{"id":"https://openalex.org/W2054972003","doi":"https://doi.org/10.3109/14397595.2014.953668","title":"Drug retention rates of second biologic agents after switching from tumor necrosis factor inhibitors for rheumatoid arthritis in Japanese patients on low-dose methotrexate or without methotrexate","display_name":"Drug retention rates of second biologic agents after switching from tumor necrosis factor inhibitors for rheumatoid arthritis in Japanese patients on low-dose methotrexate or without methotrexate","publication_year":2014,"publication_date":"2014-09-11","ids":{"openalex":"https://openalex.org/W2054972003","doi":"https://doi.org/10.3109/14397595.2014.953668","mag":"2054972003","pmid":"https://pubmed.ncbi.nlm.nih.gov/25211402"},"language":"en","primary_location":{"id":"doi:10.3109/14397595.2014.953668","doi":"https://doi.org/10.3109/14397595.2014.953668","is_oa":false,"landing_page_url":"https://doi.org/10.3109/14397595.2014.953668","pdf_url":null,"source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028968443","display_name":"Tomonori Kobayakawa","orcid":"https://orcid.org/0009-0002-6814-9920","observed_orcids":["https://orcid.org/0009-0002-6814-9920"]},"institutions":[{"id":"https://openalex.org/I4210090647","display_name":"Nagoya University Hospital","ror":"https://ror.org/008zz8m46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090647"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomonori Kobayakawa","raw_affiliation_strings":["Department of Orthopedic Surgery and Rheumatology,Nagoya University Hospital , Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery and Rheumatology,Nagoya University Hospital , Nagoya Japan","institution_ids":["https://openalex.org/I4210090647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059137955","display_name":"Toshihisa Kojima","orcid":"https://orcid.org/0000-0001-8497-0212","observed_orcids":["https://orcid.org/0000-0001-8497-0212"]},"institutions":[{"id":"https://openalex.org/I4210090647","display_name":"Nagoya University Hospital","ror":"https://ror.org/008zz8m46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090647"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshihisa Kojima","raw_affiliation_strings":["Department of Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya Japan","institution_ids":["https://openalex.org/I4210090647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004086646","display_name":"Nobunori Takahashi","orcid":"https://orcid.org/0000-0001-6937-3567","observed_orcids":["https://orcid.org/0000-0001-6937-3567"]},"institutions":[{"id":"https://openalex.org/I4210090647","display_name":"Nagoya University Hospital","ror":"https://ror.org/008zz8m46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090647"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobunori Takahashi","raw_affiliation_strings":["Department of Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya Japan","institution_ids":["https://openalex.org/I4210090647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070557609","display_name":"Masatoshi Hayashi","orcid":"https://orcid.org/0000-0002-2167-8932","observed_orcids":["https://orcid.org/0000-0002-2167-8932"]},"institutions":[{"id":"https://openalex.org/I4210134554","display_name":"Nagano Red Cross Hospital","ror":"https://ror.org/041mcya16","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210134554"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatoshi Hayashi","raw_affiliation_strings":["Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Japan","institution_ids":["https://openalex.org/I4210134554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111855597","display_name":"Yuichiro Yabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132540","display_name":"Japan Community Healthcare Organization","ror":"https://ror.org/03q11y497","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210132540"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichiro Yabe","raw_affiliation_strings":["Department of Rheumatology, JCHO Tokyo Shinjyuku Medical Center, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, JCHO Tokyo Shinjyuku Medical Center, Tokyo, Japan","institution_ids":["https://openalex.org/I4210132540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026355605","display_name":"Atsushi Kaneko","orcid":"https://orcid.org/0000-0003-4392-912X","observed_orcids":["https://orcid.org/0000-0003-4392-912X"]},"institutions":[{"id":"https://openalex.org/I4210152596","display_name":"Nagoya Medical Center","ror":"https://ror.org/04ftw3n55","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210152596"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Kaneko","raw_affiliation_strings":["Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Nagoya, Japan","institution_ids":["https://openalex.org/I4210152596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040838641","display_name":"Tomone Shioura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomone Shioura","raw_affiliation_strings":["Department of Rheumatology, Shizuoka Kosei Hospital, Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Shizuoka Kosei Hospital, Shizuoka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074169870","display_name":"Kiwamu Saito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kiwamu Saito","raw_affiliation_strings":["SAITO CLINIC Orthopedics & Rheumatology, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAITO CLINIC Orthopedics & Rheumatology, Nagoya, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017609785","display_name":"Yuji Hirano","orcid":"https://orcid.org/0000-0002-0422-8139","observed_orcids":["https://orcid.org/0000-0002-0422-8139"]},"institutions":[{"id":"https://openalex.org/I4210145862","display_name":"Toyohashi Municipal Hospital","ror":"https://ror.org/03h3tds63","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145862"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Hirano","raw_affiliation_strings":["Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi, Japan","institution_ids":["https://openalex.org/I4210145862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110328476","display_name":"Yasuhide Kanayama","orcid":"https://orcid.org/0000-0002-2409-1619","observed_orcids":["https://orcid.org/0000-0002-2409-1619"]},"institutions":[{"id":"https://openalex.org/I4210142153","display_name":"Toyota Kosei Hospital","ror":"https://ror.org/04fc5qm41","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210142153"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhide Kanayama","raw_affiliation_strings":["Department of Rheumatology, Toyota Kosei Hospital, Toyota, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Toyota Kosei Hospital, Toyota, Japan","institution_ids":["https://openalex.org/I4210142153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103552558","display_name":"Hiroyuki Miyake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113086","display_name":"Ichinomiya Municipal City Hospital","ror":"https://ror.org/026a4qe69","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210113086"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Miyake","raw_affiliation_strings":["Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya, Japan","institution_ids":["https://openalex.org/I4210113086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113881346","display_name":"Nobuyuki Asai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090647","display_name":"Nagoya University Hospital","ror":"https://ror.org/008zz8m46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090647"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Asai","raw_affiliation_strings":["Department of Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya Japan","institution_ids":["https://openalex.org/I4210090647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109615779","display_name":"Koji Funahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090647","display_name":"Nagoya University Hospital","ror":"https://ror.org/008zz8m46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090647"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Funahashi","raw_affiliation_strings":["Department of Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya Japan","institution_ids":["https://openalex.org/I4210090647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060118128","display_name":"Shinya Hirabara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145862","display_name":"Toyohashi Municipal Hospital","ror":"https://ror.org/03h3tds63","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145862"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya Hirabara","raw_affiliation_strings":["Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi, Japan","institution_ids":["https://openalex.org/I4210145862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086537146","display_name":"Masahiro Hanabayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113086","display_name":"Ichinomiya Municipal City Hospital","ror":"https://ror.org/026a4qe69","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210113086"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Hanabayashi","raw_affiliation_strings":["Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya, Japan","institution_ids":["https://openalex.org/I4210113086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102746610","display_name":"Shuji Asai","orcid":"https://orcid.org/0000-0002-4030-8793","observed_orcids":["https://orcid.org/0000-0002-4030-8793"]},"institutions":[{"id":"https://openalex.org/I4210090647","display_name":"Nagoya University Hospital","ror":"https://ror.org/008zz8m46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090647"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuji Asai","raw_affiliation_strings":["Department of Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya Japan","institution_ids":["https://openalex.org/I4210090647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089659933","display_name":"Naoki Ishiguro","orcid":"https://orcid.org/0000-0003-2041-4035","observed_orcids":["https://orcid.org/0000-0003-2041-4035"]},"institutions":[{"id":"https://openalex.org/I4210090647","display_name":"Nagoya University Hospital","ror":"https://ror.org/008zz8m46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090647"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Ishiguro","raw_affiliation_strings":["Department of Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya Japan","institution_ids":["https://openalex.org/I4210090647"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5059137955"],"corresponding_institution_ids":["https://openalex.org/I4210090647"],"apc_list":{"value":3208,"currency":"USD","value_usd":3208},"apc_paid":null,"fwci":1.854,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.83757746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"2","first_page":"251","last_page":"256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-inhibitors","display_name":"tumor necrosis factor inhibitors","score":0.8080000281333923},{"id":"https://openalex.org/keywords/biologic-switching","display_name":"biologic switching","score":0.6859999895095825},{"id":"https://openalex.org/keywords/drug-retention-rate","display_name":"drug retention rate","score":0.75},{"id":"https://openalex.org/keywords/low-dose-methotrexate","display_name":"low-dose methotrexate","score":0.890999972820282},{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":0.9470000267028809},{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":0.996999979019165},{"id":"https://openalex.org/keywords/adalimumab","display_name":"adalimumab","score":1.0},{"id":"https://openalex.org/keywords/etanercept","display_name":"etanercept","score":0.996999979019165},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.8091574907302856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8083305358886719},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6520510315895081},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.6253625750541687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.613670289516449},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.5942220091819763},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.40829312801361084},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2860393226146698}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D057915","descriptor_name":"Drug Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/14397595.2014.953668","doi":"https://doi.org/10.3109/14397595.2014.953668","is_oa":false,"landing_page_url":"https://doi.org/10.3109/14397595.2014.953668","pdf_url":null,"source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},{"id":"pmid:25211402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25211402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern rheumatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2923893185","display_name":"Inhibitory effects of combination therapy of denosumab, anti-RANKL antibody, and biological DMARD on bone and cartilage destruction in patients with rheumatoid arthritis","funder_award_id":"26462290","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7410561551","display_name":"The development of new measurement methods in radiographic image.","funder_award_id":"25861307","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1761300068","https://openalex.org/W1840538016","https://openalex.org/W1874236485","https://openalex.org/W1966874995","https://openalex.org/W1970375970","https://openalex.org/W1986252550","https://openalex.org/W2007486550","https://openalex.org/W2025385472","https://openalex.org/W2028921790","https://openalex.org/W2065419533","https://openalex.org/W2074018301","https://openalex.org/W2097874407","https://openalex.org/W2098077764","https://openalex.org/W2102207725","https://openalex.org/W2104669609","https://openalex.org/W2105969691","https://openalex.org/W2112234440","https://openalex.org/W2114308202","https://openalex.org/W2118986661","https://openalex.org/W2119046820","https://openalex.org/W2123170396","https://openalex.org/W2127696180","https://openalex.org/W2128952811","https://openalex.org/W2132624379","https://openalex.org/W2133103918","https://openalex.org/W2133668754","https://openalex.org/W2146166312","https://openalex.org/W2152245204","https://openalex.org/W2152348310","https://openalex.org/W2155580802","https://openalex.org/W2166232525","https://openalex.org/W2166771071","https://openalex.org/W2168841149","https://openalex.org/W2272291172","https://openalex.org/W2607079988","https://openalex.org/W4210768724","https://openalex.org/W4308769923"],"related_works":["https://openalex.org/W2552602777","https://openalex.org/W2755547878","https://openalex.org/W2329212825","https://openalex.org/W2314906058","https://openalex.org/W2755566013","https://openalex.org/W2334193309","https://openalex.org/W2089883381","https://openalex.org/W2552710750","https://openalex.org/W2024549371","https://openalex.org/W1857270174"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,117,192],"purpose":[2],"of":[3,12,43,82,91,130,148,173,213,229],"this":[4],"study":[5],"was":[6],"to":[7,136,227],"explore":[8],"drug":[9],"retention":[10,124,146,171,211],"rates":[11,81,147,172,212],"second":[13,65,83,95,132,150,175],"biologic":[14,66,84,96,133,151,176],"agents":[15],"after":[16,153,178,197,217],"switching":[17,154,179,218],"from":[18,51,70,155,180,219],"tumor":[19],"necrosis":[20],"factor":[21],"inhibitors":[22],"(TNFi)":[23],"in":[24,27,233],"clinical":[25,201],"practice":[26],"patients":[28,46,100,111,234],"with":[29,160,167,185,189],"rheumatoid":[30],"arthritis":[31],"(RA)":[32],"on":[33,235],"low-dose":[34,236],"methotrexate":[35],"(MTX)":[36],"or":[37,60,105,238],"without":[38,239],"MTX.":[39,240],"METHODS:":[40],"A":[41],"total":[42],"169":[44],"RA":[45],"who":[47],"had":[48,120],"been":[49],"withdrawn":[50],"first-course":[52,102,113],"TNFi":[53,59,93,222],"therapy":[54,134],"and":[55,94,109,163,215,231],"received":[56,101,112],"a":[57,64,121],"different":[58],"tocilizumab":[61],"(TCZ)":[62],"as":[63],"agent":[67,152,177],"were":[68,86,157,182,194,223],"selected":[69],"the":[71,89,131,137,149,174,204,220],"Tsurumai":[72],"Biologics":[73],"Communication":[74],"Registry,":[75],"an":[76],"observational":[77],"cohort":[78],"database.":[79],"Retention":[80],"treatment":[85],"compared":[87,135,226],"by":[88],"type":[90],"first":[92,221],"agents.":[97],"RESULTS:":[98],"Eighty-six":[99],"infliximab":[103],"(IFX)":[104],"adalimumab":[106],"(ADA)":[107],"therapy,":[108],"83":[110],"etanercept":[114],"(ETN)":[115],"therapy.":[116],"former":[118],"group":[119],"significantly":[122,158,183,224],"higher":[123,159,184],"rate":[125],"(IFX,":[126],"81.1%;":[127],"ADA,":[128],"83.3%)":[129],"latter":[138],"(56.6%,":[139],"p":[140],"<":[141],"0.001,":[142],"log-rank":[143],"test).":[144],"Drug":[145,170,210],"IFX/ADA":[156],"ETN":[161,181,230],"(90.0%)":[162],"TCZ":[164,186,232],"(94.7%)":[165],"than":[166,188],"ADA/IFX":[168,190],"(59.3%).":[169],"(75.9%)":[187],"(46.3%).":[191],"differences":[193],"significant":[195],"even":[196],"adjusting":[198],"for":[199],"baseline":[200],"variables":[202],"using":[203],"Cox":[205],"proportional":[206],"hazards":[207],"model.":[208],"CONCLUSIONS:":[209],"IFX":[214],"ADA":[216],"lower":[225],"those":[228],"MTX":[237]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}