{"id":"https://openalex.org/W2055068158","doi":"https://doi.org/10.4161/19336950.2014.948755","title":"Cortical KCNQ2/3 channels; insights from knockout mice","display_name":"Cortical KCNQ2/3 channels; insights from knockout mice","publication_year":2014,"publication_date":"2014-09-03","ids":{"openalex":"https://openalex.org/W2055068158","doi":"https://doi.org/10.4161/19336950.2014.948755","mag":"2055068158","pmid":"https://pubmed.ncbi.nlm.nih.gov/25483580","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4594428"},"language":"en","primary_location":{"id":"doi:10.4161/19336950.2014.948755","doi":"https://doi.org/10.4161/19336950.2014.948755","is_oa":true,"landing_page_url":"https://doi.org/10.4161/19336950.2014.948755","pdf_url":null,"source":{"id":"https://openalex.org/S202658786","display_name":"Channels","issn_l":"1933-6950","issn":["1933-6950","1933-6969"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Channels","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4161/19336950.2014.948755","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108421445","display_name":"Heun Soh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heun Soh","raw_affiliation_strings":["a Department of Physiology and Neurobiology ; University of Connecticut ; Storrs , CT USA","Department of Physiology and Neurobiology","Storrs, CT USA","University of Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Physiology and Neurobiology ; University of Connecticut ; Storrs , CT USA","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"Department of Physiology and Neurobiology","institution_ids":[]},{"raw_affiliation_string":"Storrs, CT USA","institution_ids":[]},{"raw_affiliation_string":"University of Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013485962","display_name":"Zachary Niday","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary Niday","raw_affiliation_strings":["Department of Physiology and Neurobiology; University of Connecticut; Storrs, CT USA","Department of Physiology and Neurobiology","Storrs, CT USA","University of Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Neurobiology; University of Connecticut; Storrs, CT USA","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"Department of Physiology and Neurobiology","institution_ids":[]},{"raw_affiliation_string":"Storrs, CT USA","institution_ids":[]},{"raw_affiliation_string":"University of Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016597293","display_name":"Anastasios V. Tzingounis","orcid":"https://orcid.org/0000-0002-4605-3437","observed_orcids":["https://orcid.org/0000-0002-4605-3437"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anastasios V Tzingounis","raw_affiliation_strings":["Department of Physiology and Neurobiology; University of Connecticut; Storrs, CT USA","Department of Physiology and Neurobiology","Storrs, CT USA","University of Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Neurobiology; University of Connecticut; Storrs, CT USA","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"Department of Physiology and Neurobiology","institution_ids":[]},{"raw_affiliation_string":"Storrs, CT USA","institution_ids":[]},{"raw_affiliation_string":"University of Connecticut","institution_ids":["https://openalex.org/I140172145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016597293"],"corresponding_institution_ids":["https://openalex.org/I140172145"],"apc_list":{"value":1880,"currency":"GBP","value_usd":2306},"apc_paid":{"value":1880,"currency":"GBP","value_usd":2306},"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"5","first_page":"389","last_page":"390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kcnq2","display_name":"KCNQ2","score":0.9319999814033508},{"id":"https://openalex.org/keywords/kcnq3","display_name":"KCNQ3","score":1.0},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.859000027179718},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.8610000014305115},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.796999990940094},{"id":"https://openalex.org/keywords/pediatric-epilepsy","display_name":"pediatric epilepsy","score":0.7620000243186951},{"id":"https://openalex.org/keywords/kcnq2-mutations","display_name":"KCNQ2 mutations","score":0.7400000095367432},{"id":"https://openalex.org/keywords/brain-function","display_name":"brain function","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.7237022519111633},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.6843529939651489},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5845491290092468},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.5600327253341675},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.4771158993244171},{"id":"https://openalex.org/C3018390542","wikidata":"https://www.wikidata.org/wiki/Q1073","display_name":"Brain function","level":2,"score":0.4432280659675598},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33347249031066895},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32212018966674805},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18237319588661194},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17981237173080444},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.179151713848114},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12577566504478455}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051658","descriptor_name":"KCNQ2 Potassium Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051659","descriptor_name":"KCNQ3 Potassium Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.4161/19336950.2014.948755","doi":"https://doi.org/10.4161/19336950.2014.948755","is_oa":true,"landing_page_url":"https://doi.org/10.4161/19336950.2014.948755","pdf_url":null,"source":{"id":"https://openalex.org/S202658786","display_name":"Channels","issn_l":"1933-6950","issn":["1933-6950","1933-6969"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Channels","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3596567","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4594428","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4594428","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4594428","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Channels (Austin)","raw_type":"Text"},{"id":"pmid:25483580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25483580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Channels (Austin, Tex.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/19336950.2014.948755","doi":"https://doi.org/10.4161/19336950.2014.948755","is_oa":true,"landing_page_url":"https://doi.org/10.4161/19336950.2014.948755","pdf_url":null,"source":{"id":"https://openalex.org/S202658786","display_name":"Channels","issn_l":"1933-6950","issn":["1933-6950","1933-6969"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Channels","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7203041780","display_name":"Cellular physiology of epilepsy-associated KCNQ2 channels","funder_award_id":"R01NS073981","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1952394902","https://openalex.org/W1971100304","https://openalex.org/W1983417104","https://openalex.org/W1993691506","https://openalex.org/W2002812952","https://openalex.org/W2051925110","https://openalex.org/W2088826438","https://openalex.org/W2094902307"],"related_works":["https://openalex.org/W2019942525","https://openalex.org/W3156174213","https://openalex.org/W2010817599","https://openalex.org/W1611821860","https://openalex.org/W2912783001","https://openalex.org/W2053268514","https://openalex.org/W1989194458","https://openalex.org/W4408530290","https://openalex.org/W3130060663","https://openalex.org/W4386065305"],"abstract_inverted_index":{"KCNQ2":[0],"and":[1],"KCNQ3":[2],"potassium":[3],"channels":[4],"are":[5],"critical":[6],"for":[7],"proper":[8],"brain":[9],"function,":[10],"as":[11],"mutations":[12],"in":[13],"either":[14],"Kcnq2":[15],"or":[16],"Kcnq3":[17],"have":[18],"been":[19],"associated":[20],"with":[21],"multiple":[22],"pediatric":[23],"epilepsy":[24],"disorders.1":[25],"In":[26],"most":[27],"neurons,":[28],"K...":[29]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}