{"id":"https://openalex.org/W2054972298","doi":"https://doi.org/10.1387/ijdb.041890mt","title":"Genetics of photoreceptor development and function in zebrafish","display_name":"Genetics of photoreceptor development and function in zebrafish","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2054972298","doi":"https://doi.org/10.1387/ijdb.041890mt","mag":"2054972298","pmid":"https://pubmed.ncbi.nlm.nih.gov/15558483"},"language":"en","primary_location":{"id":"doi:10.1387/ijdb.041890mt","doi":"https://doi.org/10.1387/ijdb.041890mt","is_oa":true,"landing_page_url":"https://doi.org/10.1387/ijdb.041890mt","pdf_url":"http://www.ijdb.ehu.es/article/pdf/041890mt","source":{"id":"https://openalex.org/S47908780","display_name":"The International Journal of Developmental Biology","issn_l":"0214-6282","issn":["0214-6282","1696-3547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321029","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/P4310321029"],"host_organization_lineage_names":["University of the Basque Country"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.ijdb.ehu.es/article/pdf/041890mt","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110518117","display_name":"Motokazu Tsujikawa","orcid":"https://orcid.org/0009-0008-1084-7340","observed_orcids":["https://orcid.org/0009-0008-1084-7340"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Motokazu Tsujikawa","raw_affiliation_strings":["Department of Ophthalmology, Harvard Medical School, Boston, MA 02110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Boston, MA 02110, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017966771","display_name":"Jarema J. Malicki","orcid":"https://orcid.org/0000-0002-5947-8805","observed_orcids":["https://orcid.org/0000-0002-5947-8805"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jarema Malicki","raw_affiliation_strings":["Department of Ophthalmology, Harvard Medical School, 243 Charles St., Boston, MA 02110. USA","Department of Ophthalmology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, 243 Charles St., Boston, MA 02110. USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017966771"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":0.3139,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.28143564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"48","issue":"8-9","first_page":"925","last_page":"934"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photoreceptor-development","display_name":"photoreceptor development","score":0.9129999876022339},{"id":"https://openalex.org/keywords/photoreceptor-function","display_name":"photoreceptor function","score":0.8820000290870667},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.9860000014305115},{"id":"https://openalex.org/keywords/outer-segment","display_name":"outer segment","score":0.8309999704360962},{"id":"https://openalex.org/keywords/ribbon-synapses","display_name":"ribbon synapses","score":0.9940000176429749},{"id":"https://openalex.org/keywords/phototransduction","display_name":"phototransduction","score":0.8050000071525574},{"id":"https://openalex.org/keywords/retinal-development","display_name":"retinal development","score":0.718999981880188},{"id":"https://openalex.org/keywords/genetic-screen","display_name":"genetic screen","score":0.6169999837875366},{"id":"https://openalex.org/keywords/photoreceptor-morphology","display_name":"photoreceptor morphology","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.9590532183647156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9305402636528015},{"id":"https://openalex.org/C2778961482","wikidata":"https://www.wikidata.org/wiki/Q25241","display_name":"Vertebrate","level":3,"score":0.660071611404419},{"id":"https://openalex.org/C2780916184","wikidata":"https://www.wikidata.org/wiki/Q748049","display_name":"Photoreceptor cell","level":3,"score":0.6505693793296814},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.618079662322998},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5604034662246704},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5380039215087891},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5255650281906128},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.49645406007766724},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.45198360085487366},{"id":"https://openalex.org/C38120836","wikidata":"https://www.wikidata.org/wiki/Q7322268","display_name":"Ribbon synapse","level":5,"score":0.44524991512298584},{"id":"https://openalex.org/C134486438","wikidata":"https://www.wikidata.org/wiki/Q3123214","display_name":"Forward genetics","level":4,"score":0.4233022630214691},{"id":"https://openalex.org/C15526883","wikidata":"https://www.wikidata.org/wiki/Q6657126","display_name":"Live cell imaging","level":3,"score":0.4114246964454651},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39377105236053467},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3356914818286896},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2913040518760681},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.15989699959754944},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.0},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014785","descriptor_name":"Vision, Ocular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1387/ijdb.041890mt","doi":"https://doi.org/10.1387/ijdb.041890mt","is_oa":true,"landing_page_url":"https://doi.org/10.1387/ijdb.041890mt","pdf_url":"http://www.ijdb.ehu.es/article/pdf/041890mt","source":{"id":"https://openalex.org/S47908780","display_name":"The International Journal of Developmental Biology","issn_l":"0214-6282","issn":["0214-6282","1696-3547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321029","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/P4310321029"],"host_organization_lineage_names":["University of the Basque Country"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Developmental Biology","raw_type":"journal-article"},{"id":"pmid:15558483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15558483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of developmental biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1387/ijdb.041890mt","doi":"https://doi.org/10.1387/ijdb.041890mt","is_oa":true,"landing_page_url":"https://doi.org/10.1387/ijdb.041890mt","pdf_url":"http://www.ijdb.ehu.es/article/pdf/041890mt","source":{"id":"https://openalex.org/S47908780","display_name":"The International Journal of Developmental Biology","issn_l":"0214-6282","issn":["0214-6282","1696-3547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321029","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/P4310321029"],"host_organization_lineage_names":["University of the Basque Country"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2054972298.pdf","grobid_xml":"https://content.openalex.org/works/W2054972298.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W100217110","https://openalex.org/W1488709092","https://openalex.org/W1516708974","https://openalex.org/W1525882285","https://openalex.org/W1535979497","https://openalex.org/W1544083434","https://openalex.org/W1573633304","https://openalex.org/W1579987409","https://openalex.org/W1597109281","https://openalex.org/W1601138296","https://openalex.org/W1892432877","https://openalex.org/W1902196155","https://openalex.org/W1932232911","https://openalex.org/W1943362480","https://openalex.org/W1959436961","https://openalex.org/W1965903362","https://openalex.org/W1969212379","https://openalex.org/W1971063924","https://openalex.org/W1972757014","https://openalex.org/W1979756417","https://openalex.org/W1982986130","https://openalex.org/W1989683816","https://openalex.org/W1991201077","https://openalex.org/W1995698561","https://openalex.org/W1996743997","https://openalex.org/W2000643824","https://openalex.org/W2002108807","https://openalex.org/W2003161345","https://openalex.org/W2005325630","https://openalex.org/W2006249044","https://openalex.org/W2008255883","https://openalex.org/W2011491131","https://openalex.org/W2012569825","https://openalex.org/W2012750970","https://openalex.org/W2017567461","https://openalex.org/W2024801753","https://openalex.org/W2033852655","https://openalex.org/W2034369933","https://openalex.org/W2039830515","https://openalex.org/W2042592516","https://openalex.org/W2043982544","https://openalex.org/W2048501294","https://openalex.org/W2050891655","https://openalex.org/W2051716552","https://openalex.org/W2060342120","https://openalex.org/W2064207737","https://openalex.org/W2070412516","https://openalex.org/W2072823072","https://openalex.org/W2074316017","https://openalex.org/W2076585835","https://openalex.org/W2084699385","https://openalex.org/W2086790354","https://openalex.org/W2088018354","https://openalex.org/W2091051874","https://openalex.org/W2091684557","https://openalex.org/W2092088744","https://openalex.org/W2092096245","https://openalex.org/W2099545629","https://openalex.org/W2104531203","https://openalex.org/W2120971498","https://openalex.org/W2123700457","https://openalex.org/W2123938765","https://openalex.org/W2126057356","https://openalex.org/W2129618668","https://openalex.org/W2130738806","https://openalex.org/W2131577885","https://openalex.org/W2133333740","https://openalex.org/W2140128594","https://openalex.org/W2141735759","https://openalex.org/W2145527032","https://openalex.org/W2146404892","https://openalex.org/W2154870286","https://openalex.org/W2155455079","https://openalex.org/W2157773282","https://openalex.org/W2166724532","https://openalex.org/W2168230734","https://openalex.org/W2168441478","https://openalex.org/W2171747124","https://openalex.org/W2181534894","https://openalex.org/W2195220474","https://openalex.org/W2491906158","https://openalex.org/W2886829003","https://openalex.org/W3024845111","https://openalex.org/W3149593974","https://openalex.org/W4211143281","https://openalex.org/W4232795761","https://openalex.org/W4237170276","https://openalex.org/W4246673719","https://openalex.org/W6645992653","https://openalex.org/W6829006312"],"related_works":["https://openalex.org/W2015712858","https://openalex.org/W1965903362","https://openalex.org/W2011491131","https://openalex.org/W1121832625","https://openalex.org/W3149593974","https://openalex.org/W3133453488","https://openalex.org/W4246453591","https://openalex.org/W2377315825","https://openalex.org/W2993620015","https://openalex.org/W1528991601"],"abstract_inverted_index":{"The":[0,72],"vertebrate":[1,79],"photoreceptor":[2,26,80,119,153],"is":[3,12,30,101],"a":[4,33,63],"cell":[5,48,81,120],"of":[6,43,59,66,77,118,127],"unique":[7],"morphology":[8],"and":[9,19,75,145,148],"function.":[10,27],"It":[11],"an":[13,92,102,115],"exquisite":[14],"light":[15,44],"detector,":[16],"both":[17,143],"sensitive":[18],"adaptable.":[20],"Several":[21],"unusual":[22],"morphological":[23,129],"features":[24,130],"facilitate":[25],"Signal":[28],"detection":[29],"accomplished":[31],"by":[32],"specialized":[34],"apical":[35],"structure,":[36],"the":[37,41,56,60,69,78,99,123],"outer":[38],"segment.":[39],"There,":[40],"capture":[42],"produces":[45],"fluctuations":[46],"in":[47,86,111],"membrane":[49],"potential,":[50],"which":[51],"are":[52,139],"then":[53],"transmitted":[54],"to":[55,94,106],"downstream":[57],"circuitry":[58],"retina":[61],"via":[62],"rare":[64],"type":[65],"synaptic":[67],"junction,":[68],"ribbon":[70],"synapse.":[71],"development,":[73],"maintenance":[74],"function":[76],"have":[82,113],"been":[83],"studied":[84,141],"mainly":[85],"four":[87],"model":[88],"organisms,":[89],"ranging":[90],"from":[91],"amphibian":[93],"man.":[95],"A":[96],"teleost":[97],"fish,":[98],"zebrafish,":[100],"important":[103,150],"recent":[104],"addition":[105],"this":[107],"group.":[108],"Genetic":[109],"screens":[110],"zebrafish":[112],"identified":[114],"impressive":[116],"collection":[117],"mutants,":[121],"including":[122],"absence":[124],"or":[125],"malformation":[126],"specific":[128],"as":[131,133],"well":[132],"functional":[134],"abnormalities.":[135],"These":[136],"mutant":[137],"strains":[138],"currently":[140],"using":[142],"molecular":[144],"embryological":[146],"tools":[147],"provide":[149],"insights":[151],"into":[152],"biology.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
