://openalex.org/keywords/rapid-acting-insulin","display_name":"rapid-acting insulin","score":0.921999990940094},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.7409999966621399},{"id":"https://openalex.org/keywords/glucose-insulin-model","display_name":"glucose-insulin model","score":0.7310000061988831},{"id":"https://openalex.org/keywords/intra-individual-variability","display_name":"within-person variability","score":0.6869999766349792},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.7260000109672546},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8949999809265137},{"id":"https://openalex.org/keywords/continuous-glucose-monitoring","display_name":"continuous glucose monitoring","score":0.6150000095367432},{"id":"https://openalex.org/keywords/insulin-pump","display_name":"insulin pump","score":0.32100000977516174}],"concepts":[{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.7737510800361633},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.7733139991760254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7583888173103333},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6905142664909363},{"id":"https://openalex.org/C2780353609","wikidata":"https://www.wikidata.org/wiki/Q1569064","display_name":"Artificial pancreas","level":4,"score":0.517468273639679},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.5124135613441467},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.47412896156311035},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.4675881564617157},{"id":"https://openalex.org/C2994527087","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin delivery","level":4,"score":0.4276527762413025},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3282589316368103},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.32378631830215454},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3012707233428955},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2700137794017792}],"mesh":[{"descriptor_ui":"D000069036","descriptor_name":"Insulin Glargine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049528","descriptor_name":"Insulin, Long-Acting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061268","descriptor_name":"Insulin Lispro","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/dia.2009.0173","doi":"https://doi.org/10.1089/dia.2009.0173","is_oa":false,"landing_page_url":"https://doi.org/10.1089/dia.2009.0173","pdf_url":null,"source":{"id":"https://openalex.org/S67495602","display_name":"Diabetes Technology & Therapeutics","issn_l":"1520-9156","issn":["1520-9156","1557-8593"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Technology &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:20597831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20597831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes technology & therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/17","score":0.46000000834465027,"display_name":"Partnerships for the goals"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308797","display_name":"University of California Institute for Mexico and the United States","ror":"https://ror.org/03nawhv43"},{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1964693647","https://openalex.org/W1967837568","https://openalex.org/W1971122468","https://openalex.org/W1984693019","https://openalex.org/W1998051333","https://openalex.org/W2007369785","https://openalex.org/W2025709654","https://openalex.org/W2037208057","https://openalex.org/W2099719924","https://openalex.org/W2102340435","https://openalex.org/W2104464442","https://openalex.org/W2116088335","https://openalex.org/W2117748324","https://openalex.org/W2119971695","https://openalex.org/W2131405796","https://openalex.org/W2132228725","https://openalex.org/W2139342606","https://openalex.org/W2140153499","https://openalex.org/W2142962347","https://openalex.org/W2166102860","https://openalex.org/W2168091777","https://openalex.org/W2171613573","https://openalex.org/W2790374560","https://openalex.org/W4376544090"],"related_works":["https://openalex.org/W1995520961","https://openalex.org/W2133356014","https://openalex.org/W1507703291","https://openalex.org/W4378554180","https://openalex.org/W2159506186","https://openalex.org/W2105805134","https://openalex.org/W2463281698","https://openalex.org/W2980281598","https://openalex.org/W2116088335","https://openalex.org/W2037208057"],"abstract_inverted_index":{"BACKGROUND:":[0],"Emerging":[1],"technology,":[2],"such":[3,272],"as":[4,273],"an":[5,154,256],"artificial":[6],"pancreatic":[7],"beta-cell,":[8],"is":[9,88,94,108,116,145,151],"not":[10],"likely":[11],"to":[12,15,124,135,179,255],"be":[13,33,136,252],"affordable":[14],"people":[16],"who":[17],"live":[18],"in":[19,22,68,205,211,216,269],"developing":[20],"nations":[21],"the":[23,69,82,85,89,101,121,125,129,143,147,161,184,217,245,263],"next":[24],"20-30":[25],"years.":[26],"However,":[27],"multiple-daily":[28],"injection":[29],"(MDI)":[30],"therapy":[31],"can":[32,251],"improved":[34],"using":[35,139],"similar":[36],"advanced":[37],"control":[38,56,86,190],"algorithms":[39],"designed":[40],"for":[41,59,81,96,194,248],"continuous":[42,46],"glucose":[43,76],"monitoring":[44],"and":[45,63,74,104,112,171,198,208,213],"insulin":[47,91,105,126,249],"infusion":[48],"pumps.":[49],"METHODS:":[50],"A":[51],"simulation":[52],"study":[53],"of":[54,84,160,183,266],"run-to-run":[55,148,246],"was":[57,164],"developed":[58],"MDI":[60,156,258],"therapy.":[61,157],"Rapid-":[62],"slow-acting":[64],"insulins":[65],"were":[66,233],"used":[67],"protocol,":[70],"which":[71],"uses":[72],"pre-":[73],"postprandial":[75],"measurements.":[77],"The":[78,158],"key":[79],"information":[80,107,119,133],"synthesis":[83],"algorithm":[87,163],"subject":[90],"sensitivity":[92,144],"that":[93,244],"calculated":[95],"two":[97],"cases:":[98],"(a)":[99],"when":[100,114],"subject's":[102,122],"glycemia":[103],"dosing":[106],"known":[109],"(sensitivity":[110],"response)":[111],"(b)":[113],"there":[115],"no":[117,223],"previous":[118],"about":[120],"response":[123],"protocol.":[127,259],"In":[128,220],"latter":[130],"case,":[131],"this":[132,267],"needs":[134],"estimated":[137],"recursively":[138],"online":[140],"data.":[141],"After":[142],"recalculated,":[146],"correction":[149],"scheme":[150,268],"updated,":[152],"obtaining":[153],"adaptive":[155,257],"robustness":[159],"advisory":[162],"evaluated":[165],"by":[166],"constant":[167],"random":[168],"parameter":[169],"variations":[170,215],"superimposing":[172],"sinusoidal":[173],"oscillations":[174],"on":[175,235],"glucose-insulin":[176,218],"model":[177],"parameters":[178],"simulate":[180],"intra-individual":[181],"variability":[182],"glucoregulatory":[185],"system.":[186],"RESULTS:":[187],"Optimal":[188],"glycemic":[189],"has":[191],"been":[192],"achieved":[193],"both":[195],"cases":[196],"(a":[197],"b)":[199],"despite":[200],"variable":[201],"meals":[202],"(15%":[203],"variation":[204,210],"carbohydrate":[206],"content":[207],"15-min":[209],"timing)":[212],"parametric":[214],"model.":[219],"Case":[221],"(b),":[222],"profound":[224],"hypoglycemic":[225],"(<60":[226],"mg/dL)":[227,231],"or":[228,277],"hyperglycemic":[229],"(>180":[230],"events":[232],"observed":[234],"average":[236],"during":[237],"all":[238],"evaluations.":[239],"CONCLUSIONS:":[240],"This":[241],"work":[242],"shows":[243],"framework":[247],"updating":[250],"successfully":[253],"extended":[254],"These":[260],"results":[261],"motivate":[262],"practical":[264],"implementation":[265],"portable":[270],"units":[271],"personal":[274],"digital":[275],"assistants":[276],"smartphones.":[278]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
