{"id":"https://openalex.org/W2055083952","doi":"https://doi.org/10.1093/nar/15.3.1259","title":"Role in translation of a triple tandemly repeated sequence in the 5\u2032-untranslated region of human thymidylate synthase mRNA","display_name":"Role in translation of a triple tandemly repeated sequence in the 5\u2032-untranslated region of human thymidylate synthase mRNA","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2055083952","doi":"https://doi.org/10.1093/nar/15.3.1259","mag":"2055083952","pmid":"https://pubmed.ncbi.nlm.nih.gov/3029702","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/340522"},"language":"en","primary_location":{"id":"doi:10.1093/nar/15.3.1259","doi":"https://doi.org/10.1093/nar/15.3.1259","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/15.3.1259","pdf_url":"https://academic.oup.com/nar/article-pdf/15/3/1259/3988240/15-3-1259.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/nar/article-pdf/15/3/1259/3988240/15-3-1259.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054802225","display_name":"Sumiko Kaneda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210123465","display_name":"Saitama Cancer Center","ror":"https://ror.org/03a4d7t12","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123465"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Sumiko Kaneda","raw_affiliation_strings":["+ Department of Biology, Yale University New Haven, CT 06520, USA","Saitama Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"+ Department of Biology, Yale University New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Saitama Cancer Center","institution_ids":["https://openalex.org/I4210123465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011428083","display_name":"Keiichi Takeishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210123465","display_name":"Saitama Cancer Center","ror":"https://ror.org/03a4d7t12","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123465"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Keiichi Takeishi","raw_affiliation_strings":["+ Department of Biology, Yale University New Haven, CT 06520, USA","Saitama Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"+ Department of Biology, Yale University New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Saitama Cancer Center","institution_ids":["https://openalex.org/I4210123465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005220870","display_name":"Dai Ayusawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210123465","display_name":"Saitama Cancer Center","ror":"https://ror.org/03a4d7t12","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123465"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Dai Ayusawa","raw_affiliation_strings":["+ Department of Biology, Yale University New Haven, CT 06520, USA","Saitama Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"+ Department of Biology, Yale University New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Saitama Cancer Center","institution_ids":["https://openalex.org/I4210123465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012921973","display_name":"Kimiko Shimizu","orcid":"https://orcid.org/0000-0003-4943-2552","observed_orcids":["https://orcid.org/0000-0003-4943-2552"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210123465","display_name":"Saitama Cancer Center","ror":"https://ror.org/03a4d7t12","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123465"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Kimiko Shimizu","raw_affiliation_strings":["+ Department of Biology, Yale University New Haven, CT 06520, USA","Saitama Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"+ Department of Biology, Yale University New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Saitama Cancer Center","institution_ids":["https://openalex.org/I4210123465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111745559","display_name":"Takeshi Seno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210123465","display_name":"Saitama Cancer Center","ror":"https://ror.org/03a4d7t12","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123465"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Takeshi Seno","raw_affiliation_strings":["+ Department of Biology, Yale University New Haven, CT 06520, USA","Saitama Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"+ Department of Biology, Yale University New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Saitama Cancer Center","institution_ids":["https://openalex.org/I4210123465"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003873129","display_name":"Sidney Altman","orcid":"https://orcid.org/0000-0001-7287-0337","observed_orcids":["https://orcid.org/0000-0001-7287-0337"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sidney Altman","raw_affiliation_strings":["+ Department of Biology, Yale University New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"+ Department of Biology, Yale University New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011428083"],"corresponding_institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210123465"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":1.0455,"has_fulltext":true,"cited_by_count":157,"citation_normalized_percentile":{"value":0.75725418,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"3","first_page":"1259","last_page":"1270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymidylate-synthase","display_name":"thymidylate synthase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/5-untranslated-region","display_name":"5' untranslated region","score":0.8009999990463257},{"id":"https://openalex.org/keywords/translation-efficiency","display_name":"translation efficiency","score":0.7369999885559082},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.6269999742507935},{"id":"https://openalex.org/keywords/mrna-structure","display_name":"mRNA structure","score":0.6079999804496765},{"id":"https://openalex.org/keywords/transient-expression","display_name":"transient expression","score":0.6010000109672546},{"id":"https://openalex.org/keywords/initiator-codon","display_name":"initiator codon","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5093816518783569},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.44527560472488403},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4355941116809845},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.41737908124923706},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.4163632392883301},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3190258741378784},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21159622073173523},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1623450219631195}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004262","descriptor_name":"DNA Restriction Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013940","descriptor_name":"Thymidylate Synthase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D013940","descriptor_name":"Thymidylate Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/15.3.1259","doi":"https://doi.org/10.1093/nar/15.3.1259","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/15.3.1259","pdf_url":"https://academic.oup.com/nar/article-pdf/15/3/1259/3988240/15-3-1259.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:340522","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/340522","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:3029702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3029702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1028.6833","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1028.6833","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/15/3/1259.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/nar/15.3.1259","doi":"https://doi.org/10.1093/nar/15.3.1259","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/15.3.1259","pdf_url":"https://academic.oup.com/nar/article-pdf/15/3/1259/3988240/15-3-1259.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323572","display_name":"Foundation for Promotion of Cancer Research","ror":"https://ror.org/029aqdy80"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2055083952.pdf","grobid_xml":"https://content.openalex.org/works/W2055083952.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1485505865","https://openalex.org/W1496130682","https://openalex.org/W1518322853","https://openalex.org/W1520070573","https://openalex.org/W1525939557","https://openalex.org/W1536062643","https://openalex.org/W1549660657","https://openalex.org/W1560623478","https://openalex.org/W1572756764","https://openalex.org/W1602254003","https://openalex.org/W1821652777","https://openalex.org/W1911700867","https://openalex.org/W1918119607","https://openalex.org/W1966904492","https://openalex.org/W1983706728","https://openalex.org/W2011240428","https://openalex.org/W2014036948","https://openalex.org/W2021978074","https://openalex.org/W2059195864","https://openalex.org/W2061105847","https://openalex.org/W2077534044","https://openalex.org/W2083477989","https://openalex.org/W2132897827","https://openalex.org/W2138270253","https://openalex.org/W2154214377","https://openalex.org/W2177042266","https://openalex.org/W2183530045","https://openalex.org/W2332949416","https://openalex.org/W6611527762","https://openalex.org/W6831682679"],"related_works":["https://openalex.org/W1990763949","https://openalex.org/W7099339777","https://openalex.org/W2283720628","https://openalex.org/W2069596772","https://openalex.org/W3197643644","https://openalex.org/W7160780821","https://openalex.org/W2021978074","https://openalex.org/W2122663153","https://openalex.org/W2016733711","https://openalex.org/W103672606"],"abstract_inverted_index":{"A":[0],"triple":[1],"tandem":[2],"repeat":[3],"(TTR)":[4],"consisting":[5],"of":[6,12,28,34,49,76,87,93,103,120,135,138,157,184,195],"90":[7],"nucleotides":[8],"exists":[9],"immediately":[10],"upstream":[11],"the":[13,26,29,32,35,50,72,77,84,91,104,112,118,121,125,139,145,163,169,175,185,191],"ATG":[14,126],"initiator":[15,127],"codon":[16],"in":[17,31,46,100],"human":[18],"thymidylate":[19],"synthase":[20],"(TS)":[21],"cDNA":[22,44,62],"(pcHTS-1).":[23],"To":[24],"investigate":[25],"role":[27],"TTR":[30,51],"expression":[33,86,102],"TS":[36,88,94,186],"cDNA,":[37],"we":[38],"used":[39],"pcHTS-1":[40],"to":[41,124,190],"construct":[42],"mutant":[43,61,69,78],"clones":[45],"which":[47],"part":[48,119],"was":[52,58,64,106,130,151],"deleted":[53],"or":[54],"an":[55,158],"additional":[56,159],"element":[57,161],"inserted.":[59],"The":[60,97,148],"plasmid":[63],"introduced":[65],"into":[66,162],"murine":[67],"TS-negative":[68],"cells":[70],"and":[71,90,117],"relative":[73],"translation":[74,98,149,183],"efficiencies":[75],"cDNAs":[79],"were":[80],"determined":[81],"by":[82,108,133,155],"measuring":[83],"transient":[85,101],"activity":[89],"amount":[92],"mRNA":[95],"transcribed.":[96],"efficiency":[99,150],"mutants":[105],"increased":[107],"deletions":[109,134],"covering":[110],"all":[111],"first":[113,140,170],"two":[114,141,171],"repeated":[115,142,160,172],"elements,":[116],"third":[122],"closest":[123],"codon,":[128],"but":[129],"not":[131,153],"affected":[132,154],"only":[136],"parts":[137],"elements":[143,173],"at":[144,174],"5'":[146,176],"end.":[147],"also":[152],"insertion":[156],"TTR.":[164],"These":[165],"results":[166],"suggest":[167],"that":[168],"end":[177],"both":[178],"have":[179],"inhibitory":[180],"effects":[181],"on":[182],"mRNA,":[187],"probably":[188],"due":[189],"unique":[192],"structural":[193],"feature":[194],"this":[196],"element.":[197]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
