{"id":"https://openalex.org/W2055070038","doi":"https://doi.org/10.1159/000341581","title":"Mesial Temporal Astrocyte Tau Pathology in the MRC-CFAS Ageing Brain Cohort","display_name":"Mesial Temporal Astrocyte Tau Pathology in the MRC-CFAS Ageing Brain Cohort","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2055070038","doi":"https://doi.org/10.1159/000341581","mag":"2055070038","pmid":"https://pubmed.ncbi.nlm.nih.gov/22868294"},"language":"en","primary_location":{"id":"doi:10.1159/000341581","doi":"https://doi.org/10.1159/000341581","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000341581","pdf_url":null,"source":{"id":"https://openalex.org/S195598543","display_name":"Dementia and Geriatric Cognitive Disorders","issn_l":"1420-8008","issn":["1420-8008","1421-9824"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia and Geriatric Cognitive Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hull-repository.worktribe.com/output/4454707","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077917861","display_name":"G. Lace","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. Lace","raw_affiliation_strings":["Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK","Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield,","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035247509","display_name":"Paul G. Ince","orcid":"https://orcid.org/0000-0001-6677-8753","observed_orcids":["https://orcid.org/0000-0001-6677-8753"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P.G. Ince","raw_affiliation_strings":["Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield,","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085651175","display_name":"Carol Brayne","orcid":"https://orcid.org/0000-0001-5307-663X","observed_orcids":["https://orcid.org/0000-0001-5307-663X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Brayne","raw_affiliation_strings":["Department of Public Health and Primary Care and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and Primary Care and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006449166","display_name":"George M. Savva","orcid":"https://orcid.org/0000-0001-9190-124X","observed_orcids":["https://orcid.org/0000-0001-9190-124X"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"G.M. Savva","raw_affiliation_strings":["The Irish Longitudinal Study on Ageing, Department of Medical Gerontology, Trinity College Dublin, Dublin, Republic of Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Irish Longitudinal Study on Ageing, Department of Medical Gerontology, Trinity College Dublin, Dublin, Republic of Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086720829","display_name":"Fiona E. Matthews","orcid":"https://orcid.org/0000-0002-1728-2388","observed_orcids":["https://orcid.org/0000-0002-1728-2388"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210134973","display_name":"MRC Biostatistics Unit","ror":"https://ror.org/046vje122","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210134973","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F.E. Matthews","raw_affiliation_strings":["MRC Biostatistics Unit, Institute of Public Health, University of Cambridge, Cambridge, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Biostatistics Unit, Institute of Public Health, University of Cambridge, Cambridge, and","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210134973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103254936","display_name":"Rohan de Silva","orcid":"https://orcid.org/0000-0002-5052-5775","observed_orcids":["https://orcid.org/0000-0002-5052-5775"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. de Silva","raw_affiliation_strings":["Reta Lila Weston Institute, UCL Institute of Neurology, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reta Lila Weston Institute, UCL Institute of Neurology, London, UK","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091901475","display_name":"Julie E. Simpson","orcid":"https://orcid.org/0000-0002-3753-4271","observed_orcids":["https://orcid.org/0000-0002-3753-4271"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J.E. Simpson","raw_affiliation_strings":["Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield,","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057685617","display_name":"Stephen B. Wharton","orcid":"https://orcid.org/0000-0003-2785-333X","observed_orcids":["https://orcid.org/0000-0003-2785-333X"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S.B. Wharton","raw_affiliation_strings":["Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield,","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7554,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.63785887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"34","issue":"1","first_page":"15","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medial-temporal-lobe","display_name":"medial temporal lobe","score":0.8960000276565552},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.8659999966621399},{"id":"https://openalex.org/keywords/4r-tau","display_name":"4R tau","score":0.7350000143051147},{"id":"https://openalex.org/keywords/coiled-bodies","display_name":"coiled bodies","score":0.8100000023841858},{"id":"https://openalex.org/keywords/argyrophilic-grains","display_name":"argyrophilic grains","score":0.9900000095367432},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6359999775886536},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.9440000057220459},{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"entorhinal cortex","score":0.9700000286102295},{"id":"https://openalex.org/keywords/white-matter","display_name":"white matter","score":0.5509999990463257},{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.6719355583190918},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.6208084225654602},{"id":"https://openalex.org/C3017833866","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tau pathology","level":4,"score":0.5416226387023926},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5273768901824951},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.45878320932388306},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.45128896832466125},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4496578872203827},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43274474143981934},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38520753383636475},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.35701262950897217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34971165657043457},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.34319812059402466},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.17704173922538757},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17545592784881592},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13286563754081726}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002102","descriptor_name":"Cadaver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016622","descriptor_name":"Silver Staining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1159/000341581","doi":"https://doi.org/10.1159/000341581","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000341581","pdf_url":null,"source":{"id":"https://openalex.org/S195598543","display_name":"Dementia and Geriatric Cognitive Disorders","issn_l":"1420-8008","issn":["1420-8008","1421-9824"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia and Geriatric Cognitive Disorders","raw_type":"journal-article"},{"id":"pmid:22868294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22868294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia and geriatric cognitive disorders","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1354586","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1354586/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DEMENTIA AND GERIATRIC COGNITIVE DISORDERS , 34 (1) pp. 15-24. (2012)","raw_type":"Article"},{"id":"pmh:oai:https://hull-repository.worktribe.com/:4454707","doi":null,"is_oa":true,"landing_page_url":"https://hull-repository.worktribe.com/output/4454707","pdf_url":null,"source":{"id":"https://openalex.org/S4306400827","display_name":"Repository@Hull (Worktribe) (University of Hull)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I191240316","host_organization_name":"University of Hull","host_organization_lineage":["https://openalex.org/I191240316"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:ueaeprints.uea.ac.uk:44920","doi":null,"is_oa":false,"landing_page_url":"https://ueaeprints.uea.ac.uk/id/eprint/44920/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:https://hull-repository.worktribe.com/:4454707","doi":null,"is_oa":true,"landing_page_url":"https://hull-repository.worktribe.com/output/4454707","pdf_url":null,"source":{"id":"https://openalex.org/S4306400827","display_name":"Repository@Hull (Worktribe) (University of Hull)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I191240316","host_organization_name":"University of Hull","host_organization_lineage":["https://openalex.org/I191240316"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5687650934","display_name":"Oxidative DNA Damage and Transcriptional Impairment in Brain Ageing as an Early Contributor to Cognitive Impairment","funder_award_id":"MR/J004308/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6845694547","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0611-10084","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1237501959","https://openalex.org/W1492537286","https://openalex.org/W1556490889","https://openalex.org/W1572208210","https://openalex.org/W1859451507","https://openalex.org/W1983768810","https://openalex.org/W1991313924","https://openalex.org/W1992758695","https://openalex.org/W1998319561","https://openalex.org/W2018505720","https://openalex.org/W2023272535","https://openalex.org/W2023754965","https://openalex.org/W2028570069","https://openalex.org/W2035318781","https://openalex.org/W2048078395","https://openalex.org/W2052742260","https://openalex.org/W2054237190","https://openalex.org/W2070446123","https://openalex.org/W2078840669","https://openalex.org/W2079220186","https://openalex.org/W2109646121","https://openalex.org/W2111983005","https://openalex.org/W2119523390","https://openalex.org/W2135771073","https://openalex.org/W2140429385"],"related_works":["https://openalex.org/W2932957054","https://openalex.org/W2140429385","https://openalex.org/W2940787922","https://openalex.org/W2420668518","https://openalex.org/W2195527239","https://openalex.org/W2265209254","https://openalex.org/W2899221794","https://openalex.org/W7202166423","https://openalex.org/W7171445339","https://openalex.org/W7124702397"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glial":[1],"tau":[2,26,65,163,199],"pathology":[3,128,164],"is":[4,165,175,181],"seen":[5,114],"in":[6,10,16,28,88,96,108,115,131,151,167],"certain":[7],"tauopathies":[8],"and":[9,21,43,56,58,63,84,99,104,142,200],"ageing.":[11],"We":[12],"determined":[13],"its":[14,22],"frequency":[15],"ageing":[17,169],"mesial":[18,170,191],"temporal":[19,36,171,192],"lobe":[20],"relationship":[23],"to":[24,54,61,72,121],"other":[25],"pathologies":[27],"the":[29,51,168],"MRC-CFAS":[30],"population-representative":[31],"neuropathology":[32],"cohort.":[33],"METHODS:":[34],"Mesial":[35],"lobe,":[37],"including":[38],"hippocampus,":[39],"amygdala,":[40],"entorhinal":[41],"cortex":[42],"white":[44,100],"matter,":[45],"was":[46,70],"examined":[47],"using":[48],"immunohistochemistry":[49],"with":[50,81,136,159],"AT8":[52],"antibody":[53],"phospho-tau":[55],"RD3":[57],"RD4":[59,83],"antibodies":[60],"3R":[62],"4R":[64,183,194],"isoforms.":[66],"Gallyas":[67],"silver":[68],"stain":[69],"used":[71],"detect":[73],"fibrillar":[74],"aggregates.":[75],"RESULTS:":[76],"Thorn-shaped":[77],"astrocytes":[78],"(TSA),":[79],"positive":[80],"AT8,":[82],"Gallyas,":[85],"were":[86,93,105,113,118,134,149],"present":[87],"49%":[89],"of":[90,153,177,189],"cases.":[91,154],"They":[92,155],"particularly":[94],"prevalent":[95],"subpial,":[97],"periventricular":[98],"matter":[101,133],"perivascular":[102],"locations":[103],"less":[106],"frequent":[107],"grey":[109,132],"matter.":[110],"Coiled":[111],"bodies":[112,138],"18.8%.":[116],"TSA":[117,130],"not":[119,157],"related":[120],"Braak":[122],"neurofibrillary":[123],"tangle":[124,127],"or":[125],"hippocampal":[126],"stages.":[129],"associated":[135],"coiled":[137],"(p":[139,145],"=":[140,146],"0.011)":[141],"argyrophilic":[143,201],"grains":[144],"0.048),":[147],"which":[148,185],"identified":[150],"11.5%":[152],"did":[156],"correlate":[158],"dementia.":[160],"CONCLUSIONS:":[161],"Astrocyte":[162],"common":[166],"lobe.":[172],"Its":[173],"formation":[174],"independent":[176],"Alzheimer-type":[178],"pathology.":[179],"It":[180],"a":[182,190],"tauopathy,":[184],"may":[186],"form":[187],"part":[188],"age-related":[193],"tauopathy":[195],"that":[196],"includes":[197],"oligodendroglial":[198],"grains.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}