{"id":"https://openalex.org/W2055040751","doi":"https://doi.org/10.1159/000238783","title":"Penetration of Aztreonam into Pleural Exudate following Rapid Intravenous Bolus or Constant Infusion","display_name":"Penetration of Aztreonam into Pleural Exudate following Rapid Intravenous Bolus or Constant Infusion","publication_year":2009,"publication_date":"2009-09-09","ids":{"openalex":"https://openalex.org/W2055040751","doi":"https://doi.org/10.1159/000238783","mag":"2055040751","pmid":"https://pubmed.ncbi.nlm.nih.gov/2209165"},"language":"en","primary_location":{"id":"doi:10.1159/000238783","doi":"https://doi.org/10.1159/000238783","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000238783","pdf_url":null,"source":{"id":"https://openalex.org/S92531173","display_name":"Chemotherapy","issn_l":"0009-3157","issn":["0009-3157","1421-9794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111692090","display_name":"P.A. Miglioli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P.A. Miglioli","raw_affiliation_strings":["Department of Pharmacology, University of Padua, Italy","Department of Pharmacology, University of Padua"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Padua, Italy","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"Department of Pharmacology, University of Padua","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059190976","display_name":"P. Pivetta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Pivetta","raw_affiliation_strings":["Department of Pharmacology, University of Padua"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Padua","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010914065","display_name":"Umberto Fantoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146744","display_name":"Azienda Ospedale - Universit\u00e0 Padova","ror":"https://ror.org/04bhk6583","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146744"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"U. Fantoni","raw_affiliation_strings":["Pneumology Division, Civil Hospital of Padua"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology Division, Civil Hospital of Padua","institution_ids":["https://openalex.org/I4210146744"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113587372","display_name":"F Nodari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Nodari","raw_affiliation_strings":["Surgical Clinic, University of Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Clinic, University of Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.19016245,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"36","issue":"5","first_page":"321","last_page":"324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11356","display_name":"Pleural and Pulmonary Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aztreonam","display_name":"aztreonam","score":1.0},{"id":"https://openalex.org/keywords/pleural-effusion","display_name":"pleural effusion","score":0.8650000095367432},{"id":"https://openalex.org/keywords/pleural-exudate","display_name":"pleural exudate","score":0.8349999785423279},{"id":"https://openalex.org/keywords/intravenous-bolus","display_name":"intravenous bolus","score":0.6869999766349792},{"id":"https://openalex.org/keywords/continuous-infusion","display_name":"continuous infusion","score":0.8100000023841858},{"id":"https://openalex.org/keywords/route-of-administration","display_name":"route of administration","score":0.7409999966621399},{"id":"https://openalex.org/keywords/drug-penetration","display_name":"drug penetration","score":0.6399999856948853},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.6959999799728394},{"id":"https://openalex.org/keywords/area-under-the-curve","display_name":"area under the curve","score":0.7839999794960022},{"id":"https://openalex.org/keywords/beta-lactam-antibiotics","display_name":"beta-lactam antibiotics","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C2780416669","wikidata":"https://www.wikidata.org/wiki/Q418546","display_name":"Aztreonam","level":5,"score":0.7569191455841064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6733498573303223},{"id":"https://openalex.org/C2779634585","wikidata":"https://www.wikidata.org/wiki/Q1334541","display_name":"Pleural effusion","level":2,"score":0.6723581552505493},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.667154848575592},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5402173399925232},{"id":"https://openalex.org/C3020190219","wikidata":"https://www.wikidata.org/wiki/Q640448","display_name":"Intravenous bolus","level":2,"score":0.5199341177940369},{"id":"https://openalex.org/C2993292583","wikidata":"https://www.wikidata.org/wiki/Q192398","display_name":"Pleural fluid","level":3,"score":0.5033394694328308},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4865797758102417},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.4845122694969177},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4524586796760559},{"id":"https://openalex.org/C2778978224","wikidata":"https://www.wikidata.org/wiki/Q55998","display_name":"Pleurisy","level":3,"score":0.442920982837677},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34231966733932495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.242441326379776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18002501130104065},{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.0},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001398","descriptor_name":"Aztreonam","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001398","descriptor_name":"Aztreonam","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001398","descriptor_name":"Aztreonam","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010996","descriptor_name":"Pleural Effusion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000238783","doi":"https://doi.org/10.1159/000238783","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000238783","pdf_url":null,"source":{"id":"https://openalex.org/S92531173","display_name":"Chemotherapy","issn_l":"0009-3157","issn":["0009-3157","1421-9794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"journal-article"},{"id":"pmid:2209165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2209165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2467374759","https://openalex.org/W2124576297","https://openalex.org/W2049483554","https://openalex.org/W1976679876","https://openalex.org/W2080137056","https://openalex.org/W3163222789","https://openalex.org/W1979285834","https://openalex.org/W1988561170","https://openalex.org/W1998262456","https://openalex.org/W2066291312"],"abstract_inverted_index":{"A":[0],"study":[1],"on":[2,10],"the":[3,6,61,81],"effects":[4],"of":[5,8,25,45,98],"mode":[7],"administration":[9],"aztreonam":[11],"(AZ)":[12],"concentrations":[13,63,77,97],"in":[14,19,100],"pleural":[15,49,75,101],"fluid":[16,50],"was":[17,27],"performed":[18],"human":[20],"subjects.":[21],"The":[22,71],"same":[23],"dose":[24],"AZ":[26,99],"given":[28],"as":[29,38],"an":[30],"intravenous":[31],"bolus":[32],"injection":[33],"to":[34,42],"one":[35],"group":[36,44],"and":[37,48,60,74,78],"a":[39,68],"drip":[40,87,93],"infusion":[41,94],"another":[43],"patients.":[46],"Serum":[47],"samples":[51],"were":[52,64,84],"collected":[53],"at":[54],"different":[55],"times":[56],"after":[57,86],"drug":[58],"administration,":[59],"antibiotic":[62],"measured":[65],"by":[66],"using":[67],"microbiological":[69],"method.":[70],"highest":[72],"serum":[73],"exudate":[76],"area":[79],"under":[80],"curve":[82],"values":[83],"obtained":[85],"infusion.":[88],"These":[89],"results":[90],"indicate":[91],"that":[92],"gives":[95],"higher":[96],"effusion.":[102]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
