{"id":"https://openalex.org/W2055074706","doi":"https://doi.org/10.1523/jneurosci.1150-09.2009","title":"Immunization with Amyloid-\u03b2 Attenuates Inclusion Body Myositis-Like Myopathology and Motor Impairment in a Transgenic Mouse Model","display_name":"Immunization with Amyloid-\u03b2 Attenuates Inclusion Body Myositis-Like Myopathology and Motor Impairment in a Transgenic Mouse Model","publication_year":2009,"publication_date":"2009-05-13","ids":{"openalex":"https://openalex.org/W2055074706","doi":"https://doi.org/10.1523/jneurosci.1150-09.2009","mag":"2055074706","pmid":"https://pubmed.ncbi.nlm.nih.gov/19439591","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3049190"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.1150-09.2009","doi":"https://doi.org/10.1523/jneurosci.1150-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1150-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/19/6132.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/29/19/6132.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009317100","display_name":"Masashi Kitazawa","orcid":"https://orcid.org/0000-0003-2165-8197","observed_orcids":["https://orcid.org/0000-0003-2165-8197"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masashi Kitazawa","raw_affiliation_strings":["Department of Neurobiology and Behavior and Neurology, University of California, Irvine, California 92697-4545, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Behavior and Neurology, University of California, Irvine, California 92697-4545, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008959840","display_name":"Vitaly Vasilevko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vitaly Vasilevko","raw_affiliation_strings":["Gillespie Neuroscience Facility , University of California , Irvine , Irvine , CA 92697-4545","Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697-4545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gillespie Neuroscience Facility , University of California , Irvine , Irvine , CA 92697-4545","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697-4545","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030274546","display_name":"David H. Cribbs","orcid":"https://orcid.org/0000-0002-6870-4480","observed_orcids":["https://orcid.org/0000-0002-6870-4480"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Cribbs","raw_affiliation_strings":["Department of Neurobiology and Behavior , 1109","Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697-4545","Neurology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Behavior , 1109","institution_ids":[]},{"raw_affiliation_string":"Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697-4545","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Neurology, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026487650","display_name":"Frank M. LaFerla","orcid":"https://orcid.org/0000-0003-2324-6911","observed_orcids":["https://orcid.org/0000-0003-2324-6911"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank M. LaFerla","raw_affiliation_strings":["Departments of Neurobiology and Behavior and 2 Neurology , and","Institute for Brain Aging and Dementia , University of California , Irvine , Irvine , California 92697-4545","[University of California, Irvine]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurobiology and Behavior and 2 Neurology , and","institution_ids":[]},{"raw_affiliation_string":"Institute for Brain Aging and Dementia , University of California , Irvine , Irvine , California 92697-4545","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"[University of California, Irvine]","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":2.8922,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.90776692,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"29","issue":"19","first_page":"6132","last_page":"6141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.11400000005960464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.050200000405311584,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inclusion-body-myositis","display_name":"inclusion body myositis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9869999885559082},{"id":"https://openalex.org/keywords/active-immunization","display_name":"active immunization","score":0.9860000014305115},{"id":"https://openalex.org/keywords/amyloid-beta-oligomers","display_name":"amyloid-beta oligomers","score":0.8040000200271606},{"id":"https://openalex.org/keywords/skeletal-muscle-degeneration","display_name":"skeletal muscle degeneration","score":0.8700000047683716},{"id":"https://openalex.org/keywords/motor-impairment","display_name":"motor impairment","score":0.9729999899864197},{"id":"https://openalex.org/keywords/anti-amyloid-beta-antibodies","display_name":"anti-amyloid beta antibodies","score":0.8119999766349792},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.8109999895095825},{"id":"https://openalex.org/keywords/t-cell-mediated-inflammation","display_name":"T cell-mediated inflammation","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2777327098","wikidata":"https://www.wikidata.org/wiki/Q1848471","display_name":"Inclusion body myositis","level":3,"score":0.8420684337615967},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.750465989112854},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6537411212921143},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6173080801963806},{"id":"https://openalex.org/C2777300911","wikidata":"https://www.wikidata.org/wiki/Q692536","display_name":"Myopathy","level":2,"score":0.6061779260635376},{"id":"https://openalex.org/C2781232998","wikidata":"https://www.wikidata.org/wiki/Q1433212","display_name":"Myositis","level":2,"score":0.6038820743560791},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4300293028354645},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4221554100513458},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3601701259613037},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3337947726249695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3260572552680969},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2530668377876282},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24030140042304993},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1228938102722168},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009069","descriptor_name":"Movement Disorders","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009069","descriptor_name":"Movement Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016233","descriptor_name":"Immunotherapy, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018979","descriptor_name":"Myositis, Inclusion Body","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018979","descriptor_name":"Myositis, Inclusion Body","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018979","descriptor_name":"Myositis, Inclusion Body","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058255","descriptor_name":"Protease Nexins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.1150-09.2009","doi":"https://doi.org/10.1523/jneurosci.1150-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1150-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/19/6132.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3049190","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3049190","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:19439591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19439591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.1150-09.2009","doi":"https://doi.org/10.1523/jneurosci.1150-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1150-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/19/6132.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1220092839","display_name":"Behavioral and Neural Plasticity in the Aged","funder_award_id":"P01AG000538","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1513139207","display_name":"Modulating IBM pathology in transgenic mice","funder_award_id":"R01AG020335","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1747621735","display_name":null,"funder_award_id":"R01 AG-020241","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1904525057","display_name":null,"funder_award_id":"R01\u2010AG20241","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3759868739","display_name":null,"funder_award_id":"AG 00538","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3976291280","display_name":"Pathogenic Role of Abeta, tau and Inflammation in Inclusion Body Myositis","funder_award_id":"K99AR054695","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4358608740","display_name":"The Alzheimer's Disease Research Center at the University of California, Irvine","funder_award_id":"P50AG016573","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8022867278","display_name":"Gene Interactions in a Model of Alzheimer's Disease","funder_award_id":"R01AG021982","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8170862162","display_name":"Multiple Approaches to Abeta Vaccination in Animal Models","funder_award_id":"4r01ag020241-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000119970","display_name":null,"funder_award_id":"AG00538","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000328687","display_name":null,"funder_award_id":"R01AG20241","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332688","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2055074706.pdf","grobid_xml":"https://content.openalex.org/works/W2055074706.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W203134634","https://openalex.org/W1518571728","https://openalex.org/W1531060628","https://openalex.org/W1647386363","https://openalex.org/W1966977299","https://openalex.org/W1967549235","https://openalex.org/W1972011377","https://openalex.org/W1972850054","https://openalex.org/W1973276273","https://openalex.org/W1990724312","https://openalex.org/W1992317581","https://openalex.org/W1992481658","https://openalex.org/W1994095021","https://openalex.org/W2013274571","https://openalex.org/W2018333394","https://openalex.org/W2018447297","https://openalex.org/W2020497815","https://openalex.org/W2021696285","https://openalex.org/W2024036714","https://openalex.org/W2024517044","https://openalex.org/W2025920010","https://openalex.org/W2029232434","https://openalex.org/W2037223188","https://openalex.org/W2037988019","https://openalex.org/W2040721710","https://openalex.org/W2043209404","https://openalex.org/W2056607803","https://openalex.org/W2058528490","https://openalex.org/W2064105273","https://openalex.org/W2067038697","https://openalex.org/W2073540852","https://openalex.org/W2074203661","https://openalex.org/W2074666645","https://openalex.org/W2074866899","https://openalex.org/W2075481535","https://openalex.org/W2075725519","https://openalex.org/W2077798289","https://openalex.org/W2079990598","https://openalex.org/W2082429191","https://openalex.org/W2086281676","https://openalex.org/W2089469670","https://openalex.org/W2092509822","https://openalex.org/W2097773756","https://openalex.org/W2097965815","https://openalex.org/W2100036008","https://openalex.org/W2100866942","https://openalex.org/W2115574704","https://openalex.org/W2121448546","https://openalex.org/W2121963977","https://openalex.org/W2122974699","https://openalex.org/W2126395089","https://openalex.org/W2129412868","https://openalex.org/W2137284362","https://openalex.org/W2138321088","https://openalex.org/W2145250227","https://openalex.org/W2150999725","https://openalex.org/W2156193029","https://openalex.org/W2158118180","https://openalex.org/W2163175900","https://openalex.org/W2164627569","https://openalex.org/W2165531374","https://openalex.org/W2168930459","https://openalex.org/W2346624188","https://openalex.org/W2758601031","https://openalex.org/W4246137212"],"related_works":["https://openalex.org/W2165531374","https://openalex.org/W2077798289","https://openalex.org/W2095427358","https://openalex.org/W2029232434","https://openalex.org/W2100866942","https://openalex.org/W2027773647","https://openalex.org/W1996016181","https://openalex.org/W2097773756","https://openalex.org/W2158118180","https://openalex.org/W2006067401"],"abstract_inverted_index":{"Inclusion":[0],"body":[1,51],"myositis":[2],"(IBM),":[3],"the":[4,11,61,80,106,124,133,142,147,151,154,165,173,180],"most":[5],"common":[6],"muscle":[7,20,77,136,190],"disease":[8],"to":[9,60,69,123],"afflict":[10],"elderly,":[12],"causes":[13],"slow":[14],"but":[15],"progressive":[16],"degeneration":[17],"of":[18,35,52,72,153,179],"skeletal":[19,47,76,135,189],"and":[21,32,44,104,187],"ultimately":[22],"paralysis.":[23],"Hallmark":[24],"pathological":[25],"features":[26,83],"include":[27],"T-cell":[28],"mediated":[29],"inflammatory":[30],"infiltrates":[31],"aberrant":[33,56],"accumulations":[34],"proteins,":[36],"including":[37],"amyloid-beta":[38],"(Abeta),":[39],"tau,":[40],"ubiquitinated-proteins,":[41],"apolipoprotein":[42],"E,":[43],"alpha-synuclein":[45],"in":[46,89,132,146,157,184],"muscle.":[48],"A":[49],"large":[50],"work":[53],"indicates":[54],"that":[55,96,119,175],"Abeta":[57,73,102,120,155,176],"accumulation":[58],"contributes":[59],"myodegeneration.":[62],"Here,":[63],"we":[64],"investigated":[65],"whether":[66],"active":[67,97],"immunization":[68,98],"promote":[70],"clearance":[71],"from":[74,114,137],"affected":[75,134],"fibers":[78],"mitigates":[79],"IBM-like":[81],"myopathological":[82],"as":[84,86,127],"well":[85],"motor":[87,107],"impairment":[88,108],"a":[90,160],"transgenic":[91],"mouse":[92],"model.":[93],"We":[94],"report":[95],"markedly":[99],"reduces":[100],"intracellular":[101],"deposits":[103],"attenuates":[105],"compared":[109],"with":[110],"untreated":[111],"mice.":[112,139],"Results":[113],"our":[115],"current":[116],"study":[117],"indicate":[118],"oligomers":[121,156],"contribute":[122],"myopathy":[125],"process":[126],"they":[128],"were":[129],"significantly":[130],"reduced":[131],"immunized":[138,148],"In":[140],"addition,":[141],"anti-Abeta":[143],"antibodies":[144],"produced":[145],"mice":[149],"blocked":[150],"toxicity":[152],"vitro,":[158],"providing":[159],"possible":[161],"key":[162,181],"mechanism":[163],"for":[164,172],"functional":[166],"recovery.":[167],"These":[168],"findings":[169],"provide":[170],"support":[171],"hypothesis":[174],"is":[177],"one":[178],"pathogenic":[182],"components":[183],"IBM":[185],"pathology":[186],"subsequent":[188],"degeneration.":[191]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
