{"id":"https://openalex.org/W2055037784","doi":"https://doi.org/10.1172/jci109049","title":"Relationship between Para-aminohippurate Secretion and Cellular Morphology in Rabbit Proximal Tubules","display_name":"Relationship between Para-aminohippurate Secretion and Cellular Morphology in Rabbit Proximal Tubules","publication_year":1978,"publication_date":"1978-05-01","ids":{"openalex":"https://openalex.org/W2055037784","doi":"https://doi.org/10.1172/jci109049","mag":"2055037784","pmid":"https://pubmed.ncbi.nlm.nih.gov/659594","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/372654"},"language":"en","primary_location":{"id":"doi:10.1172/jci109049","doi":"https://doi.org/10.1172/jci109049","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109049","pdf_url":"http://www.jci.org/articles/view/109049/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/109049/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089495276","display_name":"Philip B. Woodhall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip B. Woodhall","raw_affiliation_strings":["Department of Pathology , Duke University Medical Center , Durham , North Carolina 27710","Division of Nephrology , Department of Medicine , and the","Division of Nephrology, Department of Medicine, and the Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology , Duke University Medical Center , Durham , North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Division of Nephrology , Department of Medicine , and the","institution_ids":[]},{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, and the Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000218151","display_name":"C. Craig Tisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Craig Tisher","raw_affiliation_strings":["Department of Pathology , Duke University Medical Center , Durham , North Carolina 27710","Division of Nephrology , Department of Medicine , and the","Division of Nephrology, Department of Medicine, and the Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology , Duke University Medical Center , Durham , North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Division of Nephrology , Department of Medicine , and the","institution_ids":[]},{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, and the Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049150830","display_name":"Charles A. Simonton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. Simonton","raw_affiliation_strings":["Department of Pathology , Duke University Medical Center , Durham , North Carolina 27710","Division of Nephrology , Department of Medicine , and the","Division of Nephrology, Department of Medicine, and the Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology , Duke University Medical Center , Durham , North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Division of Nephrology , Department of Medicine , and the","institution_ids":[]},{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, and the Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110010784","display_name":"Roscoe R. Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roscoe R. Robinson","raw_affiliation_strings":["Department of Pathology , Duke University Medical Center , Durham , North Carolina 27710","Division of Nephrology , Department of Medicine , and the","Division of Nephrology, Department of Medicine, and the Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology , Duke University Medical Center , Durham , North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Division of Nephrology , Department of Medicine , and the","institution_ids":[]},{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, and the Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":4.5375,"has_fulltext":true,"cited_by_count":118,"citation_normalized_percentile":{"value":0.95001312,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"61","issue":"5","first_page":"1320","last_page":"1329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.8910999894142151,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.8910999894142151,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proximal-tubule","display_name":"proximal tubule","score":0.968999981880188},{"id":"https://openalex.org/keywords/rabbit-kidney","display_name":"rabbit kidney","score":0.5950000286102295},{"id":"https://openalex.org/keywords/pars-recta","display_name":"pars recta","score":0.9679999947547913},{"id":"https://openalex.org/keywords/isolated-perfused-kidney","display_name":"isolated perfused kidney","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C2780222010","wikidata":"https://www.wikidata.org/wiki/Q2916078","display_name":"Proximal tubule","level":3,"score":0.7789096832275391},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7401636838912964},{"id":"https://openalex.org/C2779010597","wikidata":"https://www.wikidata.org/wiki/Q5166601","display_name":"Convoluted tubule","level":3,"score":0.5941306948661804},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5878902077674866},{"id":"https://openalex.org/C2780498532","wikidata":"https://www.wikidata.org/wiki/Q7850941","display_name":"Tubule","level":3,"score":0.5565304160118103},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4586681127548218},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40908753871917725},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.39875781536102295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3717522919178009},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.32806700468063354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08732706308364868}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000618","descriptor_name":"Aminohippuric Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009399","descriptor_name":"Nephrons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010042","descriptor_name":"Ouabain","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010130","descriptor_name":"p-Aminohippuric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci109049","doi":"https://doi.org/10.1172/jci109049","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109049","pdf_url":"http://www.jci.org/articles/view/109049/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:659594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/659594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:372654","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC372654/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1172/jci109049","doi":"https://doi.org/10.1172/jci109049","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109049","pdf_url":"http://www.jci.org/articles/view/109049/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2055037784.pdf","grobid_xml":"https://content.openalex.org/works/W2055037784.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W51312476","https://openalex.org/W266231267","https://openalex.org/W633175178","https://openalex.org/W1986716322","https://openalex.org/W1993413886","https://openalex.org/W2000437112","https://openalex.org/W2037993913","https://openalex.org/W2042560530","https://openalex.org/W2049549250","https://openalex.org/W2054338131","https://openalex.org/W2144432455","https://openalex.org/W2408032074","https://openalex.org/W2409515555","https://openalex.org/W2410203954","https://openalex.org/W2436485827"],"related_works":["https://openalex.org/W2281564467","https://openalex.org/W2177641088","https://openalex.org/W2404942096","https://openalex.org/W2091195035","https://openalex.org/W2405136787","https://openalex.org/W2465814959","https://openalex.org/W2038868114","https://openalex.org/W2409320766","https://openalex.org/W2460415053","https://openalex.org/W585400758"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"in":[2,17,25,67,101,188,203,207,223,255],"the":[3,18,26,33,36,61,171,195,259,269,273],"mammalian":[4],"proximal":[5,80,111,121,177,209,225,248,260,274,298],"tubule":[6,48,198,261,275],"have":[7],"suggested":[8],"that":[9,35,119,253],"para-aminohippurate":[10],"(PAH)":[11],"secretion":[12,41,69,100,185,202,237,257],"is":[13,251],"approximately":[14],"threefold":[15],"greater":[16],"straight":[19],"segment,":[20,28],"or":[21,29,63],"pars":[22,30,277,280],"recta,":[23],"than":[24,128,268],"convoluted":[27],"convoluta.":[31],"However,":[32],"possibility":[34],"site":[37],"of":[38,65,74,93,98,106,173,190,244,272,288,294],"maximal":[39],"PAH":[40,68,184,201,236,256],"might":[42],"be":[43],"related":[44],"better":[45],"to":[46,283],"particular":[47],"segments":[49,165,193,243,293],"as":[50,179],"identified":[51],"by":[52,181,194],"cell":[53,182,265],"type":[54,266],"had":[55],"not":[56,83,239,301],"been":[57,84],"explored.":[58],"In":[59],"addition,":[60],"presence":[62],"absence":[64],"differences":[66,254],"between":[70,241,291],"morphologically":[71],"identical":[72],"regions":[73],"superficial":[75],"(SF)":[76],"vs.":[77,137],"juxtamedullary":[78],"(JM)":[79],"tubules":[81,112,122,130,178,210,226,299],"has":[82],"examined.":[85],"These":[86],"issues":[87],"were":[88,123,227],"studied":[89],"using":[90],"a":[91],"combination":[92],"histologic":[94],"methods":[95],"and":[96,109,115,159,168,175,232,246,279,296],"measurement":[97],"[(3)H]PAH":[99],"isolated":[102,196],"perfused":[103,197],"tubules.":[104,249],"Measurements":[105],"microdissected":[107],"SF":[108,120,174,208,245,295],"JM":[110,129,176,224,247,297],"from":[113],"young":[114],"adult":[116],"rabbits":[117],"revealed":[118,162],"slightly":[124],"but":[125],"significantly":[126],"longer":[127],"([young":[131],"rabbits:":[132,146],"SF,":[133,147],"8.69+/-SE":[134],"0.14":[135],"mm":[136],"JM,":[138,151],"7.97+/-SE":[139],"0.13":[140],"mm;":[141,150,154],"P":[142,155],"<":[143,156],"0.01]":[144],"[adult":[145],"10.61+/-SE":[148],"0.28":[149],"9.17+/-SE":[152],"0.19":[153],"0.001]).":[157],"Light":[158],"electron":[160],"microscopy":[161],"three":[163,192],"sequential":[164],"(S(1),":[166],"S(2),":[167,215],"S(3))":[169],"along":[170,258],"length":[172],"defined":[180],"type.":[183],"was":[186,300],"measured":[187],"each":[189],"these":[191],"technique.":[199],"Net":[200,235],"fmol/mm":[204],"per":[205],"min":[206],"was:":[211],"S(1),":[212],"281+/-SE":[213],"21;":[214],"1,508+/-SE":[216],"104;":[217],"S(3),":[218],"318+/-SE":[219],"46.":[220],"Corresponding":[221],"values":[222],"353+/-SE":[228],"31,":[229],"1,391+/-SE":[230],"72,":[231],"188+/-SE":[233],"23.":[234],"did":[238],"differ":[240],"comparable":[242,292],"It":[250],"concluded":[252],"correlate":[262],"best":[263],"with":[264],"rather":[267],"arbitrary":[270],"division":[271],"into":[276],"convoluta":[278],"recta":[281],"according":[282],"its":[284],"external":[285],"configuration.":[286],"Evidence":[287],"functional":[289],"heterogeneity":[290],"observed.":[302]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
