{"id":"https://openalex.org/W2055084890","doi":"https://doi.org/10.1016/j.sbi.2013.01.008","title":"Modeling G protein-coupled receptors and their interactions with ligands","display_name":"Modeling G protein-coupled receptors and their interactions with ligands","publication_year":2013,"publication_date":"2013-02-15","ids":{"openalex":"https://openalex.org/W2055084890","doi":"https://doi.org/10.1016/j.sbi.2013.01.008","mag":"2055084890","pmid":"https://pubmed.ncbi.nlm.nih.gov/23415855"},"language":"en","primary_location":{"id":"doi:10.1016/j.sbi.2013.01.008","doi":"https://doi.org/10.1016/j.sbi.2013.01.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.sbi.2013.01.008","pdf_url":null,"source":{"id":"https://openalex.org/S175155502","display_name":"Current Opinion in Structural Biology","issn_l":"0959-440X","issn":["0959-440X","1879-033X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Structural Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021219075","display_name":"Stefano Costanzi","orcid":"https://orcid.org/0000-0003-3183-7332","observed_orcids":["https://orcid.org/0000-0003-3183-7332"]},"institutions":[{"id":"https://openalex.org/I181401687","display_name":"American University","ror":"https://ror.org/052w4zt36","country_code":"US","type":"education","lineage":["https://openalex.org/I181401687"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stefano Costanzi","raw_affiliation_strings":["Department of Chemistry and Center for Behavioral Neuroscience, American University, Washington, DC 20016, USA. costanzi@american.edu","Department of Chemistry and Center for Behavioral Neuroscience, American University, Washington, DC, 20016, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Center for Behavioral Neuroscience, American University, Washington, DC 20016, USA. costanzi@american.edu","institution_ids":["https://openalex.org/I181401687"]},{"raw_affiliation_string":"Department of Chemistry and Center for Behavioral Neuroscience, American University, Washington, DC, 20016, USA,","institution_ids":["https://openalex.org/I181401687"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021219075"],"corresponding_institution_ids":["https://openalex.org/I181401687"],"apc_list":{"value":4360,"currency":"USD","value_usd":4360},"apc_paid":null,"fwci":0.7203,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.57612386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"2","first_page":"185","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":1.0},{"id":"https://openalex.org/keywords/gpcr-crystal-structures","display_name":"GPCR crystal structures","score":0.7590000033378601},{"id":"https://openalex.org/keywords/ligand-binding","display_name":"ligand binding","score":0.6259999871253967},{"id":"https://openalex.org/keywords/receptor-ligand-complex","display_name":"receptor-ligand complex","score":0.7789999842643738},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"homology modeling","score":0.8389999866485596},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7519999742507935},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/computer-aided-drug-discovery","display_name":"computational drug discovery","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.9176101684570312},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.8063048124313354},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.7827442288398743},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.7029081583023071},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.6461931467056274},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5194761157035828},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5016779899597168},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.4465376138687134},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4249928891658783},{"id":"https://openalex.org/C82714645","wikidata":"https://www.wikidata.org/wiki/Q438331","display_name":"Template","level":2,"score":0.4108675420284271},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3580281734466553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3517823815345764},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1671980619430542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1270730197429657},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.09399732947349548},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.sbi.2013.01.008","doi":"https://doi.org/10.1016/j.sbi.2013.01.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.sbi.2013.01.008","pdf_url":null,"source":{"id":"https://openalex.org/S175155502","display_name":"Current Opinion in Structural Biology","issn_l":"0959-440X","issn":["0959-440X","1879-033X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Structural Biology","raw_type":"journal-article"},{"id":"pmid:23415855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23415855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in structural biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W60778029","https://openalex.org/W142246363","https://openalex.org/W148895274","https://openalex.org/W1559711086","https://openalex.org/W1603274157","https://openalex.org/W1968001320","https://openalex.org/W1973228989","https://openalex.org/W1974734322","https://openalex.org/W1975691556","https://openalex.org/W1981636172","https://openalex.org/W1983371169","https://openalex.org/W1984977206","https://openalex.org/W1988097700","https://openalex.org/W1988477436","https://openalex.org/W1989855172","https://openalex.org/W1997340548","https://openalex.org/W2000655486","https://openalex.org/W2001302355","https://openalex.org/W2011522291","https://openalex.org/W2020601776","https://openalex.org/W2021750784","https://openalex.org/W2043209972","https://openalex.org/W2043636502","https://openalex.org/W2044853688","https://openalex.org/W2046274153","https://openalex.org/W2047144511","https://openalex.org/W2049617698","https://openalex.org/W2051106500","https://openalex.org/W2053549636","https://openalex.org/W2063273962","https://openalex.org/W2076481851","https://openalex.org/W2077399441","https://openalex.org/W2080192851","https://openalex.org/W2080231167","https://openalex.org/W2082904424","https://openalex.org/W2100201978","https://openalex.org/W2104477830","https://openalex.org/W2111373319","https://openalex.org/W2117003397","https://openalex.org/W2123563726","https://openalex.org/W2151784842","https://openalex.org/W2152853006","https://openalex.org/W2167086539","https://openalex.org/W2167857702","https://openalex.org/W2271577227","https://openalex.org/W2404302832","https://openalex.org/W2413436809","https://openalex.org/W2418341685"],"related_works":["https://openalex.org/W38732814","https://openalex.org/W142246363","https://openalex.org/W2163394542","https://openalex.org/W2401168217","https://openalex.org/W4298881099","https://openalex.org/W3084146972","https://openalex.org/W2618932375","https://openalex.org/W2907949855","https://openalex.org/W2073812411","https://openalex.org/W2100201978"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}