{"id":"https://openalex.org/W205523733","doi":null,"title":"Use of a composite skin graft composed of cultured human keratinocytes and fibroblasts and a collagen-GAG matrix to cover full-thickness wounds on athymic mice.","display_name":"Use of a composite skin graft composed of cultured human keratinocytes and fibroblasts and a collagen-GAG matrix to cover full-thickness wounds on athymic mice.","publication_year":1991,"publication_date":"1991-02-01","ids":{"openalex":"https://openalex.org/W205523733","mag":"205523733","pmid":"https://pubmed.ncbi.nlm.nih.gov/1992553"},"language":"en","primary_location":{"id":"pmid:1992553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1992553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M L Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132395","display_name":"University of California San Diego Medical Center","ror":"https://ror.org/03aw5sn18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4210132395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M L Cooper","raw_affiliation_strings":["Department of Surgery, University of California, San Diego Medical Center 92103"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of California, San Diego Medical Center 92103","institution_ids":["https://openalex.org/I4210132395"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109938647","display_name":"John F. Hansbrough","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J F Hansbrough","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.3423,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.96325979,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"109","issue":"2","first_page":"198","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/composite-skin-graft","display_name":"composite skin graft","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cultured-keratinocytes","display_name":"cultured keratinocytes","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cultured-fibroblasts","display_name":"cultured fibroblasts","score":0.953000009059906},{"id":"https://openalex.org/keywords/burn-wound-coverage","display_name":"burn wound coverage","score":0.5830000042915344},{"id":"https://openalex.org/keywords/skin-substitutes","display_name":"skin substitutes","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.8399999737739563},{"id":"https://openalex.org/keywords/graft-acceptance","display_name":"graft acceptance","score":0.9129999876022339},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.8299999833106995},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.8799999952316284},{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":0.9909999966621399},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9520000219345093},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/graft-attachment","display_name":"graft attachment","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.6356521248817444},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.6008584499359131},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.5807519555091858},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5752391815185547},{"id":"https://openalex.org/C2777750529","wikidata":"https://www.wikidata.org/wiki/Q1591440","display_name":"Skin grafting","level":2,"score":0.5119177103042603},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5057086944580078},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.50420081615448},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.5021417140960693},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.49984216690063477},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.49133697152137756},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.4821062386035919},{"id":"https://openalex.org/C175933922","wikidata":"https://www.wikidata.org/wiki/Q3344895","display_name":"Artificial skin","level":2,"score":0.42714375257492065},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.426916241645813},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31861746311187744},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3175370693206787},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.293712854385376},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.24506983160972595},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.17638686299324036},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16697552800178528},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16300803422927856},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009779","descriptor_name":"Occlusive Dressings","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D016038","descriptor_name":"Skin Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016378","descriptor_name":"Tissue Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1992553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1992553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Journal Article"},{"id":"mag:205523733","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1992553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4582942878","display_name":"LIVING PROSTHETIC SKIN","funder_award_id":"R01GM035068","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2116456356","https://openalex.org/W2081839245","https://openalex.org/W2410084752","https://openalex.org/W1966549550","https://openalex.org/W1991479248","https://openalex.org/W2466659658","https://openalex.org/W2105745595","https://openalex.org/W2363869350","https://openalex.org/W2001255199","https://openalex.org/W2013396957"],"abstract_inverted_index":{"In":[0,33],"patients":[1,41],"with":[2,93,130,154,206],"extensive":[3],"full-thickness":[4,116],"burns,":[5],"wound":[6,27,203],"coverage":[7],"may":[8,39],"be":[9,14],"accelerated":[10],"if":[11],"skin":[12,19,37,58,144,223],"can":[13],"expanded":[15],"to":[16,25,81,175,201,221],"produce":[17],"a":[18,56,85,94,98,155,159,217],"replacement":[20,46,59,224],"that":[21],"reproducibly":[22],"supplies":[23],"blood":[24],"the":[26,74,82,107,110,119,186,199,202,209,222],"and":[28,66,76,158,166,178,182,207],"has":[29,97],"good":[30],"structural":[31],"qualities.":[32],"addition,":[34],"development":[35],"of":[36,47,50,61,84,88,121,170,188,198,211],"replacements":[38],"benefit":[40],"who":[42],"require":[43],"reconstruction":[44],"or":[45],"large":[48],"areas":[49],"abnormal":[51],"skin.":[52],"We":[53],"have":[54],"developed":[55],"composite":[57,111],"composed":[60,87],"cultured":[62,77],"human":[63,69,134,212],"keratinocytes":[64],"(HK)":[65],"fibroblasts.":[67],"Cultured":[68],"fibroblasts":[70,165],"are":[71,79,113],"seeded":[72],"into":[73],"interstices,":[75],"HKs":[78,103],"applied":[80],"surface":[83],"matrix":[86,108],"type":[89,179],"I":[90],"collagen":[91,181],"crosslinked":[92],"glycosaminoglycan,":[95],"which":[96],"defined":[99,143],"physical":[100],"structure.":[101],"After":[102],"reach":[104],"confluence":[105],"on":[106,115,118,137,228],"surface,":[109],"grafts":[112],"placed":[114],"wounds":[117],"dorsum":[120],"athymic":[122],"mice.":[123],"Graft":[124],"acceptance,":[125],"confirmed":[126],"by":[127,149,164,192],"positive":[128],"staining":[129],"antibodies":[131],"specific":[132],"for":[133],"HLA-ABC":[135],"antigens":[136],"HKs,":[138],"is":[139,146,204],"approximately":[140],"90%.":[141],"A":[142],"structure":[145],"present":[147],"histologically":[148],"day":[150],"10":[151,193],"after":[152,195],"grafting,":[153],"differentiated":[156],"epithelium":[157],"subepidermal":[160],"layer":[161],"densely":[162],"populated":[163],"capillaries":[167],"without":[168,208],"evidence":[169],"inflammation.":[171],"Fluorescent":[172],"light":[173],"microscopy":[174,184],"identify":[176],"laminin":[177],"IV":[180],"electron":[183],"confirm":[185],"presence":[187],"basement":[189],"membrane":[190],"components":[191],"days":[194],"grafting.":[196],"Attachment":[197],"graft":[200,226],"similar":[205],"addition":[210],"basic":[213],"fibroblast":[214],"growth":[215],"factor,":[216],"potent":[218],"angiogenic":[219],"agent,":[220],"before":[225],"placement":[227],"wounds.":[229]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
